公开(公告)号：US4477437A

公开(公告)日：1984-10-16

申请号：US347871

申请日：1982-02-11

Applicant: Kenzo Tamai ,  Isamu Saikawa ,  Takashi Yasuda ,  Shohachi Murakami ,  Toyoo Maeda ,  Hisatsugu Tsuda ,  Hiroshi Sakai ,  Masatoshi Sugita ,  Yoshiko Yamamoto ,  Hisashi Minami ,  Takako Hori

Inventor： Kenzo Tamai ,  Isamu Saikawa ,  Takashi Yasuda ,  Shohachi Murakami ,  Toyoo Maeda ,  Hisatsugu Tsuda ,  Hiroshi Sakai ,  Masatoshi Sugita ,  Yoshiko Yamamoto ,  Hisashi Minami ,  Takako Hori

IPC: C12P1/04 ,  A61K31/715 ,  C08B37/00

CPC classification number: C12R1/01 ,  C12P1/04

Abstract: Novel TF-2 substances having carcinostatic and immunostimulating activity, which are obtained from a culture or its supernatant fluid prepared by culturing bacteria belonging to Fusobacterium genus. Said substances are useful for the treatment of cancerous diseases of the mammals including human being. This disclosure concerns such substances and a process for preparing the same and a carcinostatic agent containing the same.

Abstract translation: 具有制癌和免疫刺激活性的新型TF-2物质，其通过培养属于Fusobacterium属的细菌制备的培养物或其上清液获得。 所述物质可用于治疗包括人在内的哺乳动物的癌性疾病。 本公开涉及这些物质及其制备方法和含有该物质的制癌剂。

公开(公告)号：US4444753A

公开(公告)日：1984-04-24

申请号：US431563

申请日：1982-09-30

Applicant: Isamu Saikawa ,  Takashi Yasuda ,  Shohachi Murakami ,  Toyoo Maeda ,  Akira Yotsuji ,  Masahiro Takahata ,  Hisatsugu Tsuda ,  Hidetada Mikami ,  Hiroshi Sakai ,  Toshinori Ohashi

Inventor： Isamu Saikawa ,  Takashi Yasuda ,  Shohachi Murakami ,  Toyoo Maeda ,  Akira Yotsuji ,  Masahiro Takahata ,  Hisatsugu Tsuda ,  Hidetada Mikami ,  Hiroshi Sakai ,  Toshinori Ohashi

IPC: A61K35/64 ,  A61P31/04 ,  A61P35/00 ,  A61P37/04 ,  A61K35/58 ,  A61K35/56

CPC classification number: A61K35/64

Abstract: A composition comprising a component obtained by deproteinizing an extract from the poison pouch contents of bee has an immunostimulating activity, a carcinostatic activity, an effect of enhancing the antibacterial activity of an antibacterial substance and an effect of enhancing the carcinostatic activity of a carcinostatic substance. This invention is directed to a carcinostatic, immunostimulating and antibacterial agent comprising said composition.

Abstract translation: 包含通过从蜜毒毒囊含量中提取物脱蛋白获得的成分的组合物具有免疫刺激活性，制癌活性，增强抗菌物质的抗菌活性的作用和增强制癌物质的制癌活性的作用。 本发明涉及包含所述组合物的制癌，免疫刺激和抗菌剂。

公开(公告)号：US4379152A

公开(公告)日：1983-04-05

申请号：US39904

申请日：1979-05-17

Applicant: Isamu Saikawa ,  Shuntaro Takano ,  Chosaku Yoshida ,  Okuta Takashima ,  Kaishu Momonoi ,  Seietsu Kuroda ,  Miwako Komatsu ,  Takashi Yasuda ,  Yutaka Kodama

Inventor： Isamu Saikawa ,  Shuntaro Takano ,  Chosaku Yoshida ,  Okuta Takashima ,  Kaishu Momonoi ,  Seietsu Kuroda ,  Miwako Komatsu ,  Takashi Yasuda ,  Yutaka Kodama

IPC: C07D241/08 ,  C07D499/00 ,  C07D501/22 ,  C07D501/26 ,  A61K31/545

CPC classification number: C07D241/08 ,  C07D499/00

Abstract: Novel penicillins and cephalosporins and non-toxic salts thereof, which contain a mono- or di-oxo- or thioxo-piperazino(thio)carbonylamino group in molecule. These compounds are valuable antibacterial compounds for use in mammals including man. This disclosure relates to such compounds and a process for the preparation thereof.

