公开(公告)号：US20050124639A1

公开(公告)日：2005-06-09

申请号：US11004755

申请日：2004-12-03

申请人： Narendra Joshi ,  Shekhar Bhirud ,  Batchu Chandrasekhar ,  K. Rao ,  Subhash Damle

发明人： Narendra Joshi ,  Shekhar Bhirud ,  Batchu Chandrasekhar ,  K. Rao ,  Subhash Damle

IPC分类号： C07D239/42 ,  A61K31/513 ,  A61K31/505 ,  C07D239/34

CPC分类号： C07D239/42 ,  Y02P20/55

摘要： An improved process for the preparation of pyrimidine derivatives is provided comprising reacting a Wittig reagent of the general formula wherein R is an alkyl of from 1 to 10 carbon atoms, aryl or arylalkyl, R1 is a substituted or unsubstituted hydrocarbon group, R2 and R3 are the same or different and are hydrogen or a substituted or unsubstituted hydrocarbon group; Z is sulfur, oxygen, sulfonyl, or imino which may be substituted by formyl, acetyl, propionyl, butyryl, isobutyryl, valeryl, isovaleryl, amino substituted by sulfonyl or alkylsulfonyl, and sulfonyl substituted by alkyl, amino or alkylamino and X is a halogen; with an aldehyde of the general formula wherein R4 is hydrogen, a lower alkyl or a cation capable of forming a non-toxic pharmaceutically acceptable salt and each R5 are the same or different and are hydrogen or a hydrolyzable protecting group, or each R5, together with the oxygen atom to which each is bonded, form a hydrolyzable cyclic protecting group, or each R5 is bonded to the same substituent which is bonded to each oxygen atom to form a hydrolyzable protecting group; in the presence of a base.

摘要翻译： 提供了制备嘧啶衍生物的改进方法，包括使通式为Wittig试剂反应其中R为1至10个碳原子的烷基，芳基或芳基烷基，R 1是被取代或 未取代的烃基，R 2和R 3相同或不同，为氢或取代或未取代的烃基; Z可以被甲酰基，乙酰基，丙酰基，丁酰基，异丁酰基，戊酰基，异戊酰基，被磺酰基或烷基磺酰基取代的氨基，和被烷基，氨基或烷基氨基取代的磺酰基取代的硫，氧，磺酰基或亚氨基，X是卤素 ; 与其中R 4为氢的通式的醛，能够形成无毒的药学上可接受的盐的低级烷基或阳离子和每个R 5相同 或不同的是氢或可水解保护基团，或每个R 5与每个键合的氧原子一起形成可水解的环保护基团，或每个R 5， SUP>键合到与每个氧原子键合的相同取代基以形成可水解保护基团; 在一个基地的存在。

公开(公告)号：US20050043870A1

公开(公告)日：2005-02-24

申请号：US10604870

申请日：2003-08-22

申请人： Narendra Joshi ,  Richard Frantz

发明人： Narendra Joshi ,  Richard Frantz

IPC分类号： F01D25/00 ,  F02C7/00 ,  G07C3/00 ,  G06F19/00

CPC分类号： B23P6/002 ,  G07C3/00

摘要： Information storage devices are permanently deployed on individual components of turbine engines to permanently record operating, repair, and maintenance data on the parts that comprise the individual components. Ensuring that such data will not be lost when individual components or their parts are replaced in an engine, allows the use of life limited parts in turbine engines and improves their reliability. The information storage devices can be accessed to record maintenance or to record changes when repairs are done. They can also be attached to external circuitry for the purpose of analyzing, downloading or recording data remotely, allowing analysis of component operating, repair, and maintenance information.

摘要翻译： 信息存储设备被永久部署在涡轮发动机的各个部件上，以便在构成各个部件的部件上永久地记录操作，修理和维护数据。 确保在发动机中更换各个部件或其零件时不会丢失此类数据，从而允许在涡轮发动机中使用生命有限的部件并提高其可靠性。 可以访问信息存储设备来记录维护或在进行维修时记录更改。 它们也可以连接到外部电路，用于远程分析，下载或记录数据，从而允许对组件操作，维修和维护信息进行分析。

公开(公告)号：US20050034458A1

公开(公告)日：2005-02-17

申请号：US10762993

申请日：2004-01-22

申请人： David Burrus ,  Narendra Joshi ,  Joel Haynes ,  Alan Feitelberg

发明人： David Burrus ,  Narendra Joshi ,  Joel Haynes ,  Alan Feitelberg

IPC分类号： F23R3/18 ,  F02C7/18 ,  F23R3/06 ,  F23R3/28 ,  F23R3/32 ,  F23R3/34 ,  F23R3/58 ,  F23R3/42

CPC分类号： F23R3/346 ,  F23C2900/07001 ,  F23D2900/14004 ,  F23R3/283 ,  F23R3/286 ,  F23R3/58 ,  F23R2900/00015

摘要： A gas turbine engine combustor can downstream of a pre-mixer has a pre-mixer flowpath therein and circumferentially spaced apart swirling vanes disposed across the pre-mixer flowpath. A primary fuel injector is positioned for injecting fuel into the pre-mixer flowpath. A combustion chamber surrounded by an annular combustor liner disposed in supply flow communication with the pre-mixer. An annular trapped dual vortex cavity located at an upstream end of the combustor liner is defined between an annular aft wall, an annular forward wall, and a circular radially outer wall formed therebetween. A cavity opening at a radially inner end of the cavity is spaced apart from the radially outer wall. Air injection first holes are disposed through the forward wall and air injection second holes are disposed through the aft wall. Fuel injection holes are disposed through at least one of the forward and aft walls.

摘要翻译： 在预混合器下游的燃气涡轮发动机燃烧器具有预混合器流动路径，并且横跨预混合器流动路径设置周向间隔开的涡流叶片。 主燃料喷射器定位成将燃料喷射到预混合器流路中。 由环形燃烧器衬套围绕的燃烧室，其设置成与预混合器供应流动连通。 位于燃烧器衬套的上游端的环形捕获双涡流腔限定在环形后壁，环形前壁和形成在其间的圆形径向外壁。 在空腔的径向内端处的空腔开口与径向外壁间隔开。 空气注入第一孔穿过前壁设置，空气注入第二孔穿过后壁。 燃料喷射孔通过前壁和后壁中的至少一个设置。