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公开(公告)号：US20090118244A1
公开(公告)日：2009-05-07
申请号：US12266239
申请日：2008-11-06
Applicant: Gary D. Glick
Inventor： Gary D. Glick
IPC: A61K31/5513 , C07D243/14 , A61K31/56 , A61K31/59 , C12N5/08 , A61P17/06 , A61P17/00
CPC classification number: C07D243/24 , A61K31/5513 , A61K45/06
Abstract: The present invention provides a family of benzodiazepinone compounds and pharmaceutical compositions thereof. The present invention also provides methods of treating certain skin conditions, e.g., atopic dermatitis, rosacea, or psoriasis, by administering a benzodiazepinone and methods of reducing the proliferation of keratinocyte cells by exposing such cells to a benzodiazepinone.
Abstract translation: 本发明提供一种苯并二氮杂酮化合物及其药物组合物。 本发明还提供了通过施用苯并二氮杂酮来治疗某些皮肤病症例如特应性皮炎，红斑痤疮或银屑病的方法以及通过将这些细胞暴露于苯并二氮杂酮来降低角化细胞细胞的增殖的方法。
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42.发明授权公开(公告)号：US09139532B2
公开(公告)日：2015-09-22
申请号：US13992255
申请日：2011-12-08
Applicant: Gary D. Glick , Alexander R. Hurd , Clarke B. Taylor , Chad A. Van Huis
Inventor： Gary D. Glick , Alexander R. Hurd , Clarke B. Taylor , Chad A. Van Huis
IPC: A61K31/5377 , A61K31/4439 , A61K31/425 , A61K31/42 , A61K31/415 , C07D231/38 , C07D231/40 , C07D401/12 , C07D405/12 , C07D409/12 , C07D417/12 , C07D487/14 , C07D413/12 , C07D409/04 , C07D401/14 , C07D413/14
CPC classification number: C07D231/38 , A61K31/44 , A61K31/4439 , A61K31/5377 , C07D231/40 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D409/04 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D487/14
Abstract: The invention provides pyrazolyl guanidine compounds that inhibit F1Fo-ATPase, and methods of using pyrazolyl guanidine compounds as therapeutic agents to treat medical disorders, such as an immune disorder, inflammatory condition, or cancer.
Abstract translation: 本发明提供了抑制F1Fo-ATP酶的吡唑基胍化合物，以及使用吡唑基胍化合物作为治疗药物治疗医学病症如免疫疾病，炎性病症或癌症的方法。
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43.发明申请公开(公告)号：US20140051727A1
公开(公告)日：2014-02-20
申请号：US13992254
申请日：2011-12-08
Applicant: Gary D. Glick , Alexander R. Hurd , Matthew N. Mattson , Clarke B. Taylor , Chad A. Van Huis
Inventor： Gary D. Glick , Alexander R. Hurd , Matthew N. Mattson , Clarke B. Taylor , Chad A. Van Huis
IPC: C07D213/75 , C07D401/12 , C07D213/76 , C07D413/12 , C07D405/12
CPC classification number: A61K31/44 , A61K31/4433 , A61K31/4439 , A61K31/444 , C07D213/75 , C07D213/76 , C07D401/12 , C07D405/12 , C07D413/12
Abstract: The invention provides pyridonyl guanidine compounds that inhibit F1F0-ATPase, and methods of using pyridonyl guanidine compounds as therapeutic agents to treat medical disorders, such as an immune disorder, inflammatory condition, or cancer.
Abstract translation: 本发明提供抑制F1F0-ATP酶的吡啶酮胍化合物，以及使用吡啶酮胍化合物作为治疗药物治疗诸如免疫病症，炎性病症或癌症的医学病症的方法。
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公开(公告)号：US08497307B2
公开(公告)日：2013-07-30
申请号：US13062741
申请日：2009-09-11
Applicant: Gary D. Glick , Peter Toogood , Gina Ney
Inventor： Gary D. Glick , Peter Toogood , Gina Ney
IPC: A61K31/155 , A01N37/52 , C07C277/00 , C07C279/00
CPC classification number: A61K31/40 , A61K31/70 , C07D209/34 , C07D231/56 , C07D233/64 , C07D235/26 , C07D239/54 , C07D241/44 , C07D263/58 , C07D277/68
Abstract: The invention provides to a family of aryl guanidine—based F1F0—ATPase inhibitors, e.g., mitochondrial F1F0—ATPase inhibitors, methods for their discovery, and their use as therapeutic agents for treating certain disorders.
