公开(公告)号：US09138491B2

公开(公告)日：2015-09-22

申请号：US14110138

申请日：2011-04-07

申请人： Moon-Hee Sung ,  Yong Taik Lim ,  Young-Woock Noh ,  Il Han Lee ,  Hyun Min Kim

发明人： Moon-Hee Sung ,  Yong Taik Lim ,  Young-Woock Noh ,  Il Han Lee ,  Hyun Min Kim

IPC分类号： A61K49/12 ,  A61B5/055 ,  A61K49/18

CPC分类号： A61K49/126 ,  A61K49/1863 ,  A61K49/1872

摘要： The present invention relates to a nano-composite containing anionic and cationic polymers and a method for preparing thereof, and more particularly to a poly-gamma-glutamic acid (γ-PGA)/chitosan/manganese iron oxide nanoparticle composite prepared by encapsulating iron oxide-based nanoparticles in a γ-PGA/chitosan polymer composite using the ionic self-assembly properties of poly-gamma-glutamic acid (γ-PGA) and chitosan, which are biocompatible polymer materials, and to a method for preparing thereof.The present invention provides a magnetic resonance imaging nano-contrast agent based on a nanoparticle composite including iron oxide-based nanoparticles encapsulated in a self-assembled composite of anionic poly-gamma-glutamic acid (γPGA) and cationic chitosan. The iron oxide-based nanoparticles encapsulated in the composite interact with each other to produce a synergistic effect on the amplification of magnetic resonance signals, and thus have an relatively excellent contrast effect compared to when they exist as single particles.

摘要翻译： 本发明涉及含有阴离子和阳离子聚合物的纳米复合物及其制备方法，更具体地涉及通过包封氧化铁制备的聚-γ-谷氨酸（γ-PGA）/壳聚糖/锰铁氧体纳米颗粒复合材料 基于聚-γ-谷氨酸（γ-PGA）和壳聚糖的离子自组装性质的γ-PGA /壳聚糖复合材料的生物相容性聚合物材料的制备方法。 本发明提供一种基于纳米颗粒复合材料的磁共振成像纳米造影剂，其包括封装在阴离子聚-γ-谷氨酸（γPGA）和阳离子壳聚糖的自组装复合物中的基于氧化铁的纳米颗粒。 封装在复合材料中的基于氧化铁的纳米颗粒彼此相互作用以对磁共振信号的扩增产生协同效应，因此与作为单个颗粒存在时相比具有相对优异的对比效果。

公开(公告)号：US20080305511A1

公开(公告)日：2008-12-11

申请号：US12011275

申请日：2008-01-24

申请人： Jeong-Kug Lee ,  Hae-Jin Rhee ,  Eui-Jin Kim ,  Moon-Hee Sung

发明人： Jeong-Kug Lee ,  Hae-Jin Rhee ,  Eui-Jin Kim ,  Moon-Hee Sung

IPC分类号： C12Q1/26

CPC分类号： C12Q1/025 ,  G01N2333/90283

摘要： Disclosed is a method for screening an antioxidant using mutant bacteria and chlorophyllide, and an antioxidant screened by the same method. More specifically, provided is a method for easy screening of an antioxidant by monitoring growth profiles of specific mutant bacteria in filter discs or medium blocks containing chlorophyllide added thereto, and an antioxidant screened by the same method.The present invention enables easy screening of an antioxidant on an industrial scale, by monitoring growth profiles of mutant bacteria via the use of mutant bacteria and chlorophyllide. In particular, the antioxidant screening method in accordance with the present invention is very useful for selective screening of an amphiphilic antioxidant. Therefore, the present invention is applicable to screen and commercialize low-toxic and effective antioxidants which will be used in various food and cosmetic additives as well as therapeutic medicines.

摘要翻译： 公开了使用突变细菌和叶绿素来筛选抗氧化剂的方法，以及通过相同方法筛选的抗氧化剂。 更具体地，提供了通过监测添加有叶绿素的过滤盘或介质块中的特定突变体细菌的生长曲线以及通过相同方法筛选的抗氧化剂来容易地筛选抗氧化剂的方法。 通过使用突变细菌和叶绿素来监测突变细菌的生长情况，本发明能够在工业规模上容易地筛选抗氧化剂。 特别地，根据本发明的抗氧化剂筛选方法对于选择性筛选两亲抗氧化剂是非常有用的。 因此，本发明适用于将用于各种食品和化妆品添加剂以及治疗药物的低毒和有效的抗氧化剂的筛选和商业化。