公开(公告)号：US08273032B2

公开(公告)日：2012-09-25

申请号：US12182847

申请日：2008-07-30

申请人： James Kevin Carney ,  Can Cinbis

发明人： James Kevin Carney ,  Can Cinbis

IPC分类号： A61B5/02

CPC分类号： A61B5/02427 ,  A61B5/14552 ,  A61B5/1459 ,  A61B5/6846 ,  A61B5/7207 ,  A61B5/7214 ,  A61B2562/0233 ,  A61B2562/043

摘要： An implanted system includes at least two optical sensors implanted proximate to an artery of a patient such that one optical sensor is upstream of another optical sensor. Arterial pulses of the patient may be detected based on electrical signals from at least one of the optical sensors. In addition, electrical signals from the optical sensors may be used to minimize the effects of motion artifacts on the detection of arterial pulses. For example, a detected pulse may be determined to be a spurious pulse if the optical sensors indicate the occurrence of the pulse within a predetermined range of time. As another example, a first optical sensor signal may be shifted in time relative to a second optical sensor signal, and the signals may be correlated. An arterial pulse may be detected at a time at which a peak or trough amplitude value of the correlated signal is observed.

摘要翻译： 植入系统包括在患者的动脉附近植入的至少两个光学传感器，使得一个光学传感器在另一个光学传感器的上游。 可以基于来自至少一个光学传感器的电信号来检测患者的动脉。 此外，可以使用来自光学传感器的电信号来最小化运动假象对动脉脉冲检测的影响。 例如，如果光学传感器指示在预定的时间范围内出现脉冲，则检测到的脉冲可以被确定为杂散脉冲。 作为另一示例，第一光学传感器信号可以相对于第二光学传感器信号在时间上移位，并且信号可以相关。 可以在观察到相关信号的峰值或谷值振幅值的时间检测到动脉脉冲。

公开(公告)号：US08165662B2

公开(公告)日：2012-04-24

申请号：US12039281

申请日：2008-02-28

申请人： Can Cinbis ,  James K. Carney

发明人： Can Cinbis ,  James K. Carney

IPC分类号： A61B6/00

CPC分类号： A61B5/1459 ,  A61B5/0059 ,  A61B5/024 ,  A61B5/046 ,  A61B5/0464 ,  A61B5/14542 ,  A61B5/7214 ,  A61N1/3925

摘要： A medical device for sensing cardiac events that includes a plurality of electrodes sensing cardiac signals utilized to identify a cardiac event, a plurality of light sources capable of emitting light at a plurality of wavelengths, and a detector to detect the emitted light. A processor determines a plurality of light measurements in response to the emitted light detected by the detector, and generates a blood volume index in response to a light source of the plurality of light sources emitting light at an isobestic wavelength. The blood volume index is then utilized to verify the identifying of the cardiac event.

摘要翻译： 一种用于感测心脏事件的医疗装置，其包括感测用于识别心脏事件的心脏信号的多个电极，能够发射多个波长的光的多个光源以及检测发射光的检测器。 处理器响应于由检测器检测到的发射光来确定多个光测量，并且响应于以异常波长发射光的多个光源的光源产生血液体积指数。 然后利用血容量指数来验证心脏事件的识别。

公开(公告)号：US20110190608A1

公开(公告)日：2011-08-04

申请号：US12765345

申请日：2010-04-22

申请人： Jonathan L. Kuhn ,  Thomas A. Anderson ,  Can Cinbis ,  Jeffrey M. Jelen ,  Timothy Davis ,  James K. Carney

发明人： Jonathan L. Kuhn ,  Thomas A. Anderson ,  Can Cinbis ,  Jeffrey M. Jelen ,  Timothy Davis ,  James K. Carney

IPC分类号： A61B5/1455 ,  A61B5/00 ,  H05K13/00

CPC分类号： A61N1/3702 ,  A61B5/14503 ,  A61B5/14532 ,  A61B5/1455 ,  A61B5/6846 ,  A61N1/36557 ,  Y10T29/49002

摘要： An optical sensor for a medical device includes a fixed lens spacing between emit and receive modules to achieve target sensor sensitivity, while varying other sensor parameters in order to increase signal amplitude without increasing power demand. The size of at least one of emit and receive module lenses of an optical sensor, and the offset between the opto-electronic component and the respective lens of at least one of emit and receive modules is decreased to increase amplitude of the signal received by the receive module from the emit module.

摘要翻译： 用于医疗装置的光学传感器包括发射和接收模块之间的固定透镜间隔，以实现目标传感器灵敏度，同时改变其它传感器参数，以便增加信号幅度而不增加功率需求。 光传感器的发射和接收模块透镜中的至少一个的尺寸以及光电元件与发射模块和接收模块中的至少一个的相应透镜之间的偏移被减小以增加由 从发射模块接收模块。

公开(公告)号：US20100317947A1

公开(公告)日：2010-12-16

申请号：US12797823

申请日：2010-06-10

申请人： Can Cinbis ,  James K. Carney ,  Jonathan L. Kuhn ,  David A. Anderson

发明人： Can Cinbis ,  James K. Carney ,  Jonathan L. Kuhn ,  David A. Anderson

IPC分类号： A61B5/1455

CPC分类号： A61N1/36557

摘要： A medical device system and associated method control the delivery of a therapy to a patient. The system includes an activity sensor and detects a change in activity level of the patient. The system further include an optical sensor to sense signal corresponding to tissue light attenuation. The system computes a tissue oxygenation measurement in response to detecting a change in activity level. A parameter controlling delivery of the therapy is adjusted in response to detecting the decreased tissue oxygenation.