公开(公告)号：US4327097A

公开(公告)日：1982-04-27

申请号：US47818

申请日：1979-06-12

Applicant: Isamu Saikawa ,  Shuntaro Takano ,  Chosaku Yoshida ,  Okuta Takashima ,  Kaishu Momonoi ,  Seietsu Kuroda ,  Miwako Komatsu ,  Takashi Yasuda ,  Yutaka Kodama

Inventor： Isamu Saikawa ,  Shuntaro Takano ,  Chosaku Yoshida ,  Okuta Takashima ,  Kaishu Momonoi ,  Seietsu Kuroda ,  Miwako Komatsu ,  Takashi Yasuda ,  Yutaka Kodama

IPC: C07D241/08 ,  C07D499/00 ,  C07D499/64 ,  A61K31/495 ,  C07D499/70

CPC classification number: C07D241/08 ,  C07D499/00

Abstract: Novel penicillins and cephalosporins and non-toxic salts thereof, which contain a mono- or di-oxo- or thioxo-piperazino(thio)carbonylamino group have been prepared. These compounds are valuable anti-bacterial compounds for use in mammals including man. A process for the preparation of the compounds has also been discovered.

Abstract translation: 已经制备了含有单 - 或二 - 氧代或硫代 - 哌嗪子基（硫代）羰基氨基的新型青霉素和头孢菌素及其无毒盐。 这些化合物是用于包括人在内的哺乳动物的有价值的抗菌化合物。 还已经发现了制备化合物的方法。

公开(公告)号：US4219554A

公开(公告)日：1980-08-26

申请号：US915873

申请日：1978-06-15

Applicant: Isamu Saikawa ,  Shuntaro Takano ,  Chosaku Yoshida ,  Okuta Takashima ,  Kaishu Momonoi ,  Seietsu Kuroda ,  Miwako Komatsu ,  Takashi Yasuda ,  Yutaka Kodama

Inventor： Isamu Saikawa ,  Shuntaro Takano ,  Chosaku Yoshida ,  Okuta Takashima ,  Kaishu Momonoi ,  Seietsu Kuroda ,  Miwako Komatsu ,  Takashi Yasuda ,  Yutaka Kodama

IPC: C07D241/08 ,  C07D499/00 ,  C07D499/64 ,  C07D501/20 ,  A61K31/43 ,  C07D499/68

CPC classification number: C07D499/00 ,  C07D241/08

Abstract: Novel penicillins and non-toxic salts thereof, which contain a mono- or di-oxo- or thioxo-piperazino(thio)carbonylamino group have been prepared. These compounds are valuable antibacterial compounds for use in mammals including man. A process for the preparation of the compounds has also been discovered.

Abstract translation: 已经制备了含有单 - 或二 - 氧代 - 或硫代 - 哌嗪子基（硫代）羰基氨基的新型青霉素及其无毒盐。 这些化合物是用于包括人在内的哺乳动物的有价值的抗菌化合物。 还已经发现了制备化合物的方法。

公开(公告)号：US4199566A

公开(公告)日：1980-04-22

申请号：US913105

申请日：1978-06-06

Applicant: Isamu Saikawa ,  Takashi Yasuda ,  Masaru Tai ,  Yutaka Takashita ,  Hiroshi Sakai ,  Michiko Mae ,  Masahiro Takahata ,  Susumu Mitsuhashi

