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1.发明授权Pharmaceutical composition comprising extract from poison pouch contents of bee useful for treating decreased immunity 失效药物组合物，其包含从用于治疗免疫力降低的蜂的毒囊含量提取物
公开(公告)号：US4370316A
公开(公告)日：1983-01-25
申请号：US147530
申请日：1980-05-07
申请人： Isamu Saikawa , Takashi Yasuda , Shohachi Murakami , Toyoo Maeda , Akira Yotsuji , Masahiro Takahata , Hisatsugu Tsuda , Hidetada Mikami , Hiroshi Sakai , Toshinori Ohashi
发明人： Isamu Saikawa , Takashi Yasuda , Shohachi Murakami , Toyoo Maeda , Akira Yotsuji , Masahiro Takahata , Hisatsugu Tsuda , Hidetada Mikami , Hiroshi Sakai , Toshinori Ohashi
CPC分类号： A61K35/64
摘要： A method for treating a host mammal having a decreased immunity, comprising administering to said host mammal an immunostimulating effective amount of the deproteinized extract from the poison pouch contents of bee B-T, is disclosed.
摘要翻译： 一种用于治疗免疫力降低的宿主哺乳动物的方法，包括向所述宿主哺乳动物施用免疫刺激有效量的来自蜜蜂B-T的毒囊含量的去蛋白质提取物。
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2.发明授权Pharmaceutical composition comprising extract from poison pouch contents of bee 失效药物组合物，其包含从蜜蜂的毒袋内容物提取物
公开(公告)号：US4444753A
公开(公告)日：1984-04-24
申请号：US431563
申请日：1982-09-30
申请人： Isamu Saikawa , Takashi Yasuda , Shohachi Murakami , Toyoo Maeda , Akira Yotsuji , Masahiro Takahata , Hisatsugu Tsuda , Hidetada Mikami , Hiroshi Sakai , Toshinori Ohashi
发明人： Isamu Saikawa , Takashi Yasuda , Shohachi Murakami , Toyoo Maeda , Akira Yotsuji , Masahiro Takahata , Hisatsugu Tsuda , Hidetada Mikami , Hiroshi Sakai , Toshinori Ohashi
CPC分类号： A61K35/64
摘要： A composition comprising a component obtained by deproteinizing an extract from the poison pouch contents of bee has an immunostimulating activity, a carcinostatic activity, an effect of enhancing the antibacterial activity of an antibacterial substance and an effect of enhancing the carcinostatic activity of a carcinostatic substance. This invention is directed to a carcinostatic, immunostimulating and antibacterial agent comprising said composition.
摘要翻译： 包含通过从蜜毒毒囊含量中提取物脱蛋白获得的成分的组合物具有免疫刺激活性，制癌活性，增强抗菌物质的抗菌活性的作用和增强制癌物质的制癌活性的作用。 本发明涉及包含所述组合物的制癌，免疫刺激和抗菌剂。
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公开(公告)号：US4477437A
公开(公告)日：1984-10-16
申请号：US347871
申请日：1982-02-11
申请人： Kenzo Tamai , Isamu Saikawa , Takashi Yasuda , Shohachi Murakami , Toyoo Maeda , Hisatsugu Tsuda , Hiroshi Sakai , Masatoshi Sugita , Yoshiko Yamamoto , Hisashi Minami , Takako Hori
发明人： Kenzo Tamai , Isamu Saikawa , Takashi Yasuda , Shohachi Murakami , Toyoo Maeda , Hisatsugu Tsuda , Hiroshi Sakai , Masatoshi Sugita , Yoshiko Yamamoto , Hisashi Minami , Takako Hori
IPC分类号： C12P1/04 , A61K31/715 , C08B37/00
摘要： Novel TF-2 substances having carcinostatic and immunostimulating activity, which are obtained from a culture or its supernatant fluid prepared by culturing bacteria belonging to Fusobacterium genus. Said substances are useful for the treatment of cancerous diseases of the mammals including human being. This disclosure concerns such substances and a process for preparing the same and a carcinostatic agent containing the same.
摘要翻译： 具有制癌和免疫刺激活性的新型TF-2物质，其通过培养属于Fusobacterium属的细菌制备的培养物或其上清液获得。 所述物质可用于治疗包括人在内的哺乳动物的癌性疾病。 本公开涉及这些物质及其制备方法和含有该物质的制癌剂。
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4.发明授权
公开(公告)号：US4744985A
公开(公告)日：1988-05-17
申请号：US180040
申请日：1980-08-21
申请人： Kenzo Tamai , Isamu Saikawa , Takashi Yasuda , Shohachi Murakami , Toyoo Maeda , Hisatsugu Tsuda , Hiroshi Sakai , Masatoshi Sugita , Yoshiko Yamamoto , Hisashi Minami , Takako Hori
发明人： Kenzo Tamai , Isamu Saikawa , Takashi Yasuda , Shohachi Murakami , Toyoo Maeda , Hisatsugu Tsuda , Hiroshi Sakai , Masatoshi Sugita , Yoshiko Yamamoto , Hisashi Minami , Takako Hori
摘要： Novel substances having carcinostatic and immunostimulating activity, which are obtained from a culture or its supernatant fluid prepared by culturing bacteria belonging to Fusobacterium genus. Said substances are useful for the treatment of cancerous diseases lower warm-blooded animals. This disclosure concerns such substances and a process for preparing the same and a carcinostatic agent containing the same.
