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    SYSTEMS AND DESIGN FACILITATING REMOTELY CONTROLLING AN IMITATION CANDLE DEVICE
    41.
    发明申请
    SYSTEMS AND DESIGN FACILITATING REMOTELY CONTROLLING AN IMITATION CANDLE DEVICE 审中-公开

    公开(公告)号：US20180031219A1

    公开(公告)日：2018-02-01

    申请号：US15336553

    申请日：2016-10-27

    申请人： Xiaofeng Li

    发明人： Xiaofeng Li

    IPC分类号： F21V23/00 ,  F21S6/00 ,  F21S10/04 ,  F21V14/00

    CPC分类号： F21V23/009 ,  F21S6/001 ,  F21S10/043 ,  F21S10/046 ,  F21V14/00 ,  F21V23/0435 ,  F21W2121/00

    摘要： Apparatus and configurations for imitation candle devices that facilitate remote operation and usage of electronic candles are described. The disclosed features include an assembly to hold a detachable electronic module for an imitation candle device. The assembly comprises an installation cavity formed inside of a body of the imitation candle device, including: a first subspace extending between a first surface and an opening; a second subspace extending between a second surface and the opening, wherein the second surface is recessed and is situated at a first distance from the opening; and a third subspace extending between a third surface and the opening, wherein the third surface is recessed and is situated at a second distance that is greater than the first distance from the opening; and an engagement element that extends into the installation cavity through the opening.

    Sulfation of Wnt pathway proteins
    46.
    发明授权
    Sulfation of Wnt pathway proteins 有权

    公开(公告)号：US09403882B2

    公开(公告)日：2016-08-02

    申请号：US13170634

    申请日：2011-06-28

    申请人： Joshua Rabbani ,  James J. Donegan ,  Xiaofeng Li

    发明人： Joshua Rabbani ,  James J. Donegan ,  Xiaofeng Li

    IPC分类号： A61K38/10 ,  C07K14/47 ,  C07K14/51 ,  C07K14/705 ,  C07K14/71

    CPC分类号： A61K38/1709 ,  A61K38/08 ,  A61K38/10 ,  C07K14/47 ,  C07K14/51 ,  C07K14/705 ,  C07K14/71

    摘要： Provided is a composition comprising a peptide comprising amino acids and/or amino acid analogs comprising a continuous sequence of a sclerostin fragment comprising Tyr43 or Tyr213. Also provided is a composition comprising a peptide comprising less than about 75 amino acids and/or amino acid analogs including an amino acid or amino acid analog capable of being sulfated, where the composition is capable of inhibiting sclerostin binding to an LRP. Further provided is a composition comprising a peptide comprising less than about 75 amino acids and/or amino acid analogs including an amino acid or amino acid analog capable of being post-translationally sulfated, where the composition is capable of inhibiting binding of a protein ligand comprising a sulfation site to its binding partner. Additionally provided is a method of enhancing a Wnt signaling pathway comprising contacting an LRP5/6 receptor in the Wnt signaling pathway with either of the above-described compositions that comprise a sequence of a sclerostin fragment or is capable of inhibiting sclerostin binding to an LRP, where the tyrosine or tyrosine analog is not sulfated, in a manner sufficient to enhance the Wnt signaling pathway. Further provided is a method of treating a subject having a disease exacerbated by inhibition of a Wnt signaling pathway comprising administering either of the above-described compositions that comprise a sequence of a sclerostin fragment or is capable of inhibiting sclerostin binding to an LRP, where the tyrosine or tyrosine analog is not sulfated, to the subject in a manner sufficient to reduce the inhibition of the Wnt signaling pathway. Also, a method of inhibiting binding of a protein ligand comprising a sulfation site to its binding partner is provided. The method comprises adding the above-described composition that is capable of inhibiting binding of a protein ligand to its binding partner to the protein ligand and its binding partner in a manner sufficient to inhibit binding of the protein ligand to its binding partner.

    ELECTRIC CANDLE WITH ILLUMINATING PANEL
    49.
    发明申请
    ELECTRIC CANDLE WITH ILLUMINATING PANEL 审中-公开
    带有照明面板的电动手柄

    公开(公告)号：US20150369431A1

    公开(公告)日：2015-12-24

    申请号：US14449865

    申请日：2014-08-01

    申请人： Xiaofeng Li

    发明人： Xiaofeng Li

    IPC分类号： F21S6/00 ,  F21V23/04 ,  H05B33/08 ,  F21S10/04

    CPC分类号： F21S6/001 ,  F21K9/232 ,  F21S9/02 ,  F21S10/046 ,  F21V23/04 ,  F21W2121/00 ,  F21Y2101/00 ,  F21Y2105/16 ,  F21Y2113/13 ,  F21Y2115/10 ,  H05B33/0803 ,  H05B33/0815 ,  H05B33/0842 ,  H05B33/0857

    摘要： The present disclosure, in one embodiment, relates to an electric flameless candle, comprising a body configured in shape and size to simulate a true flame candle. The electric flameless candle further comprising a light source operably connected to the body and positioned to be generally protruding from an exterior surface of the body, the light source comprising a plurality of illuminators electrically operated to illuminate in a way that simulates the movement of a real candle's flame.

    摘要翻译： 在一个实施例中，本公开涉及一种电动无焰蜡烛，其包括被配置成模拟真实火焰蜡烛的形状和尺寸的主体。 电动无焰蜡烛还包括光源，其可操作地连接到主体并且定位成大致从主体的外表面突出，光源包括多个照明器，电子操作以照亮模拟真实的移动的方式 蜡烛的火焰