公开(公告)号：US20240317861A1

公开(公告)日：2024-09-26

申请号：US18539509

申请日：2023-12-14

Applicant: GENMAB A/S

Inventor： Isil ALTINTAS ,  David SATIJN ,  Edward VAN DEN BRINK ,  Dennis VERZIJL ,  Rik RADEMAKER ,  Paul PARREN ,  Bart DE GOEIJ

IPC: C07K16/28 ,  A61K39/395 ,  A61K45/06 ,  A61P35/00 ,  C07K16/42

CPC classification number: C07K16/2827 ,  A61K39/3955 ,  A61K45/06 ,  A61P35/00 ,  C07K16/2809 ,  C07K16/4258 ,  C07K2317/14 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/35 ,  C07K2317/524 ,  C07K2317/526 ,  C07K2317/53 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/71 ,  C07K2317/732 ,  C07K2317/76 ,  C07K2317/92

Abstract: The present invention relates to novel antibodies and their use in medicine. In particular, the invention relates to bispecific antibodies capable of binding human PD-L1 and capable of binding human CD3. Novel classes of antibodies capable of binding human PD-L1 are also provided. The invention furthermore relates to uses of the antibodies of the invention and to methods, nucleic acid constructs and host cells for producing antibodies of the invention.

公开(公告)号：US20240132620A1

公开(公告)日：2024-04-25

申请号：US18235550

申请日：2023-08-17

Applicant: GENMAB A/S

Inventor： Michel DE WEERS ,  Yvo GRAUS ,  Judith OPRINS ,  Paul PARREN ,  Jan VAN DE WINKEL ,  Martine VAN VUGT

IPC: C07K16/40 ,  A61K39/395 ,  A61K49/00 ,  C07K14/705 ,  C07K16/28 ,  C12N5/10 ,  C12N15/63 ,  G01N33/566

CPC classification number: C07K16/40 ,  A61K39/3955 ,  A61K49/0004 ,  C07K14/70596 ,  C07K16/2896 ,  C12N5/10 ,  C12N15/63 ,  G01N33/566 ,  A61K2039/505 ,  C07K2317/34

Abstract: Isolated human monoclonal antibodies which bind to human CD38, and related antibody-based compositions and molecules, are disclosed. Also disclosed are pharmaceutical compositions comprising the human antibodies, and therapeutic and diagnostic methods for using the human antibodies.

公开(公告)号：US20210395384A1

公开(公告)日：2021-12-23

申请号：US17198199

申请日：2021-03-10

Applicant: Genmab A/S

Inventor： David SATJIN ,  Sandra VERPLOEGEN ,  Wim BLEEKER ,  Steen LISBY ,  Jan VAN DE WINKEL ,  Patrick VAN BERKEL ,  Paul PARREN

IPC: C07K16/30 ,  C07K16/36 ,  A61K47/68 ,  A61K45/06

Abstract: Antibody drug conjugates against tissue factor. Also disclosed are pharmaceutical compositions comprising the antibodies and antibody drug conjugates, and therapeutic and diagnostic methods for using the antibodies and antibody drug conjugates.

公开(公告)号：US20210269509A1

公开(公告)日：2021-09-02

申请号：US17253286

申请日：2019-06-24

Applicant: GENMAB A/S

Inventor： Richard HIBBERT ,  Rob DE JONG ,  Aran Frank LABRIJN ,  Arnout GERRITSEN ,  Janine SCHUURMAN ,  Paul PARREN

IPC: C07K16/00 ,  C07K1/22 ,  C07K1/18

Abstract: The present invention relates to a method for controlling the composition of a mixture of two or more different antibodies, such as tow or more different monoclonal antibodies, using chromatography. The mixture is for use as a drug product and the method includes a controlled downstream process for the production of a predetermined ratio of the two or more different antibodies.

公开(公告)号：US20210230296A1

公开(公告)日：2021-07-29

申请号：US17228023

申请日：2021-04-12

Applicant: GENMAB A/S

Inventor： David SATIJN ,  Esther C. W. BREIJ ,  Bart E. C. G. DE GOEIJ ,  Kristel KEMPER ,  Patrick ENGELBERTS ,  Edward N. VAN DEN BRINK ,  Rik RADEMAKER ,  Dennis VERZIJL ,  Sjeng HORBACH ,  Paul PARREN

IPC: C07K16/30 ,  A61P35/00 ,  C12N15/79

Abstract: The present invention relates to antibodies binding to 5T4, including bispecific antibodies binding to 5T4 and CD3. The invention further provides pharmaceutical compositions comprising the antibodies and use of the antibodies for therapeutic and diagnostic procedures, in particular in cancer therapy.

