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41.发明授权Microorganism and method for the fermentative production of an organic-chemical compound 有权用于发酵生产有机化合物的微生物和方法公开(公告)号：US09359413B2
公开(公告)日：2016-06-07
申请号：US13438665
申请日：2012-04-03
申请人： Stephan Hans , Brigitte Bathe , Alexander Reth , Wilfried Claes , Reinhard Krämer , Gerd Seibold , Alexander Henrich
发明人： Stephan Hans , Brigitte Bathe , Alexander Reth , Wilfried Claes , Reinhard Krämer , Gerd Seibold , Alexander Henrich
摘要： The invention relates to a microorganism which produces and/or secretes an organic-chemical compound, wherein the microorganism has increased expression, compared to the particular starting strain, of one or more protein subunits of the ABC transporter having the activity of a trehalose importer, said microorganism being capable of taking up trehalose from the medium; and to a method for the production of an organic-chemical compound, using the microorganism according to the invention, wherein accumulation of trehalose in the fermentation broth is reduced or avoided.
摘要翻译： 本发明涉及产生和/或分泌有机化合物的微生物，其中与具有海藻糖进料器活性的ABC转运蛋白的一个或多个蛋白质亚单位的特定起始菌株相比，微生物具有增加的表达， 所述微生物能够从介质中吸收海藻糖; 以及使用根据本发明的微生物生产有机化合物的方法，其中减少或避免了发酵液中海藻糖的积累。
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42.发明申请公开(公告)号：US20120252075A1
公开(公告)日：2012-10-04
申请号：US13438665
申请日：2012-04-03
申请人： Stephan Hans , Brigitte Bathe , Alexander Reth , Wilfried Claes , Reinhard Krämer , Gerd Seibold , Alexander Henrich
发明人： Stephan Hans , Brigitte Bathe , Alexander Reth , Wilfried Claes , Reinhard Krämer , Gerd Seibold , Alexander Henrich
摘要： The invention relates to a microorganism which produces and/or secretes an organic-chemical compound, wherein the microorganism has increased expression, compared to the particular starting strain, of one or more protein subunits of the ABC transporter having the activity of a trehalose importer, said microorganism being capable of taking up trehalose from the medium; and to a method for the production of an organic-chemical compound, using the microorganism according to the invention, wherein accumulation of trehalose in the fermentation broth is reduced or avoided.
摘要翻译： 本发明涉及产生和/或分泌有机化合物的微生物，其中与具有海藻糖进料器活性的ABC转运蛋白的一个或多个蛋白质亚单位的特定起始菌株相比，微生物具有增加的表达， 所述微生物能够从介质中吸收海藻糖; 以及使用根据本发明的微生物生产有机化合物的方法，其中减少或避免了发酵液中海藻糖的积累。
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43.发明授权Methods and apparatus for stenting comprising enhanced embolic protection coupled with improved protections against restenosis and thrombus formation 有权用于支架置入的方法和装置包括增强的栓塞保护以及改进的针对再狭窄和血栓形成的保护公开(公告)号：US08088157B2
公开(公告)日：2012-01-03
申请号：US11731882
申请日：2007-03-30
IPC分类号： A61F2/06
CPC分类号： A61F2/07 , A61F2/82 , A61F2/856 , A61F2/90 , A61F2/91 , A61F2/915 , A61F2/958 , A61F2002/0086 , A61F2002/91508 , A61F2002/91533 , A61F2002/91558 , A61F2220/0008 , A61F2220/0016 , A61F2220/005
摘要： Apparatus and methods for stenting are provided comprising a stent attached to a porous biocompatible material that is permeable to endothelial cell ingrowth, but impermeable to release of emboli of predetermined size. Preferred stent designs are provided, as well as preferred manufacturing techniques. Apparatus and methods are also provided for use at a vessel branching. Moreover, embodiments of the present invention may comprise a coating configured for localized delivery of therapeutic agents. Embodiments of the present invention are expected to provide enhanced embolic protection, improved force distribution, and improved recrossability, while reducing a risk of restenosis and thrombus formation.
摘要翻译： 提供了用于支架置入的装置和方法，其包括附着于多孔生物相容性材料的支架，所述多孔生物相容性材料可渗透内皮细胞向内生长，但不能透过预定尺寸的栓塞。 提供优选的支架设计，以及优选的制造技术。 还提供了用于血管分支的装置和方法。 此外，本发明的实施方案可以包括被配置用于局部递送治疗剂的涂层。 预期本发明的实施方案可提供增强的栓塞保护，改善的力分布和改善的再交联性，同时降低再狭窄和血栓形成的风险。
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公开(公告)号：US07887577B2
公开(公告)日：2011-02-15
申请号：US10903080
申请日：2004-07-30
申请人： Randolf Von Oepen , Gerd Seibold
发明人： Randolf Von Oepen , Gerd Seibold
CPC分类号： A61F2/91 , A61F2/915 , A61F2002/91508 , A61F2002/91533 , A61F2002/91558
摘要： The present invention provides a stent comprising a tubular flexible body having a wall with a web structure that is expandable from a contracted delivery configuration to deployed configuration. The web structure comprises a plurality of neighboring web patterns, where each web patterns is composed of adjoining webs, and the web patterns are interconnected by connection elements. Each adjoining web comprises a central section interposed between two lateral sections to form concave or convex configurations.
