公开(公告)号：US06304084B1

公开(公告)日：2001-10-16

申请号：US09019967

申请日：1998-02-06

申请人： John Star-Lack ,  John M. Pauly ,  Daniel B. Vigneron

发明人： John Star-Lack ,  John M. Pauly ,  Daniel B. Vigneron

IPC分类号： G01V300

CPC分类号： G01R33/446

摘要： The present invention uses spectral-spatial 180° refocusing pulses in the point resolved spectroscopy (PRESS) localization sequence. The PRESS sequence uses a series of three pulses having a tilt angle pattern of 90°-180°-180°. The first excitation pulses in the present invention is a spatially selective 90° tilt angle pulse. The following two pulses are spectral-spatial refocusing pulses which provide multi-dimensional selectivity. This feature allows for enhanced solvent suppression, reduced chemical shift induced spatial displacement and an ability to refocus weakly coupled spins. In a preferred embodiment, the spectral-spatial pulses are time-asymmetric and identical, providing for a linear phase profile by means of phase compensation between the two refocusing pulses. Alternatively, a linear phase profile can be provided by using time-symmetric refocusing pulses. The time-asymmetric feature is preferred because it results in lower applied RF power and shorter echo times.

摘要翻译： 本发明在点解析光谱（PRESS）定位序列中使用光谱空间180重新聚焦脉冲。 PRESS序列使用一系列具有90-180 -180的倾斜角度图案的三个脉冲。 本发明中的第一激发脉冲是空间选择性90°倾斜角脉冲。 以下两个脉冲是提供多维选择性的光谱 - 空间重聚焦脉冲。 该特征允许增强溶剂抑制，减少化学位移引起的空间位移和重新聚焦弱耦合旋转的能力。 在优选实施例中，频谱空间脉冲是时间不对称的和相同的，通过两个重聚焦脉冲之间的相位补偿提供线性相位分布。 或者，可以通过使用时间对称重新聚焦脉冲来提供线性相位分布。 时间不对称特征是优选的，因为它导致较低的施加的RF功率和较短的回波时间

公开(公告)号：US6020739A

公开(公告)日：2000-02-01

申请号：US845343

申请日：1997-04-25

申请人： Craig H. Meyer ,  John M. Pauly

发明人： Craig H. Meyer ,  John M. Pauly

IPC分类号： G01V3/00

CPC分类号： G01R33/4824

摘要： Spiral gradient design for a k-space trajectory using gradient amplifier parameters includes first determining an angle between a given gradient, g.sub.n, and the next gradient, g.sub.n+1, and then determining the magnitude of .vertline.g.sub.n+1 .vertline. based on gradient constraints represented by a circle or other shape surrounding and offset from the distal end of g.sub.n, where g.sub.n+1 extends along

摘要翻译： 使用梯度放大器参数的k空间轨迹的螺旋梯度设计包括首先确定给定梯度gn和下一个梯度gn + 1之间的角度，然后确定| gn + 1 | 基于由围绕和偏离gn的远端的圆或其他形状表示的梯度约束，其中gn + 1沿着

公开(公告)号：US5957843A

公开(公告)日：1999-09-28

申请号：US515090

申请日：1995-08-14

申请人： Gerard T. Luk Pat ,  Craig H. Meyer ,  John M. Pauly ,  Dwight G. Nishimura

发明人： Gerard T. Luk Pat ,  Craig H. Meyer ,  John M. Pauly ,  Dwight G. Nishimura

IPC分类号： G01R33/561 ,  A61B5/055

CPC分类号： G01R33/5615 ,  G01R33/5616

摘要： Flyback imaging is combined with echo planar imaging (EPI) for improved readout flow properties. For increases in imaging time of 50% or less, significant improvements in imaging are realized. The partial flyback improves partial-Fourier EPI and inside-out EPI and can be applied to any EPI trajectory.

摘要翻译： 反激成像与回波平面成像（EPI）相结合，可提高读数流动特性。 对于50％以下的成像时间的增加，可以实现成像的显着改善。 部分回扫提高了部分傅里叶EPI和内向外EPI，并且可以应用于任何EPI轨迹。

公开(公告)号：US5588431A

公开(公告)日：1996-12-31

申请号：US516243

申请日：1995-08-17

申请人： Sanjay Mani ,  Dwight G. Nishimura ,  Steven M. Conolly ,  John M. Pauly

发明人： Sanjay Mani ,  Dwight G. Nishimura ,  Steven M. Conolly ,  John M. Pauly

IPC分类号： A61B5/026 ,  G01R33/563 ,  A61B5/055

CPC分类号： G01R33/5635 ,  A61B5/0263 ,  G01R33/5602

摘要： Multiple inversion recovery flow imaging employs at least four spin inversion pulses following saturation of static nuclei spins to null nuclei in static material having different spin-lattice relaxation times (T.sub.1) with the inversion pulses being spaced in time to substantially reduce the longitudinal magnetization of the T.sub.1 species present. The saturation of static nuclei spins includes applying a sequence of saturation pulses with adjacent pulses being separated by a diphasing gradient to avoid refocusing coherence. The detection of signals includes applying at least one RF read-out pulse near the nulling point.

