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公开(公告)号：US20240238285A1
公开(公告)日：2024-07-18
申请号：US18543923
申请日：2023-12-18
IPC分类号： A61K31/4985 , C07D471/14 , C07D471/18
CPC分类号： A61K31/4985 , C07D471/14 , C07D471/18
摘要： Compounds for use in the treatment of human immunodeficiency virus (HIV) infection are disclosed. The compounds have the following Formula (I):
including stereoisomers and pharmaceutically acceptable salts thereof, wherein L, R1, R5, W, X, Y1, Y2, and Z are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.-
![Substituted pyrido[1,2-a]pyrrolo[1,2-d]pyrazines for treating viral infections](/abs-image/US/2024/01/30/US11883397B2/abs.jpg.150x150.jpg)
公开(公告)号：US11883397B2
公开(公告)日：2024-01-30
申请号：US17532148
申请日：2021-11-22
IPC分类号： A61K31/4985 , C07D487/22 , C07D471/18 , C07D471/14
CPC分类号： A61K31/4985 , C07D471/14 , C07D471/18
摘要： Compounds for use in the treatment of human immunodeficiency virus (HIV) infection are disclosed. The compounds have the following Formula (I):
including stereoisomers and pharmaceutically acceptable salts thereof, wherein L, R1, R5, W, X, Y1, Y2, and Z are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.-
公开(公告)号：US11078208B1
公开(公告)日：2021-08-03
申请号：US16805933
申请日：2020-03-02
发明人： Elizabeth M. Bacon , Elbert Chin , Jeromy J. Cottell , Ashley Anne Katana , Darryl Kato , John O. Link , Nathan Shapiro , Teresa Alejandra Trejo Martin , Zheng-Yu Yang
IPC分类号： C07D405/14 , C07D487/08 , C07D491/04 , A61P31/18 , A61K45/06 , C07C275/16 , C07D401/12 , C07D471/08 , C07D487/10 , C07C243/28 , A61K31/52 , A61K31/55 , A61K31/553 , A61K31/685 , A61K31/688 , C07D403/12
摘要： The invention provides a compound of Formula I: or a pharmaceutically acceptable salt thereof as described herein. The invention also provides pharmaceutical compositions comprising a compound of Formula I, processes for preparing compounds of Formula I, therapeutic methods for treating the proliferation of the HIV virus, treating AIDS or delaying the onset of AIDS symptoms in a mammal using compounds of Formula I.
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公开(公告)号：US20200215062A1
公开(公告)日：2020-07-09
申请号：US16572159
申请日：2019-09-16
IPC分类号： A61K31/4985 , C07D471/18 , C07D471/14
摘要： Compounds for use in the treatment of human immunodeficiency virus (HIV) infection are disclosed. The compounds have the following Formula (I): including stereoisomers and pharmaceutically acceptable salts thereof, wherein L, R1, R5, W, X, Y1, Y2, and Z are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.
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公开(公告)号：US20180244684A1
公开(公告)日：2018-08-30
申请号：US15876909
申请日：2018-01-22
IPC分类号： C07D491/052 , A61K45/06 , A61K31/352 , C07D491/04 , A61K38/21 , A61K31/7068 , A61K31/7056 , A61K31/4188 , A61K31/7072
CPC分类号： C07D491/052 , A61K31/352 , A61K31/4188 , A61K31/7056 , A61K31/7068 , A61K31/7072 , A61K38/21 , A61K45/06 , C07D491/04
摘要： The disclosure is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
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![SUBSTITUTED 1,2,3,4,6,8,12,12a-OCTAHYDRO-1,4-METHANODIPYRIDO[1,2-a:1',2'-d]PYRAZINES AND METHODS FOR TREATING VIRAL INFECTIONS](/abs-image/US/2016/06/23/US20160176885A1/abs.jpg.150x150.jpg)
6.发明申请SUBSTITUTED 1,2,3,4,6,8,12,12a-OCTAHYDRO-1,4-METHANODIPYRIDO[1,2-a:1',2'-d]PYRAZINES AND METHODS FOR TREATING VIRAL INFECTIONS 有权取代的1,2,3,4,6,8,12,12a-咔唑-1,4-甲基吡啶并[1,2-a：1'，2'-d]吡啶和治疗病毒感染的方法公开(公告)号：US20160176885A1
公开(公告)日：2016-06-23
申请号：US14815504
申请日：2015-07-31
发明人： Haolun Jin , Scott E. Lazerwith , Hyung-Jung Pyun , Manoj C. Desai , Teresa Alejandra Trejo Martin , Elizabeth Bacon , Jeromy J. Cottell , Zhenhong R. Cai , Philip Anthony Morganelli , Mingzhe Ji , James G. Taylor , Xiaowu Chen , Michael R. Mish
IPC分类号： C07D487/14
CPC分类号： C07D498/14 , A61K31/498 , A61K31/4985 , A61K31/529 , A61K31/537 , A61K31/551 , A61K31/553 , A61K45/06 , C07D471/18 , C07D471/22 , C07D487/14 , C07D498/18 , A61K2300/00
摘要： Compounds for use in the treatment of human immunodeficiency virus (HIV) infection are disclosed. The compounds have the following Formula (I): including stereoisomers and pharmaceutically acceptable salts thereof, wherein R1, X, W, Y1, Y2, Z1, and Z4 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.
