公开(公告)号：US08941380B2

公开(公告)日：2015-01-27

申请号：US12936540

申请日：2009-04-13

申请人： Ingmar Graesslin ,  Sven Biederer ,  Ulrich Katscher ,  Ferdinand Schweser ,  Peter Boernert ,  Paul Royston Harvey ,  Wilhelmus Reinerius Maria Mens

发明人： Ingmar Graesslin ,  Sven Biederer ,  Ulrich Katscher ,  Ferdinand Schweser ,  Peter Boernert ,  Paul Royston Harvey ,  Wilhelmus Reinerius Maria Mens

IPC分类号： G01R33/44 ,  G01R33/58 ,  G01R33/561 ,  G01R33/28 ,  G01R33/565

CPC分类号： G01R33/583 ,  G01R33/288 ,  G01R33/5612 ,  G01R33/5659

摘要： In a method and apparatus to enable increased RF duty cycle in high field MR scans, a specific energy absorption rate (SAR) calculation processor calculates the local and global SAR or even a spatial SAR map. By incorporating additional information as, e.g. patient position, the SAR calculation accuracy can be increased as well as by using more patient specific pre-calculated information (e.g. based on different bio meshes), the so called Q-matrices. A sequence controller maybe provided to create a global SAR optimal RF pulse. After the optimal RF pulse is applied, the SAR and its spatial distribution are determined. SAR hotspots are also determined. Q-matrices within an appropriate radius around the hotspots are averaged and added to a global Q-matrix in a weighted fashion. After the global Q-matrix is updated, a new optimal RF pulse is created.

摘要翻译： 在能够在高场MR扫描中增加RF占空比的方法和装置中，比能量吸收率（SAR）计算处理器计算局部和全局SAR或甚至空间SAR图。 通过引入附加信息，例如。 患者位置，SAR计算精度以及通过使用更多患者特定的预先计算的信息（例如，基于不同的生物网格），即所谓的Q矩阵。 可以提供序列控制器以创建全局SAR最优RF脉冲。 在施加最佳RF脉冲之后，确定SAR及其空间分布。 SAR热点也是决定的。 在热点周围的适当半径内的Q矩阵被平均，并以加权的方式加到全局Q矩阵上。 在更新全局Q矩阵之后，创建一个新的最优RF脉冲。

公开(公告)号：US20140121492A1

公开(公告)日：2014-05-01

申请号：US14127037

申请日：2012-06-20

申请人： Peter Boernert ,  Holger Eggers

发明人： Peter Boernert ,  Holger Eggers

IPC分类号： G01R33/48 ,  A61B5/055

CPC分类号： G01R33/4828 ,  A61B5/055

摘要： The invention relates to a method of MR imaging of at least two chemical species having different MR spectra. The method comprises the steps of: generating MR signals of the chemical species by subjecting a portion of a body (10) to an imaging sequence of RF pulses and switched magnetic field gradients, which imaging sequence is determined by a set of imaging parameters (TR, α, TE); acquiring the MR signals; determining a spectral model of at least one of the chemical species, which spectral model is associated with the set of imaging parameters (TR, α, TE); separating signal contributions of the at least two chemical species to the acquired MR signals on the basis of the spectral model; and computing a MR image from the signal contributions of one of the chemical species. Moreover, the invention related to a MR device (1) and to a computer program for a MR device (1).

摘要翻译： 本发明涉及至少两种具有不同MR谱的化学物质的MR成像方法。 该方法包括以下步骤：通过对身体（10）的一部分进行RF脉冲和切换磁场梯度的成像序列来产生化学物质的MR信号，该成像序列由一组成像参数（TR ，α，TE）; 获取MR信号; 确定所述化学物质中的至少一个的光谱模型，所述光谱模型与所述成像参数集合（TR，α，TE）相关联; 基于光谱模型将所述至少两种化学物质的信号贡献分离成所获取的MR信号; 以及从所述化学物质之一的信号贡献计算MR图像。 此外，本发明涉及一种MR装置（1）和一种用于MR装置（1）的计算机程序。

公开(公告)号：US20130089271A1

公开(公告)日：2013-04-11

申请号：US13805799

申请日：2011-05-30

申请人： Peter Boernert ,  Mariya Doneva

发明人： Peter Boernert ,  Mariya Doneva

IPC分类号： G06T5/00

CPC分类号： G06T5/007 ,  G01N24/08 ,  G01R33/4828 ,  G01R33/5601 ,  G01R33/5607 ,  G01R33/5611 ,  G01R33/5615 ,  G01R33/56308 ,  G01R33/5635

摘要： The present invention relates to a method of performing dynamic contrast enhanced magnetic resonance imaging of an object (10) with signal separation for water and fat, the method comprising acquiring magnetic resonance datasets in the k-space using Dixon acquisition in a chemical shift encoding space and dynamic time resolution in a dynamic time space, wherein the dataset acquisition is performed employing undersampling, wherein the method further comprises: applying a compressed sensing reconstruction technique in the k-space, the chemical shift encoding space and the dynamic time space, said compressed sensing reconstruction resulting in reconstructed datasets, —performing Dixon reconstruction on the reconstructed datasets and dynamic contrast analysis on the Dixon reconstructed datasets.