Abstract translation: 本发明提供了一种基于芳基胍的F1F0-ATP酶抑制剂，例如线粒体F1F0-ATP酶抑制剂，其发现方法及其作为治疗某些疾病的治疗剂的用途。
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45.发明申请公开(公告)号：US20120289498A1
公开(公告)日：2012-11-15
申请号：US13545546
申请日：2012-07-10
Applicant: Gary D. Glick
Inventor： Gary D. Glick
IPC: A61K31/5513 , A61P37/00 , A61P35/00 , A61P29/00 , A61P37/06 , A61P17/06 , A61P25/00 , A61P1/00 , A61P7/02 , A61P35/02 , A61P11/06 , C07D243/24 , A61P19/04
CPC classification number: C07D403/04 , C07D243/24
Abstract: The present invention relates to novel chemical compounds, methods for their discovery, and their therapeutic use. In particular, the present invention provides benzodiazepine compounds, and structurally and functionally related compounds, and methods of using such compounds as therapeutic agents to treat a number of conditions associated with the faulty regulation of the processes of programmed cell death, autoimmunity, inflammation, hyperproliferation, vascular abnormalities, and the like.
Abstract translation: 本发明涉及新型化合物，其发现方法及其治疗用途。 特别地，本发明提供了苯并二氮杂类化合物以及结构和功能上相关的化合物，以及使用这些化合物作为治疗剂来治疗与程序性细胞死亡，自身免疫，炎症，过度增生过程的错误调控相关的许多病症的方法 ，血管异常等。
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Patent Agency Ranking
46.发明申请1,4-BENZODIAZEPINE-2,5-DIONES AND RELATED COMPOUNDS WITH THERAPEUTIC PROPERTIES 有权1,4-苯并二氮杂-2,5-DIONES及相关化合物与治疗性质公开(公告)号：US20120283229A1
公开(公告)日：2012-11-08
申请号：US13508256
申请日：2010-11-03
Applicant: Gary D. Glick
Inventor： Gary D. Glick
IPC: A61K31/5513 , A61P9/00 , A61P37/00 , A61P9/10 , A61P9/04 , A61P7/02 , A61P7/04 , A61P9/12 , A61P11/06 , A61P27/06 , A61P15/00 , A61P29/00 , A61P19/02 , A61P25/00 , A61P1/00 , A61P37/02 , A61K31/56 , A61P19/06 , A61P31/00 , C12N5/071 , C12N5/09 , C07D401/06
CPC classification number: A61K31/5513 , A61K45/06 , C07D401/10 , C07D487/04 , Y02A50/401 , Y02A50/475 , Y02A50/481
Abstract: The present invention provides novel chemical compounds characterized as Rho kinase (ROCK) inhibitors, methods for their discovery, and their therapeutic, research, and diagnostic use. In particular, the present invention provides 1,4-benzodiazepine-2,5-dione compounds and related compounds having ROCK inhibitory activity, and methods of using such compounds as therapeutic agents to treat a number of conditions associated with ROCK activity.
Abstract translation: 本发明提供以Rho激酶（ROCK）抑制剂为特征的新型化合物，其发现方法及其治疗，研究和诊断用途。 特别地，本发明提供具有ROCK抑制活性的1,4-苯并二氮杂-2,5-二酮化合物和相关化合物，以及使用这些化合物作为治疗剂来治疗与ROCK活性相关的许多病症的方法。
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47.发明申请公开(公告)号：US20120214801A1
公开(公告)日：2012-08-23
申请号：US13327345
申请日：2011-12-15
Applicant: Gary D. Glick
Inventor： Gary D. Glick
IPC: A61K31/5513 , A61P37/00 , A61P35/00 , A61P17/06 , A61P37/06 , A61P19/02 , A61P35/02 , A61P11/06 , C07D243/24 , A61P29/00
CPC classification number: C07D401/12 , C07D243/24 , C07D403/10 , C07D403/12 , C07D405/10 , C07D409/12
Abstract: The present invention relates to novel chemical compounds, methods for their discovery, and their therapeutic use. In particular, the present invention provides benzodiazepine derivatives and related compounds and methods of using benzodiazepine derivatives and related compounds as therapeutic agents to treat a number of conditions associated with the faulty regulation of the processes of programmed cell death, autoimmunity, inflammation, hyperproliferation, and the like.
