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公开(公告)号：US07572810B2
公开(公告)日：2009-08-11
申请号：US11749445
申请日：2007-05-16
申请人： Tao Wang , Ying Han , John F. Kadow , Zhongxing Zhang , Nicholas A. Meanwell
发明人： Tao Wang , Ying Han , John F. Kadow , Zhongxing Zhang , Nicholas A. Meanwell
IPC分类号： A61K31/445 , A61K31/4545 , A61P31/12 , C07D215/20 , C07D295/00
CPC分类号： A61K31/445 , A61K31/4545 , A61K45/06 , C07D211/70 , C07D401/06 , C07D401/12 , C07D401/14 , C07D413/06 , C07D413/14 , A61K2300/00
摘要： This disclosure provides compounds having drug and bio-affecting properties, their pharmaceutical compositions and method of use. In particular, the disclosure is concerned with alkene piperidine derivatives that possess unique antiviral activity. More particularly, the present disclosure relates to compounds useful for the treatment of HIV and AIDS.
摘要翻译： 本公开提供具有药物和生物影响性质的化合物，其药物组合物和使用方法。 特别地，本公开涉及具有独特抗病毒活性的烯烃哌啶衍生物。 更具体地，本公开涉及可用于治疗HIV和AIDS的化合物。
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公开(公告)号：US20070287712A1
公开(公告)日：2007-12-13
申请号：US11748699
申请日：2007-05-15
申请人： Tao Wang , John F. Kadow , Zhongxing Zhang , Zhiwei Yin , Nicholas A. Meanwell
发明人： Tao Wang , John F. Kadow , Zhongxing Zhang , Zhiwei Yin , Nicholas A. Meanwell
IPC分类号： A61K31/497 , A61P31/00 , C07D401/00
CPC分类号： C07D209/30 , C07D209/18 , C07D209/32 , C07D471/04
摘要： This disclosure provides compounds having drug and bio-affecting properties, their pharmaceutical compositions and method of use. In particular, the disclosure is concerned with indole and azaindole piperazine enamine derivatives that possess unique antiviral activity. More particularly, the present disclosure relates to compounds useful for the treatment of HIV and AIDS.
摘要翻译： 本公开提供具有药物和生物影响性质的化合物，其药物组合物和使用方法。 特别地，本公开涉及具有独特抗病毒活性的吲哚和氮杂吲哚哌嗪烯胺衍生物。 更具体地，本公开涉及可用于治疗HIV和AIDS的化合物。
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43.发明授权Thioamide, amidoxime and amidrazone derivatives as HIV attachment inhibitors 有权硫酰胺，偕胺肟和氨喋呤衍生物作为HIV附着抑制剂公开(公告)号：US08685982B2
公开(公告)日：2014-04-01
申请号：US13444104
申请日：2012-04-11
IPC分类号： A61K31/497
CPC分类号： C07D471/04 , A61K31/496 , A61K45/06 , C07D209/12 , C07D209/18 , C07D403/06 , A61K2300/00
摘要： A compound of Formula I, including pharmaceutically acceptable salts thereof: wherein A is selected from the group of:
摘要翻译： 式I的化合物，包括其药学上可接受的盐：其中A选自：
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44.发明申请SPIRO BICYCLIC DIAMINE DERIVATIVES AS HIV ATTACHMENT INHIBITORS 有权作为艾滋病毒附着抑制剂的SPIRO BICYCLIC DIAMINE DERIVATIVES公开(公告)号：US20130231324A1
公开(公告)日：2013-09-05
申请号：US13596211
申请日：2012-08-28
IPC分类号： C07D471/04
CPC分类号： C07D471/04 , C07D519/00
摘要： Compounds of Formula I, including pharmaceutically acceptable salts thereof: wherein A is selected from the group consisting of: are useful as HIV attachment inhibitors.
摘要翻译： 式I化合物，包括其药学上可接受的盐：其中A选自：可用作HIV附着抑制剂。
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公开(公告)号：US20130225635A1
公开(公告)日：2013-08-29
申请号：US13596219
申请日：2012-08-28
申请人： TAO WANG , Zhongxing Zhang , John F. Kadow , Nicholas A. Meanwell
发明人： TAO WANG , Zhongxing Zhang , John F. Kadow , Nicholas A. Meanwell
IPC分类号： C07D471/04
CPC分类号： C07D471/04 , C07D519/00
摘要： Compounds of Formula I, including pharmaceutically acceptable salts thereof: wherein A is selected from the group of: are useful as HIV attachment inhibitors.
