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公开(公告)号：US11952633B2
公开(公告)日：2024-04-09
申请号：US17101904
申请日：2020-11-23
Inventor： David A. Ahlquist , William R. Taylor , Hongzhi Zou , Graham P. Lidgard
IPC: C12Q1/6886 , C12Q1/6827 , C12Q1/6858
CPC classification number: C12Q1/6886 , C12Q1/6827 , C12Q1/6858 , C12Q2600/154 , C12Q1/6827 , C12Q2521/331 , C12Q2523/125 , C12Q2563/159 , C12Q1/6858 , C12Q2523/125 , C12Q2563/159
Abstract: The present invention relates to methods and compositions for determination of and uses of specific methylation patterns indicative of adenoma and carcinoma. In particular, the invention relates to analysis of defined CpG loci that are coordinately methylated in DNAs from cancer and adenoma samples, methods for identifying coordinately methylated loci, and methods of using analysis of coordinately methylated loci in one or more marker regions in the design of assays for adenoma and cancer.
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公开(公告)号：US11859254B2
公开(公告)日：2024-01-02
申请号：US16782841
申请日：2020-02-05
Inventor： David A. Ahlquist , William R. Taylor , John B. Kisiel , Tracy C. Yab , Douglas W. Mahoney , Hatim T. Allawi
IPC: C07H21/04 , C12Q1/68 , C12Q1/6886
CPC classification number: C12Q1/6886 , C12Q2600/154 , C12Q2600/16
Abstract: Provided herein is technology relating to detecting neoplasia and particularly, but not exclusively, to methods, compositions, and related uses for detecting premalignant and malignant neoplasms such as gastric cancer.
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公开(公告)号：US20230190243A1
公开(公告)日：2023-06-22
申请号：US17996032
申请日：2021-04-16
Inventor： Robert F. Eisele , Michael E. Williams , Prasad G. Iyer , Paul Marrione , Hatim T. Allawi , Graham P. Lidgard , Maria Giakoumopoulos , William R. Taylor , Tracy C. Yab , Douglas W. Mahoney , John B. Kisiel , David A. Ahlquist
IPC: A61B10/02 , A61B10/00 , C12Q1/6883
CPC classification number: A61B10/02 , A61B10/0096 , C12Q1/6883 , A61B2010/0061 , C12Q2600/156
Abstract: The invention relates to cell sampling devices. In particular, the present invention relates to ingestible cell sampling devices for sampling cells in a subject, and methods of use for detecting abnormalities in a subject using the same.
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公开(公告)号：US11365451B2
公开(公告)日：2022-06-21
申请号：US16399467
申请日：2019-04-30
Inventor： David A. Ahlquist , William R. Taylor , Douglas W. Mahoney , Graham P. Lidgard , Hatim T. Allawi
IPC: C12Q1/6886
Abstract: Provided herein is technology relating to detecting neoplasia and particularly, but not exclusively, to methods, compositions, and related uses for detecting premalignant and malignant neoplasms such as colorectal cancer.
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公开(公告)号：US20220162709A1
公开(公告)日：2022-05-26
申请号：US17600854
申请日：2020-04-03
Inventor： William R. Taylor , John B. Kisiel , Douglas W. Mahoney , David A. Ahlquist , Hatim T. Allawi
IPC: C12Q1/6886 , C12Q1/6806 , G01N33/574
Abstract: Provided herein is technology for pancreatic ductal adenocarcinoma (PDAC) screening and particularly, but not exclusively, to methods, compositions, and related uses for detecting the presence of PDAC.
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Patent Agency Ranking
公开(公告)号：US20220136058A1
公开(公告)日：2022-05-05
申请号：US17297356
申请日：2019-11-26
Applicant: Exact Sciences Development Company, LLC , Mayo Foundation for Medical Education and Research
Inventor： Hatim Allawi , Graham P. Lidgard , Maria Giakoumopoulos , David A. Ahlquist , William R. Taylor , Douglas Mahoney
IPC: C12Q1/6886 , G01N33/574
Abstract: Provided herein is technology relating to detecting neoplasia and particularly, but not exclusively, to methods, compositions, and related uses for detecting neoplasms such as lung cancer.
