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1.发明授权Methods and apparatus for stenting comprising enhanced embolic protection coupled with improved protections against restenosis and thrombus formation 有权用于支架置入的方法和装置包括增强的栓塞保护以及改进的针对再狭窄和血栓形成的保护公开(公告)号：US07927365B2
公开(公告)日：2011-04-19
申请号：US11731820
申请日：2007-03-29
IPC分类号： A61F2/06
CPC分类号： A61F2/07 , A61F2/82 , A61F2/856 , A61F2/90 , A61F2/91 , A61F2/915 , A61F2/958 , A61F2002/0086 , A61F2002/91508 , A61F2002/91533 , A61F2002/91558 , A61F2220/0008 , A61F2220/0016 , A61F2220/005
摘要： Apparatus and methods for stenting are provided comprising a stent attached to a porous biocompatible material that is permeable to endothelial cell ingrowth, but impermeable to release of emboli of predetermined size. Preferred stent designs are provided, as well as preferred manufacturing techniques. Apparatus and methods are also provided for use at a vessel branching. Moreover, embodiments of the present invention may comprise a coating configured for localized delivery of therapeutic agents. Embodiments of the present invention are expected to provide enhanced embolic protection, improved force distribution, and improved recrossability, while reducing a risk of restenosis and thrombus formation.
摘要翻译： 提供了用于支架置入的装置和方法，其包括附着于多孔生物相容性材料的支架，所述多孔生物相容性材料可渗透内皮细胞向内生长，但不能透过预定尺寸的栓塞。 提供优选的支架设计，以及优选的制造技术。 还提供了用于血管分支的装置和方法。 此外，本发明的实施方案可以包括被配置用于局部递送治疗剂的涂层。 预期本发明的实施方案可提供增强的栓塞保护，改善的力分布和改善的再交联性，同时降低再狭窄和血栓形成的风险。
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2.发明授权Methods and apparatus for stenting comprising enhanced embolic protection coupled with improved protections against restenosis and thrombus formation 有权用于支架置入的方法和装置包括增强的栓塞保护以及改进的针对再狭窄和血栓形成的保护公开(公告)号：US08088157B2
公开(公告)日：2012-01-03
申请号：US11731882
申请日：2007-03-30
IPC分类号： A61F2/06
CPC分类号： A61F2/07 , A61F2/82 , A61F2/856 , A61F2/90 , A61F2/91 , A61F2/915 , A61F2/958 , A61F2002/0086 , A61F2002/91508 , A61F2002/91533 , A61F2002/91558 , A61F2220/0008 , A61F2220/0016 , A61F2220/005
摘要： Apparatus and methods for stenting are provided comprising a stent attached to a porous biocompatible material that is permeable to endothelial cell ingrowth, but impermeable to release of emboli of predetermined size. Preferred stent designs are provided, as well as preferred manufacturing techniques. Apparatus and methods are also provided for use at a vessel branching. Moreover, embodiments of the present invention may comprise a coating configured for localized delivery of therapeutic agents. Embodiments of the present invention are expected to provide enhanced embolic protection, improved force distribution, and improved recrossability, while reducing a risk of restenosis and thrombus formation.
