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    EYELID ILLUMINATION SYSTEMS AND METHODS FOR IMAGING MEIBOMIAN GLANDS FOR MEIBOMIAN GLAND ANALYSIS
    42.
    发明申请
    EYELID ILLUMINATION SYSTEMS AND METHODS FOR IMAGING MEIBOMIAN GLANDS FOR MEIBOMIAN GLAND ANALYSIS 审中-公开

    公开(公告)号：US20190209014A1

    公开(公告)日：2019-07-11

    申请号：US16355039

    申请日：2019-03-15

    申请人： TearScience, Inc.

    发明人： Stephen M. Grenon ,  Donald R. Korb ,  Joshua Grenon ,  Scott Liddle ,  Steve Bacich ,  John M. Jans

    IPC分类号： A61B5/00

    CPC分类号： A61B5/0082 ,  A61B5/0077 ,  A61B5/6821

    摘要： Eyelid illumination systems and methods for imaging meibomian glands for meibomian gland analysis are disclosed. In one embodiment, a patient's eyelid is IR trans-illuminated with an infrared (IR) light. A trans-illumination image of the patient's eyelid is captured showing meibomian glands in dark outlined areas, whereas non-gland material is shown in light areas. This provides a high contrast image of the meibomian glands that is X-ray like. The lid trans-illumination image of the meibomian glands can be analyzed to determine to diagnose the meibomian glands in the patient's eyelid. The eyelid may be trans-illuminated by a lid-flipping device configured to grasp and flip the eyelid for imaging the interior surface of the eyelid. Also, an IR surface meibography image of the meibomian glands may also be captured and combined with the trans-illumination image of the meibomian glands to provide a higher contrast image of the meibomian glands.

    OCULAR SURFACE INTERFEROMETRY (OSI) DEVICES AND SYSTEMS FOR IMAGING, PROCESSING, AND/OR DISPLAYING AN OCULAR TEAR FILM
    48.
    发明申请
    OCULAR SURFACE INTERFEROMETRY (OSI) DEVICES AND SYSTEMS FOR IMAGING, PROCESSING, AND/OR DISPLAYING AN OCULAR TEAR FILM 有权
    用于成像，处理和/或显示眼镜片的OCULAR SURFACE INTERFEROMETRY（OSI）设备和系统

    公开(公告)号：US20160242640A1

    公开(公告)日：2016-08-25

    申请号：US15143834

    申请日：2016-05-02

    申请人： TearScience Inc.

    发明人： Donald R. Korb ,  William L. Weber ,  Randal B. Chinnock ,  Benjamin T. Gravely ,  Stephen M. Grenon

    IPC分类号： A61B3/10 ,  A61B3/00 ,  A61B3/14

    CPC分类号： A61B3/101 ,  A61B3/0025 ,  A61B3/0041 ,  A61B3/1005 ,  A61B3/14 ,  G06T7/0012 ,  G06T2207/30041

    摘要： Ocular surface interferometry (OSI) devices, systems, and methods are disclosed for measuring a tear film layer thickness (TFLT) of the ocular tear film, including lipid layer thickness (LLT) and/or aqueous layer thickness (ALT). The measured TFLT can be used to diagnosis dry eye syndrome (DES). In certain disclosed embodiments, a multi-wavelength light source can be controlled to illuminate the ocular tear film. Light emitted from the multi-wavelength light source undergoes optical wave interference interactions in the tear film. An imaging device can be focused on the lipid layer of the tear film to capture optical wave interference interactions of specularly reflected light from the tear film combined with a background signal(s) in a first image. The imaging device can also be focused on the lipid layer of the tear film to capture a second image containing the background signal(s) present in the first image. The second image can be subtracted from the first image to reduce and/or eliminate the background signal(s) in the first image to produce a resulting image. The resulting image can be processed and analyzed to measure a tear film layer thickness (TFLT), including lipid layer thickness (LLT) and/or aqueous layer thickness (ALT).

    摘要翻译： 公开了用于测量眼泪膜的泪膜层厚度（TFLT），包括脂质层厚度（LLT）和/或水层厚度（ALT）的眼表干涉测量（OSI）装置，系统和方法。 测量的TFLT可用于诊断干眼综合征（DES）。 在某些公开的实施例中，可以控制多波长光源以照射眼泪膜。 从多波长光源发射的光在泪膜中经历光波干涉相互作用。 成像装置可以集中在泪膜的脂质层上，以捕获与第一图像中的背景信号结合的来自泪膜的镜面反射光的光波干涉相互作用。 成像装置还可以聚焦在泪膜的脂质层上，以捕获包含存在于第一图像中的背景信号的第二图像。 可以从第一图像中减去第二图像以减少和/或消除第一图像中的背景信号以产生所得图像。 可以对所得图像进行处理和分析，以测量泪膜层厚度（TFLT），包括脂质层厚度（LLT）和/或水层厚度（ALT）。

    APPARATUSES AND METHODS FOR DIAGNOSING AND/OR TREATING LIPID TRANSPORT DEFICIENCY IN OCULAR TEAR FILMS, AND RELATED COMPONENTS AND DEVICES
    49.
    发明申请
    APPARATUSES AND METHODS FOR DIAGNOSING AND/OR TREATING LIPID TRANSPORT DEFICIENCY IN OCULAR TEAR FILMS, AND RELATED COMPONENTS AND DEVICES 审中-公开
    用于诊断和/或治疗眼泪膜中的脂质运输缺陷的装置和方法，以及相关组件和装置

    公开(公告)号：US20150216725A1

    公开(公告)日：2015-08-06

    申请号：US14422948

    申请日：2013-08-22

    申请人： TearScience, Inc.