摘要翻译： 具有制癌和免疫刺激活性的新型物质，其通过培养属于Fusobacterium属的细菌制备的培养物或其上清液获得。 所述物质可用于治疗较低温血动物的癌性疾病。 本公开涉及这些物质及其制备方法和含有该物质的制癌剂。
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5.发明授权Novel substances having antitumor and immunostimulating activity, process for preparing the same and antitumor agent containing the same 失效具有抗肿瘤和免疫刺激活性的新物质，其制备方法和含有该物质的抗肿瘤剂
公开(公告)号：US4591558A
公开(公告)日：1986-05-27
申请号：US619895
申请日：1984-08-06
申请人： Kenzo Tamai , Isamu Saikawa , Takashi Yasuda , Shohachi Murakami , Toyoo Maeda , Hisatsugu Tsuda , Hiroshi Sakai , Masatoshi Sugita , Yoshiko Yamamoto , Hisashi Minami , Takako Hori
发明人： Kenzo Tamai , Isamu Saikawa , Takashi Yasuda , Shohachi Murakami , Toyoo Maeda , Hisatsugu Tsuda , Hiroshi Sakai , Masatoshi Sugita , Yoshiko Yamamoto , Hisashi Minami , Takako Hori
CPC分类号： C12R1/01 , C12P1/04 , Y10S435/822
摘要： Novel TF-2 substances having antitumor and immunostimulating activity, which are obtained from a culture or its supernatant fluid prepared by culturing bacteria belonging to Fusobacterium genus. Said substances are useful for the treatment of cancerous diseases of the mammals including human beings. This disclosure concerns such substances and a process for preparing the same and an antitumor agent containing the same.
摘要翻译： 具有抗肿瘤和免疫刺激活性的新型TF-2物质，其通过培养属于Fusobacterium属的细菌制备的培养物或其上清液获得。 所述物质可用于治疗包括人在内的哺乳动物的癌性疾病。 本公开涉及这些物质及其制备方法和含有该物质的抗肿瘤剂。
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6.发明授权Process for preparing substance having carcinostatic and immunostimulating activity 失效制备具有制癌和免疫刺激活性的物质的方法
公开(公告)号：US4547462A
公开(公告)日：1985-10-15
申请号：US523438
申请日：1983-08-16
申请人： Kenzo Tamai , Isamu Saikawa , Takashi Yasuda , Shohachi Murakami , Toyoo Maeda , Hisatsugu Tsuda , Hiroshi Sakai , Masatoshi Sugita , Yoshiko Yamamoto , Hisashi Minami , Takako Hori
发明人： Kenzo Tamai , Isamu Saikawa , Takashi Yasuda , Shohachi Murakami , Toyoo Maeda , Hisatsugu Tsuda , Hiroshi Sakai , Masatoshi Sugita , Yoshiko Yamamoto , Hisashi Minami , Takako Hori
IPC分类号： C12P1/02 , A61K35/74 , A61K38/00 , A61P35/00 , A61P37/04 , C07G11/00 , C07K14/005 , C07K14/195 , C07K14/41 , C12P1/04 , C12P21/00 , C12R1/01 , C12P19/00
CPC分类号： A61K35/74 , C12P1/04 , Y10S435/822
摘要： This invention relates to a process for producing a TF-500 substance having carcinostatic and immunostimulating activities, which comprises subjecting organisms belonging to the Fusobacterium genus to extraction treatment with a dialkyl sulfoxide and obtaining said TF-500 substance from the resulting extract.
摘要翻译： 本发明涉及制备具有制癌和免疫刺激活性的TF-500物质的方法，该方法包括使属于所述Fusobacterium属的生物体用二烷基亚砜进行提取处理，并从所得提取物中获得所述TF-500物质。
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公开(公告)号：US4428936A
公开(公告)日：1984-01-31
申请号：US187755
申请日：1980-09-16
申请人： Isamu Saikawa , Takashi Yasuda , Masaru Tai , Yutaka Takashita , Hiroshi Sakai , Michiko Mae , Masahiro Takahata , Susumu Mitsuhashi
发明人： Isamu Saikawa , Takashi Yasuda , Masaru Tai , Yutaka Takashita , Hiroshi Sakai , Michiko Mae , Masahiro Takahata , Susumu Mitsuhashi
IPC分类号： C07D501/34 , A61K31/545 , A61K31/546 , C07D501/36 , A61K35/00
CPC分类号： A61K31/545
摘要： An antibacterial composition for medical use comprising a cephalosporin or a pharmaceutically acceptable salt thereof and a .beta.-lactamase-inhibiting compound having a .beta.-lactam ring. The composition exhibits synergistic effect which is much greater than the sum of antibacterial effects of each component used alone.
