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41.发明授权公开(公告)号：US07207964B2
公开(公告)日：2007-04-24
申请号：US10390558
申请日：2003-03-17
CPC分类号： A61M1/3681 , A61L2/0011 , A61M1/3431 , A61M1/3468 , A61M1/3472 , A61M1/3482 , A61M1/3683 , A61M2205/053 , A61M2205/75 , A61M2230/207
摘要： A method and apparatus for preventing and treating septicemia in patient blood is provided. The extracorporeal system includes an antimicrobial device to inactivate at least 99% of bloodborne microorganisms, a hemoconcentrator/filtration unit to remove approximately 50–75% of target molecules from the patient blood and a filter unit to remove target molecules from patient blood from the sieved plasma filtrate. Target molecules are produced by microorganisms, as well as by the patient's cells. These molecules include endotoxins from Gram negative bacteria, exotoxins from Gram negative and Gram positive bacteria, as well as RAP protein mediator from Staphylococcus aureus, and cell mediators such as tumor necrosis factor-alpha, and interleukin 1-beta, interleukin 6, complement proteins C3a and C5a, and bradykinin.
摘要翻译： 提供了一种预防和治疗患者血液中败血症的方法和装置。 体外系统包括用于灭活至少99％的血源性微生物的抗微生物装置，血液浓缩器/过滤单元以从患者血液中除去大约50-75％的靶分子，以及过滤器单元以从筛选的患者血液中除去靶分子 血浆滤液。 靶分子由微生物以及患者的细胞产生。 这些分子包括来自革兰氏阴性细菌的内毒素，来自革兰阴性和革兰氏阳性细菌的外毒素，以及来自金黄色葡萄球菌的RAP蛋白质介质，以及细胞介质如肿瘤坏死因子-α和白介素1-β，白细胞介素6，补体蛋白 C3a和C5a以及缓激肽。
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公开(公告)号：US07201730B2
公开(公告)日：2007-04-10
申请号：US10391443
申请日：2003-03-17
CPC分类号： A61M1/3681 , A61L2/0011 , A61L2/0017 , A61L2/0082 , A61M1/3431 , A61M1/3468 , A61M1/3472 , A61M1/3482 , A61M1/3683 , A61M2205/75
摘要： A method and apparatus for preventing and treating septicemia in patient blood is provided. The extracorporeal system includes an antimicrobial device to inactivate at least 99% of bloodborne microorganisms, a hemoconcentrator/filtration unit to remove approximately 50–75% of target molecules from the patient blood and a filter unit to remove target molecules from patient blood from the sieved plasma filtrate. Target molecules are produced by microorganisms, as well as by the patient's cells. These molecules include endotoxins from Gram negative bacteria, exotoxins from Gram negative and Gram positive bacteria, as well as RAP protein mediator from Staphylococcus aureus, and cell mediators such as tumor necrosis factor-alpha, and interleukin 1-beta, interleukin 6, complement proteins C3a and C5a, and bradykinin.
摘要翻译： 提供了一种预防和治疗患者血液中败血症的方法和装置。 体外系统包括用于灭活至少99％的血源性微生物的抗微生物装置，血液浓缩器/过滤单元以从患者血液中除去大约50-75％的靶分子，以及过滤器单元以从筛选的患者血液中除去靶分子 血浆滤液。 靶分子由微生物以及患者的细胞产生。 这些分子包括来自革兰氏阴性细菌的内毒素，来自革兰阴性和革兰氏阳性细菌的外毒素，以及来自金黄色葡萄球菌的RAP蛋白质介质，以及细胞介质如肿瘤坏死因子-α和白介素1-β，白细胞介素6，补体蛋白 C3a和C5a以及缓激肽。
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公开(公告)号：US07229427B2
公开(公告)日：2007-06-12
申请号：US10390572
申请日：2003-03-17
CPC分类号： A61L2/0011 , A61M1/3431 , A61M1/3468 , A61M1/3472 , A61M1/3681 , A61M1/3683 , A61M2205/75
摘要： A method and apparatus for preventing and treating septicemia in patient blood is provided. The extracorporeal system includes an antimicrobial device to inactivate at least 99% of bloodborne microorganisms, a hemoconcentrator/filtration unit to remove approximately 50–75% of target molecules from the patient blood and a filter unit to remove target molecules from patient blood from the sieved plasma filtrate. Target molecules are produced by microorganisms, as well as by the patient's cells. These molecules include endotoxins from Gram negative bacteria, exotoxins from Gram negative and Gram positive bacteria, as well as RAP protein mediator from Staphylococcus aureus, and cell mediators such as tumor necrosis factor-alpha, and interleukin 1-beta, interleukin 6, complement proteins C3a and C5a, and bradykinin.