Inventor： Isamu Saikawa ,  Takashi Yasuda ,  Masaru Tai ,  Yutaka Takashita ,  Hiroshi Sakai ,  Michiko Mae ,  Masahiro Takahata ,  Susumu Mitsuhashi

IPC: C07D499/68 ,  A61K31/43 ,  A61K31/545 ,  A61P31/04 ,  C07D499/64 ,  A61K35/00

CPC classification number: A61K31/43 ,  A61K31/545

Abstract: An antibacterial composition for medical use comprising 6-[-)-.alpha.-(4-ethyl-2,3-dioxo-1-piperazinylcarbonylamino)phenylacetamido]penicillanic acid or a pharmaceutically acceptable salt thereof and a .beta.-lactamase-inhibiting penicillin or cephalosporin. The composition exhibits synergistic effect which is much greater than the sum of antibacterial effects of each component used alone.

Abstract translation: 一种用于医疗用途的抗菌组合物，其包含6 - [ - ） - α-（4-乙基-2,3-二氧代-1-哌嗪基羰基氨基）苯乙酰胺基]青霉烷酸或其药学上可接受的盐和β-内酰胺酶抑制青霉素或 头孢菌素 组合物显示出比单独使用的每种组分的抗菌作用的总和大得多的协同效应。

公开(公告)号：US09080913B2

公开(公告)日：2015-07-14

申请号：US14005849

申请日：2012-02-21

Applicant: Takashi Yasuda ,  Yoichi Kawada ,  Atsushi Nakanishi ,  Kouichiro Akiyama ,  Hironori Takahashi

Inventor： Takashi Yasuda ,  Yoichi Kawada ,  Atsushi Nakanishi ,  Kouichiro Akiyama ,  Hironori Takahashi

IPC: G01J5/02 ,  G01J3/42 ,  G01N21/3581 ,  G01J3/02 ,  G01N21/552

CPC classification number: G01J3/42 ,  G01J3/0205 ,  G01N21/3581 ,  G01N21/552

Abstract: By mating a main part with a first prism part or second prism part, a terahertz-wave spectrometer can easily switch between optical paths of a terahertz wave T propagating within a spectroscopic prism. When the main part mates with the first prism part, the terahertz wave T incident on an entrance surface passes through a depression, so as to be reflected by an arrangement part, whereby reflection spectrometry can be performed. When the main part mates with the second prism part, the terahertz wave T incident on the entrance surface is refracted by the depression, so as to pass through an object to be measured within a groove, whereby transmission spectrometry can be preformed.

Abstract translation: 通过将主要部分与第一棱镜部分或第二棱镜部分配合，太赫兹波谱仪可以容易地在分光棱镜内传播的太赫兹波T的光路之间切换。 当主体与第一棱镜部分配合时，入射表面上的太赫兹波T穿过凹陷，以便被布置部反射，从而可以进行反射光谱测定。 当主要部分与第二棱镜部分配合时，入射表面上的太赫兹波T被凹陷折射，以便在沟槽内通过待测物体，从而可进行透射光谱测定。

公开(公告)号：US08810890B2

公开(公告)日：2014-08-19

申请号：US13809468

申请日：2011-07-13

Applicant: Haruyasu Ito ,  Takashi Yasuda

Inventor： Haruyasu Ito ,  Takashi Yasuda

IPC: G02F1/01

CPC classification number: G02F1/01 ,  G02B27/0927 ,  G02B27/0944 ,  G02B27/095 ,  G02B27/0977

Abstract: A laser light shaping and wavefront controlling optical system 1 in accordance with an embodiment of the present invention comprises an intensity conversion lens 24 for converting and shaping an intensity distribution of laser light incident thereon into a desirable intensity distribution; an optical modulation device 34 for modulating the laser light emitted from the intensity conversion lens 24 so as to control a wavefront thereof; a condenser optical system 36 for converging the laser light issued from the optical modulation device 34; and an image-forming optical system 30, arranged between the optical modulation device 34 and the condenser optical system 36, having an entrance-side imaging plane between a plane 24x where the laser light emitted from the intensity conversion lens 24 attains the desirable intensity distribution and a modulation plane 34a of the optical modulation device 34 and an exit-side imaging plane on a pupil plane 36a of the condenser optical system 36.

