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公开(公告)号：US06645941B1
公开(公告)日：2003-11-11
申请号：US10397923
申请日：2003-03-26
申请人： Guoqiang Wang , Yat Sun Or , Ly Tam Phan , Marina Busuyek
发明人： Guoqiang Wang , Yat Sun Or , Ly Tam Phan , Marina Busuyek
IPC分类号： A61K3170
CPC分类号： C07H17/08
摘要： The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.
摘要翻译： 本发明公开了式I化合物或其药学上可接受的盐，酯或前药：其表现出抗菌性质。 本发明还涉及包含上述化合物的药物组合物，用于给予需要抗生素治疗的受试者。 本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的细菌感染的方法。 本发明还包括制备本发明化合物的方法。
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公开(公告)号：US06436906B1
公开(公告)日：2002-08-20
申请号：US09824318
申请日：2001-04-02
申请人： Yat Sun Or , Nha Vo , Jianchao Wang , Ly Tam Phan
发明人： Yat Sun Or , Nha Vo , Jianchao Wang , Ly Tam Phan
IPC分类号： A61K3170
摘要： Novel 9-amino-14-membered macrolides and pharmaceutically-acceptable compositions comprising a therapeutically effective amount of a compound of the invention in combination with a pharmaceutically acceptable carrier, a method for treating bacterial infections by administering to a mammal a pharmaceutical composition containing a therapeutically-effective amount of a compound of the invention and processes for the preparation of such compounds.
摘要翻译： 新型9-氨基-14-元大环内酯和药学上可接受的组合物，其包含治疗有效量的本发明化合物与药学上可接受的载体的组合，通过向哺乳动物施用药物组合物来治疗细菌感染的方法， - 本发明化合物的有效量和制备这些化合物的方法。
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公开(公告)号：US06355620B1
公开(公告)日：2002-03-12
申请号：US09312517
申请日：1999-05-14
申请人： Zhenkun Ma , Yat Sun Or , Ly Tam Phan , Suoming Zhang , Richard F. Clark
发明人： Zhenkun Ma , Yat Sun Or , Ly Tam Phan , Suoming Zhang , Richard F. Clark
IPC分类号： A61K3170
CPC分类号： C07H17/08
摘要： A compound having the formula selected from the group consisting of a compound of formula I a compound of formula II a compound of formula III as well as and pharmaceutically acceptable salts, esters, solvates, metabolites, and prodrugs thereof, are useful in treating bacterial infections. Also provided are pharmaceutically acceptible compositions, methods of treating bacterial infections, and processes for the preparation of the compounds.
摘要翻译： 具有下式的化合物选自式Ia化合物式IIa化合物式III化合物及其药学上可接受的盐，酯，溶剂合物，代谢物和前药，可用于治疗细菌感染。 还提供了药学上可接受的组合物，治疗细菌感染的方法和化合物的制备方法。
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公开(公告)号：US20080262208A1
公开(公告)日：2008-10-23
申请号：US12123874
申请日：2008-05-20
申请人： Guoqiang Wang , Ly Tam Phan , Yat Sun Or , Yao-Ling Qiu , Deqiang Niu , Yulin Peng , Marina Busuyek , Yanchun Wang , Suanne Nakajima
发明人： Guoqiang Wang , Ly Tam Phan , Yat Sun Or , Yao-Ling Qiu , Deqiang Niu , Yulin Peng , Marina Busuyek , Yanchun Wang , Suanne Nakajima
IPC分类号： C07H17/08
CPC分类号： C07H17/08
摘要： The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes processes by which to make the compounds of the present invention.
摘要翻译： 本发明公开了式I化合物或其药学上可接受的盐，酯或前药：其表现出抗菌性质。 本发明还涉及包含上述化合物的药物组合物，用于给予需要抗生素治疗的受试者。 本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的细菌感染的方法。 本发明还包括制备本发明化合物的方法。
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公开(公告)号：US07384922B2
公开(公告)日：2008-06-10
申请号：US11416609
申请日：2006-05-03
申请人： Guoqiang Wang , Ly Tam Phan , Yat Sun Or
发明人： Guoqiang Wang , Ly Tam Phan , Yat Sun Or
CPC分类号： C07H17/08
摘要： The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes processes by which to make the compounds of the present invention.
摘要翻译： 本发明公开了式I化合物或其药学上可接受的盐，酯或前药：其表现出抗菌性质。 本发明还涉及包含上述化合物的药物组合物，用于给予需要抗生素治疗的受试者。 本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的细菌感染的方法。 本发明还包括制备本发明化合物的方法。
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公开(公告)号：US07271155B2
公开(公告)日：2007-09-18
申请号：US11324502
申请日：2006-01-03
申请人： Yat Sun Or , Ly Tam Phan , Guoqiang Wang , Yanchun Wang , Yulin Peng
发明人： Yat Sun Or , Ly Tam Phan , Guoqiang Wang , Yanchun Wang , Yulin Peng
CPC分类号： C07H17/08
摘要： The present invention discloses compounds of formulae I and II, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.