摘要翻译： 提供了一种预防和治疗患者血液中败血症的方法和装置。 体外系统包括用于灭活至少99％的血源性微生物的抗微生物装置，血液浓缩器/过滤单元以从患者血液中除去大约50-75％的靶分子，以及过滤器单元以从筛选的患者血液中除去靶分子 血浆滤液。 靶分子由微生物以及患者的细胞产生。 这些分子包括来自革兰氏阴性细菌的内毒素，来自革兰阴性和革兰氏阳性细菌的外毒素，以及来自金黄色葡萄球菌的RAP蛋白质介质，以及细胞介质如肿瘤坏死因子-α和白介素1-β，白细胞介素6，补体蛋白 C3a和C5a以及缓激肽。
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44.发明申请公开(公告)号：US20110006004A1
公开(公告)日：2011-01-13
申请号：US12834719
申请日：2010-07-12
CPC分类号： A61M1/3681 , A61L2/0011 , A61M1/3431 , A61M1/3468 , A61M1/3472 , A61M1/3482 , A61M1/3683 , A61M2205/053 , A61M2205/75 , A61M2230/207
摘要： A method and apparatus for preventing and treating septicemia in patient blood is provided. The extracorporeal system includes an antimicrobial device to inactivate at least 99% of bloodborne microorganisms, a hemoconcentrator/filtration unit to remove approximately 50-75% of target molecules from the patient blood and a filter unit to remove target molecules from patient blood from the sieved plasma filtrate. Target molecules are produced by microorganisms, as well as by the patient's cells. These molecules include endotoxins from Gram negative bacteria, exotoxins from Gram negative and Gram positive bacteria, as well as RAP protein mediator from Staphylococcus aureus, and cell mediators such as tumor necrosis factor-alpha, and interleukin 1-beta, interleukin 6, complement proteins C3a and C5a, and bradykinin.
摘要翻译： 提供了一种预防和治疗患者血液中败血症的方法和装置。 体外系统包括用于灭活至少99％的血源性微生物的抗微生物装置，血液浓缩器/过滤单元以从患者血液中除去大约50-75％的靶分子，以及过滤器单元以从筛选的患者血液中除去靶分子 血浆滤液。 靶分子由微生物以及患者的细胞产生。 这些分子包括来自革兰氏阴性细菌的内毒素，来自革兰阴性和革兰氏阳性细菌的外毒素，以及来自金黄色葡萄球菌的RAP蛋白质介质，以及细胞介质如肿瘤坏死因子-α和白介素1-β，白细胞介素6，补体蛋白 C3a和C5a以及缓激肽。
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45.发明申请公开(公告)号：US20130325727A1
公开(公告)日：2013-12-05
申请号：US13636325
申请日：2011-03-21
申请人： Mark MacDonell , Alan A. Davidner
IPC分类号： G06Q10/00
CPC分类号： G06Q10/30 , A61B50/10 , A61B50/13 , A61B50/36 , A61B90/90 , A61B90/94 , A61B90/96 , A61B90/98 , A61B2017/00221 , A61B2050/0056 , Y02W90/20
摘要： A system for disposing of medical waste is generally configured to sort waste items into a plurality of containers according to applicable rules and regulations governing the handling and/or disposal of such items. In some embodiments, a system comprises sorting stations each of which houses a number of disposable containers. Each station can identify an item of waste, determine the most appropriate container for the item, and facilitate disposal of the item in the appropriate container. In some embodiments, a container or receptacle is configured to receive waste that comprises a controlled substance (e.g., a narcotic, other CII pharmaceutical waste, etc.). Such controlled waste can be discarded into the container or receptacle directly or indirectly (e.g., by placing the waste in a cup or other enclosure).
摘要翻译： 处置医疗废物的系统通常被配置为根据管理这些物品的处理和/或处理的适用的规则和条例将废物分类成多个容器。 在一些实施例中，系统包括分类站，每个站容纳多个一次性容器。 每个车站都可以识别一件废物，确定物品最合适的容器，并便于在相应容器中处理物品。 在一些实施例中，容器或容器构造成容纳包含受控物质（例如麻醉剂，其它CII药物废物等）的废物。 这种受控的废物可以直接或间接地丢弃到容器或容器中（例如，通过将废物放置在杯子或其它外壳中）。
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46.发明授权Retractable-needle cannula insertion set with refinements to better control leakage, retraction speed, and reuse 失效可伸缩针套管插入装置具有改进以更好地控制泄漏，回缩速度和再利用
公开(公告)号：US5702367A
公开(公告)日：1997-12-30
申请号：US681644
申请日：1996-07-29
申请人： Walter E. Cover , Alan A. Davidner
发明人： Walter E. Cover , Alan A. Davidner
CPC分类号： A61M25/0631 , A61M25/0606 , A61M25/0693 , A61M2005/3226 , A61M5/3232
摘要： Leakage of blood from the insertion set, during and after safety-needle retraction, is suppressed by components that receive and retain flash blood for viewing--notwithstanding forces developed within the device in retraction. One preferred such system includes a flash chamber that moves with the retracting needle, within a hollow handle, carrying a relatively high flow-impedance element which allows air exhaust from the chamber into the handle to admit flash blood--but isolates blood in the chamber from retraction-generated increase in air pressure in the handle. Energy-absorbing components control or compensate for retraction speed, to provide quiet smooth retraction--while yet enabling use of ample retraction force to make retraction reliable. Among several energy absorbing systems disclosed is a preferred one that includes a viscous material introduced within the hollow handle to damp the retracting motion; and an injection port to facilitate introduction of the viscous material. Needle reuse, and concomitant risk of spreading disease, are avoided through components that deter needle redeployment--by deterring access to or forward motion of the needle, or trigger reengagement.
