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公开(公告)号：US06908986B2
公开(公告)日：2005-06-21
申请号：US10141938
申请日：2002-05-10
申请人： Jian Ni , Haodong Li , Jeffrey Su
发明人： Jian Ni , Haodong Li , Jeffrey Su
CPC分类号： C07K14/522
摘要： Human chemokine Alpha-3 polypeptides and DNA (RNA) encoding such chemotactic cytokines and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such chemotactic cytokines for the treatment of leukemia, tumors, chronic infections, auto-immune disease, fibrotic disorders, sepsis, wound healing and psoriasis and to stimulate stem cell mobilization. Antagonists against such chemotactic cytokines and their use as a therapeutic to treat rheumatoid arthritis, auto-immune and chronic and acute inflammatory and infective diseases, allergic reactions, prostaglandin-independent fever, ARDS and bone marrow failure are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to mutations in the nucleic acid sequences and altered concentrations of the polypeptides. Also disclosed are diagnostic assays for detecting mutations in the polynucleotides encoding the chemotactic cytokines and for detecting altered levels of the polypeptide in a host.
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公开(公告)号：US06852506B1
公开(公告)日：2005-02-08
申请号：US08839525
申请日：1997-04-11
申请人： Henrik S. Olsen , Haodong Li
发明人： Henrik S. Olsen , Haodong Li
IPC分类号： C07K14/485 , C12N1/21 , C12P21/02 , C12N5/10
CPC分类号： C07K14/485
摘要： The present invention discloses an extracellular/epidermal growth factor polypeptides and polynucleotides encoding such polypeptides. Also provided is a procedure for producing such polypeptides by recombinant techniques and therapeutic uses of the polypeptides which include induction of DNA synthesis, stimulating wound healing, treating neurological disorders, treating ocular disorders, treating kidney and liver disorders and stimulating embryogenesis and angiogenesis. Also disclosed are antagonists against such polypeptide and their use as a therapeutic to treat neoplasia. Also disclosed are diagnostic assays for detecting altered levels of the polypeptide of the present invention and mutations in the nucleic acid sequences which encode the polypeptides of the present invention.
摘要翻译： 本发明公开了细胞外/表皮生长因子多肽和编码这些多肽的多核苷酸。 还提供了通过重组技术和多肽的治疗用途产生此类多肽的方法，其包括诱导DNA合成，刺激伤口愈合，治疗神经障碍，治疗眼部疾病，治疗肾脏和肝脏疾病以及刺激胚胎发生和血管发生。 还公开了抗这种多肽的拮抗剂及其作为治疗瘤形成的治疗剂的用途。 还公开了用于检测本发明多肽的改变水平的诊断测定和编码本发明多肽的核酸序列中的突变。
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公开(公告)号：US20050019834A1
公开(公告)日：2005-01-27
申请号：US10935306
申请日：2004-09-08
申请人： Jian Ni , Haodong Li , Jeffrey Su
发明人： Jian Ni , Haodong Li , Jeffrey Su
CPC分类号： C07K14/522
摘要： Human chemokine Alpha-3 polypeptides and DNA (RNA) encoding such chemotactic cytokines and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such chemotactic cytokines for the treatment of leukemia, tumors, chronic infections, auto-immune disease, fibrotic disorders, sepsis, wound healing and psoriasis and to stimulate stem cell mobilization. Antagonists against such chemotactic cytokines and their use as a therapeutic to treat rheumatoid arthritis, auto-immune and chronic and acute inflammatory and infective diseases, allergic reactions, prostaglandin-independent fever, ARDS and bone marrow failure are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to mutations in the nucleic acid sequences and altered concentrations of the polypeptides. Also disclosed are diagnostic assays for detecting mutations in the polynucleotides encoding the chemotactic cytokines and for detecting altered levels of the polypeptide in a host.
摘要翻译： 公开了人趋化因子α-3多肽和编码这种趋化性细胞因子的DNA（RNA）和通过重组技术产生这种多肽的方法。 还公开了利用这种趋化性细胞因子治疗白血病，肿瘤，慢性感染，自身免疫疾病，纤维化病症，败血症，伤口愈合和牛皮癣并刺激干细胞移动的方法。 还公开了抗这种趋化性细胞因子的拮抗剂及其作为治疗类风湿性关节炎，自身免疫和慢性和急性炎性和感染性疾病，过敏反应，前列腺素依赖性发烧，ARDS和骨髓衰竭的治疗剂的用途。 还公开了用于检测与核酸序列中的突变和多肽的改变的浓度相关的疾病的诊断测定。 还公开了用于检测编码趋化性细胞因子的多核苷酸中的突变并用于检测宿主中多肽的改变水平的诊断测定。
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公开(公告)号：US06534630B1
公开(公告)日：2003-03-18
申请号：US09348815
申请日：1999-07-08
申请人： Haodong Li , Mark D. Adams
发明人： Haodong Li , Mark D. Adams
IPC分类号： C07K100
CPC分类号： C07K14/475 , A61K38/00 , A61K48/00 , A61K2039/505 , C07K2319/00
摘要： The present invention relates to a human CTGF-2 polypeptide and DNA (RNA) encoding such polypeptide. Also provided is a procedure for producing such polypeptide by recombinant techniques and antibodies and antagonist/inhibitors against such polypeptide. Also provided are methods of using the polypeptide therapeutically for enhancing the repair of connective and support tissue, promoting the attachment, fixation and stabilization of tissue implants and enhancing wound healing. Diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention are also disclosed.
