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公开(公告)号：US20240024458A1
公开(公告)日：2024-01-25
申请号：US18462340
申请日：2023-09-06
申请人： The United States of America, as represented by the Secretary, Department of Health and Human Servic , Institute For Research in Biomedicine
发明人： Peter Kwong , Michael Gordon Joyce , Baoshan Zhang , Yongping Yang , Peter Collins , Ursula Buchholz , Davide Corti , Antonio Lanzavecchia , Guillaume Stewart-Jones
IPC分类号： A61K39/155 , A61K39/39 , C07K14/005 , A61K48/00 , C07K14/135
CPC分类号： A61K39/155 , A61K39/39 , C07K14/005 , A61K48/00 , C07K14/135 , C07K2319/73 , C12N2760/18322 , C12N2760/18334 , C07K2319/70 , C12N2760/18522 , C12N2760/18534
摘要： Metapneumovirus (MPV) F proteins stabilized in a prefusion conformation, nucleic acid molecules and vectors encoding these proteins, and methods of their use and production are disclosed. In several embodiments, the MPV F proteins and/or nucleic acid molecules can be used to generate an immune response to MPV in a subject. In additional embodiments, the therapeutically effective amount of the MPV F ectodomain trimers and/or nucleic acid molecules can be administered to a subject in a method of treating or preventing MPV infection.
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公开(公告)号：US11261245B2
公开(公告)日：2022-03-01
申请号：US16691338
申请日：2019-11-21
发明人： Davide Corti , Antonio Lanzavecchia , Luca Piccoli
摘要： The present invention provides multispecific antibodies, and antigen binding fragments thereof, that potently neutralize a cytokine and that may thus be useful in the prevention and/or treatment of inflammatory and/or autoimmune diseases. In particular, the present invention provides a multispecific antibody, or an antigen binding fragment thereof, comprising at least two different domains specifically binding to at least two different, non-overlapping sites in a cytokine and an Fc moiety. The invention also relates to nucleic acids that encode such antibodies and antibody fragments and immortalized B cells and cultured plasma cells that produce such antibodies and antibody fragments. In addition, the invention relates to the use of the antibodies and antibody fragments of the invention in screening methods as well as in the diagnosis, prophylaxis and treatment of inflammatory and/or autoimmune diseases.
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43.发明授权公开(公告)号：US11192926B2
公开(公告)日：2021-12-07
申请号：US16500331
申请日：2018-04-03
发明人： Neil P. King , David Baker , Brooke Nickerson , Lance Joseph Stewart , Laurent Perez , Antonio Lanzavecchia , Jessica Marcandalli
IPC分类号： A61K39/00 , A61K39/12 , A61K39/155 , C07K14/005 , A61K39/385 , A61P31/14 , B82Y5/00 , C12N7/00
摘要： Disclosed herein are nanostructures and their use, where the nanostructures include (a) a plurality of first assemblies, each first assembly comprising a plurality of identical first polypeptides; (b) a plurality of second assemblies, each second assembly comprising a plurality of identical second polypeptides, wherein the second polypeptide differs from the first polypeptide; wherein the plurality of first assemblies non-covalently interact with the plurality of second assemblies to form a nanostructures; and wherein the nanostructure displays multiple copies of one or more paramyxovirus and/or pneumovirus F proteins or antigenic fragments thereof, on an exterior of the nanostructure.
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公开(公告)号：US11167015B2
公开(公告)日：2021-11-09
申请号：US16340337
申请日：2017-10-12
IPC分类号： A61K31/164 , A61K38/43 , A61P35/00 , A61K31/198 , A61K35/17 , A61K38/17 , A61K38/18 , C07K14/47 , A61P31/00 , A61K31/00 , A61P31/02 , A61K48/00
摘要： The present invention provides novel uses and methods for T cell based immunotherapies. Specifically, the invention relates to novel ligands, targets and nucleic acids and vectors encoding said targets that are useful for modulating T cell responses.
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公开(公告)号：US11084850B2
公开(公告)日：2021-08-10
申请号：US16468174
申请日：2017-12-15
申请人： INSTITUTE FOR RESEARCH IN BIOMEDICINE , THE PIRBRIGHT INSTITUTE , THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
发明人： Lei Chen , Baoshan Zhang , Peter D. Kwong , Davide Corti , Antonio Lanzavecchia , Geraldine Taylor
IPC分类号： C07K14/135 , A61K39/12 , A61K39/155 , C07K14/005 , A61P31/14 , A61K39/39 , A61K45/06 , C07K16/10 , G01N33/536 , G01N33/569 , A61K39/00
摘要： The present invention provides immunogens comprising a recombinant Respiratory Syncytial Virus (RSV) F protein stabilized in a prefusion conformation and nucleic acids encoding such immunogens. In particular the present invention provides polypeptides, polynucleotides, compositions, and uses thereof for eliciting an immune response to bovine respiratory syncytial virus (bRSV). Methods for generating an immune response in a subject are also disclosed. In some embodiments, the method is a method for treating or preventing a RSV infection in a subject by administering a therapeutically effective amount of the antigen to the subject.