摘要翻译： 插入组，安全针回缩期间和之后的血液泄漏受到接收和保留闪烁血液观察的组分的抑制，尽管在收缩装置内产生的力也是如此。 一种优选的这种系统包括闪络室，其与缩回针一起在空心手柄内移动，承载相对较高的流动阻抗元件，其允许从腔室排出到手柄中的空气进入闪电血液，但将腔室中的血液隔离 缩回产生的手柄气压升高。 能量吸收部件控制或补偿回退速度，提供安静的平滑回缩，同时又能使用充足的回缩力使收缩可靠。 在所公开的几种能量吸收系统中，优选包括引入中空手柄内的粘性材料以阻尼回缩运动; 以及便于引入粘性材料的注射口。 通过防止针头重新部署的部件，通过阻止针的进入或向前运动或触发重新接合来避免针头再次使用和伴随的疾病蔓延的风险。
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公开(公告)号：US5104373A
公开(公告)日：1992-04-14
申请号：US555097
申请日：1990-07-19
IPC分类号： A61M1/36
CPC分类号： A61M1/36 , A61M1/3603 , A61M1/3681 , A61M1/369
摘要： Disclosed is a multimodal method and apparatus for extracorporeally treating certain blood borne infections, such as the infection of T-lymphocytes with the Human Immunodeficiency Virus. The method and apparatus of the invention includes (a) hyperthermic, (b) mechanical shear inducing, and (c) irradiation treatment modalities. These three treatment modalities may be carried out separately, in any order, or simultaneously, in any combination. The irradiation treatment mode preferably includes methods and means for subjecting at least a fraction of the blood to ultraviolet and/or x-ray and/or laser radiation. Before the blood is withdrawn from the human subject a chemical agent such as heparin may be administered to the subject for purposes of inducing lymphocyte migration from the lymph system into the circulatory system. Following extraction of a desired maximal volume of blood from the human subject, volume extenders may be mixed with the blood, thereby adjusting the extracorporeal blood volume as required or desired. Following completion of the extracorporeal treatment(s) the treated blood is returned to the patient.
摘要翻译： 公开了一种用于体外治疗某些血源性感染的多模式方法和装置，例如用人免疫缺陷病毒感染T淋巴细胞。 本发明的方法和装置包括（a）高热，（b）机械剪切诱导和（c）照射治疗方式。 这三种治疗方式可以以任何顺序或同时，以任何组合分开进行。 照射处理方式优选包括用于使至少一部分血液进行紫外线和/或X射线和/或激光辐射的方法和装置。 在从人类受试者取出血液之前，可以向受试者施用化学药剂，例如用于诱导淋巴细胞从淋巴系迁移到循环系统中。 在从人受试者中提取期望的最大体积的血液之后，可以将体积增加剂与血液混合，从而根据需要或期望调节体外血液体积。 在完成体外治疗之后，将处理的血液返回给患者。
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公开(公告)号：US4950225A
公开(公告)日：1990-08-21
申请号：US247767
申请日：1988-09-22
IPC分类号： A61M1/36
CPC分类号： A61M1/36 , A61M1/3603 , A61M1/3681 , A61M1/369
摘要： Disclosed is a multimodal method and apparatus for extracorporeally treating certain blood borne infections, such as the infection of T-lymphocytes with the Human Immunodeficiency Virus. The method and apparatus of the invention includes (a) hyperthermic, (b) mechanical shear inducing, and (c) irradiation treatment modalities. These three treatment modalities may be carried out separately, in any order, or simultaneously, in any combination. The irradiation treatment mode preferably includes methods and means for subjecting at least a fraction of the blood to ultraviolet and/or x-ray and/or laser radiation. Before the blood is withdrawn from the human subject a chemical agent such as heparin may be administered to the subject for purposes of inducing lymphocyte migration from the lymph system into the circulatory system. Following extraction of a desired maximal volume of blood from the human subject, volume extenders may be mixed with the blood, thereby adjusting the extracorporeal blood volume as required or desired. Following completion of the extracorporeal treatment(s) the treated blood is returned to the patient.
