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60 条记录 (耗时 0.035 秒)

    Process for the production of metalloporphyrin-metal complex conjugates
    41.
    发明授权
    Process for the production of metalloporphyrin-metal complex conjugates 失效
    金属卟啉 - 金属络合物的制备方法

    公开(公告)号：US06194566B1

    公开(公告)日：2001-02-27

    申请号：US09400993

    申请日：1999-09-21

    申请人： Johannes Platzek ,  Ulrich Niedballa

    发明人： Johannes Platzek ,  Ulrich Niedballa

    IPC分类号： A61K5100

    CPC分类号： C07D487/22

    摘要： Metalloporphyrin-metal complex conjugates are prepared by reacting a porphyrin-metal complex conjugate with a metal acetylacetoane in a solvent or solvent mixture at a temperature from room temperature to 150° C. in concentrations of 3-30% in the metalloporphyrin-metal complex conjugate.

    摘要翻译： 金属卟啉 - 金属络合物缀合物是通过卟啉 - 金属络合物与金属乙酰乙醯胺在溶剂或溶剂混合物中在室温至150℃的温度下以3-30％的浓度在金属卟啉 - 金属络合物共轭物 。

    Process for the production of perbenzylated 1-O-glycosides
    43.
    发明授权
    Process for the production of perbenzylated 1-O-glycosides 失效
    过苄基化1-O-糖苷的生产方法

    公开(公告)号：US06908989B2

    公开(公告)日：2005-06-21

    申请号：US10174508

    申请日：2002-06-19

    申请人： Johannes Platzek ,  Ulrich Niedballa ,  Klaus-Dieter Graske

    发明人： Johannes Platzek ,  Ulrich Niedballa ,  Klaus-Dieter Graske

    IPC分类号： C07H15/203 ,  C07H1/00

    CPC分类号： C07H15/203

    摘要： The invention relates to a process for the production of perbenzylated 1-O-glycosides of general formula I or salts thereof in which sugar1 is a monosaccharide that is functionalized in 1-OH-position, R represents benzyl, n means 2, 3 or 4, X means —COO— or —NH— and L means a straight-chain, branched, saturated or unsaturated C1-C30 carbon chain, which optionally is interrupted or substituted by groups. The process according to the invention starts from economical starting materials, provides good yields and allows the production of perbenzylated saccharides with 1-O-functionalized side chains on an industrial scale.

    摘要翻译： 本发明涉及制备通式I的过苄氧基化的1-O-糖苷或其盐，其中糖1是在1-OH位官能化的单糖，R代表苄基 ，n表示2,3或4，X表示-COO-或-NH-，L表示直链，支链，饱和或不饱和的C 1 -C 30烷基， 碳链，其任选地被中断或被基团取代。 根据本发明的方法从经济起始材料开始，提供良好的产率并且允许以工业规模生产具有1-O-官能化侧链的过苄基化糖。

    Process for the production of peracylated 1-0-glycosides
    44.
    发明授权
    Process for the production of peracylated 1-0-glycosides 失效
    过氧化1-0-糖苷的生产方法

    公开(公告)号：US06831164B2

    公开(公告)日：2004-12-14

    申请号：US10192856

    申请日：2002-07-11

    申请人： Johannes Platzek ,  Klaus-Dieter Graske ,  Ulrich Niedballa

    发明人： Johannes Platzek ,  Klaus-Dieter Graske ,  Ulrich Niedballa

    IPC分类号： C07H1500

    CPC分类号： C07H15/18 ,  C07H15/04 ,  C07H15/26

    摘要： The invention relates to a process for the production of peracylated 1-O-glycosides of general formula I or salts thereof in which sugar1 is a monosaccharide that is functionalized in 1-OH-position, R represents methyl, ethyl, propyl, isopropyl, tbutyl, phenyl, n means 2, 3 or 4, X means —COO— or —NH—and L means a straight-chain, branched, saturated or unsaturated C1-C30 carbon chain, which optionally is interrupted or substituted by groups. The process according to the invention starts from economical starting materials, provides good yields and allows the production of peracylated saccharides with 1-O-functionalized side chains on an enlarged scale.

    摘要翻译： 本发明涉及一种制备通式I的过酰基化的1-O-糖苷或其盐的方法，其中1是在1-OH位官能化的单糖，R代表甲基，乙基，丙基，异丙基， 叔丁基，苯基，n表示2,3或4，X表示-COO-或-NH-，并且L表示直链，支链，饱和或不饱和的C1-C30碳链，其任选被中间或被基团取代。 根据本发明从经济起始材料开始，提供良好的产率并且允许以1-O官能化的侧链扩大生产过酰基化糖。

    Antiinflammatory-4,5-diphenyl-2-substituted-thio-imidazoles and their corresponding sulfoxides and sulfones
    49.
    发明授权
    Antiinflammatory-4,5-diphenyl-2-substituted-thio-imidazoles and their corresponding sulfoxides and sulfones 失效
    抗炎-4,5-二苯基-2-取代 - 硫代 - 咪唑及其相应的亚砜和砜

    公开(公告)号：US4269847A

    公开(公告)日：1981-05-26

    申请号：US41367

    申请日：1979-05-22

    申请人： Ulrich Niedballa ,  Irmgard Bottcher

    发明人： Ulrich Niedballa ,  Irmgard Bottcher

    IPC分类号： A61K31/415 ,  A61P29/00 ,  C07D233/84 ,  C07D233/88 ,  C07D401/14 ,  C07D405/14 ,  C07D409/14

    CPC分类号： C07D233/84 ,  C07D233/88 ,  Y10S514/825 ,  Y10S514/826 ,  Y10S514/926 ,  Y10S514/927

    摘要： Imidazole derivatives of the formula ##STR1## wherein Ar.sub.1 and Ar.sub.2 are each phenyl; phenyl substituted by halogen, C.sub.1-4 alkyl, C.sub.1-4 alkoxy or C.sub.2-6 dialkylamino; pyridyl; furyl; or thienyl; with the proviso that Ar.sub.1 and Ar.sub.2 are not both unsubstituted phenyl;R.sub.1 is hydrogen, C.sub.1-4 alkyl or C.sub.1-4 alkyl substituted by hydroxy, C.sub.1-4 alkoxy or C.sub.1-6 alkanoyloxy;n is 0, 1 or 2; andZ is a C.sub.2-6 -alkyl or -alkenyl residue substituted by one or two of hydroxy, C.sub.1-4 alkoxy, C.sub.2-8 alkylenedioxy, C.sub.1-6 alkanoyloxy or benzoyloxy, or by one alkoxycarbonyl group;and the salts thereof with physiologically acceptable acids, possess valuable pharmacological properties.

    摘要翻译： 其中Ar1和Ar2各自为苯基的式“IMAGE”的咪唑衍生物; 被卤素，C 1-4烷基，C 1-4烷氧基或C 2-6二烷基氨基取代的苯基; 吡啶基 呋喃 或噻吩基; 条件是Ar 1和Ar 2不是未被取代的苯基; R1是氢，C1-4烷基或被羟基，C1-4烷氧基或C1-6烷酰氧基取代的C1-4烷基; n为0,1或2; Z为被羟基，C 1-4烷氧基，C 2-8亚烷基二氧基，C 1-6烷酰氧基或苯甲酰氧基或一个烷氧基羰基中的一个或两个取代的C 2-6 - 烷基或链烯基; 其盐与生理上可接受的酸具有有价值的药理学性质。