摘要翻译： 本发明涉及对具有水分和脂肪信号分离的物体（10）进行动态对比度增强磁共振成像的方法，所述方法包括：在化学位移编码空间中使用Dixon采集在k空间中获取磁共振数据集 以及在动态时间空间中的动态时间分辨率，其中使用欠采样执行所述数据集采集，其中所述方法还包括：在所述k空间，所述化学位移编码空间和所述动态时间空间中应用压缩感测重建技术，所述压缩 感知重建导致重构数据集， - 对重构数据集执行Dixon重建，并对Dixon重建数据集进行动态对比分析。

公开(公告)号：US20120184841A1

公开(公告)日：2012-07-19

申请号：US13496208

申请日：2010-09-16

申请人： Tim Nielsen ,  Peter Boernert ,  Falk Uhlemann ,  Johannes Adrianus Overweg

发明人： Tim Nielsen ,  Peter Boernert ,  Falk Uhlemann ,  Johannes Adrianus Overweg

IPC分类号： A61B6/00

CPC分类号： A61N5/1071 ,  A61N5/1031 ,  A61N5/1039 ,  A61N5/1049 ,  A61N2005/1055 ,  A61N2005/1058 ,  G01R33/3806 ,  G01R33/381 ,  G01R33/4808 ,  G01R33/5601

摘要： A combined magnetic resonance (MR) and radiation therapy system (10) includes a bore-type magnet (12) with a magnet radiation translucent region (16) which allows radiation beams to travel radially through the magnet and a split-type gradient coil (18) includes a gradient coil radiation translucent region (20) aligned to the magnet radiation translucent region (16). A radiation source (24), disposed laterally to the magnet, administers a radiation dose through the magnet and gradient coil radiation translucent regions (16, 20) to an examination region (14). A dosage unit (66) determines the actual radiation dose delivered to each voxel of a target volume (30) and at least one non-target volume based on a pre-treatment, intra-treatment, and/or post-treatment image representation of the target volume (30) and the at least one non-target volume. A planning processor (60) updates at least one remaining radiation dose of a radiation therapy plan based on the determined actual radiation dose.

摘要翻译： 组合磁共振（MR）和放射治疗系统（10）包括具有磁体辐射半透明区域（16）的孔型磁体（12），其允许辐射束径向穿过磁体和分离式梯度线圈 18）包括与磁体辐射半透明区域（16）对准的梯度线圈辐射半透明区域（20）。 辐射源（24）横向设置在磁体上，通过磁体和梯度线圈辐射半透明区域（16,20）将辐射剂量施加到检查区域（14）。 剂量单元（66）基于预处理，治疗前和/或后处理图像表示来确定递送到目标体积（30）的每个体素的实际辐射剂量和至少一个非目标体积 目标体积（30）和至少一个非目标体积。 计划处理器（60）基于所确定的实际辐射剂量更新辐射治疗计划的至少一个剩余辐射剂量。

公开(公告)号：US20100016708A1

公开(公告)日：2010-01-21

申请号：US12446661

申请日：2007-10-31

申请人： Ulrich Katscher ,  Peter Vernikel ,  Peter Boernert

发明人： Ulrich Katscher ,  Peter Vernikel ,  Peter Boernert

IPC分类号： A61B5/055

CPC分类号： G01R33/4831 ,  G01R33/3415

摘要： A common method of RF encoding assumes that the Bi field generated by the RF coils is linear, which is likely not the case in many situations. It is therefore desirable to have a method of operating an MR system to reconstruct an image of a subject, wherein the method is capable of also handling arbitrary Bi fields used for RF encoding. Accordingly, such an MR system employing one or more RF coils is disclosed herein. The method comprises obtaining transmit sensitivities and weighting factors for individual RF coils. Each RF coil is activated based on its respective weighting factor to apply RF excitation to a subject under examination in the MR system. MR signals—such as free induction decays (FID) signals or echo signals—generated from the subject in response to the RF excitation are received and processed based on the transmit sensitivities to generate an MR image or spectrum representative of the subject.

