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1.发明申请IMMUNE STIMULATORY OLIGONUCLEOTIDE ANALOGS CONTAINING MODIFIED SUGAR MOIETIES 有权含有改性糖酵母的免疫刺激寡核苷酸模拟物公开(公告)号：US20110098456A1
公开(公告)日：2011-04-28
申请号：US12681800
申请日：2008-09-09
申请人： Eugen Uhlmann , Harald Debelak , Marion Jurk , Markus Weber
发明人： Eugen Uhlmann , Harald Debelak , Marion Jurk , Markus Weber
CPC分类号： A61K39/39 , A61K2039/55561 , C12N15/117 , C12N2310/17 , C12N2310/32 , C12N2310/322
摘要： The invention relates to oligonucleotides including at least one FANA substituted nucleotide analog and a pyrimidine-purine dinucleotide. The invention also relates to pharmaceutical compositions and methods of use thereof.
摘要翻译： 本发明涉及包含至少一种FANA取代的核苷酸类似物和嘧啶 - 嘌呤二核苷酸的寡核苷酸。 本发明还涉及药物组合物及其使用方法。
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2.发明授权Immune stimulatory oligonucleotide analogs containing modified sugar moieties 有权含有修饰的糖部分的免疫刺激性寡核苷酸类似物公开(公告)号：US09186399B2
公开(公告)日：2015-11-17
申请号：US12681800
申请日：2008-09-29
申请人： Eugen Uhlmann , Harald Debelak , Marion Jurk , Markus Weber
发明人： Eugen Uhlmann , Harald Debelak , Marion Jurk , Markus Weber
IPC分类号： A61K39/39 , A61K39/00 , C12N15/117
CPC分类号： A61K39/39 , A61K2039/55561 , C12N15/117 , C12N2310/17 , C12N2310/32 , C12N2310/322
摘要： The invention relates to oligonucleotides including at least one FANA substituted nucleotide analog and a pyrimidine-purine dinucleotide. The invention also relates to pharmaceutical compositions and methods of use thereof.
摘要翻译： 本发明涉及包含至少一种FANA取代的核苷酸类似物和嘧啶 - 嘌呤二核苷酸的寡核苷酸。 本发明还涉及药物组合物及其使用方法。
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3.发明申请CpG Oligonucleotide Analogs Containing Hydrophobic T Analogs with Enhanced Immunostimulatory Activity 有权含有增强免疫刺激活性的疏水性T类似物的CpG寡核苷酸类似物公开(公告)号：US20100166780A1
公开(公告)日：2010-07-01
申请号：US12442295
申请日：2007-09-27
申请人： Harald Debelak , Eugen Uhlmann , Marion Jurk
发明人： Harald Debelak , Eugen Uhlmann , Marion Jurk
IPC分类号： A61K39/00 , C07H19/06 , C07H19/16 , C07H19/052 , C07H19/056 , A61K31/702 , A61P31/12
CPC分类号： C12N15/117 , C07H21/00 , C12N2310/17 , C12N2310/31 , C12N2310/315 , C12N2310/33 , C12N2310/332 , C12N2310/335
摘要： The invention relates to oligonucleotides including at least one lipophilic substituted nucleotide analog and a pyrimidine-purine dinucleotide. The invention also relates to pharmaceutical compositions and methods of use thereof.
摘要翻译： 本发明涉及包含至少一种亲脂性取代的核苷酸类似物和嘧啶 - 嘌呤二核苷酸的寡核苷酸。 本发明还涉及药物组合物及其使用方法。
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公开(公告)号：US20100189772A1
公开(公告)日：2010-07-29
申请号：US12443224
申请日：2007-09-27
申请人： Jorg Vollmer , Marion Jurk , Eugen Uhlmann , Harald Debelak , Robert L. Bratzler , Alain Vicari
发明人： Jorg Vollmer , Marion Jurk , Eugen Uhlmann , Harald Debelak , Robert L. Bratzler , Alain Vicari
CPC分类号： A61K31/7088 , A61K45/06 , C12N15/117 , C12N2310/17 , C12N2310/315 , C12N2310/336 , C12N2310/351 , C12N2320/31 , A61K2300/00
摘要： The invention relates to methods and products for the treatment of viral infection using a combination of anti-viral agents and TLR ligands. The invention also relates to screening assays, associated products, kits, and in vitro methods.
摘要翻译： 本发明涉及使用抗病毒剂和TLR配体的组合治疗病毒感染的方法和产品。 本发明还涉及筛选测定，相关产品，试剂盒和体外方法。
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5.发明授权CpG oligonucleotide analogs containing hydrophobic T analogs with enhanced immunostimulatory activity 有权含有增强的免疫刺激活性的疏水性T类似物的CpG寡核苷酸类似物公开(公告)号：US08580268B2
公开(公告)日：2013-11-12
申请号：US12442295
申请日：2007-09-27
申请人： Harald Debelak , Eugen Uhlmann , Marion Jurk
发明人： Harald Debelak , Eugen Uhlmann , Marion Jurk
IPC分类号： A61K39/00
CPC分类号： C12N15/117 , C07H21/00 , C12N2310/17 , C12N2310/31 , C12N2310/315 , C12N2310/33 , C12N2310/332 , C12N2310/335
摘要： The invention relates to oligonucleotides including at least one lipophilic substituted nucleotide analog and a pyrimidine-purine dinucleotide. The invention also relates to pharmaceutical compositions and methods of use thereof.
