公开(公告)号：US20110117572A1

公开(公告)日：2011-05-19

申请号：US13011386

申请日：2011-01-21

申请人： Sunghoon Kim ,  Jin Woo Choi

发明人： Sunghoon Kim ,  Jin Woo Choi

IPC分类号： G01N33/566 ,  C07K16/40

CPC分类号： C07K16/30 ,  C12Q1/6886 ,  C12Q2600/136 ,  C12Q2600/158 ,  G01N33/57423 ,  G01N33/57438 ,  G01N2500/04

摘要： The present invention relates to a variant of AIMP2 lacking exon 2 gene, named as AIMP2-DX2 gene, which is specifically expressed in cancer cells. The AIMP2-DX2 gene and siRNA targeting AIMP2-DX2 can be successfully used in the development of diagnosis and treatment of cancer

摘要翻译： 本发明涉及在癌细胞中特异性表达的缺失外显子2基因的AIMP2的变体，命名为AIMP2-DX2基因。 AIMP2-DX2基因和靶向AIMP2-DX2的siRNA可以成功应用于癌症诊断和治疗的发展

公开(公告)号：US20050119175A1

公开(公告)日：2005-06-02

申请号：US10623567

申请日：2003-07-22

申请人： Sunghoon Kim

发明人： Sunghoon Kim

IPC分类号： A61K38/16 ,  A61K38/19 ,  A61P17/02 ,  A61K38/18

CPC分类号： A61K38/19

摘要： The present invention relates to a method for stimulating wound healing, and more particularly to a method for stimulating wound healing in a subject in need thereof, comprising administering to a wound of the subject an effective amount for stimulating wound healing of a composition, wherein the composition comprises p43 having an amino acid sequence set forth in SEQ ID NO: 1 or functional equivalents thereof. The composition used in the method of the present invention can be efficiently utilized for the wound healing, since p43, an effective ingredient of the composition, has an excellent effect on the wound healing by its action including the induction of macrophage/monocyte and endothelial cell, re-epithelization, proliferation of fibroblasts or angiogenesis.

摘要翻译： 本发明涉及一种刺激伤口愈合的方法，更具体地涉及刺激有需要的受试者的伤口愈合的方法，包括对受试者的伤口施用有效量刺激组合物的伤口愈合，其中 组合物包含具有SEQ ID NO：1所示氨基酸序列的p43或其功能等同物。 本发明方法中使用的组合物可有效地用于伤口愈合，因为组合物的有效成分p43通过包括诱导巨噬细胞/单核细胞和内皮细胞的作用对伤口愈合具有优异的作用 ，再上皮化，成纤维细胞增殖或血管发生。

公开(公告)号：US08901081B2

公开(公告)日：2014-12-02

申请号：US13123522

申请日：2009-10-12

申请人： Sunghoon Kim ,  Min Chul Park

发明人： Sunghoon Kim ,  Min Chul Park

IPC分类号： C07K1/00 ,  A61K38/24 ,  A61K38/27 ,  A61K38/00 ,  A61K38/53

CPC分类号： C12Y601/01014 ,  A61K38/53

摘要： The present invention is related to a anticancer composition comprising full length GRS protein or a fragment thereof, a nucleic acid encoding the GRS protein or a fragment thereof. Since the GRS proteins or fragments thereof have activity to induce apoptosis of cancer cell specifically, a composition comprising the GRS proteins or fragments thereof or a nucleic acid encoding thereof may be useful to treatment of cancer.

摘要翻译： 本发明涉及包含全长GRS蛋白或其片段，编码GRS蛋白或其片段的核酸的抗癌组合物。 由于GRS蛋白质或其片段具有特异性诱导癌细胞凋亡的活性，所以包含GRS蛋白质或其片段或其编码核酸的组合物可用于治疗癌症。

公开(公告)号：US20130202950A1

公开(公告)日：2013-08-08

申请号：US13552480

申请日：2012-07-18

申请人： Sungkab Kim ,  Sukje Kim ,  Seongwon Yoon ,  Gunho Kwak ,  Sunghoon Kim

发明人： Sungkab Kim ,  Sukje Kim ,  Seongwon Yoon ,  Gunho Kwak ,  Sunghoon Kim

IPC分类号： H01M2/30 ,  H01M2/00 ,  B05D3/02

CPC分类号： C09D1/00 ,  H01M2/026 ,  H01M2/0267 ,  H01M2/0292 ,  H01M2/32 ,  H01M10/052

摘要： A lithium rechargeable battery having corrosion resistance and a method of making the same. In the lithium rechargeable battery including a metal case, a cap plate and terminals, a protective layer is formed on at least portions of surfaces of the metal case, the cap plate and the terminals, and the protective layer is formed of a protective layer forming composition comprising at least one hydrophobic compound selected from the group consisting of substituted or unsubstituted 1,2,3-benzotriazole, alkoxysilance having 1 to 20 carbons, vinylakoxy silane having having 1 to 20 carbons, and (meth)acryl silane, and chromic oxide.

