公开(公告)号：US20120042722A1

公开(公告)日：2012-02-23

申请号：US12858204

申请日：2010-08-17

申请人： Xuedong Song ,  Ning Wei ,  Ronnie L. Phillips

发明人： Xuedong Song ,  Ning Wei ,  Ronnie L. Phillips

IPC分类号： G01N9/00

CPC分类号： G01N33/558 ,  A61F13/42 ,  A61F13/84 ,  A61F2013/00429 ,  A61F2013/0094 ,  A61F2013/00948 ,  A61F2013/15081 ,  A61F2013/15154 ,  A61F2013/8473

摘要： A lateral flow assay device for determining the relative ionic strength of urine is described. The device includes a buffering zone having a polyelectrolyte disposed therein, and an indicator zone having a pH indicator non-diffusively immobilized therein, the indicator zone being separate from the buffering zone and positioned adjacent to and in fluid communication with the buffering zone. A detection zone is part of the buffering zone, and has a buffering component comprising a weak polymeric acid and weak polymeric base with a pKa≦10−3, and a class of charged polymeric surfactants that are responsive to relative ion concentrations in a sample solution, and a charged pH indicator with a charge opposite to that of the charged polymeric surfactant. The charged polymeric surfactant is soluble in amounts of greater than or equal to about 1% by weight (≧1 wt. % solute) in water and aqueous solutions of low ionic concentration of ≦0.1 wt. % salts, but insoluble ( 0.1 wt. % salts. The present invention also describes absorbent articles incorporating such an assay device and methods of monitoring dehydration or testing ion strength of a urine sample using such a test format.

摘要翻译： 描述了用于确定尿液的相对离子强度的侧流测定装置。 该装置包括其中布置有聚电解质的缓冲区和具有非扩散固定在其中的pH指示剂的指示区，指示区与缓冲区分离并且定位成与缓冲区相邻并且与缓冲区流体连通。 检测区是缓冲区的一部分，并且具有缓冲组分，其包含弱聚合酸和具有pKa和nIE; 10-3的弱聚合物碱，以及一类对样品溶液中的相对离子浓度有响应的带电聚合物表面活性剂 和带电荷的pH指示剂，其电荷与带电聚合物表面活性剂的电荷相反。 带电的聚合物表面活性剂可溶于水和低离子浓度的水溶液中大于或等于约1重量％（≥1重量％溶质）和0.1重量％ ％盐，但不溶于（<1重量％溶质）在高离子浓度> 0.1重量％的水溶液中。 ％盐。 本发明还描述了结合这种测定装置的吸收制品以及使用这种测试形式监测尿样的脱水或测试离子强度的方法。

公开(公告)号：US08003399B2

公开(公告)日：2011-08-23

申请号：US11217099

申请日：2005-08-31

申请人： Xuedong Song ,  Rosann Marie Matthews Kaylor

发明人： Xuedong Song ,  Rosann Marie Matthews Kaylor

IPC分类号： G01N33/543 ,  G01N33/558

CPC分类号： G01N33/526 ,  G01N2800/348 ,  Y10T436/173076

摘要： A diagnostic test kit for detecting the presence or absence of nitrites within a test sample is provided. The test kit comprises an aromatic primary amine that is capable of reacting with a nitrite to form a diazonium ion. The test kit also comprises a lateral flow device that comprises a chromatographic medium and an absorbent material that receives the test sample after flowing through the chromatographic medium. The chromatographic medium defines a detection zone within which is contained a detection reagent (e.g., nucleophilic aromatic amine) that is capable of reacting with the diazonium ion to form an indicator (e.g., azo compound). The indicator exhibits a color that is different than the color of the detection reagent.

摘要翻译： 提供了用于检测测试样品中亚硝酸盐存在或不存在的诊断测试试剂盒。 测试试剂盒包括能够与亚硝酸盐反应形成重氮离子的芳族伯胺。 测试试剂盒还包括侧流装置，其包括色谱介质和在流过色谱介质之后接收测试样品的吸收材料。 色谱介质限定了检测区，其中含有能够与重氮离子反应形成指示剂（例如偶氮化合物）的检测试剂（例如亲核芳族胺）。 指示剂显示与检测试剂的颜色不同的颜色。

公开(公告)号：US20110158917A1

公开(公告)日：2011-06-30

申请号：US12826017

申请日：2010-06-29

申请人： John Gavin MacDonald ,  Stephanie M. Martin ,  Ronnie L. Phillips ,  Xuedong Song

发明人： John Gavin MacDonald ,  Stephanie M. Martin ,  Ronnie L. Phillips ,  Xuedong Song

IPC分类号： A61K31/194 ,  A61K9/70 ,  A61P31/12

CPC分类号： A61K31/194 ,  A61K31/00

摘要： Anti-viral tissues are provided with a pH indicator which can communicate to a tissue user by means of visual indicia, via color changes, that the tissue has active ingredients. Furthermore, the pH indicators can be used to illustrate neutralization of the pH of infected nasal discharge, which has a higher pH than healthy nasal discharge, giving the user a reason to believe that the product is working to deactivate virus.

