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    Transdermal therapeutic system for administering active agents to the human body via the skin
    41.
    发明授权
    Transdermal therapeutic system for administering active agents to the human body via the skin 失效
    经皮肤治疗系统，用于经由皮肤向人体施用活性剂

    公开(公告)号：US6074665A

    公开(公告)日：2000-06-13

    申请号：US983643

    申请日：1998-01-28

    申请人： Michael Horstmann ,  Johannes Leonhard ,  Walter Muller

    发明人： Michael Horstmann ,  Johannes Leonhard ,  Walter Muller

    IPC分类号： A61M35/00 ,  A61K9/70 ,  A61L15/58 ,  A61F13/02

    CPC分类号： A61K9/7053 ,  A61K9/7076

    摘要： A transdermal therapeutic system having a layered structure, comprising a backing layer (1) and at least one active substance-containing matrix layer (2), for storage purposes being placed onto a removable protective layer (4) coated with an abherent (3) is characterized in that said abherent (3) has a lower diffusion coefficient for the active substance used than the base materials used in the matrix layer (2) or in the matrix layers.

    摘要翻译： PCT No.PCT / EP96 / 02735 Sec。 371日期1998年1月28日 102（e）1998年1月28日PCT PCT 1996年6月24日PCT公布。 出版物WO97 / 04818 日期1997年2月13日具有分层结构的透皮治疗系统，包括背衬层（1）和至少一种含活性物质的基质层（2），用于存储目的被放置在涂覆有可移除的保护层 其特征在于，与基体层（2）中使用的基体材料相比，所述基体层（3）的所述活性物质的扩散系数比基体层（2）中使用的基体材料的扩散系数低。

    Transdermal therapeutic system with high rate of utilization of active substance and dosing accuracy
    44.
    发明授权
    Transdermal therapeutic system with high rate of utilization of active substance and dosing accuracy 有权
    具有高活性物质利用率和给药精度的透皮治疗系统

    公开(公告)号：US09056026B2

    公开(公告)日：2015-06-16

    申请号：US12515630

    申请日：2007-11-09

    申请人： Michael Horstmann ,  Walter Mueller

    发明人： Michael Horstmann ,  Walter Mueller

    IPC分类号： A61F13/02 ,  A61M35/00 ,  A61L15/44 ,  A61K9/70

    CPC分类号： A61K9/7061 ,  A61F13/02 ,  A61F13/0233 ,  A61F13/0246 ,  A61K9/7053 ,  A61K9/7084 ,  A61K31/4468 ,  A61L15/44 ,  A61L2300/402

    摘要： Transdermal therapeutic system for administering at least one active pharmaceutical ingredient which is involatile at room temperature with a daily dose not exceeding 30 mg, comprising a backing layer which is impermeable for the active ingredient and faces away from the skin, an adjoining polymer layer which is remote from the skin and is based on polyisobutylenes with a rate of application of at least 80 g/m2, an adhesive skin-contact layer which is adjacent to the polymer layer remote from the skin and is based on acrylate copolymers with a rate of application of not more than 50 g/m2, and a protective layer which can be detached from the skin-contact layer and is impermeable for the active ingredient.

    摘要翻译： 用于施用至少一种在室温下不挥发的日剂量不超过30mg的至少一种活性药物成分的透皮治疗系统，其包含对活性成分不透过并背离皮肤的背衬层，邻接的聚合物层是 远离皮肤并且基于至少80g / m 2的施用速率的聚异丁烯，与远离皮肤的聚合物层相邻并且基于具有施用率的丙烯酸酯共聚物的粘合性皮肤接触层 不超过50g / m 2，以及可以从皮肤接触层分离并且对于活性成分是不可渗透的保护层。

    Non-reclosable package for products prejudicial to health, as well as process for its production
    45.
    发明授权
    Non-reclosable package for products prejudicial to health, as well as process for its production 有权
    不可重复封装的产品损害健康，以及生产过程

    公开(公告)号：US08307983B2

    公开(公告)日：2012-11-13

    申请号：US11664243

    申请日：2005-10-09

    申请人： Karin Ludwig ,  Michael Horstmann

    发明人： Karin Ludwig ,  Michael Horstmann

    IPC分类号： B65D83/04

    CPC分类号： B65D75/5855 ,  B65D75/30 ,  B65D75/5805 ,  B65D2215/04

    摘要： A non-reclosable package for products which are prejudicial to health, such as pharmaceutical products. The package comprises a first packaging material element and a second packaging material element. The two packaging material elements are arranged on top of each other. The package has at least one first surface section, at the margin or margins of which the two packaging material elements are releasably connected with each other. At least one cavity, which is enclosed on all sides and receives the product to be packaged, is formed between the two packaging material elements. The package has at least one second surface section lying outside or adjoining the first surface section, and at the margin or margins of which the two packaging material elements are releasably connected with each other. At least one of the two packaging material elements has at least one structure extending within the second surface section and enables the packaging material element(s) to be torn.