摘要翻译： 提供了用于支架置入的装置和方法，其包括附着于多孔生物相容性材料的支架，所述多孔生物相容性材料可渗透内皮细胞向内生长，但不能透过预定尺寸的栓塞。 提供优选的支架设计，以及优选的制造技术。 还提供了用于血管分支的装置和方法。 此外，本发明的实施方案可以包括被配置用于局部递送治疗剂的涂层。 预期本发明的实施方案可提供增强的栓塞保护，改善的力分布和改善的再交联性，同时降低再狭窄和血栓形成的风险。
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3.发明授权Methods and apparatus for stenting comprising enhanced embolic protection, coupled with improved protection against restenosis and thrombus formation 有权用于支架置入的方法和装置包括增强的栓塞保护，以及改进的针对再狭窄和血栓形成的保护公开(公告)号：US06755856B2
公开(公告)日：2004-06-29
申请号：US09967789
申请日：2001-09-28
IPC分类号： A61F206
CPC分类号： A61F2/07 , A61F2/82 , A61F2/856 , A61F2/90 , A61F2/91 , A61F2/915 , A61F2/958 , A61F2002/0086 , A61F2002/91508 , A61F2002/91533 , A61F2002/91558 , A61F2220/0008 , A61F2220/0016 , A61F2220/005
摘要： Apparatus and methods for stenting are provided comprising a stent attached to a porous biocompatible material that is permeable to endothelial cell ingrowth, but impermeable to release of emboli of predetermined size. Preferred stent designs are provided, as well as preferred manufacturing techniques. Apparatus and methods are also provided for use at a vessel branching. Moreover, embodiments of the present invention may comprise a coating configured for localized delivery of therapeutic agents. Embodiments of the present invention are expected to provide enhanced embolic protection, improved force distribution, and improved recrossability, while reducing a risk of restenosis and thrombus formation.
摘要翻译： 提供了用于支架置入的装置和方法，其包括附着于多孔生物相容性材料的支架，所述多孔生物相容性材料可渗透内皮细胞向内生长，但不能透过预定尺寸的栓塞。 提供优选的支架设计，以及优选的制造技术。 还提供了用于血管分支的装置和方法。 此外，本发明的实施方案可以包括被配置用于局部递送治疗剂的涂层。 预期本发明的实施方案可提供增强的栓塞保护，改善的力分布和改善的再交联性，同时降低再狭窄和血栓形成的风险。
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4.发明授权Methods and apparatus for stenting comprising enhanced embolic protection coupled with improved protections against restenosis and thrombus formation 有权用于支架置入的方法和装置包括增强的栓塞保护以及改进的针对再狭窄和血栓形成的保护公开(公告)号：US08814926B2
公开(公告)日：2014-08-26
申请号：US13089039
申请日：2011-04-18
IPC分类号： A61F2/82
CPC分类号： A61F2/07 , A61F2/82 , A61F2/856 , A61F2/90 , A61F2/91 , A61F2/915 , A61F2/958 , A61F2002/0086 , A61F2002/91508 , A61F2002/91533 , A61F2002/91558 , A61F2220/0008 , A61F2220/0016 , A61F2220/005
摘要： Apparatus and methods for stenting are provided comprising a stent attached to a porous biocompatible material that is permeable to endothelial cell ingrowth, but impermeable to release of emboli of predetermined size. Preferred stent designs are provided, as well as preferred manufacturing techniques. Apparatus and methods are also provided for use at a vessel branching. Moreover, embodiments of the present invention may comprise a coating configured for localized delivery of therapeutic agents. Embodiments of the present invention are expected to provide enhanced embolic protection, improved force distribution, and improved recrossability, while reducing a risk of restenosis and thrombus formation.
摘要翻译： 提供了用于支架置入的装置和方法，其包括附着于多孔生物相容性材料的支架，所述多孔生物相容性材料可渗透内皮细胞向内生长，但不能透过预定尺寸的栓塞。 提供优选的支架设计，以及优选的制造技术。 还提供了用于血管分支的装置和方法。 此外，本发明的实施方案可以包括被配置用于局部递送治疗剂的涂层。 预期本发明的实施方案可提供增强的栓塞保护，改善的力分布和改善的再交联性，同时降低再狭窄和血栓形成的风险。
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公开(公告)号：US07927364B2
公开(公告)日：2011-04-19
申请号：US10859636
申请日：2004-06-03
IPC分类号： A61F2/06
CPC分类号： A61F2/07 , A61F2/82 , A61F2/856 , A61F2/90 , A61F2/91 , A61F2/915 , A61F2/958 , A61F2002/0086 , A61F2002/91508 , A61F2002/91533 , A61F2002/91558 , A61F2220/0008 , A61F2220/0016 , A61F2220/005
摘要： Apparatus and methods for stenting are provided comprising a stent attached to a porous biocompatible material that is permeable to endothelial cell ingrowth, but impermeable to release of emboli of predetermined size. Preferred stent designs are provided, as well as preferred manufacturing techniques. Apparatus and methods are also provided for use at a vessel branching. Moreover, embodiments of the present invention may comprise a coating configured for localized delivery of therapeutic agents. Embodiments of the present invention are expected to provide enhanced embolic protection, improved force distribution, and improved recrossability, while reducing a risk of restenosis and thrombus formation.
