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公开(公告)号：US07338963B2
公开(公告)日：2008-03-04
申请号：US11198801
申请日：2005-08-05
申请人： Donald J. P. Pinto
发明人： Donald J. P. Pinto
IPC分类号： C07D401/14 , C07D471/04 , A61K31/437 , A61K31/4412 , A61P7/02
CPC分类号： C07D471/04 , A61J1/00 , A61J1/03 , A61J1/05 , A61K31/4365 , A61K31/437 , A61K31/444 , A61K31/454 , A61K31/4545 , A61K31/496 , A61K31/513 , A61K31/55 , A61K45/06 , B65D81/3216 , C07D213/75 , C07D213/81 , C07D213/82 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D409/12 , C07D413/14 , C07D417/14
摘要： The present application describes lactam-containing compounds and derivatives thereof of Formula I: P4—P—M—M4I or pharmaceutically acceptable salt forms thereof, wherein ring P, if present is a 5-7 membered carbocycle or heterocycle and ring M is a 5-7 membered carbocycle or heterocycle. Compounds of the present invention are useful as inhibitors of trypsin-like serine proteases, specifically factor Xa.
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公开(公告)号：US06602871B2
公开(公告)日：2003-08-05
申请号：US10007195
申请日：2001-12-04
申请人： Patrick Y. S. Lam , Charles G. Clark , John M. Fevig , Robert A. Galemmo , Qi Han , Irina C. Jacobson , Renhau Li , Donald J. P. Pinto , Ruth R. Wexler
发明人： Patrick Y. S. Lam , Charles G. Clark , John M. Fevig , Robert A. Galemmo , Qi Han , Irina C. Jacobson , Renhau Li , Donald J. P. Pinto , Ruth R. Wexler
IPC分类号： C07D47104
CPC分类号： C07D213/74 , C07D221/04 , C07D401/04 , C07D401/12 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/04 , C07D471/04 , C07D491/04 , C07D495/04
摘要： This invention relates generally to inhibitors of trypsin-like serine protease enzymes, especially factor Xa or thrombin, pharmaceutical compositions containing the same, and methods of using the same as anticoagulant agents for treatment and prevention of thromboembolic disorders.
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公开(公告)号：US06586418B2
公开(公告)日：2003-07-01
申请号：US09896939
申请日：2001-06-29
申请人： Donald J. P. Pinto , Mimi L Quan
发明人： Donald J. P. Pinto , Mimi L Quan
IPC分类号： A61K3133
CPC分类号： C07D207/273 , C07D207/09 , C07D213/64 , C07D213/73 , C07D241/18 , C07D295/192 , C07D295/26 , C07D401/06 , C07D471/04 , C07D487/04 , C07D517/04
摘要： This invention relates generally to heteroaryl-phenyl substituted compounds that are inhibitors of trypsin-like serine protease enzymes, especially factor Xa or thrombin, pharmaceutical compositions containing the same, and methods of using the same as anticoagulant agents for treatment and prevention of thromboembolic disorders.
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44.发明授权Nitrogen containing heteroaromatics with ortho-substituted P1's as factor Xa inhibitors 有权含有邻位取代的P1作为因子Xa抑制剂的含氮杂芳族化合物公开(公告)号：US06548525B2
公开(公告)日：2003-04-15
申请号：US09833302
申请日：2001-04-12
IPC分类号： A61K314192
CPC分类号： C07D257/04 , C07D231/14 , C07D231/22 , C07D231/24 , C07D249/04 , C07D401/12 , C07D401/14 , C07D403/12
摘要： The present application describes nitrogen containing heteroaromatics with ortho-substituted P1's and derivatives thereof of formula I: or pharmaceutically acceptable salt or prodrug forms thereof, wherein J is N or NH and D is substituted ortho to G on E and may be CH2NH2, which are useful as inhibitors of factor Xa.
摘要翻译： 本申请描述了具有式I的邻位取代的P1及其衍生物的含氮杂芳族化合物：或其药学上可接受的盐或前药形式，其中J为N或NH且D与E上的G邻位取代，并且可为CH 2 NH 2，其为 可用作因子Xa的抑制剂。
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公开(公告)号：US06403583B1
公开(公告)日：2002-06-11
申请号：US09469835
申请日：1999-12-22
申请人： Patrick Y. S. Lam , Charles G. Clark , John M. Fevig , Robert A. Galemmo , Qi Han , Irina C. Jacobson , Renhau Li , Donald J. P. Pinto , Ruth R. Wexler
发明人： Patrick Y. S. Lam , Charles G. Clark , John M. Fevig , Robert A. Galemmo , Qi Han , Irina C. Jacobson , Renhau Li , Donald J. P. Pinto , Ruth R. Wexler
IPC分类号： C07D40300
CPC分类号： C07D213/74 , C07D221/04 , C07D401/04 , C07D401/12 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/04 , C07D471/04 , C07D491/04 , C07D495/04
摘要： This invention relates generally to inhibitors of trypsin-like serine protease enzymes, especially factor Xa or thrombin, pharmaceutical compositions containing the same, and methods of using the same as anticoagulant agents for treatment and prevention of thromboembolic disorders.
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