摘要翻译： 多反转恢复流成像在静态核自旋饱和之后采用至少四个自旋反转脉冲，使具有不同自旋晶格弛豫时间（T1）的静态材料中的零核，其中反转脉冲在时间上间隔开，从而基本上减小了 T1种存在。 静态核自旋的饱和度包括施加饱和脉冲序列，其中相邻脉冲被双相梯度分离以避免重新聚焦相干。 信号的检测包括在零点附近应用至少一个RF读出脉冲。

公开(公告)号：US5311132A

公开(公告)日：1994-05-10

申请号：US920959

申请日：1992-07-28

申请人： Douglas C. Noll ,  John M. Pauly ,  Albert Macovski

发明人： Douglas C. Noll ,  John M. Pauly ,  Albert Macovski

IPC分类号： G01R33/565 ,  G01R33/20

CPC分类号： G01R33/56563 ,  G01R33/56527

摘要： Disclosed is a method for automatically removing blur in magnetic resonance image signals introduced due to inhomogeneity in the magnetic field and variations in magnetic susceptibility of an object being imaged. Detected signals are demodulated at several different frequencies and reconstructed to create a series of base images. The amount of blur is determined by establishing a focusing measure for each point or part in each base image, and a composite image is then constructed using only the unblurred regions from each base image. Focusing criterion can include minimization of the imaginary part of the complex MRI after removal of constant and low frequency phase information.

摘要翻译： 公开了一种用于自动消除由于磁场不均匀性引起的磁共振图像信号中的模糊和被成像对象的磁化率的变化的方法。 检测到的信号在几个不同的频率下进行解调，并重构以产生一系列基本图像。 通过为每个基本图像中的每个点或部分建立聚焦测量来确定模糊的量，然后仅使用来自每个基本图像的未加密的区域来构造合成图像。 聚焦准则可以包括去除恒定和低频相位信息后复杂MRI的虚部的最小化。

公开(公告)号：US5283526A

公开(公告)日：1994-02-01

申请号：US908098

申请日：1992-07-01

申请人： Daniel M. Spielman ,  John M. Pauly

发明人： Daniel M. Spielman ,  John M. Pauly

IPC分类号： G01R33/48 ,  G01R33/54 ,  G01R33/20

CPC分类号： G01R33/446 ,  G01R33/4828

摘要： A new pulse sequence which uses inversion recovery for lipid suppression and a spectral-spatial refocusing pulse for water suppression in spectroscopic imaging of the brain. In contrast to methods which eliminate fat by restricting the excited volume to lie completely within the brain, inversion recovery techniques allow imaging of an entire slice without such restrictions. A spectral-spatial pulse provides water suppression insensitive to a reasonable range of B.sub.0 and B.sub.1 inhomogeneities. Metabolite maps covering large volumes of the human brain can be produced with images from single and multiple slices obtained.

摘要翻译： 一种新的脉冲序列，其使用用于脂质抑制的反转恢复和用于大脑光谱成像中的水抑制的光谱 - 空间重聚焦脉冲。 与通过将激发体积限制在脑内完全消除脂肪的方法相反，反转恢复技术允许整个切片的成像而没有这种限制。 光谱空间脉冲提供对B0和B1不均匀性的合理范围不敏感的水分抑制。 覆盖大量人脑的代谢物图可以通过获得单片和多片的图像产生。

公开(公告)号：US5270653A

公开(公告)日：1993-12-14

申请号：US866732

申请日：1992-04-10

申请人： John M. Pauly

发明人： John M. Pauly

IPC分类号： G01R33/48 ,  G01R33/563 ,  G01R33/20

CPC分类号： G01R33/446 ,  G01R33/563 ,  G01R33/56333

摘要： A method of selectively exciting nuclear spins in a limited three-dimensional volume comprising the steps of applying a plurality of subpulses in the presence of three orthogonal magnetic gradients (G.sub.x, G.sub.y, G.sub.z) over a period of time to define a k-space trajectory including a plurality of stacked two-dimensional k-space spirals arranged in pairs with each pair having an outward spiral and an inward spiral, the steps of one spiral to the next spiral corresponding to gradient pulses (G.sub.z) alternately at the edge and at the origin of each k-space spiral plane. The selective three-dimensional excitation pulse can be used with a non-selective 90.degree. pulse to the volume prior to applying the plurality of RF subpulses and allowing nuclear spins in the volume to precess, then applying the plurality of RF subpulses to selectively refocus nuclear spins in the volume, and detecting and echo signal. The selective three-dimensional excitation pulse can be used also to tag nuclear spins of moving fluid such as blood in the volume and detecting echo signals from the tagged nuclear spins in a selective inversion recovery angiography method for coronary artery imaging.