摘要翻译： 具有耐腐蚀性的锂可充电电池及其制造方法。 在包括金属壳体，盖板和端子的锂可充电电池中，在金属外壳，盖板和端子的至少一部分表面上形成保护层，保护层由保护层形成 包含至少一种选自取代或未取代的1,2,3-苯并三唑，碳原子数1〜20的烷氧基硅烷，碳原子数1〜20的乙烯基烷氧基硅烷，和（甲基）丙烯酰基硅烷，氧化铬 。

公开(公告)号：US20110250701A1

公开(公告)日：2011-10-13

申请号：US13123511

申请日：2009-10-09

申请人： Sunghoon Kim ,  Jung-Min Han

发明人： Sunghoon Kim ,  Jung-Min Han

IPC分类号： G01N33/566 ,  C07K16/18

CPC分类号： G01N33/564 ,  G01N2800/102

摘要： The present invention relates to a novel use of AIMP1 polypeptide, more particularly to a composition for diagnosis of arthritis comprising an antibody against AIMP1, a kit for diagnosis comprising the same, a method for diagnosis of arthritis comprising: acquiring a specimen from a subject; and detecting AIMP1 polypeptide included in the specimen, and an antibody against the AIMP1 polypeptide for diagnosis of arthritis. The present invention provides a composition for diagnosis of arthritis including an antibody against AIMP1 polypeptide as a novel diagnosis marker of arthritis, a kit for diagnosis including the same, a method for diagnosis of arthritis comprising: acquiring a specimen from a subject; and detecting AIMP1 polypeptide included in the specimen, and an antibody against the AIMP1 polypeptide for diagnosis of arthritis. The composition, kit for diagnosis, method for diagnosis and antibody against the AIMP1 polypeptide may be used to diagnose arthritis early since they allow easy diagnosis of arthritis using a specimen from the patient.

摘要翻译： 本发明涉及AIMP1多肽的新用途，更具体地涉及一种用于诊断关节炎的组合物，其包含抗AIMP1抗体，用于诊断AIMP1的诊断用试剂盒，用于诊断关节炎的方法，包括：从受试者获取标本; 并检测样品中包含的AIMP1多肽和针对AIMP1多肽的抗体用于诊断关节炎。 本发明提供了一种用于诊断关节炎的组合物，包括抗AIMP1多肽的抗体作为关节炎的新型诊断标志物，包括其的诊断用试剂盒，关节炎诊断方法，包括：从受试者获取标本; 并检测样品中包含的AIMP1多肽和针对AIMP1多肽的抗体用于诊断关节炎。 用于诊断的试剂盒，用于诊断的方法和用于AIMP1多肽的抗体可用于早期诊断关节炎，因为它们允许使用来自患者的标本容易地诊断关节炎。

公开(公告)号：US20110189195A1

公开(公告)日：2011-08-04

申请号：US13059006

申请日：2008-08-18

申请人： Sunghoon Kim ,  Jin Woo Choi

发明人： Sunghoon Kim ,  Jin Woo Choi

IPC分类号： A61K39/395 ,  C12N5/09 ,  C12N15/63 ,  C07K16/40 ,  A61K31/7088 ,  C12Q1/00 ,  C12Q1/68 ,  A61P35/00 ,  A61P35/04

CPC分类号： A61K31/7088 ,  A61K48/00 ,  C12N9/93 ,  C12N15/1137 ,  C12N2310/11 ,  C12N2310/14 ,  C12Y601/01006 ,  G01N33/5017

摘要： The present invention relates to a novel function of lysyl tRNA synthetase (KRS) which enhances tumor cell migration and affects cancer metastasis via KRS's interaction with laminin receptor (67LR) by its translocation to membrane. More particularly, the present invention relates to a method for modulating cancer metastasis or migration, which comprises regulating intracellular levels of KRS; a composition for preventing or treating cancer; use of expression vector for inhibiting the expression of KRS; a method for preventing or treating cancer; use of an agent for inhibiting an activity of KRS; a method for screening an agent which modulates cancer metastasis or migration; and a method for screening an agent which inhibits the interaction of KRS with 67LR, by said novel function. Thus, KRS can modulate cancer metastasis or migration and furthermore, can modulate intra-cellular metabolism related to 67LR. The interaction between KRS and 67LR can be used effectively in treating, preventing and/or diagnosing of various diseases or disorders related to the interaction.