公开(公告)号：US20200283542A1

公开(公告)日：2020-09-10

申请号：US16793643

申请日：2020-02-18

Applicant: GENMAB A/S

Inventor： Michel DE WEERS ,  Yvo GRAUS ,  Judith OPRINS ,  Paul PARREN ,  Jan VAN DE WINKEL ,  Martine VAN VUGT

IPC: C07K16/40 ,  C07K14/705 ,  C07K16/28 ,  A61K39/395 ,  A61K45/06 ,  A61K49/00 ,  G01N33/566

Abstract: Isolated human monoclonal antibodies which bind to human CD38, and related antibody-based compositions and molecules, are disclosed. Also disclosed are pharmaceutical compositions comprising the human antibodies, and therapeutic and diagnostic methods for using the human antibodies.

公开(公告)号：US20200277397A1

公开(公告)日：2020-09-03

申请号：US16813167

申请日：2020-03-09

Applicant: GENMAB A/S

Inventor： David SATIJN ,  Esther C. W. BREIJ ,  Bart E. C. G. DE GOEIJ ,  Kristel KEMPER ,  Patrick ENGELBERTS ,  Edward N. VAN DEN BRINK ,  Rik RADEMAKER ,  Dennis VERZIJL ,  Sjeng HORBACH ,  Paul PARREN

IPC: C07K16/30 ,  C12N15/79 ,  A61P35/00

Abstract: The present invention relates to antibodies binding to 5T4, including bispecific antibodies binding to 5T4 and CD3. The invention further provides pharmaceutical compositions comprising the antibodies and use of the antibodies for therapeutic and diagnostic procedures, in particular in cancer therapy.

公开(公告)号：US20200270366A1

公开(公告)日：2020-08-27

申请号：US16667369

申请日：2019-10-29

Applicant: GENMAB A/S

Inventor： Joost J. NEIJSSEN ,  Joyce I. MEESTERS ,  Bart DE GOEIJ ,  Aran Frank LABRIJN ,  Paul PARREN ,  Janine SCHUURMAN

IPC: C07K16/46 ,  C07K16/10 ,  C07K16/28 ,  C07K16/32 ,  A61K47/68 ,  A61K39/395 ,  C07K1/113

Abstract: Bispecific antibodies which comprise one antigen-binding region binding to an epitope of human epidermal growth factor receptor 2 (HER2) and one antigen-binding region binding to human CD3, and related antibody-based compositions and molecules, are disclosed. Pharmaceutical compositions comprising the antibodies and methods for preparing and using the antibodies are also disclosed.

公开(公告)号：US20200079872A1

公开(公告)日：2020-03-12

申请号：US16548883

申请日：2019-08-23

Applicant: GENMAB A/S

Inventor： Joost J. NEIJSSEN ,  Bart DE GOEIJ ,  Edward Norbert VAN DEN BRINK ,  Aran Frank LABRIJN ,  Rene HOET ,  Janine SCHUURMAN ,  Paul PARREN ,  Jan VAN DE WINKEL

IPC: C07K16/30 ,  C07K16/40 ,  A61K45/06 ,  A61K39/395 ,  C07K16/28 ,  G01N33/574 ,  A61P35/00

Abstract: Isolated monoclonal antibodies which bind to human c-Met, the hepatocyte growth factor receptor, and related antibody-based compositions and molecules, are disclosed. Pharmaceutical compositions comprising the antibodies and therapeutic and diagnostic methods for using the antibodies are also disclosed.

公开(公告)号：US20200048304A1

公开(公告)日：2020-02-13

申请号：US16426647

申请日：2019-05-30

Applicant: GENMAB A/S

Inventor： Michael GRAMER ,  Amitava KUNDU ,  Ewald T. J. VAN DEN BREMER ,  Muriel VAN KAMPEN ,  Patrick PRIEM ,  Aran Frank LABRIJN ,  Joyce I. MEESTERS ,  Joost J. NEIJSSEN ,  Janine SCHUURMAN ,  Paul PARREN ,  Patrick VAN BERKEL ,  Werner L. VOS ,  Arnout F. GERRITSEN

IPC: C07K1/113 ,  C07K16/46 ,  C07K16/28

Abstract: The present invention relates to an in vitro method for production of heterodimeric proteins.