公开(公告)号：US08340784B2

公开(公告)日：2012-12-25

申请号：US12354483

申请日：2009-01-15

申请人： John H. Erickson ,  Scott F. Drees ,  Terry Daglow ,  John Connell Munson, Jr.

发明人： John H. Erickson ,  Scott F. Drees ,  Terry Daglow ,  John Connell Munson, Jr.

IPC分类号： A61N1/05

CPC分类号： A61B5/0422 ,  A61B5/6852 ,  A61B17/3401 ,  A61B17/3468 ,  A61N1/0553

摘要： The present invention relates to a percutaneous insertion-capable lead, wherein insertion made through a percutaneous insertion structure. For one embodiment of such lead, the electrode-supporting stimulation portion of the lead includes at least one waisted region, relative to a transverse dimension of the lead, to facilitate lead steerability.

摘要翻译： 本发明涉及一种经皮插入性铅，其中通过经皮插入结构制成的插入物。 对于这种引线的一个实施例，引线的电极支撑刺激部分相对于引线的横向尺寸包括至少一个腰围区域，以便于引导操纵性。

公开(公告)号：US08340775B1

公开(公告)日：2012-12-25

申请号：US12423124

申请日：2009-04-14

申请人： Patrick M. Cullen ,  John H. Erickson

发明人： Patrick M. Cullen ,  John H. Erickson

IPC分类号： A61N1/00

CPC分类号： A61N1/36128 ,  A61N1/05 ,  A61N1/0553 ,  A61N1/36178 ,  A61N1/37247 ,  G06F19/00 ,  G16H40/63

摘要： In one embodiment, a method for defining a stimulation program for electrical stimulation of a patient, the method comprising: providing a single screen user interface that comprises a first plurality of controls and a second plurality of controls, the first plurality of controls allowing selection of multiple stimulation parameters for a plurality of stimulation sets, the second plurality of controls allowing selection of multiple stimulation parameters defining burst stimulation and tonic stimulation; receiving user input in one or more of the second plurality of controls; and automatically modifying parameters for one or more stimulation sets in response to receiving the user input in one or more of the second plurality of controls and modifying values displayed in one or more controls of the first plurality of controls according to the modified parameters, the modified parameters reflecting a stimulation program that includes an interleaved pattern of burst stimulation and tonic stimulation for delivery to the patient.

摘要翻译： 在一个实施例中，一种用于定义用于电刺激患者的刺激程序的方法，所述方法包括：提供包括第一多个控制和第二多个控制的单个屏幕用户界面，所述第一多个控件允许选择 用于多个刺激组的多个刺激参数，所述第二多个控制允许选择限定突发刺激和强直刺激的多个刺激参数; 在所述第二多个控制中的一个或多个中接收用户输入; 以及响应于在所述第二多个控制中的一个或多个控制中接收到所述用户输入并根据所述修改的参数修改显示在所述第一多个控件的一个或多个控制中的值，自动修改针对一个或多个刺激集的参数， 反映刺激程序的参数，其包括突发刺激的交替模式和用于递送给患者的补品刺激。

公开(公告)号：US20120286841A1

公开(公告)日：2012-11-15

申请号：US13470764

申请日：2012-05-14

申请人： Benjamin A. Tranchina ,  John H. Erickson ,  Anthony J. Varrichio

发明人： Benjamin A. Tranchina ,  John H. Erickson ,  Anthony J. Varrichio

IPC分类号： H03K3/02

CPC分类号： A61N1/025 ,  H02M3/07

摘要： Disclosed are systems and methods which provide voltage conversion in increments less than integer multiples of a power supply (e.g., battery) voltage. A representative embodiment provides power supply voltage multipliers in a binary ladder distribution to provide a desired number of output voltage steps using a relatively uncomplicated circuit design. By using different sources in various combinations and/or by “stacking” different sources in various ways, the voltage multiplier circuit may be used to provide desired voltages. In order to minimize the number of components used in a voltage converter of an embodiment, a capacitive voltage converter circuit uses one or more storage capacitors in place of pump capacitors in a voltage generation cycle. Also, certain embodiments do not operate to generate an output voltage until the time that voltage is needed.