摘要翻译： 公开了一种用于体外治疗某些血源性感染的多模式方法和装置，例如用人免疫缺陷病毒感染T淋巴细胞。 本发明的方法和装置包括（a）高热，（b）机械剪切诱导和（c）照射治疗方式。 这三种治疗方式可以以任何顺序或同时，以任何组合分开进行。 照射处理方式优选包括用于使至少一部分血液进行紫外线和/或X射线和/或激光辐射的方法和装置。 在从人类受试者取出血液之前，可以向受试者施用化学药剂，例如用于诱导淋巴细胞从淋巴系迁移到循环系统中。 在从人受试者中提取期望的最大体积的血液之后，可以将体积增加剂与血液混合，从而根据需要或期望调节体外血液体积。 在完成体外治疗之后，将处理的血液返回给患者。
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公开(公告)号：US4386948A
公开(公告)日：1983-06-07
申请号：US304515
申请日：1981-09-21
CPC分类号： B01D46/523 , B01D46/0028 , B01D46/10 , A61M16/04 , A61M16/1055 , Y10S55/31 , Y10S55/35
摘要： A filter device used to filter medical anesthesia gases and other inhalable respiratory gases. The filter device has a ported housing, and a filter member within the housing. The filter member is a porous sheet that is transversely pleated and draped to define a peripheral foot of such porous sheet. The peripheral foot is sealed along its entire periphery to the housing. Two sets of intermeshing hangers are provided with both sets of the hangers being anchored to the housing and distortingly maintaining the porous sheet in such a pleated condition.
摘要翻译： 用于过滤医疗麻醉气体和其他可吸入呼吸道气体的过滤装置。 过滤装置具有端口壳体和壳体内的过滤构件。 过滤构件是横向折叠和覆盖以限定这种多孔片的外围脚的多孔片。 周围的脚沿其整个周边被密封到壳体。 两组相互啮合的吊架设置有两组悬挂器锚固到壳体上，并且将多孔片材扭曲地维持在这种打褶状态。
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50.发明授权Retractable needle cannula insertion set with refinements to better control leakage, retraction speed and reuse 失效可伸缩的针管插入装置具有改进，以更好地控制泄漏，回缩速度和再利用
公开(公告)号：US5575777A
公开(公告)日：1996-11-19
申请号：US422662
申请日：1995-04-10
申请人： Walter E. Cover , Alan A. Davidner
发明人： Walter E. Cover , Alan A. Davidner
CPC分类号： A61M25/0631 , A61M25/0606 , A61M25/0693 , A61M2005/3226 , A61M5/3232
摘要： Leakage of blood from the insertion set, during and after safety-needle retraction, is suppressed by components that receive and retain flash blood for viewing--notwithstanding forces developed within the device in retraction. One preferred such system includes a flash chamber that moves with the retracting needle, within a hollow handle, carrying a relatively high flow-impedance element which allows air exhaust from the chamber into the handle to admit flash blood--but isolates blood in the chamber from retraction-generated increase in air pressure in the handle. Energy-absorbing components control or compensate for retraction speed, to provide quiet smooth retraction--while yet enabling use of ample retraction force to make retraction reliable. Among several energy absorbing systems disclosed is a preferred one that includes a viscous material introduced within the hollow handle to damp the retracting motion; and an injection port to facilitate introduction of the viscous material. Needle reuse, and concomitant risk of spreading disease, are avoided through components that deter needle redeployment--by deterring access to or forward motion of the needle, or trigger reengagement.
摘要翻译： 插入组，安全针回缩期间和之后的血液泄漏受到接收和保留闪烁血液观察的组分的抑制，尽管在收缩装置内产生的力也是如此。 一种优选的这种系统包括闪络室，其与缩回针一起在空心手柄内移动，承载相对较高的流动阻抗元件，其允许从腔室排出到手柄中的空气进入闪电血液，但将腔室中的血液隔离 缩回产生的手柄气压升高。 能量吸收部件控制或补偿回退速度，提供安静的平滑回缩，同时又能使用充足的回缩力使收缩可靠。 在所公开的几种能量吸收系统中，优选包括引入中空手柄内的粘性材料以阻尼回缩运动; 以及便于引入粘性材料的注射口。 通过防止针头重新部署的部件，通过阻止针的进入或向前运动或触发重新接合来避免针头再次使用和伴随的疾病蔓延的风险。
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