摘要翻译： 抗病毒组织设置有pH指示剂，其可以通过视觉标记通过颜色变化与组织使用者通信组织具有活性成分。 此外，pH指示剂可用于说明中和感染的鼻腔排泄物的pH，其具有比健康的鼻腔排出物更高的pH值，给予用户认为该产品正在致力于使病毒失活的理由。

公开(公告)号：US07935538B2

公开(公告)日：2011-05-03

申请号：US11640100

申请日：2006-12-15

申请人： Xuedong Song ,  Curtis Sayre ,  Shawn R. Feaster ,  Julie Villanueva

发明人： Xuedong Song ,  Curtis Sayre ,  Shawn R. Feaster ,  Julie Villanueva

IPC分类号： G01N33/53

CPC分类号： G01N33/54393 ,  G01N21/78 ,  G01N33/558 ,  Y10S435/97 ,  Y10S436/81

摘要： A lateral flow assay device for detecting the presence or quantity of an analyte in a test sample is provided. The device comprises a chromatographic medium that defines a detection zone, wherein a crosslinked network is non-diffusively immobilized within the detection zone. The crosslinked network contains a small molecule indicator that is configured to undergo a detectable color change in the presence of the analyte.

摘要翻译： 提供了用于检测测试样品中分析物的存在或数量的侧流测定装置。 该装置包括限定检测区的色谱介质，其中交联网络非扩散地固定在检测区内。 交联网络包含小分子指示剂，其被配置为在分析物存在下经历可检测的颜色变化。

公开(公告)号：US20110015063A1

公开(公告)日：2011-01-20

申请号：US12503380

申请日：2009-07-15

申请人： JunMo Gil ,  Xuedong Song

发明人： JunMo Gil ,  Xuedong Song

IPC分类号： B01J20/26 ,  G01N31/22 ,  B05D3/02

CPC分类号： A61L15/22 ,  A61F13/00051 ,  A61F13/00991 ,  A61F13/15577 ,  A61F13/42 ,  A61F2013/422 ,  A61F2013/427 ,  A61F2013/428 ,  A61L15/48 ,  A61L15/56 ,  C08J7/047

摘要： The present invention relates to a multiple-component material including a substrate and a film layer on the substrate. The film layer includes a color-changing composition to indicate a change in condition, such as a change in pH. The color-changing composition includes a water-insoluble, film-forming polymer, a charged surfactant, a charged colorant and a pH adjuster.

摘要翻译： 本发明涉及在基板上包括基板和薄膜层的多组分材料。 膜层包括变色组合物，以指示条件的变化，例如pH的变化。 变色组合物包括水不溶性，成膜聚合物，带电荷的表面活性剂，带电荷的着色剂和pH调节剂。

公开(公告)号：US20100062543A1

公开(公告)日：2010-03-11

申请号：US12616821

申请日：2009-11-12

申请人： Xuedong Song ,  Ning Wei ,  Curtis N. Sayre

发明人： Xuedong Song ,  Ning Wei ,  Curtis N. Sayre

IPC分类号： G01N33/558

CPC分类号： A47B13/086 ,  A47B3/0912

摘要： A flow-through assay for detecting the quantity of an analyte residing in a test sample is provided. The flow-through assay contains a porous membrane that is in fluid communication with probe conjugates that contain a specific binding member and a detectable probe. The porous membrane also defines a detection zone and a calibration zone. The calibration zone contains a polyelectrolyte substantially non-diffusively immobilized on the porous membrane. The polyelectrolyte is capable of generating a detectable calibration signal that can be readily compared (visually, quantitatively, and the like) to a detection signal to determine the amount of analyte in the test sample.

摘要翻译： 提供了用于检测驻留在测试样品中的分析物的量的流通测定。 流通测定包含多孔膜，其与含有特异性结合成员和可检测探针的探针缀合物流体连通。 多孔膜还限定了检测区域和校准区域。 校准区域包含基本上非扩散地固定在多孔膜上的聚电解质。 聚电解质能够产生可检测的校准信号，其可以容易地与检测信号进行比较（视觉上，定量等）以确定测试样品中分析物的量。

公开(公告)号：US07575887B2

公开(公告)日：2009-08-18

申请号：US11364810

申请日：2006-02-28

申请人： Xuedong Song

发明人： Xuedong Song

IPC分类号： C12Q1/37

CPC分类号： C12Q1/44 ,  G01N33/52 ,  G01N33/558 ,  G01N33/573

摘要： A diagnostic test kit for detecting the presence or absence of a protease (e.g., aminopeptidase) within a test sample is provided. The test kit comprises a substrate that is capable of being cleaved in the presence of the protease to release a compound. The kit also comprises a lateral flow device that comprises a chromatographic medium. The chromatographic medium defines a detection zone within which is contained a first reagent (e.g., diazonium ion) that is capable of reacting with the compound to form a second reagent (e.g., aromatic azo compound). The second reagent exhibits a color that is different than the color of the first reagent. The lateral flow device also includes an absorbent material located adjacent to the chromatographic medium, the absorbent material receiving the test sample after flowing through the chromatographic medium.