摘要翻译： 公开了以小于电源（例如，电池）电压的整数倍的增量提供电压转换的系统和方法。 代表性的实施例提供二进制梯形分布中的电源电压倍增器，以使用相对简单的电路设计提供期望数量的输出电压步长。 通过以各种组合使用不同的源和/或以各种方式堆叠不同的源，可以使用电压倍增器电路来提供期望的电压。 为了最小化实施例的电压转换器中使用的部件的数量，电容性电压转换器电路在电压产生循环中使用一个或多个存储电容器代替泵电容器。 而且，某些实施例在直到需要电压的时间之前不会产生输出电压。

公开(公告)号：US20120271390A1

公开(公告)日：2012-10-25

申请号：US13540361

申请日：2012-07-02

申请人： John H. Erickson

发明人： John H. Erickson

IPC分类号： A61N1/36

CPC分类号： A61N1/37 ,  A61N1/086 ,  A61N1/3718

摘要： In one embodiment, a pulse generator for generating electrical stimulation for delivery to a patient, comprises: a hermetically sealed housing containing pulse generating circuitry; a header coupled to the housing for receiving one or more stimulation leads, wherein feedthrough wires are provided to conduct electrical pulses from the pulse generating circuitry to the header; the header comprising a plurality of connectors for electrically connecting to each terminal of the one or more stimulation leads, wherein an inductive winding is disposed around or adjacent to each of the connector structures and is electrically connected between the respective connector structure and a corresponding feedthrough wire to limit MRI induced heating of a respective electrode of the one or more stimulation leads.

摘要翻译： 在一个实施例中，用于产生用于递送给患者的电刺激的脉冲发生器包括：包含脉冲发生电路的密封外壳; 连接到所述壳体以用于接收一个或多个刺激引线的头部，其中提供穿通线以将电脉冲从所述脉冲发生电路传导到所述头部; 所述头部包括用于电连接到所述一个或多个刺激引线的每个端子的多个连接器，其中感应绕组设置在每个所述连接器结构的周围或附近，并且电连接在相应的连接器结构和相应的馈通线 以限制一个或多个刺激引线的相应电极的MRI诱导加热。

公开(公告)号：US08224456B2

公开(公告)日：2012-07-17

申请号：US10996803

申请日：2004-11-24

申请人： Terry Daglow ,  Brian Franz ,  John H. Erickson ,  Sandy Hooper ,  Tim Jones

发明人： Terry Daglow ,  Brian Franz ,  John H. Erickson ,  Sandy Hooper ,  Tim Jones

IPC分类号： A61N1/00

CPC分类号： A61N1/0551 ,  A61N1/0529

摘要： A lead, method of manufacturing same, and system for stimulation is provided. The lead includes an insulative member or layer that masks a portion of the electrode(s) to effectively generate a directional lead that focuses or directs the stimulation to desired location(s). In another embodiment, the lead further includes a marking system to allow a clinician to orient the directional lead, as desired, while the lead is within a body.

摘要翻译： 提供铅，制造方法和刺激系统。 引线包括掩蔽电极的一部分的绝缘构件或层，以有效地产生将刺激聚焦或引导到所需位置的方向引线。 在另一个实施例中，引线还包括标记系统，以允许临床医生在引线位于身体内时根据需要定向方向引线。