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公开(公告)号：US20220106644A1
公开(公告)日：2022-04-07
申请号：US17424422
申请日：2020-01-24
Applicant: Mayo Foundation for Medical Education and Research , Exact Sciences Development Company, LLC
Inventor： William R. Taylor , John B. Kisiel , Douglas W. Mahoney , David A. Ahlquist , Hatim T. Allawi , Maria Giakoumopoulos
IPC: C12Q1/6886 , G16B30/10 , G16B35/20
Abstract: Provided herein is technology for endometrial cancer (EC) screening and particularly, but not exclusively, to methods, compositions, and related uses for detecting the presence of endometrial cancer and various subtypes of endometrial cancer.
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公开(公告)号：US20220071605A1
公开(公告)日：2022-03-10
申请号：US17233199
申请日：2021-04-16
Applicant: Exact Sciences Development Company, LLC , Mayo Foundation for Medical Education and Research
Inventor： Robert F. Eisele , Michael E. Williams , Prasad G. Iyer , Paul Marrione , Hatim T. Allawi , Graham P. Lidgard , Maria Giakoumopoulos , William R. Taylor , Tracy C. Yab , Douglas W. Mahoney , John B. Kisiel , David A. Ahlquist
Abstract: The invention relates to cell sampling devices. In particular, the present invention relates to ingestible cell sampling devices for sampling cells in a subject, and methods of use for detecting abnormalities in a subject using the same. Provided herein is technology for neoplasia screening, and particularly, but not exclusively, to methods, compositions, and related uses for detecting the presence of cancer.
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公开(公告)号：US20210381066A1
公开(公告)日：2021-12-09
申请号：US17410383
申请日：2021-08-24
Applicant: Exact Sciences Development Company, LLC , Mayo Foundation for Medical Education and Research
Inventor： David A. Ahlquist , William R. Taylor , John B. Kisiel , Douglas W. Mahoney , Tracy C. Yab , Graham P. Lidgard , Hatim T. Allawi
IPC: C12Q1/6886 , C12Q1/6883 , G01N33/574
Abstract: Provided herein is technology for esophageal disorder screening and particularly, but not exclusively, to methods, compositions, and related uses for detecting the presence of esophageal disorders (e.g., Barrett's esophagus, Barrett's esophageal dysplasia, etc.). In addition, the technology provides methods, compositions and related uses for distinguishing between Barrett's esophagus and Barrett's esophageal dysplasia, and between Barrett's esophageal low-grade dysplasia, Barrett's esophageal high-grade dysplasia, and esophageal adenocarcinoma within samples obtained through endoscopic brushing or nonendoscopic whole esophageal brushing or swabbing using a tethered device (e.g. such as a capsule sponge, balloon, or other device).
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公开(公告)号：US10975443B2
公开(公告)日：2021-04-13
申请号：US16202935
申请日：2018-11-28
Applicant: Mayo Foundation for Medical Education and Research , Exact Sciences Development Company, LLC
Inventor： David A. Ahlquist , William R. Taylor , Douglas W. Mahoney , Tracy C. Yab , John B. Kisiel , Hatim T. Allawi , Graham P. Lidgard , Michael W. Kaiser
IPC: C12Q1/68 , C07H21/04 , C12Q1/6886 , C12Q1/6853 , G16H50/30 , C12Q1/6806 , C12Q1/6809 , C12Q1/6811 , C12Q1/6837 , C12Q1/6827 , C12Q1/682
Abstract: Provided herein is technology for breast cancer screening and particularly, but not exclusively, to methods, compositions, and related uses for detecting the presence of breast cancer.
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