摘要翻译： 提供了用于检测测试样品中蛋白酶（例如氨基肽酶）的存在或不存在的诊断测试试剂盒。 测试试剂盒包括能够在蛋白酶存在下被切割以释放化合物的底物。 试剂盒还包括含有色谱介质的侧流装置。 色谱介质限定了检测区域，其中含有能够与化合物反应形成第二试剂（例如芳族偶氮化合物）的第一试剂（例如重氮离子）。 第二试剂显示与第一试剂的颜色不同的颜色。 侧流装置还包括位于邻近色谱介质的吸收材料，吸收材料在流过色谱介质后接收测试样品。

公开(公告)号：US20080147019A1

公开(公告)日：2008-06-19

申请号：US11641637

申请日：2006-12-19

申请人： Xuedong Song ,  Bao T. Do ,  Robert B. Johnson

发明人： Xuedong Song ,  Bao T. Do ,  Robert B. Johnson

IPC分类号： A01N25/08 ,  A01N59/16 ,  A01N59/20 ,  A01P1/00 ,  A61J15/00 ,  A61M16/04 ,  A61M25/00

CPC分类号： C09D5/14 ,  C08B37/003 ,  C08L5/08 ,  C09D105/08

摘要： A material composition, including metallic nanoparticles of silver, silver alloys, or copper, having antimicrobial properties is disclosed. The metallic nanoparticles are embedded or encapsulated in a matrix formed of chitosan or chitosan derivative-based compounds.

摘要翻译： 公开了一种材料组合物，包括具有抗微生物性质的银，银合金或铜的金属纳米颗粒。 将金属纳米颗粒嵌入或包封在由壳聚糖或壳聚糖衍生物基化合物形成的基质中。

公开(公告)号：US20080090253A1

公开(公告)日：2008-04-17

申请号：US11956397

申请日：2007-12-14

申请人： Xuedong Song

发明人： Xuedong Song

IPC分类号： C12M1/34 ,  G01N33/53

CPC分类号： G01N33/558 ,  G01N21/6428 ,  G01N33/5302 ,  G01N33/54313 ,  G01N33/54393 ,  G01N33/582 ,  G01N33/587 ,  Y10S435/805 ,  Y10S435/81 ,  Y10S435/97 ,  Y10S436/805 ,  Y10S436/81

摘要： A lateral flow, membrane-based assay device for detecting the presence or quantity of an analyte residing in a test sample is provided. The device utilizes phosphorescence to detect the signals generated by excited phosphorescent labels. The labels may have a long emission lifetime so that background interference from many sources, such as scattered light and autofluorescence, is practically eliminated during detection. In addition, the phosphorescent labels may be encapsulated within particles to shield the labels from quenchers, such as oxygen or water, which might disrupt the phosphorescent signal.

摘要翻译： 提供了用于检测驻留在测试样品中的分析物的存在或量的侧向流动的基于膜的测定装置。 该器件利用磷光来检测激发的磷光标记产生的信号。 标签可能具有长的发光寿命，从而在检测期间实际上消除了许多来源的背景干扰，例如散射光和自发荧光。 此外，磷光标记物可以被包封在颗粒内以将标记物遮蔽猝灭剂，例如氧气或水，这可能会破坏磷光信号。

公开(公告)号：US07285424B2

公开(公告)日：2007-10-23

申请号：US10228836

申请日：2002-08-27

申请人： Xuedong Song ,  Rosann Kaylor

发明人： Xuedong Song ,  Rosann Kaylor

IPC分类号： G01N33/53

CPC分类号： G01N33/54326 ,  G01N21/274 ,  G01N21/6408 ,  G01N33/525 ,  G01N33/558 ,  G01N33/582 ,  G01N2021/6439 ,  Y10S435/803 ,  Y10S435/805 ,  Y10S435/97 ,  Y10S436/80 ,  Y10S436/806 ,  Y10S436/824 ,  Y10T436/13

摘要： A membrane-based assay device for detecting the presence or quantity of an analyte residing in a test sample is provided. The device utilizes a self-calibrated magnetic binding assay format (e.g., sandwich, competitive, etc.) that includes detection probes capable of generating a detection signal (e.g., fluorescent non-magnetic particles) and calibration probes capable of generating a calibration signal (e.g., fluorescent magnetic particles). The amount of the analyte within the test sample is proportional (e.g., directly or inversely) to the intensity of the detection signal calibrated by the intensity of the calibration signal. It has been discovered that the fluidics-based device of the present invention provides an accurate, inexpensive, and readily controllable method of determining the presence of an analyte in a test sample.

摘要翻译： 提供了一种用于检测驻留在测试样品中的分析物的存在或数量的基于膜的测定装置。 该装置使用包括能够产生检测信号的检测探针（例如，荧光非磁性颗粒）和能够产生校准信号的校准探针的自校准磁结合测定格式（例如，夹层，竞争性等） 例如荧光磁性颗粒）。 测试样品内的分析物的量与由校准信号的强度校准的检测信号的强度成正比（例如，直接或反向）。 已经发现，本发明的基于流体的装置提供了确定测试样品中分析物的存在的精确，便宜且易于控制的方法。