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61 条记录 (耗时 0.045 秒)

    6-11 bridged oxime erythromycin derivatives
    41.
    发明授权
    6-11 bridged oxime erythromycin derivatives 有权
    6-11桥接肟红霉素衍生物

    公开(公告)号：US07384922B2

    公开(公告)日：2008-06-10

    申请号：US11416609

    申请日：2006-05-03

    申请人： Guoqiang Wang ,  Ly Tam Phan ,  Yat Sun Or

    发明人： Guoqiang Wang ,  Ly Tam Phan ,  Yat Sun Or

    IPC分类号： A61K31/70 ,  C07H17/08

    CPC分类号： C07H17/08

    摘要： The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes processes by which to make the compounds of the present invention.

    摘要翻译： 本发明公开了式I化合物或其药学上可接受的盐，酯或前药：其表现出抗菌性质。 本发明还涉及包含上述化合物的药物组合物，用于给予需要抗生素治疗的受试者。 本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的细菌感染的方法。 本发明还包括制备本发明化合物的方法。

    9A, 11-2C-bicyclic 9a-azalide derivatives
    42.
    发明授权
    9A, 11-2C-bicyclic 9a-azalide derivatives 有权
    9A，11-2C-双环9a-氮杂环戊二烯衍生物

    公开(公告)号：US07271155B2

    公开(公告)日：2007-09-18

    申请号：US11324502

    申请日：2006-01-03

    申请人： Yat Sun Or ,  Ly Tam Phan ,  Guoqiang Wang ,  Yanchun Wang ,  Yulin Peng

    发明人： Yat Sun Or ,  Ly Tam Phan ,  Guoqiang Wang ,  Yanchun Wang ,  Yulin Peng

    IPC分类号： A61K31/70 ,  C07H17/08

    CPC分类号： C07H17/08

    摘要： The present invention discloses compounds of formulae I and II, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.

    摘要翻译： 本发明公开了式I和II的化合物或其药学上可接受的盐，酯或前药：其表现出抗菌性质。 本发明还涉及包含上述化合物的药物组合物，用于给予需要抗生素治疗的受试者。 本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的细菌感染的方法。 本发明还包括制备本发明化合物的方法。

    6,11-4C-bicyclic 9a-azalide derivatives
    43.
    发明授权
    6,11-4C-bicyclic 9a-azalide derivatives 失效
    6,11-4C-双环9a-氮杂的衍生物

    公开(公告)号：US06764998B1

    公开(公告)日：2004-07-20

    申请号：US10464188

    申请日：2003-06-18

    申请人： Guoqiang Wang ,  Yat Sun Or ,  Ly Tam Phan

    发明人： Guoqiang Wang ,  Yat Sun Or ,  Ly Tam Phan

    IPC分类号： A61K3170

    CPC分类号： C07H17/08

    摘要： The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.

    摘要翻译： 本发明公开了式I化合物或其药学上可接受的盐，酯或前药：其表现出抗菌性质。 本发明还涉及包含上述化合物的药物组合物，用于给予需要抗生素治疗的受试者。 本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的细菌感染的方法。 本发明还包括制备本发明化合物的方法。

    2-Halo-6-O-substituted ketolide derivatives
    45.
    发明授权
    2-Halo-6-O-substituted ketolide derivatives 失效
    2-卤代-6-O-取代的酮内酯衍生物

    公开(公告)号：US6124269A

    公开(公告)日：2000-09-26

    申请号：US154294

    申请日：1998-09-16

    申请人： Ly Tam Phan ,  Yat Sun Or ,  Daniel T. Chu ,  Jacob J. Platter ,  Yan Chen ,  Richard F. Clark

    发明人： Ly Tam Phan ,  Yat Sun Or ,  Daniel T. Chu ,  Jacob J. Platter ,  Yan Chen ,  Richard F. Clark

    IPC分类号： C07H17/08 ,  A61K31/70

    CPC分类号： A61K31/7048 ,  C07H17/08

    摘要： Novel 2-halo-6-O-substituted ketolide derivatives and pharmaceutically acceptable salts and esters thereof having antibacterial activity having a formula ##STR1## compositions comprising a therapeutically effective amount of a compound of the invention in combination with a pharmaceutically acceptable carrier, a method for treating bacterial infections by administering to a mammal a pharmaceutical composition containing a therapeutically-effective amount of a compound of the invention, and processes for their preparation.

    摘要翻译： 具有抗菌活性的新型2-卤代-6-O-取代的酮内酯衍生物及其药学上可接受的盐和酯，其具有包含治疗有效量的本发明化合物与药学上可接受的载体的组合物的组合物，治疗细菌的方法 通过向哺乳动物施用含有治疗有效量的本发明化合物的药物组合物及其制备方法的感染。

    PROCESSES FOR THE PREPARATION OF O-[5-(4-AMINO-THIAZOL-2-YL)-PYRIDIN-2-YLMETHYL]-HYDROXYLAMINE
    46.
    发明申请
    PROCESSES FOR THE PREPARATION OF O-[5-(4-AMINO-THIAZOL-2-YL)-PYRIDIN-2-YLMETHYL]-HYDROXYLAMINE 有权
    制备O- [5-（4-氨基 - 噻唑-2-基） - 吡啶-2-基]甲基] - 羟基甲酰胺的方法