摘要翻译： 本发明涉及赖氨酰tRNA合成酶（KRS）的新功能，其通过Kis与层粘连蛋白受体（67LR）的相互作用通过其迁移到膜来增强肿瘤细胞迁移并影响癌症转移。 更具体地，本发明涉及一种调节癌症转移或迁移的方法，其包括调节细胞内KRS水平; 用于预防或治疗癌症的组合物; 使用表达载体抑制KRS的表达; 预防或治疗癌症的方法; 使用抑制KRS活性的药剂; 筛选调节癌症转移或迁移的药物的方法; 以及通过所述新功能筛选抑制KRS与67LR的相互作用的药剂的方法。 因此，KRS可以调节癌症转移或迁移，此外，可以调节与67LR相关的细胞内代谢。 KRS和67LR之间的相互作用可以有效地用于治疗，预防和/或诊断与相互作用相关的各种疾病或病症。

公开(公告)号：US07902165B2

公开(公告)日：2011-03-08

申请号：US11902641

申请日：2007-09-24

申请人： Sunghoon Kim

发明人： Sunghoon Kim

IPC分类号： A61K48/00

CPC分类号： A61K38/1709 ,  A01K2217/054 ,  A61K38/53 ,  A61K48/00 ,  C07K14/47 ,  C07K14/4702 ,  C12N9/93 ,  G01N33/574 ,  G01N33/6893 ,  G01N2333/4703 ,  G01N2500/04 ,  G01N2800/205

摘要： The present invention relates to novel uses of AIM3 acting as a tumor suppressor, and more particularly to methods for using an AIM3 protein or a nucleic acid encoding the protein to activate ATM or ATR and to treat ATM- or ATR-mediated diseases. The AIM3 protein according to the present invention interacts directly with ATM/ATR so as to activate ATM/ATR and proteins regulated by ATM/ATR. Also, the AIM3 protein upregulates tumor suppressor gene p53 and its target genes so as to not only inhibit the proliferation of cells but also to induce apoptosis.

摘要翻译： 本发明涉及用作肿瘤抑制因子的AIM3的新用途，更具体地涉及使用AIM3蛋白或编码该蛋白的核酸激活ATM或ATR并处理ATM或ATR介导的疾病的方法。 根据本发明的AIM3蛋白与ATM / ATR直接相互作用，以激活ATM / ATR和由ATM / ATR调节的蛋白质。 此外，AIM3蛋白上调肿瘤抑制基因p53及其靶基因，不仅抑制细胞增殖，而且诱导细胞凋亡。

公开(公告)号：US07459529B2

公开(公告)日：2008-12-02

申请号：US11264725

申请日：2005-11-01

申请人： Sunghoon Kim

发明人： Sunghoon Kim

IPC分类号： C07K5/10

CPC分类号： G01N33/57423 ,  C07K16/30 ,  G01N33/57438 ,  G01N2500/00

摘要： The present invention relates to a variant of AIMP2 lacking exon 2, named as AIMP2-DX2, which is specifically expressed in cancer cells. The AIMP2-DX2 protein and gene can be successfully used in the development of diagnosis and treatment of cancer.

摘要翻译： 本发明涉及缺少外显子2的AIMP2的变体，命名为AIMP2-DX2，其在癌细胞中特异性表达。 AIMP2-DX2蛋白和基因可以成功应用于癌症诊断和治疗的发展。

公开(公告)号：US06548060B1

公开(公告)日：2003-04-15

申请号：US09442630

申请日：1999-11-18

申请人： Sunghoon Kim

发明人： Sunghoon Kim

IPC分类号： A61K3853

CPC分类号： C07K14/4747 ,  A61K38/53

摘要： Aminoacyl-tRNA synthetases are the enzymes catalyzing ligation of their cognate amino acids and tRNAs. Human glutaminyl-tRNA synthetase (QRS) consists of the unique N-terminal extension (236 aa) and the C-terminal catalytic domain (539 aa). Here, we found that the N- and C-domains of QRS interacted with pro-apoptotic mediator, Daxx, and its downstream kinase, ASK1 (apoptosis signal-regulating kinase), respectively. The experimental results suggest that QRS may inhibit the ASK1 activity via two different ways. First, its C-terminal domain made direct inhibitory interaction with ASK1. Second, it inhibited the pro-apoptotic interaction between Daxx and ASK1. QRS also blocked the Daxx-ASK1 mediated apoptosis. Thus, QRS is not only an enzyme for protein synthesis but also plays a regulatory role in apoptosis

摘要翻译： 氨酰-tRNA合成酶是催化其同源氨基酸和tRNA的连接的酶。 人谷氨酰胺基tRNA合成酶（QRS）由独特的N-末端延伸（236aa）和C-末端催化结构域（539aa）组成。 在这里，我们发现QRS的N和C结构域分别与促凋亡介质Daxx及其下游激酶ASK1（凋亡信号调节激酶）相互作用。 实验结果表明QRS可能通过两种不同的方式抑制ASK1活性。 首先，其C末端结构域与ASK1直接抑制相互作用。 其次，它抑制Daxx和ASK1之间的促凋亡相互作用。 QRS也阻断Daxx-ASK1介导的细胞凋亡。 因此，QRS不仅是蛋白质合成的一种酶，而且在细胞凋亡中起调节作用