摘要翻译： 公开了用于治疗人类免疫缺陷病毒（HIV）感染的化合物。 所述化合物具有下式（I）：其包括立体异构体及其药学上可接受的盐，其中R1，X，W，Y1，Y2，Z1和Z4如本文所定义。 还公开了与这种化合物的制备和使用相关的方法以及包含这些化合物的药物组合物。
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公开(公告)号：US09296782B2
公开(公告)日：2016-03-29
申请号：US13934090
申请日：2013-07-02
发明人： Kyla Bjornson , Eda Canales , Jeromy J. Cottell , Kapil Kumar Karki , Ashley Anne Katana , Darryl Kato , Tetsuya Kobayashi , John O. Link , Ruben Martinez , Barton W. Phillips , Hyung-Jung Pyun , Michael Sangi , Adam James Schrier , Dustin Siegel , James G. Taylor , Chinh Viet Tran , Teresa Alejandra Trejo Martin , Randall W. Vivian , Zheng-Yu Yang , Jeff Zablocki , Sheila Zipfel
IPC分类号： A61K6/00 , C07K1/00 , C07K5/08 , C07D498/16 , A61K31/4985 , C07D498/22 , A61K31/4745 , A61K31/506 , A61K31/519 , A61K45/06 , C07K5/087 , C07K5/083 , A61K38/21 , A61K38/06 , A61K38/00
CPC分类号： A61K31/498 , A61K31/10 , A61K31/401 , A61K31/4745 , A61K31/4985 , A61K31/506 , A61K31/519 , A61K38/00 , A61K38/06 , A61K38/21 , A61K45/06 , C07D241/36 , C07D403/14 , C07D498/16 , C07D498/22 , C07K5/08 , C07K5/0808 , C07K5/0812 , C07K5/0827 , A61K2300/00
摘要： Compounds of Formula I are disclosed As well as pharmaceutically acceptable salts thereof. Methods of using said compounds and pharmaceutical compositions containing said compounds are also disclosed.
摘要翻译： 公开的式I化合物及其药学上可接受的盐。 还公开了使用所述化合物和含有所述化合物的药物组合物的方法。
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公开(公告)号：US10294234B2
公开(公告)日：2019-05-21
申请号：US15888749
申请日：2018-02-05
发明人： Elizabeth M. Bacon , Elbert Chin , Jeromy J. Cottell , Ashley Anne Katana , Darryl Kato , John O. Link , Nathan Shapiro , Teresa Alejandra Trejo Martin , Zheng-Yu Yang
IPC分类号： C07D487/08 , A61K31/444 , A61K31/506 , A61P31/18 , C07D403/12 , C07D405/14 , C07C275/16 , C07D401/12 , C07D471/08 , C07D487/10 , C07D491/04 , C07C243/28 , A61K31/52 , A61K31/55 , A61K31/553 , A61K31/685 , A61K31/688 , A61K45/06
摘要： The invention provides a compound of Formula I: or a pharmaceutically acceptable salt thereof as described herein. The invention also provides pharmaceutical compositions comprising a compound of Formula I, processes for preparing compounds of Formula I, therapeutic methods for treating the proliferation of the HIV virus, treating AIDS or delaying the onset of AIDS symptoms in a mammal using compounds of Formula I.
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![Substituted 2,3,4,5,7,9,13,13a-octahydro-1,5-methanopyrido[1′,2′:4,5]pyrazino[1,2-a][1,3]diazepines and methods for treating viral infections](/abs-image/US/2018/07/31/US10035809B2/abs.jpg.150x150.jpg)
公开(公告)号：US10035809B2
公开(公告)日：2018-07-31
申请号：US15599151
申请日：2017-05-18
发明人： Elizabeth M. Bacon , Zhenhong R. Cai , Xiaowu Chen , Jeromy J. Cottell , Manoj C. Desai , Mingzhe Ji , Haolun Jin , Scott E. Lazerwith , Michael R. Mish , Philip Anthony Morganelli , Hyung-Jung Pyun , James G. Taylor , Teresa Alejandra Trejo Martin
IPC分类号： A61K31/4985 , C07D487/04 , C07D498/14 , A61K31/537 , C07D471/22 , A61K31/529 , A61K31/551 , A61K31/553 , C07D471/18 , A61K45/06 , C07D498/18 , C07D487/14 , A61K31/498
CPC分类号： C07D498/14 , A61K31/498 , A61K31/4985 , A61K31/529 , A61K31/537 , A61K31/551 , A61K31/553 , A61K45/06 , C07D471/18 , C07D471/22 , C07D487/14 , C07D498/18 , A61K2300/00
摘要： Compounds for use in the treatment of human immunodeficiency virus (HIV) infection are disclosed. The compounds have the following Formula (I): including stereoisomers and pharmaceutically acceptable salts thereof, wherein R1, X, W, Y1, Y2, Z1, and Z4 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.
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公开(公告)号：US20170290827A1
公开(公告)日：2017-10-12
申请号：US15488035
申请日：2017-04-14
发明人： Kyla Bjornson , Eda Canales , Jeromy J. Cottell , Kapil K. Karki , Ashley A. Katana , Darryl Kato , Tetsuya Kobayashi , John O. Link , Ruben Martinez , Barton W. Phillips , Hyung-Jung Pyun , Michael Sangi , Adam J. Schrier , Dustin Siegel , James G. Taylor , Chinh V. Tran , Teresa Alejandra Trejo Martin , Randall W. Vivian , Zheng-Yu Yang , Jeff Zablocki , Sheila M. Zipfel
IPC分类号： A61K31/498 , C07D403/14 , C07D241/36 , A61K31/401 , A61K31/10
摘要： Compounds of Formula I are disclosed As well as pharmaceutically acceptable salts thereof. Methods of using said compounds and pharmaceutical compositions containing said compounds are also disclosed.
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