Abstract translation: 本发明涉及新型化合物，其发现方法及其治疗用途。 特别地，本发明提供苯并二氮杂衍生物和相关化合物以及使用苯并二氮杂衍生物和相关化合物作为治疗剂来治疗与程序性细胞死亡，自身免疫，炎症，过度增殖以及 类似。
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48.发明授权公开(公告)号：US08188072B2
公开(公告)日：2012-05-29
申请号：US12266239
申请日：2008-11-06
Applicant: Gary D. Glick
Inventor： Gary D. Glick
IPC: A61K31/55 , C07D243/18 , A61P17/00 , A61P17/06
CPC classification number: C07D243/24 , A61K31/5513 , A61K45/06
Abstract: The present invention provides a family of benzodiazepinone compounds and pharmaceutical compositions thereof. The present invention also provides methods of treating certain skin conditions, e.g., atopic dermatitis, rosacea, or psoriasis, by administering a benzodiazepinone and methods of reducing the proliferation of keratinocyte cells by exposing such cells to a benzodiazepinone.
Abstract translation: 本发明提供一种苯并二氮杂酮化合物及其药物组合物。 本发明还提供了通过施用苯并二氮杂酮来治疗某些皮肤病症例如特应性皮炎，红斑痤疮或银屑病的方法以及通过将这些细胞暴露于苯并二氮杂酮来降低角化细胞细胞的增殖的方法。
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49.发明授权Benzodiazepine compositions for treating epidermal hyperplasia and related disorders 有权用于治疗表皮增生和相关疾病的苯二氮卓类药物公开(公告)号：US08168626B2
公开(公告)日：2012-05-01
申请号：US12728716
申请日：2010-03-22
Applicant: Gary D. Glick
Inventor： Gary D. Glick
IPC: A01N43/62
CPC classification number: A61K31/5513 , A61K31/05 , A61K31/573 , A61K31/59 , A61K35/04 , Y10S514/863 , A61K2300/00
Abstract: The present invention provides, for example, pharmaceutical compositions comprising a benzodiazepine compound and an agent selected from the group consisting of a topical steroid, a keratolytic agent, a topical retinoid, a coal tar, and a vitamin D-3 analog. The pharmaceutical compositions are useful for treating medical disorders, such as epidermal hyperplasia.
Abstract translation: 本发明提供了例如包含苯并二氮杂化合物和选自局部类固醇，角质分解剂，局部类视色素，煤焦油和维生素D-3类似物的药剂的药物组合物。 药物组合物可用于治疗医学病症，例如表皮增生。
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50.发明授权公开(公告)号：US08097612B2
公开(公告)日：2012-01-17
申请号：US12303272
申请日：2007-06-08
Applicant: Gary D. Glick
Inventor： Gary D. Glick
IPC: C07D243/12 , A61K31/55
CPC classification number: C07D401/12 , C07D243/24 , C07D403/10 , C07D403/12 , C07D405/10 , C07D409/12
Abstract: The present invention relates to novel chemical compounds, methods for their discovery, and their therapeutic use. In particular, the present invention provides benzodiazepine derivatives and related compounds and methods of using benzodiazepine derivatives and related compounds as therapeutic agents to treat a number of conditions associated with the faulty regulation of the processes of programmed cell death, autoimmunity, inflammation, hyperproliferation, and the like.
Abstract translation: 本发明涉及新型化合物，其发现方法及其治疗用途。 特别地，本发明提供苯并二氮杂衍生物和相关化合物以及使用苯并二氮杂衍生物和相关化合物作为治疗剂来治疗与程序性细胞死亡，自身免疫，炎症，过度增殖以及 类似。
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