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公开(公告)号：US20100041136A1
公开(公告)日：2010-02-18
申请号：US12579542
申请日：2009-10-15
申请人： Haodong Li , Mark D. Adams
发明人： Haodong Li , Mark D. Adams
CPC分类号： C07K14/475 , A61K38/00 , A61K48/00 , A61K2039/505 , C07K2319/00
摘要： The present invention relates to a human CTGF-2 polypeptide and DNA (RNA) encoding such polypeptide. Also provided is a procedure for producing such polypeptide by recombinant techniques and antibodies and antagonist/inhibitors against such polypeptide. Also provided are methods of using the polypeptide therapeutically for enhancing the repair of connective and support tissue, promoting the attachment, fixation and stabilization of tissue implants and enhancing wound healing. Diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention are also disclosed.
摘要翻译： 本发明涉及人CTGF-2多肽和编码这种多肽的DNA（RNA）。 还提供了通过重组技术产生这种多肽的方法和针对这种多肽的抗体和拮抗剂/抑制剂。 还提供了用于治疗性地增强连接和支持组织的修复，促进组织植入物的附着，固定和稳定以及增强伤口愈合的方法。 还公开了用于鉴定编码本发明多肽的核酸序列中突变和用于检测本发明多肽的改变水平的诊断测定。
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公开(公告)号：US07419662B2
公开(公告)日：2008-09-02
申请号：US10935306
申请日：2004-09-08
申请人： Jian Ni , Haodong Li , Jeffrey Y. Su
发明人： Jian Ni , Haodong Li , Jeffrey Y. Su
IPC分类号： A61K39/395 , C07K16/10
CPC分类号： C07K14/522
摘要： Human chemokine Alpha-3 polypeptides and DNA (RNA) encoding such chemotactic cytokines and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such chemotactic cytokines for the treatment of leukemia, tumors, chronic infections, auto-immune disease, fibrotic disorders, sepsis, wound healing and psoriasis and to stimulate stem cell mobilization. Antagonists against such chemotactic cytokines and their use as a therapeutic to treat rheumatoid arthritis, auto-immune and chronic and acute inflammatory and infective diseases, allergic reactions, prostaglandin-independent fever, ARDS and bone marrow failure are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to mutations in the nucleic acid sequences and altered concentrations of the polypeptides. Also disclosed are diagnostic assays for detecting mutations in the polynucleotides encoding the chemotactic cytokines and for detecting altered levels of the polypeptide in a host.
摘要翻译： 公开了人趋化因子α-3多肽和编码这种趋化性细胞因子的DNA（RNA）和通过重组技术产生这种多肽的方法。 还公开了利用这种趋化性细胞因子治疗白血病，肿瘤，慢性感染，自身免疫疾病，纤维化病症，败血症，伤口愈合和牛皮癣并刺激干细胞移动的方法。 还公开了抗这种趋化性细胞因子的拮抗剂及其作为治疗类风湿性关节炎，自身免疫和慢性和急性炎性和感染性疾病，过敏反应，前列腺素依赖性发烧，ARDS和骨髓衰竭的治疗剂的用途。 还公开了用于检测与核酸序列中的突变和多肽的改变的浓度相关的疾病的诊断测定。 还公开了用于检测编码趋化性细胞因子的多核苷酸中的突变并用于检测宿主中多肽的改变水平的诊断测定。
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公开(公告)号：US07183081B2
公开(公告)日：2007-02-27
申请号：US10893995
申请日：2004-07-20
申请人： Haodong Li , Mark D. Adams
发明人： Haodong Li , Mark D. Adams
IPC分类号： C12P21/06
CPC分类号： C07K14/521 , A61K38/00 , G01N33/564 , G01N2500/04 , G01N2800/26
摘要： Human chemokine polypeptides and DNA (RNA) encoding such chemokine polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such chemokine polypeptides for the treatment of leukemia, tumors, chronic infections, autoimmune disease, fibrotic disorders, wound healing and psoriasis. Antagonists against such chemokine polypeptides and their use as a therapeutic to treat rheumatoid arthritis, autoimmune and chronic inflammatory and infective diseases, allergic reactions, prostaglandin-independent fever and bone marrow failure are also disclosed. Diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention are also disclosed.