摘要翻译： 本发明公开了式I和II的化合物或其药学上可接受的盐，酯或前药：其表现出抗菌性质。 本发明还涉及包含上述化合物的药物组合物，用于给予需要抗生素治疗的受试者。 本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的细菌感染的方法。 本发明还包括制备本发明化合物的方法。
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公开(公告)号：US06764998B1
公开(公告)日：2004-07-20
申请号：US10464188
申请日：2003-06-18
申请人： Guoqiang Wang , Yat Sun Or , Ly Tam Phan
发明人： Guoqiang Wang , Yat Sun Or , Ly Tam Phan
IPC分类号： A61K3170
CPC分类号： C07H17/08
摘要： The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.
摘要翻译： 本发明公开了式I化合物或其药学上可接受的盐，酯或前药：其表现出抗菌性质。 本发明还涉及包含上述化合物的药物组合物，用于给予需要抗生素治疗的受试者。 本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的细菌感染的方法。 本发明还包括制备本发明化合物的方法。
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公开(公告)号：US06680299B2
公开(公告)日：2004-01-20
申请号：US09917107
申请日：2001-07-27
申请人： Yat Sun Or , Ly Tam Phan , Zhaolin Wang , Tianying Jian
发明人： Yat Sun Or , Ly Tam Phan , Zhaolin Wang , Tianying Jian
IPC分类号： A61K3170
CPC分类号： C07H17/08
摘要： There are described novel 4′ substituted 16-membered macrolides and pharmaceutically acceptable compositions comprising a therapeutically effective amount of a compound of the invention in combination with a pharmaceutically acceptable carrier. Also described are a method for treating bacterial infections by administering to a mammal a pharmaceutical composition containing a therapeutically-effective amount of a compound of the invention, and processes for the preparation of such compounds.
摘要翻译： 描述了新颖的4'取代的16元大环内酯和药学上可接受的组合物，其包含治疗有效量的本发明化合物与药学上可接受的载体的组合。 还描述了通过向哺乳动物施用含有治疗有效量的本发明化合物的药物组合物以及制备这些化合物的方法来治疗细菌感染的方法。
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公开(公告)号：US06274715B1
公开(公告)日：2001-08-14
申请号：US08779786
申请日：1997-01-07
申请人： Yat Sun Or , Ly Tam Phan , Daniel T. Chu , Kenneth P. Spina , Robert Hallas , Richard L. Elliott , Michael Tufano
发明人： Yat Sun Or , Ly Tam Phan , Daniel T. Chu , Kenneth P. Spina , Robert Hallas , Richard L. Elliott , Michael Tufano
IPC分类号： C07H1708
摘要： Compounds, or pharmaceutically acceptable salts and esters thereof, of the formula: wherein A, B, D and E, R1, R2, and Z are specifically defined, having antibacterial activity, pharmaceutical compositions containing said compounds, treatment of bacterial infections with such compositions, and processes for the preparation of the compounds.
摘要翻译： 具有下式的化合物或其药学上可接受的盐和酯：其中A，B，D和E，R1，R2和Z被具体限定，具有抗菌活性，含有所述化合物的药物组合物，用这些组合物治疗细菌感染 ，以及化合物的制备方法。
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公开(公告)号：US6124269A
公开(公告)日：2000-09-26
申请号：US154294
申请日：1998-09-16
申请人： Ly Tam Phan , Yat Sun Or , Daniel T. Chu , Jacob J. Platter , Yan Chen , Richard F. Clark
发明人： Ly Tam Phan , Yat Sun Or , Daniel T. Chu , Jacob J. Platter , Yan Chen , Richard F. Clark
CPC分类号： A61K31/7048 , C07H17/08
摘要： Novel 2-halo-6-O-substituted ketolide derivatives and pharmaceutically acceptable salts and esters thereof having antibacterial activity having a formula ##STR1## compositions comprising a therapeutically effective amount of a compound of the invention in combination with a pharmaceutically acceptable carrier, a method for treating bacterial infections by administering to a mammal a pharmaceutical composition containing a therapeutically-effective amount of a compound of the invention, and processes for their preparation.
摘要翻译： 具有抗菌活性的新型2-卤代-6-O-取代的酮内酯衍生物及其药学上可接受的盐和酯，其具有包含治疗有效量的本发明化合物与药学上可接受的载体的组合物的组合物，治疗细菌的方法 通过向哺乳动物施用含有治疗有效量的本发明化合物的药物组合物及其制备方法的感染。
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