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公开(公告)号：US06844170B1
公开(公告)日：2005-01-18
申请号：US09263626
申请日：1999-03-05
申请人： Paul A. Moore , Craig A. Rosen , Steven M. Ruben
发明人： Paul A. Moore , Craig A. Rosen , Steven M. Ruben
IPC分类号： C07K14/715 , C07K1/00 , C07H21/04 , C12N1/20 , C12P21/06
CPC分类号： C07K14/715
摘要： The present invention relates to a novel human protein called Cytokine Receptor Common Gamma Chain Like, and isolated polynucleotides encoding this protein. Also provided are vectors, host cells, antibodies, and recombinant methods for producing this human protein. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to this novel human protein.
摘要翻译： 本发明涉及称为细胞因子受体通用γ链的新型人类蛋白质，以及编码该蛋白质的分离的多核苷酸。 还提供了用于产生该人蛋白质的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与该新型人蛋白相关的疾病的诊断和治疗方法。
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公开(公告)号：US07968689B2
公开(公告)日：2011-06-28
申请号：US12198817
申请日：2008-08-26
申请人： Craig A. Rosen , Steven M. Ruben , Paul A. Moore
发明人： Craig A. Rosen , Steven M. Ruben , Paul A. Moore
IPC分类号： C07K16/00
CPC分类号： C07K16/2803
摘要： The present invention relates to human secreted polypeptides, and isolated nucleic acid molecules encoding said polypeptides, useful for diagnosing and treating immune disorders and diseases. Antibodies that bind these polypeptides are also encompassed by the present invention. Also encompassed by the invention are vectors, host cells, and recombinant and synthetic methods for producing said polynucleotides, polypeptides, and/or antibodies. The invention further encompasses screening methods for identifying agonists and antagonists of polynucleotides and polypeptides of the invention. The present invention further encompasses methods and compositions for inhibiting or enhancing the production and function of the polypeptides of the present invention.
摘要翻译： 本发明涉及人分泌的多肽和编码所述多肽的分离的核酸分子，其可用于诊断和治疗免疫疾病和疾病。 结合这些多肽的抗体也包括在本发明中。 本发明还包括载体，宿主细胞，以及用于产生所述多核苷酸，多肽和/或抗体的重组和合成方法。 本发明还包括用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。 本发明还包括用于抑制或增强本发明多肽的产生和功能的方法和组合物。
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43.发明授权公开(公告)号：US07504105B2
公开(公告)日：2009-03-17
申请号：US10899107
申请日：2004-07-27
申请人： Steven M. Ruben , Craig A. Rosen , Paul A. Moore
发明人： Steven M. Ruben , Craig A. Rosen , Paul A. Moore
CPC分类号： C07K14/47 , A61K38/00 , C07K14/715 , C07K14/7155
摘要： The present invention relates to a novel human gene encoding a polypeptide which is a member of the Cytokine Receptor family. More specifically, the present invention relates to a polynucleotide encoding a novel human polypeptide named Cytokine Receptor Common Gamma Chain Like, or “CRCGCL.” This invention also relates to CRCGCL polypeptides, as well as vectors, host cells, antibodies directed to CRCGCL polypeptides, and the recombinant methods for producing the same. Also provided are diagnostic methods for detecting disorders related to the immune system, and therapeutic methods for treating diagnosing, detecting, and/or preventing such disorders. The invention further relates to screening methods for identifying agonists and antagonists of CRCGCL activity.
