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    Use of aminoguanidine analogs for the treatment of diseases of the nervous system
    41.
    发明授权
    Use of aminoguanidine analogs for the treatment of diseases of the nervous system 有权
    使用氨基胍类似物治疗神经系统疾病

    公开(公告)号：US06169115A

    公开(公告)日：2001-01-02

    申请号：US09316489

    申请日：1999-05-21

    申请人： Rima Kaddurah-Daouk

    发明人： Rima Kaddurah-Daouk

    IPC分类号： A61K31195

    CPC分类号： A61K31/155 ,  A61K31/195 ,  A61K31/66

    摘要： The present invention relates to the use of aminoguanidine compounds for treating diseases of the nervous system. Aminoguanidine compounds can be used as therapeutically effective agents against a variety of diseases of the nervous system such as diabetic and toxic neuropathies, peripheral nervous system diseases, Alzheimer's disease, Parkinson's disease, stroke, Huntington's disease, amyotropic lateral sclerosis, motor neuron disease, traumatic nerve injury, multiple sclerosis, dysmyelination and demyelination disorders, and mitochondrial diseases. The aminoguanidine compounds which can be used in the present method include (1) aminoguanidine and diaminoguanidine analogs which can act as substrates or substrate analogs for creatine kinase; (2) bisubstrate inhibitors of creatine kinase comprising covalently linked structural analogs of adenosine triphosphate (ATP) and aminoguanidine; (3) aminoguanidine analogs which can act as reversible or irreversible inhibitors of creatine kinase; and (4) N-phosphoroaminoguanidine analogs bearing nontransferable moieties which mimic the N-phosphoryl group.

    摘要翻译： 本发明涉及氨基胍化合物用于治疗神经系统疾病的用途。 氨基胍化合物可用作治疗性神经系统疾病的治疗有效药物，例如糖尿病和中毒性神经病，周围神经系统疾病，阿尔茨海默氏病，帕金森病，中风，亨廷顿病，肌萎缩性侧索硬化，运动神经元疾病，创伤性疾病 神经损伤，多发性硬化，脱髓鞘和脱髓鞘疾病以及线粒体疾病。 可用于本方法的氨基胍化合物包括（1）可用作肌酸激酶底物或底物类似物的氨基胍和二氨基胍类似物; （2）肌酸激酶的双底物抑制剂，其包括三磷酸腺苷（ATP）和氨基胍的共价连接的结构类似物; （3）可作为肌酸激酶的可逆或不可逆抑制剂的氨基胍类似物; 和（4）具有模拟N-磷酰基的不可转移部分的N-氨基鸟嘌呤类似物。

    Use of creatine or creatine analogs for the treatment of diseases of the nervous system
    43.
    发明申请
    Use of creatine or creatine analogs for the treatment of diseases of the nervous system 审中-公开
    使用肌酸或肌酸类似物治疗神经系统疾病

    公开(公告)号：US20080119450A1

    公开(公告)日：2008-05-22

    申请号：US11899135

    申请日：2007-09-04

    申请人： Rima Kaddurah-Daouk ,  Ghaleb Daouk ,  M. Flint Beal

    发明人： Rima Kaddurah-Daouk ,  Ghaleb Daouk ,  M. Flint Beal

    IPC分类号： A61K31/197 ,  A61K31/505 ,  A61K31/415 ,  A61K31/397 ,  A61P31/00 ,  A61P25/00

    CPC分类号： A61K31/675 ,  A61K31/197 ,  A61K31/198 ,  A61K31/397 ,  A61K31/415 ,  A61K31/505 ,  A61K31/664

    摘要： The present invention relates to the use of creatine compounds including creatine, creatine phosphate or analogs of creatine, such as cyclocreatine, for treating diseases of the nervous system. Creatine compounds can be used as therapeutically effective agents against a variety of diseases of the nervous system such as diabetic and toxic neuropathies, peripheral nervous system diseases, Alzheimer's disease, Parkinson's disease, stroke, Huntington's disease, amyotropic lateral sclerosis, motor neuron disease, traumatic nerve injury, multiple sclerosis, dysmyelination and demyelination disorders, and mitochondrial diseases. The creatine compounds which can be used in the present method include (1) creatine, creatine phosphate and analogs of these compounds which can act as substrates or substrate analogs for creatine kinase; (2) bisubstrate inhibitors of creatine kinase comprising covalently linked structural analogs of adenosine triphosphate (ATP) and creatine; (3) creatine analogs which can act as reversible or irreversible inhibitors of creatine kinase; and (4) N-phosphorocreatine analogs bearing non-transferable moieties which mimic the N-phosphoryl group.

    摘要翻译： 本发明涉及肌酸化合物的应用，包括肌酸，磷酸肌酸或肌酸类似物，如环磷酸，用于治疗神经系统疾病。 肌酸化合物可用作抗神经系统的多种疾病的治疗有效药物，例如糖尿病和毒性神经病，周围神经系统疾病，阿尔茨海默病，帕金森病，中风，亨廷顿病，肌萎缩性侧索硬化，运动神经元疾病，创伤性 神经损伤，多发性硬化，脱髓鞘和脱髓鞘疾病以及线粒体疾病。 可用于本方法的肌酸化合物包括（1）肌酸，磷酸肌酸和这些化合物的类似物，其可以作为肌酸激酶的底物或底物类似物; （2）肌酸激酶的双底物抑制剂，其包括三磷酸腺苷（ATP）和肌酸的共价连接的结构类似物; （3）可作为肌酸激酶的可逆或不可逆抑制剂的肌酸类似物; 和（4）具有模拟N-磷酰基的不可转移部分的N-磷酸肌醇类似物。