    公开(公告)号：US20090281324A1

    公开(公告)日：2009-11-12

    申请号：US12437636

    申请日：2009-05-08

    申请人： Datong Tang ,  Yinglin Han ,  Yanhe Huang ,  Ly Tam Phan ,  Yat Sun Or ,  Zhe Wang

    发明人： Datong Tang ,  Yinglin Han ,  Yanhe Huang ,  Ly Tam Phan ,  Yat Sun Or ,  Zhe Wang

    IPC分类号： C07D417/04

    CPC分类号： C07D417/04

    摘要： The present invention relates generally to novel methods for the synthesis of O-[5-(4-amino-thiazol-2-yl)-pyridin-2-ylmethyl]-hydroxylamine which is an essential reagent in the synthesis of one of the bridged erythromycin derivatives and their respective pharmaceutically acceptable salts in PCT Application WO 03/097659 A1. In particular, the present invention relates to processes and intermediates for the preparation of a compound of formula (Ia):

    摘要翻译： 本发明一般涉及合成O- [5-（4-氨基 - 噻唑-2-基） - 吡啶-2-基甲基] - 羟胺的新方法，其是合成桥接的 红霉素衍生物及其各自的药学上可接受的盐在PCT申请WO 03/097659 A1中。 特别地，本发明涉及制备式（Ia）化合物的方法和中间体：

    ANTI-BACTERIAL ACTIVITY OF 9-HYDROXY DERIVATIVES OF 6,11-BICYCLOLIDES
    48.
    发明申请
    ANTI-BACTERIAL ACTIVITY OF 9-HYDROXY DERIVATIVES OF 6,11-BICYCLOLIDES 有权
    6,11-双酚的9-羟基衍生物的抗细菌活性

    公开(公告)号：US20090281050A1

    公开(公告)日：2009-11-12

    申请号：US12437616

    申请日：2009-05-08

    申请人： Rajesh Iyengar ,  Yanchun Wang ,  Ly Tam Phan ,  Yat Sun Or

    发明人： Rajesh Iyengar ,  Yanchun Wang ,  Ly Tam Phan ,  Yat Sun Or

    IPC分类号： A61K31/7048 ,  C07H17/08 ,  A61P31/04

    CPC分类号： A61K31/706 ,  A61K31/7056 ,  C07H17/08

    摘要： The present invention discloses compounds of formula (I) or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit superior antibacterial properties, particularly against Haemophilus influenzae. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.

    摘要翻译： 本发明公开了式（I）化合物或其药学上可接受的盐，酯或前药：其表现出优异的抗菌性，特别是抗流感嗜血杆菌。 本发明还涉及包含上述化合物的药物组合物，用于给予需要抗生素治疗的受试者。 本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的细菌感染的方法。 本发明还包括制备本发明化合物的方法。

    9a, 11-3C-bicyclic 9a-azalide derivatives
    49.
    发明授权
    9a, 11-3C-bicyclic 9a-azalide derivatives 有权
    9a，11-3C-双环9a-氮杂衍生物

    公开(公告)号：US07276487B2

    公开(公告)日：2007-10-02

    申请号：US10946339

    申请日：2004-09-21

    申请人： Guoqiang Wang ,  Yulin Peng ,  Yanchun Wang ,  Ly Tam Phan ,  Yat Sun Or

    发明人： Guoqiang Wang ,  Yulin Peng ,  Yanchun Wang ,  Ly Tam Phan ,  Yat Sun Or

    IPC分类号： A61K31/70 ,  C07H17/08

    CPC分类号： C07H17/08

    摘要： The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.

    摘要翻译： 本发明公开了式I化合物或其药学上可接受的盐，酯或前药：其表现出抗菌性质。 本发明还涉及包含上述化合物的药物组合物，用于给予需要抗生素治疗的受试者。 本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的细菌感染的方法。 本发明还包括制备本发明化合物的方法。

    11-C-substituted erythromycin derivatives
    50.
    发明授权
    11-C-substituted erythromycin derivatives 有权
    11-C-取代的红霉素衍生物

    公开(公告)号：US06953782B2

    公开(公告)日：2005-10-11

    申请号：US10745856

    申请日：2003-12-24

    申请人： Ly Tam Phan ,  Yat Sun Or ,  Jay Judson Farmer

    发明人： Ly Tam Phan ,  Yat Sun Or ,  Jay Judson Farmer

    IPC分类号： A61K31/365 ,  A61K31/70 ,  A61K31/7048 ,  C07D313/00 ,  C07D313/06 ,  C07D313/20 ,  C07H17/08

    CPC分类号： C07H17/08

    摘要： The present invention discloses compounds of formulae I, II, III or IV or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.

    摘要翻译： 本发明公开了式I，II，III或IV的化合物或其药学上可接受的盐，酯或前药：其表现出抗菌性质。 本发明还涉及包含上述化合物的药物组合物，用于给予需要抗生素治疗的受试者。 本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的细菌感染的方法。 本发明还包括制备本发明化合物的方法。