摘要翻译： 本发明涉及编码作为细胞因子受体家族成员的多肽的新型人基因。 更具体地，本发明涉及一种编码新型人多肽的多核苷酸，命名为“细胞因子受体共同伽马链样”或“CRCGCL”。 本发明还涉及CRCGCL多肽，以及载体，宿主细胞，针对CRCGCL多肽的抗体及其制备方法。 还提供了用于检测与免疫系统相关的疾病的诊断方法，以及用于治疗诊断，检测和/或预防这种疾病的治疗方法。 本发明还涉及用于鉴定CRCGCL活性的激动剂和拮抗剂的筛选方法。
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公开(公告)号：US06914047B2
公开(公告)日：2005-07-05
申请号：US10004860
申请日：2001-12-07
申请人： Steven M. Ruben , Craig A. Rosen , Paul A. Moore
发明人： Steven M. Ruben , Craig A. Rosen , Paul A. Moore
CPC分类号： G01N33/68 , A61K38/00 , A61K48/00 , C07K14/47 , C07K14/4702 , C07K14/4718 , C07K2319/00 , C07K2319/02 , C12N15/11 , C12N2799/026
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
摘要翻译： 本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。 还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的病症的诊断和治疗方法。
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公开(公告)号：US06982320B2
公开(公告)日：2006-01-03
申请号：US09376430
申请日：1999-08-18
申请人： Paul A. Moore , Craig A. Rosen , Steven M. Ruben
发明人： Paul A. Moore , Craig A. Rosen , Steven M. Ruben
IPC分类号： C07K16/46 , C07K14/715
CPC分类号： C07K14/47 , A61K38/00 , C07K14/715 , C07K14/7155
摘要： The present invention relates to a novel human protein called Cytokine Receptor Common Gamma Chain Like, and isolated polynucleotides encoding this protein. Also provided are vectors, host cells, antibodies, and recombinant methods for producing this human protein. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to this novel human protein.
摘要翻译： 本发明涉及称为细胞因子受体通用γ链的新型人类蛋白质，以及编码该蛋白质的分离的多核苷酸。 还提供了用于产生该人蛋白质的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与该新型人蛋白相关的疾病的诊断和治疗方法。
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公开(公告)号：US06861227B2
公开(公告)日：2005-03-01
申请号：US10078059
申请日：2002-02-20
申请人： Steven M. Ruben , Craig A. Rosen , Paul A. Moore
发明人： Steven M. Ruben , Craig A. Rosen , Paul A. Moore
IPC分类号： A61K38/00 , C07K14/47 , C07K14/715 , G01N33/53 , C07K16/28
CPC分类号： C07K14/47 , A61K38/00 , C07K14/715 , C07K14/7155
摘要： The present invention relates to a novel human gene encoding a polypeptide which is a member of the Cytokine Receptor family. More specifically, the present invention relates to a polynucleotide encoding a novel human polypeptide named Cytokine Receptor Common Gamma Chain Like, or “CRCGCL.” This invention also relates to CRCGCL polypeptides, as well as vectors, host cells, antibodies directed to CRCGCL polypeptides, and the recombinant methods for producing the same. Also provided are diagnostic methods for detecting disorders related to the immune system, and therapeutic methods for treating diagnosing, detecting, and/or preventing such disorders. The invention further relates to screening methods for identifying agonists and antagonists of CRCGCL activity.
摘要翻译： 本发明涉及编码作为细胞因子受体家族成员的多肽的新型人基因。 更具体地，本发明涉及一种编码新型人多肽的多核苷酸，命名为“细胞因子受体共同伽马链样”或“CRCGCL”。 本发明还涉及CRCGCL多肽，以及载体，宿主细胞，针对CRCGCL多肽的抗体及其制备方法。 还提供了用于检测与免疫系统相关的疾病的诊断方法，以及用于治疗诊断，检测和/或预防这种疾病的治疗方法。 本发明还涉及用于鉴定CRCGCL活性的激动剂和拮抗剂的筛选方法。
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公开(公告)号：US07205139B2
公开(公告)日：2007-04-17
申请号：US10894043
申请日：2004-07-20
申请人： Paul A. Moore , Steven M. Ruben , Reinhard Ebner
发明人： Paul A. Moore , Steven M. Ruben , Reinhard Ebner
CPC分类号： C12N9/6456 , A61K38/00 , C07K2319/00 , C12N9/6421 , C12N2799/026 , Y10S530/827 , Y10S530/828
摘要： The present invention relates to a novel t-PALP protein which is a member of the serine protease family. In particular, isolated nucleic acid molecules are provided encoding the human t-PALP protein. t-PALP polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of t-PALP activity. Also provided are diagnostic methods for detecting circulatory system-related disorders and therapeutic methods for treating circulatory system-related disorders.
