中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

90 records (took 0.028 seconds)

    Variants derived from ActRIIB and uses therefor
    41.
    发明授权
    Variants derived from ActRIIB and uses therefor 有权
    衍生自ActRIIB的变体并用于此

    公开(公告)号：US08343933B2

    公开(公告)日：2013-01-01

    申请号：US12893976

    申请日：2010-09-29

    Applicant: John Knopf ,  Jasbir Seehra ,  Ravindra Kumar

    Inventor： John Knopf ,  Jasbir Seehra ,  Ravindra Kumar

    IPC: A61K38/16 ,  C07K14/00 ,  C07K14/705 ,  C07K14/71

    CPC classification number: C07K14/71 ,  A61K38/00 ,  C07K14/705 ,  C07K14/72 ,  C07K16/18 ,  C07K2319/30 ,  C07K2319/70

    Abstract: In certain aspects, the present invention provides compositions and methods for modulating (promoting or inhibiting) growth of a tissue, such as bone, cartilage, muscle, fat, and/or neuronal tissue. The present invention also provides methods of screening compounds that modulate activity of an ActRIIB protein and/or an ActRIIB ligand. The compositions and methods provided herein are useful in treating diseases associated with abnormal activity of an ActRIIB protein and/or an ActRIIB ligand.

    Abstract translation: 在某些方面，本发明提供用于调节（促进或抑制）组织如骨，软骨，肌肉，脂肪和/或神经元组织的生长的组合物和方法。 本发明还提供筛选调节ActRIIB蛋白和/或ActRIIB配体的活性的化合物的方法。 本文提供的组合物和方法可用于治疗与ActRIIB蛋白和/或ActRIIB配体的异常活性相关的疾病。

    Methods for increasing adiponectin in a patient in need thereof
    44.
    发明授权
    Methods for increasing adiponectin in a patient in need thereof 有权
    在有需要的患者中增加脂连蛋白的方法

    公开(公告)号：US08138142B2

    公开(公告)日：2012-03-20

    申请号：US12657146

    申请日：2010-01-13

    Applicant: Jasbir Seehra ,  Ravindra Kumar ,  Jennifer Lachey ,  Alan Koncarevic

    Inventor： Jasbir Seehra ,  Ravindra Kumar ,  Jennifer Lachey ,  Alan Koncarevic

    IPC: A61K38/00 ,  C07K16/46

    CPC classification number: C07K16/40 ,  A61K31/00 ,  A61K31/7088 ,  A61K38/179 ,  A61K2039/505 ,  C07K14/705 ,  C07K16/22 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/54 ,  C07K2317/55 ,  C07K2317/622 ,  C07K2317/76 ,  C07K2319/30

    Abstract: In certain aspects, the present invention provides compositions and methods for increasing adiponectin in a patient in need thereof by administering an antagonist of an ActRIIB signaling pathway. Examples of such antagonists include ActRIIB polypeptides, anti-ActRIIB antibodies, anti-activin A and/or B antibodies, anti-myostatin antibodies, anti-GDF3 antibodies, and anti-BMP7 antibodies. Also provided are methods for ameliorating one or more undesired effects of anti-androgen therapy, including muscle loss, bone loss, increased adiposity, and/or increased insulin resistance. A variety of disorders may be treated by causing an increase in circulating adiponectin concentrations.

    Abstract translation: 在某些方面，本发明提供了通过施用ActRIIB信号通路的拮抗剂来增加有需要的患者中的脂连蛋白的组合物和方法。 此类拮抗剂的实例包括ActRIIB多肽，抗ActRIIB抗体，抗激活素A和/或B抗体，抗肌生成抑制素抗体，抗GDF3抗体和抗BMP7抗体。 还提供了用于改善一种或多种不期望的抗雄激素治疗效果的方法，包括肌肉损失，骨丢失，增加的肥胖和/或增加的胰岛素抵抗。 可以通过引起循环中脂联素浓度的增加来治疗多种疾病。

    Method and system for managing data in storage systems
    48.
    发明授权
    Method and system for managing data in storage systems 有权
    用于管理存储系统中的数据的方法和系统

    公开(公告)号：US08135676B1

    公开(公告)日：2012-03-13

    申请号：US12111053

    申请日：2008-04-28

    Applicant: Sathisha Poojary ,  Ravindra Kumar

    Inventor： Sathisha Poojary ,  Ravindra Kumar

    IPC: G06F17/30

    CPC classification number: G06F11/1451

    Abstract: Method and system for incremental backup of data containers with fixed length records is provided. Initially, a backup application copies all stored data containers to create an initial backup container. A data structure corresponding to the first backup operation is also created. The data structure maintains unique file identifiers for each data container and information regarding when a record was added. The data structure is created and maintained by an application that also creates, updates, and modifies the fixed length records. The application updates the base data structure when records are added to a data container, after the initial backup. For a next backup operation, the initial data structure is compared to an updated data structure that is current at the next backup time. The comparison identifies the new records that were added (or updated) since the initial backup operation. The backup application then incrementally copies the new records.

    Abstract translation: 提供了具有固定长度记录的数据容器的增量备份方法和系统。 最初，备份应用程序复制所有存储的数据容器以创建初始备份容器。 还创建与第一备份操作相对应的数据结构。 数据结构为每个数据容器提供唯一的文件标识符，以及关于何时添加记录的信息。 数据结构由也创建，更新和修改固定长度记录的应用程序创建和维护。 在初始备份之后，当将记录添加到数据容器时，应用程序会更新基础数据结构。 对于下一个备份操作，将初始数据结构与在下一个备份时间当前的更新数据结构进行比较。 比较确定自初始备份操作以来添加（或更新）的新记录。 备份应用程序然后递增地复制新记录。

Patent Agency Ranking