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132 条记录 (耗时 0.04 秒)

    Reagents for the detection of protein phosphorylation in carcinoma signaling pathways
    42.
    发明申请
    Reagents for the detection of protein phosphorylation in carcinoma signaling pathways 审中-公开
    用于检测癌症信号通路中蛋白质磷酸化的试剂

    公开(公告)号：US20100151495A9

    公开(公告)日：2010-06-17

    申请号：US12074228

    申请日：2008-02-29

    申请人： Roberto Polakiewicz ,  Ailan Guo ,  Albrecht Moritz ,  Klarisa Rikova ,  Kimberly Lee ,  Erik Spek ,  Yu Li ,  Charles Farnsworth

    发明人： Roberto Polakiewicz ,  Ailan Guo ,  Albrecht Moritz ,  Klarisa Rikova ,  Kimberly Lee ,  Erik Spek ,  Yu Li ,  Charles Farnsworth

    IPC分类号： G01N33/53 ,  C07K16/18 ,  C07K14/00 ,  C12N5/18

    CPC分类号： C07K16/44 ,  G01N33/57426

    摘要： The invention discloses nearly 443 novel phosphorylation sites identified in signal transduction proteins and pathways underlying human carcinoma, and provides phosphorylation-site specific antibodies and heavy-isotope labeled peptides (AQUA peptides) for the selective detection and quantification of these phosphorylated sites/proteins, as well as methods of using the reagents for such purpose. Among the phosphorylation sites identified are sites occurring in the following protein types: Protein kinases (including Serine/Threonine dual specificity, and Tyrosine kinases), Adaptor/Scaffold proteins, Transcription factors, Phospoatases, Tumor supressors, Ubiquitin conjugating system proteins, Translation initiation complex proteins, RNA binding proteins, Apoptosis proteins, Adhesion proteins, G protein regulators/GTPase activating protein/Guanine nucleotide exchange factor proteins, and DNA binding/replication/repair proteins, as well as other protein types.

    摘要翻译： 本发明公开了在信号转导蛋白中鉴定的近443个新的磷酸化位点和人癌基因的途径，并提供磷酸化位点特异性抗体和重同位素标记肽（AQUA肽），用于选择性检测和定量这些磷酸化位点/蛋白质，如 以及使用试剂用于此目的的方法。 鉴定的磷酸化位点是发生在以下蛋白质类型中的位点：蛋白激酶（包括丝氨酸/苏氨酸双特异性和酪氨酸激酶），适配器/支架蛋白，转录因子，磷酸酶，肿瘤抑制因子，泛素缀合系统蛋白，翻译起始复合体 蛋白质，RNA结合蛋白，细胞凋亡蛋白，粘附蛋白，G蛋白调节剂/ GTPase激活蛋白/鸟嘌呤核苷酸交换因子蛋白，以及DNA结合/复制/修复蛋白，以及其他蛋白质类型。

    Reagents for the detection of protein phosphorylation in carcinoma signaling pathways
    44.
    发明申请
    Reagents for the detection of protein phosphorylation in carcinoma signaling pathways 审中-公开
    用于检测癌症信号通路中蛋白质磷酸化的试剂

    公开(公告)号：US20090258442A1

    公开(公告)日：2009-10-15

    申请号：US12074199

    申请日：2008-02-29

    申请人： Roberto Polakiewicz ,  Ailan Guo ,  Albrecht Moritz ,  Klarisa Rikova ,  Kimberly Lee ,  Erik Spek ,  Yu Li ,  Charles Farnsworth

    发明人： Roberto Polakiewicz ,  Ailan Guo ,  Albrecht Moritz ,  Klarisa Rikova ,  Kimberly Lee ,  Erik Spek ,  Yu Li ,  Charles Farnsworth

    IPC分类号： G01N33/536 ,  C07K16/18

    CPC分类号： C07K16/30 ,  C07K16/44 ,  G01N33/57426 ,  G01N33/57496

    摘要： The invention discloses nearly 474 novel phosphorylation sites identified in signal transduction proteins and pathways underlying human carcinoma, and provides phosphorylation-site specific antibodies and heavy-isotope labeled peptides (AQUA peptides) for the selective detection and quantification of these phosphorylated sites/proteins, as well as methods of using the reagents for such purpose. Among the phosphorylation sites identified are sites occurring in the following protein types: Kinase, Adaptor/Scaffold proteins, Phosphatase, G protein Regulator/Guanine Nucleotide Exchange Factors/GTPase Activating Proteins, Cytoskeleton Proteins, DNA Binding Proteins, