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63 条记录 (耗时 0.07 秒)

    Alkyl substituted-4-oxo-cyclopenta benzopyrans
    41.
    发明授权
    Alkyl substituted-4-oxo-cyclopenta benzopyrans 失效
    烷基取代-4-氧代 - 环戊基苯并吡喃

    公开(公告)号：US4007207A

    公开(公告)日：1977-02-08

    申请号：US594534

    申请日：1975-07-09

    申请人： Martin Winn ,  Raj Kumar Razdan ,  Haldean Cloyce Dalzell ,  Joyce Ruth Krei

    发明人： Martin Winn ,  Raj Kumar Razdan ,  Haldean Cloyce Dalzell ,  Joyce Ruth Krei

    IPC分类号： C07D311/78

    CPC分类号： Y10S514/96

    摘要： 1,2,3,4-Tetrahydrocyclopenta[c][1]benzopyrans of the formulae ##STR1## wherein R is a lower alkyl group having 1 to 5 carbons, R.sub.1 is hydrogen or a lower alkyl group having 1 to 5 carbons, R.sub.2 is a lower alkyl group and R.sub.3 is an alkyl group having 1 to 20 carbon atoms, a phenyl-lower alkyl group or a cycloalkyl-lower alkyl group. The compounds have anti-hypertensive, antidepressant, analgesic, anticonvulsant, anti-anxiety, sedative-hypnotic and tranquilizing activity in animals.

    摘要翻译： 其中R为具有1至5个碳原子的低级烷基，R 1为氢或低级烷基，具有1至5个碳原子的低级烷基， 5个碳，R2为低级烷基，R3为碳原子数1〜20的烷基，苯基 - 低级烷基或环烷基 - 低级烷基。 该化合物在动物体内具有抗高血压，抗抑郁，镇痛，抗惊厥，抗焦虑，镇静催眠和镇静作用。

    Pharmaceutical compositions containing alryl substituted cyclopenta benzopyrans
    42.
    发明授权
    Pharmaceutical compositions containing alryl substituted cyclopenta benzopyrans 失效
    含有烯丙基取代的环戊基苯并吡喃的药物组合物

    公开(公告)号：US3992550A

    公开(公告)日：1976-11-16

    申请号：US594533

    申请日：1975-07-09

    申请人： Martin Winn ,  Raj Kumar Razdan ,  Haldean Cloyce Dalzell ,  Joyce Ruth Krei

    发明人： Martin Winn ,  Raj Kumar Razdan ,  Haldean Cloyce Dalzell ,  Joyce Ruth Krei

    IPC分类号： A61K31/335

    摘要： 1,2,3,4-Tetrahydrocyclopenta[c] [1]benzopyrans of the formulae ##SPC1##Wherein R is a lower alkyl group having 1 to 5 carbons, R.sub.1 is hydrogen or a lower alkyl group having 1 to 5 carbons, R.sub.2 is a lower alkyl group and R.sub.3 is an alkyl group having 1 to 20 carbon atoms, a phenyl-lower alkyl group or a cycloalkyl-lower alkyl group. The compounds have anti-hypertensive, antidepressant, analgesic, anticonvulsant, anti-anxiety and tranquilizing activity in animals.

    摘要翻译： 1,2,3,4-四氢环戊二烯并[c] [1]苯并吡喃，式为WHEREIN R为碳原子数1〜5的低级烷基，R1为氢或碳原子数为1〜5的低级烷基，R2为低级 烷基，R 3为碳原子数1〜20的烷基，苯基 - 低级烷基或环烷基 - 低级烷基。 该化合物在动物中具有抗高血压，抗抑郁，止痛，抗惊厥，抗焦虑和镇静作用。

    Pyrazolyl amino imidazolines
    44.
    发明授权
    Pyrazolyl amino imidazolines 失效
    吡唑基氨基咪唑啉

    公开(公告)号：US4171367A

    公开(公告)日：1979-10-16

    申请号：US770137

    申请日：1977-02-18

    申请人： Martin Winn ,  Carl W. Nordeen

    发明人： Martin Winn ,  Carl W. Nordeen

    IPC分类号： C07D231/38 ,  C07D231/40 ,  A61K31/415 ,  C07D403/12

    CPC分类号： C07D231/38 ,  C07D231/40

    摘要： Described are compounds of the formula ##STR1## wherein R.sup.1 and R.sup.2 are hydrogen, alkyl, cycloalkyl, and aryl, R.sup.3 is hydrogen or halogen, and R.sup.4 is hydrogen or acyl, and pharmaceutically acceptable acid addition salts thereof. R.sup.3 can be located in the 4 or 5 position as can the amino imidazoline group. The compounds are useful as anti-inflammatory agents.

    摘要翻译： 描述了式IMA化合物，其中R 1和R 2是氢，烷基，环烷基和芳基，R 3是氢或卤素，R 4是氢或酰基，和其药学上可接受的酸加成盐。 R3可以位于氨基咪唑啉基团的4或5位。 该化合物可用作抗炎剂。

    Heterocyclic esters of alkylphenyl benzopyrans
    45.
    发明授权
    Heterocyclic esters of alkylphenyl benzopyrans 失效
    烷基苯基苯并吡喃的杂环酯

    公开(公告)号：US4049653A

    公开(公告)日：1977-09-20

    申请号：US442033

    申请日：1974-02-13

    申请人： Martin Winn

    发明人： Martin Winn

    IPC分类号： C07C37/055 ,  C07D295/14 ,  C07D295/15 ,  C07D311/80 ,  C07D311/94 ,  C07D405/12 ,  C07D295/00

    CPC分类号： C07D295/15 ,  C07C37/055 ,  C07D295/14 ,  C07D311/80 ,  C07D311/94

    摘要： Heterocyclic esters of benzopyrans represented by the formula ##STR1## wherein n is 1 or 2; each R and R.sub.1 are the same or different members of the group consisting of hydrogen or loweralkyl; R.sub.2 is loweralkyl; R.sub.3 is ##STR2## WITH Y' being a straight or branched chain alkylene group having from one to eight carbon atoms, a is an integer from 1 to 4, b is an integer from 1 to 4, X is CH.sub.2, O, S or NR.sub.7 with R.sub.7 being hydrogen or loweralkyl, with the limitation that when X is O, S, or NR.sub.7, a and b each must be 2; R.sub.8 is hydrogen or loweralkyl; Y is a straight or branched chain alkylene group having from one to ten carbon atoms; and each R.sub.4 and R.sub.5 and R.sub.6 are the same or different members of the group consisting of hydrogen, halo, trifluoromethyl or loweralkyl; and the pharmaceutically acceptable salts thereof.

    摘要翻译： 由式 表示的苯并吡喃的杂环酯，其中n为1或2; 每个R和R 1是由氢或低级烷基组成的组中相同或不同的成员; R2是低级烷基; R3是具有1至8个碳原子的直链或支链亚烷基，a为1至4的整数，b为1至4的整数，X为CH 2，O，S或 NR7，其中R7为氢或低级烷基，限制为当X为O，S或NR7时，a和b各自为2; R8是氢或低级烷基; Y是具有1至10个碳原子的直链或支链亚烷基; 并且每个R 4和R 5和R 6是由氢，卤素，三氟甲基或低级烷基组成的组中相同或不同的成员; 及其药学上可接受的盐。