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6.发明申请METHODS AND APPARATUS FOR STENTING COMPRISING ENHANCED EMBOLIC PROTECTION COUPLED WITH IMPROVED PROTECTIONS AGAINST RESTENOSIS AND THROMBUS FORMATION 有权用于包括增强的保护性保护的改进方法和装置与改进的保护和血栓形成的保护公开(公告)号：US20110270381A1
公开(公告)日：2011-11-03
申请号：US13089039
申请日：2011-04-18
IPC分类号： A61F2/82
CPC分类号： A61F2/07 , A61F2/82 , A61F2/856 , A61F2/90 , A61F2/91 , A61F2/915 , A61F2/958 , A61F2002/0086 , A61F2002/91508 , A61F2002/91533 , A61F2002/91558 , A61F2220/0008 , A61F2220/0016 , A61F2220/005
摘要： Apparatus and methods for stenting are provided comprising a stent attached to a porous biocompatible material that is permeable to endothelial cell ingrowth, but impermeable to release of emboli of predetermined size. Preferred stent designs are provided, as well as preferred manufacturing techniques. Apparatus and methods are also provided for use at a vessel branching. Moreover, embodiments of the present invention may comprise a coating configured for localized delivery of therapeutic agents. Embodiments of the present invention are expected to provide enhanced embolic protection, improved force distribution, and improved recrossability, while reducing a risk of restenosis and thrombus formation.
摘要翻译： 提供了用于支架置入的装置和方法，其包括附着于多孔生物相容性材料的支架，所述多孔生物相容性材料可渗透内皮细胞向内生长，但不能透过预定尺寸的栓塞。 提供优选的支架设计，以及优选的制造技术。 还提供了用于血管分支的装置和方法。 此外，本发明的实施方案可以包括被配置用于局部递送治疗剂的涂层。 预期本发明的实施方案可提供增强的栓塞保护，改善的力分布和改善的再交联性，同时降低再狭窄和血栓形成的风险。
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7.发明授权Methods and apparatus for stenting comprising enhanced embolic protection coupled with improved protections against restenosis and thrombus formation 有权用于支架置入的方法和装置包括增强的栓塞保护以及改进的针对再狭窄和血栓形成的保护公开(公告)号：US07811314B2
公开(公告)日：2010-10-12
申请号：US11732244
申请日：2007-04-02
IPC分类号： A61F2/06
CPC分类号： A61F2/07 , A61F2/82 , A61F2/856 , A61F2/90 , A61F2/91 , A61F2/915 , A61F2/958 , A61F2002/0086 , A61F2002/91508 , A61F2002/91533 , A61F2002/91558 , A61F2220/0008 , A61F2220/0016 , A61F2220/005
摘要： Apparatus and methods for stenting are provided comprising a stent attached to a porous biocompatible material that is permeable to endothelial cell ingrowth, but impermeable to release of emboli of predetermined size. Preferred stent designs are provided, as well as preferred manufacturing techniques. Apparatus and methods are also provided for use at a vessel branching. Moreover, embodiments of the present invention may comprise a coating configured for localized delivery of therapeutic agents. Embodiments of the present invention are expected to provide enhanced embolic protection, improved force distribution, and improved recrossability, while reducing a risk of restenosis and thrombus formation.
