摘要:
A process and apparatus for resistance-welding produce a welding current which pulsates in periodic half-waves, in particular an alternating current. The, welding current is generated from a primary alternating voltage which is chopped n times (n>1) in each half-wave and pulse width modulated in order to regulate the welding current. A regulator is provided and has a storage device containing the current nominal values for each chopping interval, corresponding to the welding current form, for comparison with each actual current value determined in each chopping interval.
摘要:
The components of cryostats are interconnected by means of tension members which are frequently made from a fiber glass reinforced plastic material. Such members, which exhibit a rectangular cross-section and bores for receiving the mounting bolts have shown to be not fully reliable because they tend to break easily in the areas of the bores. Consequently, loop-like tension members have been frequently used; but their production is expensive and connected with considerable production tolerances. The invention proposes to use a tension member which is cut out from a plastic sheet material reinforced by a fiber glass weave, and which comprises an elongated portion (21) with parallel edges, followed on both ends by enlarged areas (22) with bores (25) for the mounting bolts. The transition between the central area (21) and the enlarged areas (22) is formed by a transition portion (23) with arc-shaped edges (24). The tension members can be fastened directly on the walls of the components to be interconnected, by means of screws. The resilience of the sheet material enables spaces directed vertically to the plane of the sheet material of the tension member to be bridged.
摘要:
The disclosure provides multimeric oligonucleotide compounds, comprising two or more target-specific oligonucleotides (e.g., antisense oligonucleotides (ASOs)), each being resistant to cleavage, and linked together by a cleavable linker. In particular, two or more linked target-specific oligonucleotides, each to a different target, allows concomitant inhibition of multiple genes' expression levels, while exhibiting favorable pharmacokinetic and pharmacodynamic properties. Methods of making and uses of the described compounds are also provided.
摘要:
The invention relates to oligonucleotides including at least one FANA substituted nucleotide analog and a pyrimidine-purine dinucleotide. The invention also relates to pharmaceutical compositions and methods of use thereof.
摘要:
The disclosure provides multimeric oligonucleotide compounds, comprising two or more target-specific oligonucleotides (e.g., antisense oligonucleotides (ASOs)), each being resistant to cleavage, and linked together by a cleavable linker. In particular, two or more linked target-specific oligonucleotides, each to a different target, allows concomitant inhibition of multiple genes' expression levels, while exhibiting favorable pharmacokinetic and pharmacodynamic properties. Methods of making and uses of the described compounds are also provided.
摘要:
A minimally invasive system and method for vertebral body augmentation includes an expandable containment device, a chassis including an interior cavity for at least partially enclosing the expandable containment device, a first guidewire, a working cannula, a second guidewire having at least a partially flexible distal end portion and a sleeve for introducing bone filler material through a cannulated passageway of the sleeve and into an interior cavity of the containment device. The containment device preferably includes a plurality of pores for directing the outflow of bone filler material anteriorly within the vertebral body. The containment device and chassis are left interior to the vertebral body subsequent to height restoration and augmentation of the vertebral body.
摘要:
A grinding machine includes a machine frame with a work piece support surface on which a work piece may be transporter through the machine. A grinding bar arrangement including two grinding shoes positioned in parallel is arranged transversely with respect to a work piece feeding direction across the width of the work piece support surface. The two grinding shoes carry a grinding medium on their surfaces facing the work piece support surface and are suspended via an eccentric drive. The two grinding shoes perform rotary movements in a plane parallel to the work piece support surface achieving a high quality grinding result.
摘要:
The invention relates to a measurement device (10), to a measurement method, to a monitoring apparatus (1) and a monitoring method for monitoring a state of wear of a component of a reciprocating piston internal combustion engine (2) including a cylinder (3) having a cylinder cover (4) and a running surface (51) provided at a cylinder wall (5) of the cylinder (3), in which cylinder (3) a piston (6) is arranged moveable to and fro in an axial direction (A) along the running surface (51) between a bottom dead center and a top dead center such that the piston (6), the cylinder cover (4) and the cylinder wall (5) form a combustion space (7) in the cylinder (3) for the combustion of a mixture of a fuel and air, wherein an oil collection device (8) is provided for the collection of lubrication oil (9) from the cylinder (3) so that a predetermined measured quantity (91) of lubrication oil (9) is suppliable from the cylinder (3) to a measurement device (10). In accordance with the invention the measured quantity (91) of lubrication oil (9) is directly supplied from the running surface (51) of the cylinder (3) and/or is directly supplied from the combustion space (7) and/or is directly supplied from a piston ring package of the piston (6) to the oil collection device (8).
摘要:
A combination instrument has a disk that is transparent for light in the visible range and that has a dial region and an indicator region. It further has a dial imprint, which is applied to the back of the transparent disk in the dial region. In addition, a polarizing filter disk is provided, which is disposed on the back of the transparent disk aligned with the indicator region and comprises a circular polarizing filter. An optical indicator unit is provided, which is disposed in alignment with the indicator region on the back of the transparent disk and the polarizing filter disk.
摘要:
Data traffic is routed from a customer edge (CE) router to an Ethernet services router via a generic routing encapsulation (GRE) tunnel. Upon routing the data traffic from the CE router to the Ethernet services router, the data traffic is routed from the Ethernet services router to an aggregation switch. Upon routing the data traffic from the Ethernet services router to the aggregation switch, the data traffic is routed from the aggregation switch to a service switch through a security module, the security module configured to filter the data traffic. The filtered data traffic is routed from the service switch to the Ethernet services router. Upon routing the filtered data traffic from the service switch to the Ethernet services router, the filtered data traffic is routed from the Ethernet services router to a provider edge (PE) router.