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公开(公告)号：US20050272709A1
公开(公告)日：2005-12-08
申请号：US10497046
申请日：2002-10-18
申请人： Zaihui Zhang , Tim Daynard , Mikhail Chafeev , Shisen Wang , Greg Chopiuk , Serguei Sviridov
发明人： Zaihui Zhang , Tim Daynard , Mikhail Chafeev , Shisen Wang , Greg Chopiuk , Serguei Sviridov
IPC分类号： C07D231/04 , A61K31/403 , A61K31/409 , A61K31/415 , A61K31/4155 , A61K31/4184 , A61K31/4192 , A61K31/4196 , A61K31/433 , A61K31/4439 , A61K31/454 , A61K31/4545 , A61K31/4709 , A61K31/4725 , A61K31/496 , A61K31/502 , A61K31/506 , A61K31/517 , A61K31/5377 , A61K31/655 , A61K45/00 , A61P9/00 , A61P9/10 , A61P9/12 , A61P11/06 , A61P13/12 , A61P17/00 , A61P17/06 , A61P19/02 , A61P29/00 , A61P35/00 , A61P37/08 , C07D231/38 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/04 , C07D405/12 , C07D409/04 , C07D409/12 , C07D409/14 , C07D413/04 , C07D413/12 , C07D417/04 , C07D417/12
CPC分类号： C07D417/12 , A61K31/415 , A61K31/4155 , A61K31/655 , C07D231/04 , C07D231/38 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/04 , C07D405/12 , C07D409/04 , C07D409/12 , C07D409/14 , C07D413/04 , C07D413/12 , C07D417/04
摘要： Pharmaceutical compositions and compounds are provided. The compounds of the invention deomonstrate anti-proliferative activity, and may promote apoptosis in cells lacking normal regulation of cell cycle and death. In one embodiment of the invention, pharmaceutical compositions of the compounds in combination with a physiologically acceptable carrier are provided. The pharmaceutical compositions are useful in the treatment of hyperproliferative disorders, which disorders include tumor growth, lymphoproliferative diseases, angiogenesis. The compounds of the invention are substituted pyrazoles and pyrazolines.
摘要翻译： 提供药物组合物和化合物。 本发明化合物具有抗增殖活性，可促进缺乏细胞周期和死亡正常调节的细胞凋亡。 在本发明的一个实施方案中，提供了与生理上可接受的载体组合的化合物的药物组合物。 该药物组合物可用于治疗过度增殖性疾病，该疾病包括肿瘤生长，淋巴组织增生性疾病，血管生成。 本发明的化合物是取代的吡唑和吡唑啉。
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42.发明授权Enantiomers of spiro-oxindole compounds and their uses as therapeutic agents 有权螺 - 羟吲哚化合物的对映异构体及其用作治疗剂公开(公告)号：US08883840B2
公开(公告)日：2014-11-11
申请号：US13619915
申请日：2012-09-14
IPC分类号： A01N43/38 , A61K31/40 , A61K31/407 , C07D491/22 , C07D491/20
CPC分类号： C07D491/20 , A61K31/407 , C07B57/00 , C07B2200/07 , C07D491/22
摘要： This invention is directed to the (S)-enantiomer of the compound of formula (I): or a pharmaceutically acceptable solvate or prodrug thereof. This (S)-enantiomer is useful for the treatment of diseases or conditions, such as pain, which are ameliorated or alleviated by the modulation of voltage-gated sodium channels.
摘要翻译： 本发明涉及式（I）化合物的（S） - 对映异构体：或其药学上可接受的溶剂合物或前药。 该（S） - 对映体可用于治疗通过调节电压门控钠通道而改善或缓解的疾病或病症，例如疼痛。
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43.发明授权Enantiomers of spiro-oxindole compounds and their uses as therapeutic agents 有权螺 - 羟吲哚化合物的对映异构体及其用作治疗剂公开(公告)号：US08450358B2
公开(公告)日：2013-05-28
申请号：US12825168
申请日：2010-06-28
IPC分类号： A01N43/38 , A61K31/40 , C07D491/00 , C07D495/00
CPC分类号： C07D491/20 , A61K31/407 , C07B57/00 , C07B2200/07 , C07D491/22
摘要： This invention is directed to the (S)-enantiomer of the compound of formula (I): or a pharmaceutically acceptable solvate or prodrug thereof. This (S)-enantiomer is useful for the treatment of diseases or conditions, such as pain, which are ameliorated or alleviated by the modulation of voltage-gated sodium channels.
摘要翻译： 本发明涉及式（I）化合物的（S） - 对映异构体：或其药学上可接受的溶剂合物或前药。 该（S） - 对映体可用于治疗通过调节电压门控钠通道而改善或缓解的疾病或病症，例如疼痛。
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公开(公告)号：US20130072537A1
公开(公告)日：2013-03-21
申请号：US13619915
申请日：2012-09-14
IPC分类号： C07D491/20 , A61K31/407
CPC分类号： C07D491/20 , A61K31/407 , C07B57/00 , C07B2200/07 , C07D491/22
摘要： This invention is directed to the (S)-enantiomer of the compound of formula (I): or a pharmaceutically acceptable solvate or prodrug thereof. This (S)-enantiomer is useful for the treatment of diseases or conditions, such as pain, which are ameliorated or alleviated by the modulation of voltage-gated sodium channels.
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45.发明申请ENANTIOMERS OF SPIRO-OXINDOLE COMPOUNDS AND THEIR USES AS THERAPEUTIC AGENTS 有权螺旋体化合物的使用者及其作为治疗剂的用途公开(公告)号：US20100331386A1
公开(公告)日：2010-12-30
申请号：US12825168
申请日：2010-06-28
IPC分类号： A61K31/407 , C07D491/20 , A61P29/00 , A61P25/24 , A61P9/00 , A61P11/00 , A61P25/00 , A61P1/04
CPC分类号： C07D491/20 , A61K31/407 , C07B57/00 , C07B2200/07 , C07D491/22
摘要： This invention is directed to the (S)-enantiomer of the compound of formula (I): or a pharmaceutically acceptable solvate or prodrug thereof. This (S)-enantiomer is useful for the treatment of diseases or conditions, such as pain, which are ameliorated or alleviated by the modulation of voltage-gated sodium channels.
摘要翻译： 本发明涉及式（I）化合物的（S） - 对映异构体：或其药学上可接受的溶剂合物或前药。 该（S） - 对映体可用于治疗通过调节电压门控钠通道而改善或缓解的疾病或病症，例如疼痛。
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公开(公告)号：US06436915B1
公开(公告)日：2002-08-20
申请号：US09747563
申请日：2000-12-22
IPC分类号： A61K31415
CPC分类号： C07D231/38 , A61K31/415 , A61K31/4152 , A61K31/4155 , A61K31/4178 , A61K31/427 , A61K31/454 , A61K31/53 , A61K31/5377 , C07D231/46 , C07D231/52 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12
摘要： Pharmaceutical compositions and compounds are provided. The compounds of the invention have anti-proliferative activity, and may promote apoptosis in cells lacking normal regulation of cell cycle and death. In one embodiment of the invention, formulations of the compounds in combination with a physiologically acceptable carrier are provided. The pharmaceutical formulations are useful in the treatment of hyperproliferative disorders, which disorders include tumor growth, lymphoproliferative diseases, angiogenesis. The compounds of the invention are substituted pyrazoles and pyrazolines.
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