摘要翻译： 医疗装置系统和相关联的方法控制对患者的治疗的递送。 该系统包括活动传感器并检测患者的活动水平的变化。 该系统还包括用于感测对应于组织光衰减的信号的光学传感器。 响应于检测到活动水平的变化，系统计算组织氧合测量。 响应于检测到组织氧合减少而调整治疗递送的参数。

公开(公告)号：US20100317946A1

公开(公告)日：2010-12-16

申请号：US12797781

申请日：2010-06-10

申请人： Jonathan L. Kuhn ,  Can Cinbis ,  David A. Anderson ,  James K. Carney

发明人： Jonathan L. Kuhn ,  Can Cinbis ,  David A. Anderson ,  James K. Carney

IPC分类号： A61B5/145 ,  A61B5/0402

CPC分类号： A61N1/3622 ,  A61B5/02028 ,  A61B5/0215 ,  A61B5/042 ,  A61B5/1116 ,  A61B5/14542 ,  A61B5/1459 ,  A61N1/36557 ,  A61N1/3956

摘要： An implantable medical device for detecting and treating an arrhythmia includes an optical sensor adapted for positioning adjacent to a blood-perfused tissue volume. In one embodiment for controlling arrhythmia therapies delivered by the device, the optical sensor is controlled to emit light in response to detecting an arrhythmia, detect light scattered by the volume of blood perfused tissue including measuring an optical sensor output signal corresponding to the intensity of scattered light for at least four spaced-apart wavelengths, and compute a volume-independent measure of tissue oxygen saturation from the detected light. The hemodynamic status of the arrhythmia is detected in response to the measure of tissue oxygen saturation.

摘要翻译： 用于检测和治疗心律失常的可植入医疗装置包括适于邻近于血液灌注的组织体积定位的光学传感器。 在用于控制由装置传送的心律失常治疗的一个实施例中，响应于检测到心律失常，控制光学传感器发光，检测由血液灌注组织的体积散射的光，包括测量对应于散射强度的光学传感器输出信号 用于至少四个间隔波长的光，并且从检测到的光计算组织氧饱和度的体积独立测量。 响应于组织氧饱和度的测量，检测心律失常的血液动力学状态。

公开(公告)号：US20100317943A1

公开(公告)日：2010-12-16

申请号：US12797831

申请日：2010-06-10

申请人： Jonathan L. Kuhn ,  David A. Anderson ,  Can Cinbis

发明人： Jonathan L. Kuhn ,  David A. Anderson ,  Can Cinbis

IPC分类号： A61B5/145

CPC分类号： A61B5/1459 ,  A61B5/1495

摘要： A medical device system and associated method are used for monitoring tissue oxygenation. An optical sensor produces a signal corresponding to tissue light attenuation. A processor receives the optical sensor signal and computes a first measure of light attenuation at a first light wavelength and a second measure of light attenuation at a second light wavelength. In one embodiment, noise cancellation circuitry receives the first measure and the second measure and generates a guessed ratio of the first and second measures. Using the first measure, the second measure and the guessed ratio, the noise cancellation circuitry provides a peak output power when the guessed ratio corresponds to an actual ratio of the first and second measures.

摘要翻译： 医疗器械系统和相关方法用于监测组织氧合。 光学传感器产生对应于组织光衰减的信号。 处理器接收光学传感器信号并且计算第一光波长处的光衰减的第一测量值和在第二光波长处的光衰减的第二测量值。 在一个实施例中，噪声消除电路接收第一测量和第二测量并产生第一和第二测量的猜测比率。 使用第一测量，第二测量和猜测比率，当猜测比率对应于第一和第二测量的实际比率时，噪声消除电路提供峰值输出功率。

公开(公告)号：US07734345B2

公开(公告)日：2010-06-08

申请号：US11391949

申请日：2006-03-29

申请人： Can Cinbis

发明人： Can Cinbis

IPC分类号： A61N1/00

CPC分类号： A61N1/37258 ,  A61N1/0504

摘要： One method for aborting cardiac treatments includes detecting an arrhythmia in a heart of a patient with at least one electrode, which is located outside the heart of the patient. An alarm signal is generated after the detection of the arrhythmia to alert a user of an impending cardiac treatment. The cardiac treatment is cancelled if an abort signal is provided by the user within a predetermined amount of time.