摘要翻译： 式I化合物，包括其药学上可接受的盐：其中A选自：可用作HIV附着抑制剂。
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公开(公告)号：US20100210599A1
公开(公告)日：2010-08-19
申请号：US12767222
申请日：2010-04-26
申请人： Yasutsugu Ueda , Timothy P. Connolly , John F. Kadow , Nicholas A. Meanwell , Tao Wang , Chung-Pin H. Chen , Kap-Sun Yeung , Zhongxing Zhang , David Kenneth Leahy , Shawn K. Pack , Nachimuthu Soundararajan , Pierre Sirard , Kathia Levesque , Dominique Thoraval
发明人： Yasutsugu Ueda , Timothy P. Connolly , John F. Kadow , Nicholas A. Meanwell , Tao Wang , Chung-Pin H. Chen , Kap-Sun Yeung , Zhongxing Zhang , David Kenneth Leahy , Shawn K. Pack , Nachimuthu Soundararajan , Pierre Sirard , Kathia Levesque , Dominique Thoraval
IPC分类号： A61K31/661 , A61P31/18
CPC分类号： A61K31/675 , A61K31/497 , A61K45/06 , C07D471/04 , C07F9/062 , C07F9/5728 , C07F9/65515 , C07F9/65586 , C07F9/6561
摘要： This invention provides for prodrug Compounds I, pharmaceutical compositions thereof, and their use in treating HIV infection. wherein: X is C or N with the proviso that when X is N, R1 does not exist; W is C or N with the proviso that when W is N, R2 does not exist; V is C; E is hydrogen or a pharmaceutically acceptable salt thereof; and Y is selected from the group consisting of Also, this invention provides for intermediate Compounds II useful in making prodrug Compounds I. wherein: L and M are independently selected from the group consisting of C1-C6 alkyl, phenyl, benzyl, trialkylsilyl, -2,2,2-trichloroethoxy and 2-trimethylsilylethoxy.
摘要翻译： 本发明提供前药化合物I，其药物组合物及其在治疗HIV感染中的用途。 其中：X为C或N，条件是当X为N时，R1不存在; W是C或N，条件是当W是N时，R2不存在; V是C; E是氢或其药学上可接受的盐; 并且Y选自本发明另外，本发明提供了可用于制备前药化合物I的中间体化合物II。其中：L和M独立地选自C 1 -C 6烷基，苯基，苄基，三烷基甲硅烷基， 2,2,2-三氯乙氧基和2-三甲基甲硅烷基乙氧基。
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47.发明申请PHARMACEUTICAL FORMULATIONS OF SUBSTITUTED AZAINDOLEOXOACETIC PIPERAZINE DERIVATIVES WITH PROTEASE INHIBITORS 审中-公开替代酰基氨基哌啶衍生物与蛋白酶抑制剂的药物制剂公开(公告)号：US20100093752A1
公开(公告)日：2010-04-15
申请号：US12622859
申请日：2009-11-20
申请人： Tao Wang , Zhongxing Zhang , Nicholas A. Meanwell , John F. Kadow , Zhiwei Yin , Qiufen May Xue , Alicia Regueiro-Ren , John D. Matiskella , Yasutsugu Ueda
发明人： Tao Wang , Zhongxing Zhang , Nicholas A. Meanwell , John F. Kadow , Zhiwei Yin , Qiufen May Xue , Alicia Regueiro-Ren , John D. Matiskella , Yasutsugu Ueda
IPC分类号： A61K31/497 , A61P31/18 , A61P31/12
CPC分类号： C07D471/04 , A61K31/496 , A61K45/06 , C07D491/048
摘要： This invention provides compounds having drug and bio-affecting properties, their pharmaceutical compositions and method of use. In particular, the invention is concerned with azaindoleoxoacetyl piperazine derivatives. These compounds possess unique antiviral activity, whether used alone or in combination with other antivirals, antiinfectives, immunomodulators or HIV entry inhibitors. More particularly, the present invention relates to the treatment of HIV and AIDS.