摘要翻译： 提供了用于支架置入的装置和方法，其包括附着于多孔生物相容性材料的支架，所述多孔生物相容性材料可渗透内皮细胞向内生长，但不能透过预定尺寸的栓塞。 提供优选的支架设计，以及优选的制造技术。 还提供了用于血管分支的装置和方法。 此外，本发明的实施方案可以包括被配置用于局部递送治疗剂的涂层。 预期本发明的实施方案可提供增强的栓塞保护，改善的力分布和改善的再交联性，同时降低再狭窄和血栓形成的风险。
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8.发明申请METHODS AND APPARATUS FOR STENTING COMPRISING ENHANCED EMBOLIC PROTECTION COUPLED WITH IMPROVED PROTECTIONS AGAINST RESTENOSIS AND THROMBUS FORMATION 审中-公开用于包括增强的保护性保护的改进方法和装置与改进的保护和血栓形成的保护公开(公告)号：US20130190856A1
公开(公告)日：2013-07-25
申请号：US13801469
申请日：2013-03-13
申请人： Randolph von Oepen , Gerd Seibold , Silvio R. Schaffner , Marc G Gianotti , Joost J. Fierens , Erhard Huesler , Arik Zucker , Eric Marcoux , Philippe Nicaise , Sebastien Dubois
发明人： Randolph von Oepen , Gerd Seibold , Silvio R. Schaffner , Marc G Gianotti , Joost J. Fierens , Erhard Huesler , Arik Zucker , Eric Marcoux , Philippe Nicaise , Sebastien Dubois
IPC分类号： A61F2/06
CPC分类号： A61F2/06 , A61F2/07 , A61F2/90 , A61F2/91 , A61F2/915 , A61F2002/0086 , A61F2002/072 , A61F2002/075 , A61F2002/91508 , A61F2002/91533 , A61F2002/91558 , A61F2210/0076 , A61F2220/0008 , A61F2220/0016 , A61F2240/001 , A61F2250/0023 , A61L31/08 , A61L31/146 , A61L31/16 , B29C48/0012 , B29C48/0016 , B29C48/08 , B29C48/09 , B29C48/151 , B29C48/2886 , B29C48/92 , B29C2948/92571 , B29C2948/9258 , B29C2948/9259 , B29C2948/926 , B29C2948/92609 , B29C2948/92628 , B29C2948/92695 , B29C2948/92904 , B29K2023/06 , B29K2023/12 , B29K2027/18 , B29K2067/00 , B29K2071/00 , B29K2075/00 , B29K2077/00 , B29K2105/04 , B29K2105/108 , B29K2995/0056 , B29K2995/006 , B29L2023/007 , B29L2031/7532 , B29L2031/755 , D04H3/07
摘要： Apparatus and methods for stenting are provided comprising a stent attached to a porous biocompatible material that is permeable to endothelial cell ingrowth, but impermeable to release of emboli of predetermined size. Apparatus and methods are also provided for use at a vessel branching. The present invention further involves porous polymer membranes, suitable for use in medical implants, having controlled pore sizes, pore densities and mechanical properties. Methods of manufacturing such porous membranes are described in which a continuous fiber of polymer is extruded through a reciprocating extrusion head and deposited onto a substrate in a predetermined pattern. When cured, the polymeric material forms a stable, porous membrane suitable for a variety of applications, including reducing emboli release during and after stent delivery, and providing a source for release of bioactive substances to a vessel or organ and surrounding tissue.
摘要翻译： 提供了用于支架置入的装置和方法，其包括附着于多孔生物相容性材料的支架，所述多孔生物相容性材料可渗透内皮细胞向内生长，但不能透过预定尺寸的栓塞。 还提供了用于血管分支的装置和方法。 本发明还涉及适用于具有受控孔径，孔密度和机械性能的医用植入物的多孔聚合物膜。 描述制造这种多孔膜的方法，其中聚合物的连续纤维通过往复式挤出头挤出并以预定图案沉积到基底上。 当固化时，聚合物材料形成适用于各种应用的稳定的多孔膜，包括在支架输送期间和之后降低栓塞释放，以及提供用于向血管或器官和周围组织释放生物活性物质的来源。
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