摘要翻译： 用于中止心脏治疗的一种方法包括用位于患者心脏外部的至少一个电极检测患者心脏中的心律失常。 在检测到心律失常之后产生警报信号，以向用户警告即将进行的心脏治疗。 如果在预定时间内由用户提供中止信号，则心脏治疗被取消。

公开(公告)号：US20100030063A1

公开(公告)日：2010-02-04

申请号：US12183674

申请日：2008-07-31

申请人： Nathan Tyler Lee ,  Rick Dean McVenes ,  Can Cinbis ,  Jonathan Leslie Kuhn ,  James F. Kelley

发明人： Nathan Tyler Lee ,  Rick Dean McVenes ,  Can Cinbis ,  Jonathan Leslie Kuhn ,  James F. Kelley

IPC分类号： A61B5/05

CPC分类号： A61B5/06 ,  A61B5/065 ,  A61B5/6858 ,  A61B6/4441 ,  A61B6/487 ,  A61B34/20 ,  A61B2034/2046 ,  A61B2034/2051 ,  A61B2034/2055 ,  A61B2034/2061 ,  A61B2034/2072 ,  A61B2562/0266 ,  A61M25/01 ,  G01B11/18 ,  G02B6/02057

摘要： A system for tracking an instrument relative to an anatomical structure is provided. The system can include at least one tracking device, which can be coupled to the instrument. The system can also include a shape sensor coupled to the instrument that can determine a shape of the instrument. The system can include a tracking system that can track a position of the at least one tracking device relative to the anatomical structure. The system can further include a navigation system that can determine a position and shape of the instrument relative to the anatomical structure based on the position of the at least one tracking device determined by the tracking system and the shape of the instrument as sensed by the shape sensor.

摘要翻译： 提供了一种用于相对于解剖结构跟踪器械的系统。 该系统可以包括至少一个可以耦合到仪器的跟踪装置。 该系统还可以包括耦合到仪器的形状传感器，其可以确定仪器的形状。 该系统可以包括跟踪系统，其可以跟踪至少一个跟踪装置相对于解剖结构的位置。 该系统还可以包括导航系统，该导航系统可以基于由跟踪系统确定的至少一个跟踪装置的位置和由形状所感测到的乐器的形状来确定乐器相对于解剖结构的位置和形状 传感器。

公开(公告)号：US20090156912A1

公开(公告)日：2009-06-18

申请号：US11955056

申请日：2007-12-12

申请人： Jonathan L. Kuhn ,  Timothy J. Davis ,  Can Cinbis ,  Robert M. Ecker ,  Shawn D. Knowles

发明人： Jonathan L. Kuhn ,  Timothy J. Davis ,  Can Cinbis ,  Robert M. Ecker ,  Shawn D. Knowles

IPC分类号： A61B5/1459 ,  H01L31/18

CPC分类号： A61B5/14542 ,  A61B5/0084 ,  A61B5/0086 ,  A61B5/14532 ,  A61B5/14552 ,  A61B5/1459 ,  A61B5/6846 ,  A61B2562/02 ,  A61B2562/043 ,  A61B2562/146

摘要： An implantable optical sensor and associated manufacturing method include a sensor housing having an inner surface and an outer surface and a window formed in the housing extending between the housing inner surface and the housing outer surface. An opto-electronic device enclosed within the housing and having a photonic surface is operatively positioned proximate the window for emitting light through the window or detecting light through the window. An optical coupling member is positioned between the opto-electronic device and the window for reducing light reflection at a surface within the implantable optical sensor.

摘要翻译： 可植入光学传感器和相关联的制造方法包括具有内表面和外表面的传感器外壳和形成在壳体中的窗口，该壳体在壳体内表面和壳体外表面之间延伸。 封闭在壳体内并且具有光子表面的光电器件可操作地定位在窗口附近，用于通过窗口发射光或通过窗口检测光。 光耦合构件位于光电器件和窗口之间，用于减少可植入光学传感器内的表面处的光反射。

公开(公告)号：US20090030334A1

公开(公告)日：2009-01-29

申请号：US11781734

申请日：2007-07-23

申请人： David A. Anderson ,  Can Cinbis

发明人： David A. Anderson ,  Can Cinbis

IPC分类号： A61B5/02

CPC分类号： A61N1/36514 ,  A61B7/003 ,  A61B7/006 ,  A61B7/008 ,  A61B2562/0204 ,  A61N1/36578 ,  A61N1/3702

摘要： An implantable medical device system senses a first signal using a first acoustical sensor adapted to be operatively positioned in a first internal body location for sensing heart sounds in a patient. The system includes a second acoustical sensor adapted to be operatively positioned in a second internal body location for sensing sounds in the patient and generate a second signal that is less responsive to the heart sounds than the first acoustical signal. An implantable medical device including a housing and a processor enclosed in the housing receives the first signal and the second signal and generates a corrected first signal by canceling non-cardiac signals in the first signal using the second signal.

摘要翻译： 植入式医疗设备系统使用适于被操作地定位在第一内部身体位置中的第一声学传感器来感测第一信号，以感测患者心脏的声音。 该系统包括适于可操作地定位在第二内部身体位置中的第二声学传感器，用于感测患者中的声音，并产生比第一声学信号对心音响应较小的第二信号。 包括壳体和封装在壳体中的处理器的可植入医疗装置接收第一信号和第二信号，并且通过使用第二信号消除第一信号中的非心脏信号来产生校正的第一信号。