摘要翻译： 本发明涉及包含至少一种亲脂性取代的核苷酸类似物和嘧啶 - 嘌呤二核苷酸的寡核苷酸。 本发明还涉及药物组合物及其使用方法。
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公开(公告)号：US20050059619A1
公开(公告)日：2005-03-17
申请号：US10644052
申请日：2003-08-19
申请人： Arthur Krieg , Ulrike Samulowitz , Jorg Vollmer , Eugen Uhlmann , Marion Jurk , Grayson Lipford , Robert Rankin
发明人： Arthur Krieg , Ulrike Samulowitz , Jorg Vollmer , Eugen Uhlmann , Marion Jurk , Grayson Lipford , Robert Rankin
IPC分类号： A61K31/70 , A61K48/00 , C07H19/00 , C07H21/00 , C07H21/02 , C07H21/04 , C12N15/117 , C12Q1/00 , C12Q1/68
CPC分类号： C12N15/117 , A61K31/70 , A61K2039/55561 , C07H19/00 , C07H21/00 , C07H21/02 , C07H21/04 , C12N2310/312 , C12N2310/3125 , C12N2310/313 , C12N2310/315 , C12N2310/336 , C12N2310/345
摘要： The invention relates to a class of soft or semi-soft CpG immunostimulatory oligonucleotides that are useful for stimulating an immune response.
摘要翻译： 本发明涉及一类可用于刺激免疫应答的软或半软CpG免疫刺激性寡核苷酸。
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公开(公告)号：US08283328B2
公开(公告)日：2012-10-09
申请号：US10644052
申请日：2003-08-19
申请人： Arthur M. Krieg , Grayson Lipford , Ulrike Samulowitz , Jörg Vollmer , Eugen Uhlmann , Marion Jurk , Robert Rankin
发明人： Arthur M. Krieg , Grayson Lipford , Ulrike Samulowitz , Jörg Vollmer , Eugen Uhlmann , Marion Jurk , Robert Rankin
CPC分类号： C12N15/117 , A61K31/70 , A61K2039/55561 , C07H19/00 , C07H21/00 , C07H21/02 , C07H21/04 , C12N2310/312 , C12N2310/3125 , C12N2310/313 , C12N2310/315 , C12N2310/336 , C12N2310/345
摘要： The invention relates to a class of soft or semi-soft CpG immunostimulatory oligonucleotides that are useful for stimulating an immune response.
摘要翻译： 本发明涉及一类可用于刺激免疫应答的软或半软CpG免疫刺激性寡核苷酸。
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8.发明申请Phosphate-Modified Oligonucleotide Analogs with Enhanced Immunostimulatory Activity 有权磷酸修饰的寡核苷酸类似物与增强的免疫刺激活性公开(公告)号：US20100261779A1
公开(公告)日：2010-10-14
申请号：US12600368
申请日：2008-05-15
申请人： Eugen Uhlmann , Marion Jurk
发明人： Eugen Uhlmann , Marion Jurk
IPC分类号： A61K31/7125 , A61P35/00 , A61P31/00 , A61P11/06 , A61P37/08
CPC分类号： C12N15/117 , A61K31/7125 , A61K45/06 , C12N2310/17 , C12N2310/311 , C12N2310/3125 , C12N2310/315 , Y02A50/463 , A61K2300/00
摘要： The invention relates to oligonucleotides including at least one backbone modification and a pyrimidine-purine dinucleotide. The invention also relates to pharmaceutical compositions and methods of use thereof.
摘要翻译： 本发明涉及包含至少一种骨架修饰和嘧啶 - 嘌呤二核苷酸的寡核苷酸。 本发明还涉及药物组合物及其使用方法。
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公开(公告)号：US20100144846A1
公开(公告)日：2010-06-10
申请号：US12447107
申请日：2007-10-26
申请人： Marion Jurk , Jorg Vollmer , Eugen Uhlmann
发明人： Marion Jurk , Jorg Vollmer , Eugen Uhlmann
IPC分类号： A61K31/7088 , C07H21/02 , C07K2/00 , C07K14/00 , A61P35/00 , A61P37/08 , A61P31/12 , A61P11/00 , A61P37/02
CPC分类号： C12N15/117 , A61K2039/55561 , C12N2310/17 , C12N2310/315 , C12N2310/317 , C12N2310/336 , C12N2310/3511 , C12N2310/3515 , C12N2310/3517
摘要： The invention relates to immunostimulatory RNA oligonucleotides (ORN). In particular the ORN have an immunostimulatory ORN motif directly or indirectly flanked by a 3′ poly G motif and optionally a 5′ poly-G motif. The invention also relates to methods including therapeutic methods and screening methods and related kits for use of the ORN.
摘要翻译： 本发明涉及免疫刺激RNA寡核苷酸（ORN）。 特别地，ORN具有直接或间接侧接于3'poly G基序和任选的5'poly-G基序的免疫刺激性ORN基序。 本发明还涉及包括用于ORN的治疗方法和筛选方法以及相关试剂盒的方法。
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公开(公告)号：US08304396B2
公开(公告)日：2012-11-06
申请号：US11542845
申请日：2006-10-04
申请人： Arthur M. Krieg , Ulrike Samulowitz , Jörg Vollmer , Eugen Uhlmann , Marion Jurk , Grayson B. Lipford , Robert Rankin
发明人： Arthur M. Krieg , Ulrike Samulowitz , Jörg Vollmer , Eugen Uhlmann , Marion Jurk , Grayson B. Lipford , Robert Rankin
CPC分类号： C12N15/117 , A61K31/70 , A61K2039/55561 , C07H19/00 , C07H21/00 , C07H21/02 , C07H21/04 , C12N2310/312 , C12N2310/3125 , C12N2310/313 , C12N2310/315 , C12N2310/336 , C12N2310/345
摘要： The invention relates to a class of soft or semi-soft CpG immunostimulatory oligonucleotides that are useful for stimulating an immune response.
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