摘要翻译： 一种用于医疗用途的抗菌组合物，其包含头孢菌素或其药学上可接受的盐和具有β-内酰胺环的β-内酰胺酶抑制化合物。 组合物显示出比单独使用的每种组分的抗菌作用的总和大得多的协同效应。
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公开(公告)号：US4324783A
公开(公告)日：1982-04-13
申请号：US113065
申请日：1980-01-17
申请人： Isamu Saikawa , Takashi Yasuda , Masaru Tai , Yutaka Takashita , Hiroshi Sakai , Michiko Mae , Masahiro Takahata , Susumu Mitsuhashi
发明人： Isamu Saikawa , Takashi Yasuda , Masaru Tai , Yutaka Takashita , Hiroshi Sakai , Michiko Mae , Masahiro Takahata , Susumu Mitsuhashi
IPC分类号： C07D499/68 , A61K31/43 , A61K31/545 , A61P31/04 , C07D499/64 , A61K35/00
CPC分类号： A61K31/43 , A61K31/545
摘要： An antibacterial composition for medical use comprising 6-[D(-)-.alpha.-(4-ethyl-2,3-dioxo-1-piperazinylcarbonylamino)phenylacetamido]penicillanic acid or a pharmaceutically acceptable salt thereof and a .beta.-lactamase-inhibiting penicillin or cephalosporin. The composition exhibits synergistic effect which is much greater than the sum of antibacterial effects of each component used alone.
摘要翻译： 一种用于医疗用途的抗菌组合物，其包含6- [D（ - ） - α-（4-乙基-2,3-二氧代-1-哌嗪基羰基氨基）苯基乙酰胺基]青霉烷酸或其药学上可接受的盐和β-内酰胺酶抑制 青霉素或头孢菌素。 组合物显示出比单独使用的每种组分的抗菌作用的总和大得多的协同效应。
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公开(公告)号：US4199566A
公开(公告)日：1980-04-22
申请号：US913105
申请日：1978-06-06
申请人： Isamu Saikawa , Takashi Yasuda , Masaru Tai , Yutaka Takashita , Hiroshi Sakai , Michiko Mae , Masahiro Takahata , Susumu Mitsuhashi
发明人： Isamu Saikawa , Takashi Yasuda , Masaru Tai , Yutaka Takashita , Hiroshi Sakai , Michiko Mae , Masahiro Takahata , Susumu Mitsuhashi
IPC分类号： C07D499/68 , A61K31/43 , A61K31/545 , A61P31/04 , C07D499/64 , A61K35/00
CPC分类号： A61K31/43 , A61K31/545
摘要： An antibacterial composition for medical use comprising 6-[-)-.alpha.-(4-ethyl-2,3-dioxo-1-piperazinylcarbonylamino)phenylacetamido]penicillanic acid or a pharmaceutically acceptable salt thereof and a .beta.-lactamase-inhibiting penicillin or cephalosporin. The composition exhibits synergistic effect which is much greater than the sum of antibacterial effects of each component used alone.
摘要翻译： 一种用于医疗用途的抗菌组合物，其包含6 - [ - ） - α-（4-乙基-2,3-二氧代-1-哌嗪基羰基氨基）苯乙酰胺基]青霉烷酸或其药学上可接受的盐和β-内酰胺酶抑制青霉素或 头孢菌素 组合物显示出比单独使用的每种组分的抗菌作用的总和大得多的协同效应。
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公开(公告)号：US4477666A
公开(公告)日：1984-10-16
申请号：US348272
申请日：1982-02-12
申请人： Takako Hori , Chosaku Yoshida , Yasuo Kiba , Ryuko Takeno , Joji Nakano , Jun Nitta , Sumiko Kishimoto , Shohachi Murakami , Hisatsugu Tsuda , Isamu Saikawa
发明人： Takako Hori , Chosaku Yoshida , Yasuo Kiba , Ryuko Takeno , Joji Nakano , Jun Nitta , Sumiko Kishimoto , Shohachi Murakami , Hisatsugu Tsuda , Isamu Saikawa
IPC分类号： A61K31/495 , A61P35/00 , C07D241/08 , C07D241/20 , C07D401/06 , C07D401/10 , C07D401/14 , C07D403/06 , C07D403/10 , C07D403/14 , C07D405/14 , C07D417/10 , C07D241/04
CPC分类号： C07D241/08
摘要： A 1-(4-aminobenzyl)-2,3-dioxopiperazine derivative represented by the formula: ##STR1## and an acid addition salt thereof have excellent carcinostatic activity but a low toxicity. Therefore, said compounds are useful as medicines and also as intermediates.
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