    摘要翻译： 对健康有害的产品，如药品，不可重新包装的产品。 该包装包括第一包装材料元件和第二包装材料元件。 两个包装材料元件彼此顶部布置。 该包装具有至少一个第一表面部分，在其边缘或边缘处，两个包装材料元件彼此可释放地连接。 在两个包装材料元件之间形成有至少一个封闭在所有侧面并接收待包装的产品的空腔。 所述包装具有位于所述第一表面部分的外部或邻接的至少一个第二表面部分，并且在所述包装材料元件的边缘或边缘处，所述两个包装材料元件彼此可释放地连接。 两个包装材料元件中的至少一个具有在第二表面部分内延伸的至少一个结构，并使包装材料元件被撕裂。

    Method and device for improving the permeability of the human skin
    46.
    发明授权
    Method and device for improving the permeability of the human skin 有权
    提高人体皮肤渗透性的方法和装置

    公开(公告)号：US07858113B2

    公开(公告)日：2010-12-28

    申请号：US10566236

    申请日：2004-07-20

    申请人： Michael Horstmann

    发明人： Michael Horstmann

    IPC分类号： A61L15/16 ,  A61F13/02

    CPC分类号： A61K9/7023 ,  A61B18/203 ,  A61B2017/00765 ,  A61B2018/00452 ,  A61B2018/1807 ,  A61M35/00

    摘要： The invention relates to a method for improving the permeability of the human skin in order to transdermally supply active substances, permeability being improved by means of a plaster that is transparent in at least some areas, contains active substance, and is flexible in at least some areas, and at least one external light source. According to said method, light that is emitted at least for a short period of time by an external light source and normally impinges at least some areas of the plaster is focused onto the stratum corneum of the skin with the aid of a plurality of individual focusing lenses which are integrated into the plaster so as to bring about changes in the stratum corneum, said changes improving the permeability of the skin. The inventive method for improving the permeability of the human skin allows for reproducible permeability for specific active substances.

    摘要翻译： 本发明涉及一种提高人体皮肤渗透性以便透皮供应活性物质的方法，通过在至少一些区域是透明的，含有活性物质的石膏改善渗透性的方法，并且在至少一些 区域和至少一个外部光源。 根据所述方法，借助于多个个体聚焦，通过外部光源至少在短时间内被发射并且通常撞击所述石膏的至少一些区域的光聚焦到所述皮肤的角质层上 整合到石膏中以使角质层发生变化的透镜，所述改变提高了皮肤的渗透性。 用于提高人皮肤渗透性的本发明方法允许特定活性物质的可重复渗透性。

    Non-Reclosable Package for Products Prejudicial to Health, as well as Process for its Production
    48.
    发明申请
    Non-Reclosable Package for Products Prejudicial to Health, as well as Process for its Production 有权
    不可重复包装的产品有害于健康，以及生产过程

    公开(公告)号：US20080105582A1

    公开(公告)日：2008-05-08

    申请号：US11664243

    申请日：2005-10-09

    申请人： Karin Ludwig ,  Michael Horstmann

    发明人： Karin Ludwig ,  Michael Horstmann

    IPC分类号： B65D85/00 ,  B65B43/04

    CPC分类号： B65D75/5855 ,  B65D75/30 ,  B65D75/5805 ,  B65D2215/04

    摘要： A non-reclosable package for products which are prejudicial to health, such as pharmaceutical products. The package comprises a first packaging material element and a second packaging material element. The two packaging material elements are arranged on top of each other. The package has at least one first surface section, at the margin or margins of which the two packaging material elements are releasably connected with each other. At least one cavity, which is enclosed on all sides and receives the product to be packaged, is formed between the two packaging material elements. The package has at least one second surface section lying outside or adjoining the first surface section, and at the margin or margins of which the two packaging material elements are releasably connected with each other. At least one of the two packaging material elements has at least one structure extending within the second surface section and enables the packaging material element(s) to be torn.

    摘要翻译： 对健康有害的产品，如药品，不可重新包装的产品。 该包装包括第一包装材料元件和第二包装材料元件。 两个包装材料元件彼此顶部布置。 该包装具有至少一个第一表面部分，在其边缘或边缘处，两个包装材料元件彼此可释放地连接。 在两个包装材料元件之间形成有至少一个封闭在所有侧面并接收待包装的产品的空腔。 所述包装具有位于所述第一表面部分的外部或邻接的至少一个第二表面部分，并且在所述包装材料元件的边缘或边缘处，所述两个包装材料元件彼此可释放地连接。 两个包装材料元件中的至少一个具有在第二表面部分内延伸的至少一个结构，并使包装材料元件被撕裂。

    Transdermal therapeutic system containing estradiol
    50.
    发明授权
    Transdermal therapeutic system containing estradiol 有权
    含有雌二醇的透皮治疗系统

    公开(公告)号：US06521250B2

    公开(公告)日：2003-02-18

    申请号：US09522925

    申请日：2000-03-10

    申请人： Reinhold Meconi ,  Frank Seibertz ,  Michael Horstmann ,  Rainer Lichtenberger

    发明人： Reinhold Meconi ,  Frank Seibertz ,  Michael Horstmann ,  Rainer Lichtenberger

    IPC分类号： A61F1300

    CPC分类号： A61K9/7053 ,  A61K9/7069 ,  A61K9/7076 ,  A61K31/565

    摘要： An active-substance-containing transdermal therapeutic system for the controlled release of estradiol or its pharmaceutically acceptable able derivatives alone or combined with gestagens consisting of a layer, an active-substance-containing reservoir which is bonded thereto and produced by using pressure sensitive adhesives, and a removable protective layer is characterized by the fact that the pressure sensitive adhesive comprises esters of colophony.

    摘要翻译： 用于控制释放雌二醇或其药学上可接受的能力衍生物的单独或与孕妇组合的含活性物质的透皮治疗系统，其由层，含有活性物质的储存器结合并通过使用压敏粘合剂生产， 并且可移除的保护层的特征在于压敏粘合剂包括松香的酯。