公开(公告)号：US08214055B2

公开(公告)日：2012-07-03

申请号：US13356147

申请日：2012-01-23

申请人： John H. Erickson

发明人： John H. Erickson

IPC分类号： A61N1/00

CPC分类号： A61N1/37 ,  A61N1/086 ,  A61N1/3718

摘要： In one embodiment, a pulse generator for generating electrical stimulation for delivery to a patient, comprises: a hermetically sealed housing containing pulse generating circuitry; a header coupled to the housing for receiving one or more stimulation leads, wherein feedthrough wires are provided to conduct electrical pulses from the pulse generating circuitry to the header; the header comprising a plurality of connectors for electrically connecting to each terminal of the one or more stimulation leads, wherein an inductive winding is disposed around or adjacent to each of the connector structures and is electrically connected between the respective connector structure and a corresponding feedthrough wire to limit MRI induced heating of a respective electrode of the one or more stimulation leads.

摘要翻译： 在一个实施例中，用于产生用于递送给患者的电刺激的脉冲发生器包括：包含脉冲发生电路的密封外壳; 连接到所述壳体以用于接收一个或多个刺激引线的头部，其中提供穿通线以将电脉冲从所述脉冲发生电路传导到所述头部; 所述头部包括用于电连接到所述一个或多个刺激引线的每个端子的多个连接器，其中感应绕组设置在每个所述连接器结构的周围或附近，并且电连接在相应的连接器结构和相应的馈通线 以限制一个或多个刺激引线的相应电极的MRI诱导加热。

公开(公告)号：US08209020B2

公开(公告)日：2012-06-26

申请号：US13180243

申请日：2011-07-11

申请人： John H. Erickson

发明人： John H. Erickson

IPC分类号： A61N1/18

CPC分类号： A61N1/378 ,  A61N1/3708 ,  A61N1/40

摘要： The invention relates to a stimulation device for creating complex or multi-purpose tissue stimulation. Many typical stimulation devices suffer from deficiencies in providing complex stimulation patterns. Using a circuitry operable or programmable to repeat and skip stimulation settings, a complex stimulation set may be created. The repeating and skipping functionality may be implemented in hardware or software. In this manner, complex stimulations may be derived from simple circuitries. Furthermore, these stimulations may be used to treat pain, stimulate bone growth, and control motor disorders, among others.

摘要翻译： 本发明涉及一种用于产生复合或多用途组织刺激的刺激装置。 许多典型的刺激装置在提供复杂刺激模式方面存在缺陷。 使用可操作或可编程的电路来重复和跳过刺激设置，可以创建复杂的刺激集合。 重复和跳过功能可以在硬件或软件中实现。 以这种方式，可以从简单的电路中导出复杂的刺激。 此外，这些刺激可以用于治疗疼痛，刺激骨骼生长和控制运动障碍等。

公开(公告)号：US20090048643A1

公开(公告)日：2009-02-19

申请号：US12245208

申请日：2008-10-03

申请人： John H. Erickson ,  Robert L. McCormick ,  Benjamin A. Tranchina

发明人： John H. Erickson ,  Robert L. McCormick ,  Benjamin A. Tranchina

IPC分类号： A61N1/36

CPC分类号： A61N1/378 ,  A61N1/3787

摘要： In one embodiment, a method of operating an implantable pulse generator comprises: providing power to a voltage converter at a first voltage level; outputting a second voltage level by the voltage converter, the second voltage level being a variable voltage level that is controlled by a control signal provided to the voltage converter, the second voltage level being provided to pulse generating circuitry of the implantable pulse generator, the second voltage level being selectable from a plurality of voltages including non-integer multiples of the first voltage level; generating pulses by the pulse generating circuitry, the pulse generating circuitry including current control circuitry for controlling the pulses to cause the pulses to provide substantially constant current to tissue of the patient; and applying at least two different control signals to the voltage converter during individual pulses to provide successively increasing voltages to the pulse generating circuitry during a respective pulse.

