公开(公告)号：US10752636B2

公开(公告)日：2020-08-25

申请号：US16364487

申请日：2019-03-26

Applicant: Gilead Sciences, Inc.

Inventor： Elizabeth M. Bacon ,  Elbert Chin ,  Jeromy J. Cottell ,  Ashley Anne Katana ,  Darryl Kato ,  John O. Link ,  Nathan Shapiro ,  Teresa Alejandra Trejo Martin ,  Zheng-Yu Yang

IPC: C07D405/14 ,  C07D487/08 ,  C07D491/04 ,  A61P31/18 ,  C07D403/12 ,  C07C275/16 ,  C07D401/12 ,  C07D471/08 ,  C07D487/10 ,  C07C243/28 ,  A61K31/52 ,  A61K31/55 ,  A61K31/553 ,  A61K31/685 ,  A61K31/688 ,  A61K45/06

Abstract: The invention provides a compound of Formula I: or a pharmaceutically acceptable salt thereof as described herein. The invention also provides pharmaceutical compositions comprising a compound of Formula I, processes for preparing compounds of Formula I, therapeutic methods for treating the proliferation of the HIV virus, treating AIDS or delaying the onset of AIDS symptoms in a mammal using compounds of Formula I.

公开(公告)号：US20190308983A1

公开(公告)日：2019-10-10

申请号：US16364487

申请日：2019-03-26

Applicant: Gilead Sciences, Inc.

Inventor： Elizabeth M. Bacon ,  Elbert Chin ,  Jeromy J. Cottell ,  Ashley Anne Katana ,  Darryl Kato ,  John O. Link ,  Nathan Shapiro ,  Teresa Alejandra Trejo Martin ,  Zheng-Yu Yang

IPC: C07D487/08 ,  C07C243/28 ,  A61K31/688 ,  C07D487/10 ,  C07D471/08 ,  C07D401/12 ,  C07C275/16 ,  C07D405/14 ,  C07D403/12 ,  A61K45/06 ,  A61P31/18 ,  A61K31/52 ,  A61K31/55 ,  A61K31/553 ,  A61K31/685 ,  C07D491/04

Abstract: The invention provides a compound of Formula I: or a pharmaceutically acceptable salt thereof as described herin. The invention also provides pharmaceutical compositions comprising a compound of Formula I, processes for preparing compounds of Formula I, therapeutic methods for treating the proliferation of the HIV virus, treating AIDS or delaying the onset of AIDS symptoms in a mammal using compounds of Formula I.

公开(公告)号：US20170369502A1

公开(公告)日：2017-12-28

申请号：US15679014

申请日：2017-08-16

Applicant: Gilead Sciences, Inc.

Inventor： John O. Link ,  Jeromy J. Cottell ,  Teresa Alejandra Trejo Martin ,  Elizabeth M. Bacon

IPC: C07D491/052 ,  A61K45/06 ,  A61K38/21 ,  A61K31/7072 ,  A61K31/7068 ,  A61K31/7056 ,  A61K31/4188 ,  C07D491/04 ,  A61K31/352

CPC classification number: C07D491/052 ,  A61K31/352 ,  A61K31/4188 ,  A61K31/7056 ,  A61K31/7068 ,  A61K31/7072 ,  A61K38/21 ,  A61K45/06 ,  C07D491/04

Abstract: The disclosure is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.

公开(公告)号：US20130177530A1

公开(公告)日：2013-07-11

申请号：US13783056

申请日：2013-03-01

Applicant: Gilead Sciences, Inc.

Inventor： Elizabeth M. Bacon ,  Jeromy J. Cottell ,  Ashley Anne Katana ,  Darryl Kato ,  Evan S. Krygowski ,  John O. Link ,  James Taylor ,  Chinh Viet Tran ,  Teresa Alejandra Trejo Martin ,  Zheng-Yu Yang ,  Sheila Zipfel

IPC: C07D491/052 ,  A61K31/4188 ,  A61K31/7056 ,  A61K45/06 ,  A61K38/21

CPC classification number: C07D491/052 ,  A61K31/4188 ,  A61K31/7056 ,  A61K31/7064 ,  A61K31/7072 ,  A61K38/06 ,  A61K38/07 ,  A61K38/21 ,  A61K45/06 ,  A61K47/60 ,  C07D405/12 ,  C07F5/025 ,  Y10S514/894 ,  A61K2300/00

Abstract: The disclosure is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.