Abstract translation: 根据本发明的实施例的激光成形和波前控制光学系统1包括：强度转换透镜24，用于将入射到其上的激光的强度分布转换和成形为期望的强度分布; 用于调制从强度转换透镜24发射的激光以控制其波前的光调制装置34; 用于会聚从光调制装置34发出的激光的聚光光学系统36; 以及配置在光调制装置34和聚光光学系统36之间的成像光学系统30，其具有在从强度转换透镜24发射的激光达到所需强度分布的平面24x之间的入射侧成像面 以及光调制装置34的调制面34a和聚光镜36的光瞳面36a的出射侧成像面。

公开(公告)号：US20140105635A1

公开(公告)日：2014-04-17

申请号：US14136609

申请日：2013-12-20

Applicant: Fan Xu ,  Takashi Yasuda ,  Mitsuru Horinoe

Inventor： Fan Xu ,  Takashi Yasuda ,  Mitsuru Horinoe

IPC: G03G15/08

CPC classification number: G03G15/0898 ,  G03G15/0817 ,  G03G2215/0614

Abstract: A developing device for an image forming apparatus may include a seal and a casing to prevent leakage of developer. In some examples, the seal member may include multiple side surfaces while the casing may include projections that may abut and contact various surfaces of the seal member. According to one arrangement, the casing may include first, second and third protrusions, where each protrusion is configured to abut and contact a corresponding surface of the seal member. Additionally, the second projection may protrude in a position inside of the first projection while the third projection may protrude in a position between the first and second projections.

Abstract translation: 用于图像形成装置的显影装置可以包括密封件和用于防止显影剂泄漏的外壳。 在一些示例中，密封构件可以包括多个侧表面，而壳体可以包括可以邻接和接触密封构件的各个表面的突起。 根据一种布置，壳体可以包括第一，第二和第三突起，其中每个突起被构造成抵靠和接触密封构件的相应表面。 此外，第二突起可以在第一突起内部的位置突出，而第三突起可以在第一和第二突起之间的位置突出。

公开(公告)号：US20140008541A1

公开(公告)日：2014-01-09

申请号：US14005863

申请日：2012-02-28

Applicant: Kouichiro Akiyama ,  Yoichi Kawada ,  Takashi Yasuda ,  Atsushi Nakanishi ,  Hironori Takahashi

Inventor： Kouichiro Akiyama ,  Yoichi Kawada ,  Takashi Yasuda ,  Atsushi Nakanishi ,  Hironori Takahashi

IPC: G01J3/42

CPC classification number: G01J3/42 ,  G01N21/3577 ,  G01N21/3581 ,  G01N21/552

Abstract: A total reflection measurement method using a total reflection spectrometer 1 is a total reflection measurement method comprising arranging an object to be measured on a total reflection surface 31c of an internal total reflection prism 31 and measuring an optical constant concerning the object 34 according to a terahertz wave totally reflected by the total reflection surface 31c after passing the prism 31, wherein a liquid 50 incapable of dissolving the object 34 is interposed at least between the total reflection surface 31c and the object 34. A force such as an adhesion force acting between the liquid 50 and the object 34 can place the object 34 closer to the total reflection surface 31c, thereby stably generating an interaction between an evanescent component and the object 34.

Abstract translation: 使用全反射光谱仪1的全反射测量方法是全反射测量方法，包括在内部全反射棱镜31的全反射表面31c上布置被测物体，并根据太赫兹测量关于物体34的光常数 在通过棱镜31之后，由全反射面31c全反射的波形，其中不能溶解物体34的液体50至少插入在全反射面31c和物体34之间。诸如作用在物体34之间的粘附力的力 液体50和物体34可以使物体34更靠近全反射面31c，从而稳定地产生ev逝部件与物体34之间的相互作用。