摘要翻译： 在一个实施例中，一种操作可植入脉冲发生器的方法包括：在第一电压电平下向电压转换器供电; 由所述电压转换器输出第二电压电平，所述第二电压电平是由提供给所述电压转换器的控制信号控制的可变电压电平，所述第二电压电平被提供给所述可植入脉冲发生器的脉冲发生电路，所述第二电压电平 电压电平可从包括第一电压电平的非整数倍的多个电压中选择; 由脉冲发生电路产生脉冲，脉冲发生电路包括电流控制电路，用于控制脉冲以使脉冲向患者的组织提供基本恒定的电流; 以及在单个脉冲期间将至少两个不同的控制信号施加到所述电压转换器，以在相应脉冲期间向所述脉冲发生电路提供连续增加的电压。

公开(公告)号：US07450991B2

公开(公告)日：2008-11-11

申请号：US11138120

申请日：2005-05-26

申请人： Galen L. Smith ,  John H. Erickson

发明人： Galen L. Smith ,  John H. Erickson

IPC分类号： A61N1/00

CPC分类号： A61N1/3708 ,  A61N1/3787

摘要： Techniques are disclosed which provide a substantially constant battery reserve capacity with respect to therapeutic medical devices. Accordingly, a battery control system may be operable to maintain a substantially constant reserve capacity throughout the life of the battery. The battery reserve capacity activation threshold may be set and continuously or periodically updated so that a battery's remaining capacity equals the predetermined reserve capacity when the measured parameter reaches the activation threshold, thereby allowing a maximum amount of a battery's total capacity to be employed for therapeutic use and reserve only that portion of that capacity determined to provide for a desired level and/or period of device function after reaching the reserve threshold.

摘要翻译： 公开了相对于治疗医疗装置提供基本上恒定的电池储备容量的技术。 因此，电池控制系统可操作以在电池的整个寿命期间保持基本上恒定的储备容量。 可以设置并持续或周期性地更新电池储备容量激活阈值，使得当测量的参数达到激活阈值时，电池的剩余容量等于预定的储备容量，从而允许最大量的电池的总容量用于治疗用途 并且仅保留该容量的那部分以确定在达到预定阈值之后提供期望的等级和/或设备功能的周期。

公开(公告)号：US20080125702A1

公开(公告)日：2008-05-29

申请号：US12021967

申请日：2008-01-29

申请人： Brian Blischak ,  John H. Erickson ,  Terry Daglow ,  Sandra Marie Hooper ,  Bruce David Wigness

发明人： Brian Blischak ,  John H. Erickson ,  Terry Daglow ,  Sandra Marie Hooper ,  Bruce David Wigness

IPC分类号： A61M5/142

CPC分类号： A61M5/14276 ,  A61M5/1452 ,  A61M5/16881 ,  A61M2005/14264 ,  A61M2005/14506 ,  A61M2205/33 ,  A61M2205/3372

摘要： The present invention relates to an implantable infusion pump having a refillable infusate reservoir in fluid communication with a delivery site via a flow path. This flow path includes a flow resistance. The infusion pump includes a sensing device(s), positioned relative to the flow path, to provide data regarding a flow rate along the flow path. The infusion pump effects a division of a total flow period into at least a plurality of unit dose periods, each unit dose period effecting delivery of a unit dose of infusate. The cumulative effect of delivering the total number of unit dose periods is the delivery of a desired dose over the total flow period. The present invention permits a reservoir pressure to vary over any portion of total flow period but effects a constant-pressure state over each unit dose cycle.

摘要翻译： 本发明涉及一种植入式输注泵，其具有经由流路与输送部位流体连通的可再填充输液管储存器。 该流路包括流动阻力。 输液泵包括相对于流动路径定位的感测装置，以提供关于沿着流动路径的流量的数据。 输注泵将总流动周期分成至少多个单位剂量周期，每个单位剂量周期影响输送单位剂量的输注液。 递送单位剂量周期总数的累积效应是在总流动周期内递送期望的剂量。 本发明允许储存器压力在总流动周期的任何部分上变化，但是在每个单位剂量周期上影响恒定压力状态。