摘要翻译： RF编码的常见方法假设由RF线圈产生的Bi场线是线性的，这在许多情况下可能不是这种情况。 因此，期望具有操作MR系统以重建对象的图像的方法，其中该方法还能够处理用于RF编码的任意Bi字段。 因此，本文公开了采用一个或多个RF线圈的这种MR系统。 该方法包括获得单个RF线圈的发射灵敏度和加权因子。 每个RF线圈基于其相应的加权因子被激活，以将RF激励施加到在MR系统中被检查的受试者。 基于发射灵敏度接收和处理MR信号，例如响应于RF激励从受试者产生的自由感应衰减（FID）信号或回波信号，以产生代表对象的MR图像或频谱。

公开(公告)号：US20050131290A1

公开(公告)日：2005-06-16

申请号：US10498594

申请日：2002-12-19

申请人： Ulrich Katscher ,  Peter Boernert

发明人： Ulrich Katscher ,  Peter Boernert

IPC分类号： G01R33/48 ,  A61B5/055 ,  G01R33/561 ,  G01V3/00 ,  A61B5/05

CPC分类号： G01R33/5611

摘要： The invention relates to a parallel MR imaging method in which first a first MR imaging sequence is formed with a selectable minimum number of phase encoding steps and at least two separate MR signal data sets are acquired by means of at least two MR receiving coils. A first MR image is reconstructed from this data while taking into account the spatial sensitivity profiles of the MR receiving coils. In order to improve parallel MR imaging methods of this kind, the invention proposes to evaluate the quality of the reconstructed MR image in a subsequent step of the method and, in dependence upon the result of the evaluation, to either terminate the imaging method or to form a further MR imaging sequence with a number of further phase encoding steps. This procedure can be continued until an adequate MR image quality is reached.

摘要翻译： 本发明涉及一种并行MR成像方法，其中首先通过可选择的最小数量的相位编码步骤形成第一MR成像序列，并且借助于至少两个MR接收线圈获取至少两个单独的MR信号数据集。 从该数据重建第一MR图像，同时考虑MR接收线圈的空间灵敏度分布。 为了改进这种并行MR成像方法，本发明提出了在该方法的后续步骤中评价重建的MR图像的质量，并且根据评估结果来终止成像方法或者 形成具有多个进一步的相位编码步骤的另外的MR成像序列。 可以继续该过程，直到达到足够的MR图像质量。

公开(公告)号：US10073160B2

公开(公告)日：2018-09-11

申请号：US14112253

申请日：2012-04-11

申请人： Peter Boernert ,  Mariya Ivanova Doneva ,  Christian Stehning

发明人： Peter Boernert ,  Mariya Ivanova Doneva ,  Christian Stehning

IPC分类号： G01V3/00 ,  G01R33/565 ,  G01R33/561 ,  G01R33/567

CPC分类号： G01R33/565 ,  G01R33/5611 ,  G01R33/56509 ,  G01R33/5673 ,  G01R33/5676

摘要： A magnetic resonance imaging method includes acquisition of datasets of magnetic resonance data from an object. At least some of the datasets are undersampled in k-space. Each dataset relating to a motion state of the object. Images are reconstructed from each of the datasets by way of a compressed sensing reconstruction. Motion correction is applied to the reconstructed images relative to a selected motion state, so as to generate motion corrected images. A diagnostic image for the selected motion state is derived, e.g. by averaging from the motion corrected images.

公开(公告)号：US09575153B2

公开(公告)日：2017-02-21

申请号：US13990050

申请日：2011-11-24

申请人： Arjan Willem Simonetti ,  Gwenael Henri Herigault ,  Peter Boernert

发明人： Arjan Willem Simonetti ,  Gwenael Henri Herigault ,  Peter Boernert

IPC分类号： G01R33/385 ,  G01R33/58 ,  G01R33/48

CPC分类号： G01R33/583 ,  G01R33/385 ,  G01R33/4828

摘要： At least a portion of a body (10) of a patient positioned in an examination volume of a MR device (1). A portion of the body (10) is subject to a calibration sequence including RF pulses and switched magnetic field gradients controlled in such a manner that a calibration signal data set is acquired by a multi-point Dixon technique at a first image resolution. Calibration parameters are derived from the calibration signal data set. The MR device (1) is controlled according to the derived calibration parameters. The portion of the body (10) is subject to an imaging sequence including RF pulses and switched magnetic field gradients controlled in such a manner that a diagnostic signal data set is acquired at a second image resolution which is higher than the first image resolution. A diagnostic MR image is reconstructed from the diagnostic signal data set.