摘要翻译： 本发明提供了一种支架，其包括管状柔性体，其具有壁，所述壁具有可从收缩输送构型扩展到展开构造的腹板结构。 网状结构包括多个相邻的网状图案，其中每个网状图案由邻接的网构成，并且网状图案通过连接元件互连。 每个邻接的腹板包括插入在两个横向部分之间以形成凹形或凸形构造的中心部分。
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公开(公告)号：US07794491B2
公开(公告)日：2010-09-14
申请号：US10903014
申请日：2004-07-30
申请人： Randolf Von Oepen , Gerd Seibold
发明人： Randolf Von Oepen , Gerd Seibold
CPC分类号： A61F2/91 , A61F2/915 , A61F2002/91508 , A61F2002/91533 , A61F2002/91558
摘要： The present invention provides a stent comprising a tubular flexible body having a wall with a web structure that is expandable from a contracted delivery configuration to deployed configuration. The web structure comprises a plurality of neighboring web patterns, where each web patterns is composed of adjoining webs, and the web patterns are interconnected by transition sections. Each adjoining web comprises a central section interposed between two lateral sections to form concave or convex configurations. A delivery system for the stent is also provided.
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46.发明申请公开(公告)号：US20080172083A1
公开(公告)日：2008-07-17
申请号：US11953816
申请日：2007-12-10
申请人： Ib Erling Joergensen , Gerd Seibold , Bodo Stefan Josef Quint , Kenneth J. Michlitsch , Martina Stueven , Randolf von Oepen
发明人： Ib Erling Joergensen , Gerd Seibold , Bodo Stefan Josef Quint , Kenneth J. Michlitsch , Martina Stueven , Randolf von Oepen
IPC分类号： A61M29/00
CPC分类号： A61M25/104 , A61F2/013 , A61F2002/018 , A61F2230/0006 , A61F2230/0069
摘要： Apparatus and methods for providing distal protection during a medical procedure that include a vascular filter having a self-expanding, porous foam body that conformably seals against a vessel wall and captures emboli within one or more recesses. The filter is coupled to a distal region of an elongated member, such as a guide wire. Delivery systems for use with filters of the present invention and methods of using the apparatus of the present invention also are provided.
摘要翻译： 在医疗过程中提供远端保护的装置和方法，其包括血管过滤器，所述血管过滤器具有自膨胀多孔泡沫体，所述自扩张多孔泡沫体适形地密封血管壁并在一个或多个凹部内捕获栓塞。 过滤器联接到诸如导丝的细长构件的远侧区域。 还提供了与本发明的过滤器一起使用的输送系统和使用本发明的装置的方法。
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47.发明申请Method and apparatus for stenting comprising enhanced embolic protection coupled with improved protections against restenosis and thrombus formation 有权用于支架置入的方法和装置包括增强的栓塞保护以及改进的针对再狭窄和血栓形成的保护公开(公告)号：US20070213800A1
公开(公告)日：2007-09-13
申请号：US11731882
申请日：2007-03-30
IPC分类号： A61F2/06
CPC分类号： A61F2/07 , A61F2/82 , A61F2/856 , A61F2/90 , A61F2/91 , A61F2/915 , A61F2/958 , A61F2002/0086 , A61F2002/91508 , A61F2002/91533 , A61F2002/91558 , A61F2220/0008 , A61F2220/0016 , A61F2220/005
摘要： Apparatus and methods for stenting are provided comprising a stent attached to a porous biocompatible material that is permeable to endothelial cell ingrowth, but impermeable to release of emboli of predetermined size. Preferred stent designs are provided, as well as preferred manufacturing techniques. Apparatus and methods are also provided for use at a vessel branching. Moreover, embodiments of the present invention may comprise a coating configured for localized delivery of therapeutic agents. Embodiments of the present invention are expected to provide enhanced embolic protection, improved force distribution, and improved recrossability, while reducing a risk of restenosis and thrombus formation.