    发明人： Donald R. Korb ,  Steve Bacich ,  Caroline Blackie ,  Stephen M. Grenon

    IPC分类号： A61F9/007

    CPC分类号： A61F9/00718 ,  A61B17/32002 ,  A61B2017/320008 ,  A61B2017/320012 ,  A61B2090/0817

    摘要： Methods and apparatuses are disclosed for the diagnosis and removal of the devitalized and/or dead cell material formed in the lid margin to attempt to restore a normal lid margin. In this manner, the devitalized and/or dead cell material are removed or the amount present is reduced or no longer present to prevent, reduce, or affect the transport of lipid secreted by the meibomian glands to the tear film to reduce evaporative dry eye and improve dry eye conditions in patients. The diagnosis and removal of devitalized and/or dead cell material may be performed at desired intervals. Patients that suffer from conditions that block meibomian gland orifices, partial, infrequent, or inhibited blinking resulting in reduced lipid secretions from meibomian glands, and/or blockages in meibomian gland channels reducing secretion of lipids through the meibomian gland orifices may require more frequent diagnosis and treatment to remove devitalized and/or dead cell material.

    摘要翻译： 公开了用于诊断和去除在盖边缘中形成的失活的和/或死细胞材料以尝试恢复正常盖边缘的方法和装置。 以这种方式，去除失活的和/或死细胞材料，或者减少或不再存在量以防止，减少或影响由睑板腺分泌的脂质转移到泪膜以减少蒸发干眼， 改善患者的干眼症状。 可以以期望的间隔进行失活和/或死细胞材料的诊断和去除。 患有阻塞睑板腺腺泡，部分，不频繁或抑制性眨眼，导致睑板腺脂肪分泌减少和/或睑板腺通道阻塞的病症的患者减少通过睑板腺腺泡分泌脂质可能需要更频繁的诊断和 处理以除去失活的和/或死细胞材料。

    Full-eye illumination ocular surface imaging of an ocular tear film for determining tear film thickness and/or providing ocular topography
    50.
    发明授权
    Full-eye illumination ocular surface imaging of an ocular tear film for determining tear film thickness and/or providing ocular topography 有权
    用于确定泪膜厚度和/或提供眼部形貌的眼泪膜的全眼照明眼表面成像

    公开(公告)号：US08888286B2

    公开(公告)日：2014-11-18

    申请号：US14137105

    申请日：2013-12-20

    申请人： TearScience, Inc.

    发明人： Stephen M. Grenon ,  Donald R. Korb

    IPC分类号： A61B3/14 ,  A61B3/10 ,  A61B3/02 ,  A61B5/05 ,  A61B3/00 ,  A61B3/107 ,  G06T7/00

    CPC分类号： A61B3/0025 ,  A61B3/0058 ,  A61B3/1005 ,  A61B3/101 ,  A61B3/107 ,  A61B3/14 ,  G06T7/0012 ,  G06T2207/10016 ,  G06T2207/10144 ,  G06T2207/20224 ,  G06T2207/30041

    摘要： Ocular surface interferometry (OSI) devices, systems, and methods are disclosed for measuring a tear film layer thickness (TFLT) of the ocular tear film, including the lipid layer thickness (LLT) and/or the aqueous layer thickness (ALT). The TFLT can be used to diagnose dry eye syndrome (DES). Certain embodiments also include ocular topography devices, systems and methods for deducing corneal shape by capturing an image of a target reflecting from the surface of the cornea. The image of the target contains topography information that is reviewable by a clinician to diagnose the health of the patient's eye by detecting corneal aberrations and/or abnormalities in corneal shape. Certain embodiments also include a combination of the OSI and ocular topography devices, systems and methods to provide imaging that can be used to yield a combined diagnosis of the patient's tear film and corneal shape.

    摘要翻译： 公开了用于测量眼泪膜的泪膜层厚度（TFLT），包括脂质层厚度（LLT）和/或水层厚度（ALT）的眼表干涉测量（OSI）装置，系统和方法。 TFLT可用于诊断干眼综合征（DES）。 某些实施例还包括眼部地形设备，用于通过捕获从角膜表面反射的目标的图像来推导角膜形状的系统和方法。 目标的图像包含地形信息，临床医生可以通过检测角膜畸形和/或角膜形状的异常来诊断患者眼睛的健康状况。 某些实施方案还包括OSI和眼部形貌设备的组合，用于提供可用于产生患者的泪膜和角膜形状的组合诊断的成像的系统和方法。