摘要翻译： 公开了人趋化因子多肽和编码这种趋化因子多肽的DNA（RNA）和通过重组技术产生此类多肽的方法。 还公开了利用这种趋化因子多肽治疗白血病，肿瘤，慢性感染，自身免疫疾病，纤维化病症，伤口愈合和牛皮癣的方法。 还公开了抗这种趋化因子多肽的拮抗剂及其作为治疗类风湿性关节炎，自身免疫性和慢性炎性和感染性疾病，过敏反应，前列腺素依赖性发烧和骨髓衰竭的治疗剂的用途。 还公开了用于鉴定编码本发明多肽的核酸序列中突变和用于检测本发明多肽的改变水平的诊断测定。
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公开(公告)号：US06458349B1
公开(公告)日：2002-10-01
申请号：US09261201
申请日：1999-03-03
申请人： Haodong Li , Mark D. Adams
发明人： Haodong Li , Mark D. Adams
IPC分类号： A61K3819
CPC分类号： C07K14/521 , A61K38/00 , G01N33/564 , G01N2500/04 , G01N2800/26
摘要： Human chemokine polypeptides and DNA (RNA) encoding such chemokine polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such chemokine polypeptides for the treatment of leukemia, tumors, chronic infections, autoimmune disease, fibrotic disorders, wound healing and psoriasis. Antagonists against such chemokine polypeptides and their use as a therapeutic to treat rheumatoid arthritis, autoimmune and chronic inflammatory and infective diseases, allergic reactions, prostaglandin-independent fever and bone marrow failure are also disclosed. Diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention are also disclosed.
摘要翻译： 公开了人趋化因子多肽和编码这种趋化因子多肽的DNA（RNA）和通过重组技术产生此类多肽的方法。 还公开了利用这种趋化因子多肽治疗白血病，肿瘤，慢性感染，自身免疫疾病，纤维化病症，伤口愈合和牛皮癣的方法。 还公开了抗这种趋化因子多肽的拮抗剂及其作为治疗类风湿性关节炎，自身免疫性和慢性炎性和感染性疾病，过敏反应，前列腺素依赖性发烧和骨髓衰竭的治疗剂的用途。 还公开了用于鉴定编码本发明多肽的核酸序列中突变和用于检测本发明多肽的改变水平的诊断测定。
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公开(公告)号：US5981230A
公开(公告)日：1999-11-09
申请号：US458355
申请日：1995-06-02
申请人： Haodong Li , Mark D. Adams
发明人： Haodong Li , Mark D. Adams
摘要： Human chemokine polypeptides and DNA (RNA) encoding such chemokine polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such chemokine polypeptides for the treatment of leukemia, tumors, chronic infections, autoimmune disease, fibrotic disorders, wound healing and psoriasis. Antagonists against such chemokine polypeptides and their use as a therapeutic to treat rheumatoid arthritis, autoimmune and chronic inflammatory and infective diseases, allergic reactions, prostaglandin-independent fever and bone marrow failure are also disclosed. Diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention are also disclosed.
摘要翻译： 公开了人趋化因子多肽和编码这种趋化因子多肽的DNA（RNA）和通过重组技术产生此类多肽的方法。 还公开了利用这种趋化因子多肽治疗白血病，肿瘤，慢性感染，自身免疫疾病，纤维化病症，伤口愈合和牛皮癣的方法。 还公开了抗这种趋化因子多肽的拮抗剂及其作为治疗类风湿性关节炎，自身免疫性和慢性炎性和感染性疾病，过敏反应，前列腺素依赖性发烧和骨髓衰竭的治疗剂的用途。 还公开了用于鉴定编码本发明多肽的核酸序列中突变和用于检测本发明多肽的改变水平的诊断测定。
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公开(公告)号：US5958400A
公开(公告)日：1999-09-28
申请号：US766620
申请日：1996-12-13
申请人： Steven Ruben , Haodong Li , Mark D. Adams
发明人： Steven Ruben , Haodong Li , Mark D. Adams
IPC分类号： G01N33/50 , A61K31/70 , A61K31/7088 , A61K38/00 , A61K45/00 , A61K48/00 , A61P3/10 , A61P7/00 , A61P7/04 , A61P9/00 , A61P29/00 , A61P31/00 , A61P31/12 , A61P35/00 , A61P35/02 , A61P37/02 , A61P43/00 , C07H21/04 , C07K14/54 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12P21/02 , C12Q1/02 , C12Q1/68 , C12R1/19 , G01N33/15 , G01N33/566 , A61K38/20 , C12N15/24 , C12N15/63
CPC分类号： C07K14/5412 , A61K38/00 , A61K48/00
摘要： Polynucleotides which encode the polypeptide IL-6SV, as well as such polypeptides, antibodies and antagonist inhibitors against the polypeptide and the use of the polypeptide as a pharmaceutical for treating cancer, auto-immune diseases, platelet reducing conditions, anemias, bone marrow and organ transplantation.
摘要翻译： 编码多肽IL-6SV的多核苷酸，以及针对多肽的多肽，抗体和拮抗剂抑制剂以及多肽作为治疗癌症的药物，自身免疫疾病，血小板减少病症，贫血，骨髓和器官的用途 移植。
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