    Use of creatine or creatine analogs for the treatment of diseases of the nervous system
    45.
    发明授权
    Use of creatine or creatine analogs for the treatment of diseases of the nervous system 有权
    使用肌酸或肌酸类似物治疗神经系统疾病

    公开(公告)号：US07285573B2

    公开(公告)日：2007-10-23

    申请号：US10718846

    申请日：2003-11-21

    申请人： Rima Kaddurah-Daouk ,  Ghaleb Daouk ,  M. Flint Beal

    发明人： Rima Kaddurah-Daouk ,  Ghaleb Daouk ,  M. Flint Beal

    IPC分类号： A01N37/52

    CPC分类号： A61K31/675 ,  A61K31/197 ,  A61K31/198 ,  A61K31/397 ,  A61K31/415 ,  A61K31/505 ,  A61K31/664

    摘要： The present invention relates to the use of creatine compounds including creatine, creatine phosphate or analogs of creatine, such as cyclocreatine, for treating diseases of the nervous system. Creatine compounds can be used as therapeutically effective agents against a variety of diseases of the nervous system such as diabetic and toxic neuropathies, peripheral nervous system diseases, Alzheimer's disease, Parkinson's disease, stroke, Huntington's disease, amyotropic lateral sclerosis, motor neuron disease, traumatic nerve injury, multiple sclerosis, dysmyelination and demyelination disorders, and mitochondrial diseases. The creatine compounds which can be used in the present method include (1) creatine, creatine phosphate and analogs of these compounds which can act as substrates or substrate analogs for creatine kinase; (2) bisubstrate inhibitors of creatine kinase comprising covalently linked structural analogs of adenosine triphosphate (ATP) and creatine; (3) creatine analogs which can act as reversible or irreversible inhibitors of creatine kinase; and (4) N-phosphorocreatine analogs bearing non-transferable moieties which mimic the N-phosphoryl group.

    摘要翻译： 本发明涉及肌酸化合物的应用，包括肌酸，磷酸肌酸或肌酸类似物，如环磷酸，用于治疗神经系统疾病。 肌酸化合物可用作抗神经系统的多种疾病的治疗有效药物，例如糖尿病和毒性神经病，周围神经系统疾病，阿尔茨海默病，帕金森病，中风，亨廷顿病，肌萎缩性侧索硬化，运动神经元疾病，创伤性 神经损伤，多发性硬化，脱髓鞘和脱髓鞘疾病以及线粒体疾病。 可用于本方法的肌酸化合物包括（1）肌酸，磷酸肌酸和这些化合物的类似物，其可以作为肌酸激酶的底物或底物类似物; （2）肌酸激酶的双底物抑制剂，其包括三磷酸腺苷（ATP）和肌酸的共价连接的结构类似物; （3）可作为肌酸激酶的可逆或不可逆抑制剂的肌酸类似物; 和（4）具有模拟N-磷酰基的不可转移部分的N-磷酸肌醇类似物。

    Compositions containing a combination of a creatine compound and a second agent
    50.
    发明申请
    Compositions containing a combination of a creatine compound and a second agent 审中-公开
    含有肌酸化合物和第二药剂组合的组合物

    公开(公告)号：US20060128643A1

    公开(公告)日：2006-06-15

    申请号：US11342727

    申请日：2006-01-30

    申请人： Rima Kaddurah-Daouk ,  M. Beal

    发明人： Rima Kaddurah-Daouk ,  M. Beal

    IPC分类号： A61K31/7072 ,  A61K31/675 ,  A61K31/205 ,  A61K31/66

    CPC分类号： A61K45/06 ,  A61K31/195

    摘要： The present invention relates to the use of creatine compound and neuroprotective combinations including creatine, creatine phosphate or analogs of creatine, such as cyclocreatine, for treating diseases of the nervous system. Creatine compounds in combination with neuroprotective agents can be used as therapeutically effective compositions against a variety of diseases of the nervous system such as diabetic and toxic neuropathies, peripheral nervous system diseases, Alzheimer disease, Parkinson's disease, stroke, Huntington's disease, amyotropic lateral sclerosis, motor neuron disease, traumatic nerve injury, multiple sclerosis, dysmyelination and demyelination disorders, and mitochondrial diseases. The creatine compounds which can be used in the present method include (1) creatine, creatine phosphate and analogs of these compounds which can act as substrates or substrate analogs for creatine kinase; (2) bisubstrate inhibitors of creatine kinase comprising covalently linked structural analogs of adenosine triphosphate (ATP) and creatine; (3) creatine analogs which can act as reversible or irreversible inhibitors of creatine kinase; and (4) N-phosphorocreatine analogs bearing non-transferable moieties which mimic the N-phosphoryl group.

    摘要翻译： 本发明涉及肌酸化合物和神经保护组合的用途，包括肌酸，磷酸肌酸或肌酸类似物，如环磷酸，用于治疗神经系统疾病。 肌酸化合物与神经保护剂组合可用作治疗有效的组合物，用于治疗神经系统的多种疾病，例如糖尿病和毒性神经病，周围神经系统疾病，阿尔茨海默氏病，帕金森病，中风，亨廷顿舞蹈病，肌萎缩性侧索硬化， 运动神经元疾病，外伤性神经损伤，多发性硬化，脱髓鞘和脱髓鞘疾病以及线粒体疾病。 可用于本方法的肌酸化合物包括（1）肌酸，磷酸肌酸和这些化合物的类似物，其可以作为肌酸激酶的底物或底物类似物; （2）肌酸激酶的双底物抑制剂，其包括三磷酸腺苷（ATP）和肌酸的共价连接的结构类似物; （3）可作为肌酸激酶的可逆或不可逆抑制剂的肌酸类似物; 和（4）具有模拟N-磷酰基的不可转移部分的N-磷酸肌醇类似物。