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公开(公告)号：US11078239B2
公开(公告)日：2021-08-03
申请号：US16344772
申请日：2017-10-25
申请人： The United States of America, as represented by the Secretary, Dept. of Health and Human Services , Institute for Research in Biomedicine
发明人： Baoshan Zhang , Guillaume Stewart-Jones , Tongqing Zhou , John Mascola , Kai Xu , Yongping Yang , Paul Thomas , Gwo-Yu Chuang , Li Ou , Peter Kwong , Yaroslav Tsybovsky , Wing-Pui Kong , Aliaksandr Druz , Davide Corti , Antonio Lanzavecchia
IPC分类号： A61K39/155 , C07K14/005 , A61P31/14 , C12N7/00
摘要： Embodiments of a recombinant human Parainfluenza Virus (hPIV) F ectodomain trimer stabilized in a prefusion conformation are provided. Also disclosed are nucleic acids encoding the hPIV F ectodomain trimer and methods of producing the hPIV F ectodomain trimer. Methods for inducing an immune response in a subject are also disclosed. In some embodiments, the method can be a method for treating or inhibiting a hPIV infection in a subject by administering a effective amount of the recombinant hPIV F ectodomain trimer to the subject.
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公开(公告)号：US20190248874A1
公开(公告)日：2019-08-15
申请号：US16178497
申请日：2018-11-01
发明人： Antonio Lanzavecchia
IPC分类号： C07K16/10 , G01N33/569 , C07K14/005
摘要： The invention relates to antibodies, and antigen binding fragments thereof, that specifically bind to an epitope in the stem region of an influenza A hemagglutinin trimer and neutralize a group 1 subtype and a group 2 subtype of influenza A virus. The invention also relates to nucleic acids that encode, immortalized B cells and cultured single plasma cells that produce, and to epitopes that bind to such antibodies and antibody fragments. In addition, the invention relates to the use of the antibodies, antibody fragments, and epitopes in screening methods as well as in the diagnosis, treatment and prevention of influenza A virus infection.
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公开(公告)号：US09527902B2
公开(公告)日：2016-12-27
申请号：US15154178
申请日：2016-05-13
CPC分类号： C07K16/088 , A01D34/63 , A01D34/71 , A01D2101/00 , A61K38/00 , A61K39/00 , A61K39/42 , A61K2039/505 , A61K2039/507 , C07K14/005 , C07K2317/21 , C07K2317/34 , C07K2317/41 , C07K2317/54 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/76 , C07K2317/92 , C12N2710/16122
摘要： The invention relates to neutralizing antibodies, and antibody fragments thereof, having high potency in neutralizing hCMV, wherein said antibodies and antibody fragments are specific for one, or a combination of two or more, hCMV gene UL products. The invention also relates to immortalized B cells that produce, and to epitopes that bind to, such antibodies and antibody fragments. In addition, the invention relates to the use of the antibodies, antibody fragments, and epitopes in screening methods as well as in the diagnosis, prevention, and therapy of disease.
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公开(公告)号：US09491906B2
公开(公告)日：2016-11-15
申请号：US15156786
申请日：2016-05-17
CPC分类号： C07K16/088 , A01D34/63 , A01D34/71 , A01D2101/00 , A61K38/00 , A61K39/00 , A61K39/42 , A61K2039/505 , A61K2039/507 , C07K14/005 , C07K2317/21 , C07K2317/34 , C07K2317/41 , C07K2317/54 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/76 , C07K2317/92 , C12N2710/16122
摘要： The invention relates to neutralizing antibodies, and antibody fragments thereof, having high potency in neutralizing hCMV, wherein said antibodies and antibody fragments are specific for one, or a combination of two or more, hCMV gene UL products. The invention also relates to immortalized B cells that produce, and to epitopes that bind to, such antibodies and antibody fragments. In addition, the invention relates to the use of the antibodies, antibody fragments, and epitopes in screening methods as well as in the diagnosis, prevention, and therapy of disease.
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公开(公告)号：US09149524B2
公开(公告)日：2015-10-06
申请号：US14041799
申请日：2013-09-30
IPC分类号： A61K39/42 , A61K39/395 , C07K16/08
CPC分类号： A61K39/3955 , A61K39/42 , C07K16/088 , C07K2317/21 , C07K2317/32 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要： The invention relates to neutralizing antibodies which are specific for human cytomegalovirus and bind with high affinity as well as immortalized B cells that produce such antibodies. The invention also relates to the epitopes that the antibodies bind to as well as the use of the antibodies and the epitopes in screening methods as well as the diagnosis and therapy of disease.
摘要翻译： 本发明涉及对人巨细胞病毒特异性并以高亲和力结合的中和抗体以及产生这种抗体的永生化B细胞。 本发明还涉及抗体结合的表位以及筛选方法中抗体和表位的使用以及疾病的诊断和治疗。
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