摘要翻译： 本发明涉及一种作为丝氨酸蛋白酶家族成员的新型t-PALP蛋白。 特别地，提供编码人t-PALP蛋白的分离的核酸分子。 还提供t-PALP多肽，载体，宿主细胞和用于制备它们的重组方法。 本发明还涉及用于鉴定t-PALP活性的激动剂和拮抗剂的筛选方法。 还提供了用于检测循环系统相关疾病的诊断方法和用于治疗循环系统相关疾病的治疗方法。
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公开(公告)号：US06815534B2
公开(公告)日：2004-11-09
申请号：US10057951
申请日：2002-01-29
申请人： Paul A. Moore , Steven M. Ruben , Reinhard Ebner
发明人： Paul A. Moore , Steven M. Ruben , Reinhard Ebner
IPC分类号： C07K1640
CPC分类号： C12N9/6456 , A61K38/00 , C07K2319/00 , C12N9/6421 , C12N2799/026 , Y10S530/827 , Y10S530/828
摘要： The present invention relates to a novel t-PALP protein which is a member of the serine protease family. In particular, isolated nucleic acid molecules are provided encoding the human t-PALP protein. t-PALP polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of t-PALP activity. Also provided are diagnostic methods for detecting circulatory system-related disorders and therapeutic methods for treating circulatory system-related disorders.
摘要翻译： 本发明涉及一种作为丝氨酸蛋白酶家族成员的新型t-PALP蛋白。 特别地，提供编码人t-PALP蛋白的分离的核酸分子。 还提供t-PALP多肽，载体，宿主细胞和用于制备它们的重组方法。 本发明还涉及用于鉴定t-PALP活性的激动剂和拮抗剂的筛选方法。 还提供了用于检测循环系统相关疾病的诊断方法和用于治疗循环系统相关疾病的治疗方法。
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公开(公告)号：US06372473B1
公开(公告)日：2002-04-16
申请号：US09411977
申请日：1999-10-04
申请人： Paul A. Moore , Steven M. Ruben , Reinhard Ebner
发明人： Paul A. Moore , Steven M. Ruben , Reinhard Ebner
IPC分类号： C12N948
CPC分类号： C12N9/6456 , A61K38/00 , C07K2319/00 , C12N9/6421 , C12N2799/026 , Y10S530/827 , Y10S530/828
摘要： The present invention relates to a novel t-PALP protein which is a member of the serine protease family. In particular, isolated nucleic acid molecules are provided encoding the human t-PALP protein. t-PALP polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of t-PALP activity. Also provided are diagnostic methods for detecting circulatory system-related disorders and therapeutic methods for treating circulatory system-related disorders.
摘要翻译： 本发明涉及一种作为丝氨酸蛋白酶家族成员的新型t-PALP蛋白。 特别地，提供编码人t-PALP蛋白的分离的核酸分子。 还提供t-PALP多肽，载体，宿主细胞和用于制备它们的重组方法。 本发明还涉及用于鉴定t-PALP活性的激动剂和拮抗剂的筛选方法。 还提供了用于检测循环系统相关疾病的诊断方法和用于治疗循环系统相关疾病的治疗方法。
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公开(公告)号：US5652117A
公开(公告)日：1997-07-29
申请号：US411635
申请日：1995-04-11
申请人： Paul A. Moore , Craig A. Rosen
发明人： Paul A. Moore , Craig A. Rosen
CPC分类号： C07K14/4705 , C07K16/18 , A61K38/00
摘要： The small (.gamma.) subunit of human Transcription Factor IIA and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques. Also disclosed are methods for utilizing such polypeptide for regulating gene-specific and global transcription. Antagonists against such polypeptide and their use to inhibit transcription are also disclosed.
摘要翻译： PCT No.PCT / US94 / 10644 Sec。 371日期1995年04月11日 102（e）日期1995年4月11日PCT 1994年9月20日PCT PCT。 公开号WO96 / 09311 日期1996年3月28日编码这种多肽的人转录因子IIA和DNA（RNA）的小（γ）亚基和通过重组技术产生这种多肽的方法。 还公开了利用这种多肽调节基因特异性和全局转录的方法。 还公开了抗这种多肽的拮抗剂及其抑制转录的用途。
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