摘要翻译： 位于MR装置（1）的检查体积中的患者的身体（10）的至少一部分。 身体（10）的一部分经受包括RF脉冲和切换磁场梯度的校准序列，其以这样的方式进行控制，使得通过多点Dixon技术以第一图像分辨率获取校准信号数据集。 校准参数来自校准信号数据集。 MR装置（1）根据导出的校准参数进行控制。 身体（10）的部分受到包括RF脉冲和切换磁场梯度的成像序列的控制，使得以比第一图像分辨率高的第二图像分辨率获取诊断信号数据集。 从诊断信号数据集重建诊断MR图像。

公开(公告)号：US09523753B2

公开(公告)日：2016-12-20

申请号：US14112267

申请日：2012-04-13

申请人： Jinnan Wang ,  Michael Günter Helle ,  William Sean Kerwin ,  Peter Boernert ,  Chun Yuan

发明人： Jinnan Wang ,  Michael Günter Helle ,  William Sean Kerwin ,  Peter Boernert ,  Chun Yuan

IPC分类号： G01V3/00 ,  G01R33/563 ,  G01R33/56

CPC分类号： G01R33/5635 ,  G01R33/5602

摘要： Magnetic resonance (MR) spins are inverted by applying an inversion recovery (IR) radio frequency pulse (50). MR signals are acquired at an inversion time (TI) after the IR radio frequency pulse. TI is selected such that a first tissue of interest (e.g., blood) exhibits negative magnetism excited by the IR radio frequency pulse and a second tissue (e.g., intraplaque hemorrhage tissue) exhibits positive magnetism excited by the IR radio frequency pulse. The acquired magnetic resonance signals are reconstructed to generate spatial pixels or voxels wherein positive pixel or voxel values indicate spatial locations of positive magnetism and negative pixel or voxel values indicates spatial locations of negative magnetism. A first image (28) representative of the first tissue is generated from spatial pixels or voxels having negative signal intensities, and a second image (26) representative of the second tissue is generated from spatial pixels or voxels having positive signal intensities.

摘要翻译： 通过应用反转恢复（IR）射频脉冲（50）来反转磁共振（MR）自旋。 在IR射频脉冲之后，在反转时间（TI）获取MR信号。 选择TI，使得感兴趣的第一组织（例如血液）表现出由IR射频脉冲激发的负磁性，并且第二组织（例如，intraplaque出血组织）表现出由IR射频脉冲激发的正磁性。 所获取的磁共振信号被重建以产生空间像素或像素，其中正像素或体元值表示正磁性的空间位置，负像素或体素值表示负磁性的空间位置。 从具有负信号强度的空间像素或体素生成代表第一组织的第一图像（28），并且从具有正信号强度的空间像素或体素生成代表第二组织的第二图像（26）。

公开(公告)号：US20130249553A1

公开(公告)日：2013-09-26

申请号：US13990050

申请日：2011-11-24

申请人： Arjan Willem Simonetti ,  Gwenael Henri Herigault ,  Peter Boernert

发明人： Arjan Willem Simonetti ,  Gwenael Henri Herigault ,  Peter Boernert

IPC分类号： G01R33/58 ,  G01R33/385

CPC分类号： G01R33/583 ,  G01R33/385 ,  G01R33/4828

摘要： The invention relates to a method of MR imaging of at least a portion of a body (10) of a patient positioned in an examination volume of a MR device (1). It is an object of the invention to provide a method that enables improved fat saturation. The method of the invention comprises the steps of:—subjecting the portion of the body (10) to a calibration sequence comprising RF pulses and switched magnetic field gradients controlled in such a manner that a calibration signal data set is acquired by means of a multi-point Dixon technique at a first image resolution;—deriving calibration parameters from the calibration signal data set;—controlling the MR device (1) according to the derived calibration parameters;—subjecting the portion of the body (10) to an imaging sequence comprising RF pulses and switched magnetic field gradients controlled in such a manner that a diagnostic signal data set is acquired at a second image resolution which is higher than the first image resolution; and—reconstructing a diagnostic MR image from the diagnostic signal data set. Moreover, the invention relates to a MR device (1) for carrying out the method and to a computer program to be run on a MR device (1).

摘要翻译： 本发明涉及一种定位在MR装置（1）的检查体积中的患者的身体（10）的至少一部分的MR成像方法。 本发明的目的是提供一种能够改善脂肪饱和度的方法。 本发明的方法包括以下步骤： - 将身体（10）的部分施加到包括RF脉冲和切换磁场梯度的校准序列，该校准序列以如下方式进行控制：校准信号数据集通过多 在第一图像分辨率下的Dixon技术; - 从校准信号数据集得到校准参数; - 根据导出的校准参数控制MR装置（1）; - 将身体（10）的部分投射到成像序列 包括以这样的方式控制的RF脉冲和切换磁场梯度，使得以比第一图像分辨率高的第二图像分辨率获取诊断信号数据集; 并从诊断信号数据集重建诊断MR图像。 此外，本发明涉及一种用于执行该方法的MR设备（1）和一个在MR设备（1）上运行的计算机程序。