摘要翻译： 本发明提供具有药物和生物影响性质的化合物，其药物组合物和使用方法。 特别地，本发明涉及氮杂吲哚乙酰基哌嗪衍生物。 这些化合物具有独特的抗病毒活性，无论是单独使用还是与其他抗病毒药，抗感染剂，免疫调节剂或HIV进入抑制剂组合使用。 更具体地说，本发明涉及艾滋病毒和艾滋病的治疗。
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48.发明授权Pharmaceutical formulations of substituted azaindoleoxoacetic piperazine derivatives 有权取代的氮杂吲哚氧乙酸哌嗪衍生物的药物制剂公开(公告)号：US07662823B2
公开(公告)日：2010-02-16
申请号：US12354308
申请日：2009-01-15
申请人： Tao Wang , Zhongxing Zhang , Nicholas A. Meanwell , John F. Kadow , Zhiwei Yin , Qiufen May Xue , Alicia Regueiro-Ren , John D. Matiskella , Yasutsugu Ueda
发明人： Tao Wang , Zhongxing Zhang , Nicholas A. Meanwell , John F. Kadow , Zhiwei Yin , Qiufen May Xue , Alicia Regueiro-Ren , John D. Matiskella , Yasutsugu Ueda
IPC分类号： A61K31/437
CPC分类号： C07D471/04 , A61K31/496 , A61K45/06 , C07D491/048
摘要： This invention provides compounds having drug and bio-affecting properties, their pharmaceutical compositions and method of use. In particular, the invention is concerned with azaindoleoxoacetyl piperazine derivatives. These compounds possess unique antiviral activity, whether used alone or in combination with other antivirals, antiinfectives, immunomodulators or HIV entry inhibitors. More particularly, the present invention relates to the treatment of HIV and AIDS.
摘要翻译： 本发明提供具有药物和生物影响性质的化合物，其药物组合物和使用方法。 特别地，本发明涉及氮杂吲哚乙酰基哌嗪衍生物。 这些化合物具有独特的抗病毒活性，无论是单独使用还是与其他抗病毒药，抗感染剂，免疫调节剂或HIV进入抑制剂组合使用。 更具体地说，本发明涉及艾滋病毒和艾滋病的治疗。
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49.发明申请COMPOSITION AND ANTIVIRAL ACTIVITY OF SUBSTITUTED AZAINDOLEOXOACETIC PIPERAZINE DERIVATIVES 有权取代的氮杂双环氧哌嗪衍生物的组成和抗病毒活性公开(公告)号：US20090306095A1
公开(公告)日：2009-12-10
申请号：US12354308
申请日：2009-01-15
申请人： TAO WANG , Zhongxing Zhang , Nicholas A. Meanwell , John F. Kadow , Zhiwei Yin , Qiufen May Xue , Alicia Regueiro-Ren , John D. Matiskella , Yasutsugu Ueda
发明人： TAO WANG , Zhongxing Zhang , Nicholas A. Meanwell , John F. Kadow , Zhiwei Yin , Qiufen May Xue , Alicia Regueiro-Ren , John D. Matiskella , Yasutsugu Ueda
IPC分类号： A61K31/496 , A61P31/18
CPC分类号： C07D471/04 , A61K31/496 , A61K45/06 , C07D491/048
摘要： This invention provides compounds having drug and bio-affecting properties, their pharmaceutical compositions and method of use. In particular, the invention is concerned with azaindoleoxoacetyl piperazine derivatives. These compounds possess unique antiviral activity, whether used alone or in combination with other antivirals, antiinfectives, immunomodulators or HIV entry inhibitors. More particularly, the present invention relates to the treatment of HIV and AIDS.
摘要翻译： 本发明提供具有药物和生物影响性质的化合物，其药物组合物和使用方法。 特别地，本发明涉及氮杂吲哚乙酰基哌嗪衍生物。 这些化合物具有独特的抗病毒活性，无论是单独使用还是与其他抗病毒药，抗感染剂，免疫调节剂或HIV进入抑制剂组合使用。 更具体地说，本发明涉及艾滋病毒和艾滋病的治疗。
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公开(公告)号：US07531552B2
公开(公告)日：2009-05-12
申请号：US11960885
申请日：2007-12-20
IPC分类号： A61K31/437 , C07D471/04
CPC分类号： C07D403/06 , C07D403/04 , C07D403/12 , C07D403/14 , C07D471/04
摘要： This invention provides compounds having drug and bio-affecting properties, their pharmaceutical compositions and method of use. In particular, the invention is concerned with amido piperazine derivatives. These compounds possess unique antiviral activity, whether used alone or in combination with other antivirals, antiinfectives, immunomodulators or HIV entry inhibitors. More particularly, the present invention relates to the treatment of HIV and AIDS.
摘要翻译： 本发明提供具有药物和生物影响性质的化合物，其药物组合物和使用方法。 特别地，本发明涉及酰胺哌嗪衍生物。 这些化合物具有独特的抗病毒活性，无论是单独使用还是与其他抗病毒药，抗感染剂，免疫调节剂或HIV进入抑制剂组合使用。 更具体地说，本发明涉及艾滋病毒和艾滋病的治疗。
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