摘要翻译： 提供了用于支架置入的装置和方法，其包括附着于多孔生物相容性材料的支架，所述多孔生物相容性材料可渗透内皮细胞向内生长，但不能透过预定尺寸的栓塞。 提供优选的支架设计，以及优选的制造技术。 还提供了用于血管分支的装置和方法。 此外，本发明的实施方案可以包括被配置用于局部递送治疗剂的涂层。 预期本发明的实施方案可提供增强的栓塞保护，改善的力分布和改善的再交联性，同时降低再狭窄和血栓形成的风险。
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48.发明申请Methods and apparatus for stenting comprising enhanced embolic protections coupled with improved protections against restenosis and trombus formation 有权用于支架置入的方法和装置包括增强的栓塞保护以及改进的针对再狭窄和慢性淋巴细胞形成的保护公开(公告)号：US20070179601A1
公开(公告)日：2007-08-02
申请号：US11732244
申请日：2007-04-02
IPC分类号： A61F2/06
CPC分类号： A61F2/07 , A61F2/82 , A61F2/856 , A61F2/90 , A61F2/91 , A61F2/915 , A61F2/958 , A61F2002/0086 , A61F2002/91508 , A61F2002/91533 , A61F2002/91558 , A61F2220/0008 , A61F2220/0016 , A61F2220/005
摘要： Apparatus and methods for stenting are provided comprising a stent attached to a porous biocompatible material that is permeable to endothelial cell ingrowth, but impermeable to release of emboli of predetermined size. Preferred stent designs are provided, as well as preferred manufacturing techniques. Apparatus and methods are also provided for use at a vessel branching. Moreover, embodiments of the present invention may comprise a coating configured for localized delivery of therapeutic agents. Embodiments of the present invention are expected to provide enhanced embolic protection, improved force distribution, and improved recrossability, while reducing a risk of restenosis and thrombus formation.
摘要翻译： 提供了用于支架置入的装置和方法，其包括附着于多孔生物相容性材料的支架，所述多孔生物相容性材料可渗透内皮细胞向内生长，但不能透过预定尺寸的栓塞。 提供优选的支架设计，以及优选的制造技术。 还提供了用于血管分支的装置和方法。 此外，本发明的实施方案可以包括被配置用于局部递送治疗剂的涂层。 预期本发明的实施方案可提供增强的栓塞保护，改善的力分布和改善的再交联性，同时降低再狭窄和血栓形成的风险。
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49.发明授权Methods and apparatus for stenting comprising enhanced embolic protection, coupled with improved protection against restenosis and thrombus formation 有权用于支架置入的方法和装置包括增强的栓塞保护，以及改进的针对再狭窄和血栓形成的保护公开(公告)号：US06755856B2
公开(公告)日：2004-06-29
申请号：US09967789
申请日：2001-09-28
IPC分类号： A61F206
CPC分类号： A61F2/07 , A61F2/82 , A61F2/856 , A61F2/90 , A61F2/91 , A61F2/915 , A61F2/958 , A61F2002/0086 , A61F2002/91508 , A61F2002/91533 , A61F2002/91558 , A61F2220/0008 , A61F2220/0016 , A61F2220/005
摘要： Apparatus and methods for stenting are provided comprising a stent attached to a porous biocompatible material that is permeable to endothelial cell ingrowth, but impermeable to release of emboli of predetermined size. Preferred stent designs are provided, as well as preferred manufacturing techniques. Apparatus and methods are also provided for use at a vessel branching. Moreover, embodiments of the present invention may comprise a coating configured for localized delivery of therapeutic agents. Embodiments of the present invention are expected to provide enhanced embolic protection, improved force distribution, and improved recrossability, while reducing a risk of restenosis and thrombus formation.
摘要翻译： 提供了用于支架置入的装置和方法，其包括附着于多孔生物相容性材料的支架，所述多孔生物相容性材料可渗透内皮细胞向内生长，但不能透过预定尺寸的栓塞。 提供优选的支架设计，以及优选的制造技术。 还提供了用于血管分支的装置和方法。 此外，本发明的实施方案可以包括被配置用于局部递送治疗剂的涂层。 预期本发明的实施方案可提供增强的栓塞保护，改善的力分布和改善的再交联性，同时降低再狭窄和血栓形成的风险。
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公开(公告)号：US06682554B2
公开(公告)日：2004-01-27
申请号：US09742144
申请日：2000-12-19
申请人： Randolf Von Oepen , Gerd Seibold
发明人： Randolf Von Oepen , Gerd Seibold
IPC分类号： A61F206
CPC分类号： A61F2/91 , A61F2/915 , A61F2002/91508 , A61F2002/91533 , A61F2002/91558
摘要： The present invention provides a stent comprising a tubular flexible body having a wall with a web structure that is expandable from a contracted delivery configuration to deployed configuration. The web structure comprises a plurality of neighboring web patterns, where each web patterns is composed of adjoining webs, and the web patterns are interconnected. Each adjoining web comprises a central section interposed between two lateral sections to form concave or convex configurations.
摘要翻译： 本发明提供了一种支架，其包括管状柔性体，其具有壁，所述壁具有可从收缩输送构型扩展到展开构造的腹板结构。 网状结构包括多个相邻的网状图案，其中每个网状图案由邻接的网构成，并且网状图案互连。 每个邻接的腹板包括插入在两个横向部分之间以形成凹形或凸形构造的中心部分。
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