摘要翻译： 一种在有限的三维体积中选择性地激励核自旋的方法，包括以下步骤：在三个正交磁梯度（Gx，Gy，Gz）存在下在一段时间内施加多个子脉冲以定义k空间轨迹 包括与每对成对配置的多个具有向外螺旋和向内螺旋的堆叠的二维k空间螺旋，在边缘处和在边缘处交替地对应于梯度脉冲（Gz）的一个螺旋到下一个螺旋的步骤 每个k空间螺旋平面的起点。 选择性三维激励脉冲可以在施加多个RF子脉冲之前以非选择性90度脉冲与体积一起使用，并允许体积中的核自旋进动，然后施加多个RF子脉冲以选择性地重新聚焦核 旋转体积，并检测和回波信号。 选择性三维激发脉冲还可以用于标记体积中的运动流体如血液的核自旋，并且在用于冠状动脉成像的选择性反转恢复血管造影术中检测来自标记的核自旋的回波信号。

公开(公告)号：US5212448A

公开(公告)日：1993-05-18

申请号：US743547

申请日：1991-08-09

申请人： Patrick L. Le Roux ,  John M. Pauly

发明人： Patrick L. Le Roux ,  John M. Pauly

IPC分类号： A61B5/055 ,  G01R33/46 ,  G01R33/48 ,  G01R33/561

CPC分类号： G01R33/446 ,  G01R33/5615 ,  G01R33/5617

摘要： An NMR system acquires data for producing an image using a spin-warp burst excitation pulse sequence. RF phase and flip-angle of each RF excitation pulse in the burst is separately controlled to maximize the SNR of the corresponding set of acquired NMR echo signals. The phase and amplitude of each acquired NMR echo signal is adjusted by an amount determined by its corresponding excitation pulse before being used for image reconstruction.

摘要翻译： NMR系统使用自旋脉冲脉冲串脉冲序列获取用于产生图像的数据。 分别控制脉冲串中的每个RF激励脉冲的RF相位和翻转角，以使相应的一组获取的NMR回波信号的SNR最大化。 每个采集的NMR回波信号的相位和振幅在被用于图像重构之前由其对应的激励脉冲确定的量调整。

公开(公告)号：US10096109B1

公开(公告)日：2018-10-09

申请号：US15475760

申请日：2017-03-31

申请人： Greg Zaharchuk ,  Enhao Gong ,  John M. Pauly

发明人： Greg Zaharchuk ,  Enhao Gong ,  John M. Pauly

IPC分类号： G06K9/00 ,  G06T7/00 ,  G06T3/60

摘要： A method of improving diagnostic and functional imaging is provided by obtaining at least two input images of a subject, using a medical imager, where each input image includes a different contrast, generating a plurality of copies of the input images using non-local mean (NLM) filtering, using an appropriately programmed computer, where each input image copy of the subject includes different spatial characteristics, obtaining at least one reference image of the subject, using the medical imager, where the reference image includes imaging characteristics that are different form the input images of the subject, training a deep network model, using data augmentation on the appropriately programmed computer, to adaptively tune model parameters to approximate the reference image from an initial set of the input and reference images, with the goal of outputting an improved quality image of other sets of low SNR low resolution images, for analysis by a physician.

公开(公告)号：US09170312B2

公开(公告)日：2015-10-27

申请号：US13360510

申请日：2012-01-27

申请人： Peder Larson ,  Adam B. Kerr ,  John M. Pauly ,  Daniel B. Vigneron

发明人： Peder Larson ,  Adam B. Kerr ,  John M. Pauly ,  Daniel B. Vigneron

IPC分类号： G01V3/00 ,  G01R33/46 ,  G01R33/563 ,  G01R33/485 ,  G01R33/56

CPC分类号： G01R33/4608 ,  G01R33/4616 ,  G01R33/485 ,  G01R33/5601 ,  G01R33/5605 ,  G01R33/56333

摘要： A method for imaging a substrate and product over time is provided. The substrate and product are magnetically tagged with at least one magnetic gradient where magnetically tagging provides a tag-dependent signal phase for the substrate and a different tag-dependent signal phase for the product. At least one readout of magnetically tagged substrate and product is provided over time. The tag-dependent signal phase is used to determine product that has been transformed from magnetically tagged substrate and substrate that has been transformed from magnetically tagged product over time.

摘要翻译： 提供了一种用于对衬底和产品随时间成像的方法。 衬底和产品用至少一个磁梯度进行磁性标记，其中磁性标签为衬底提供与标签相关的信号相位，并为产品提供不同的标签依赖信号相位。 随着时间的推移，提供至少一个磁性标记的基板和产品读数。 标签依赖信号相位用于确定已经从磁标记的产品随时间变换的磁性标记的基底和底物转变的产物。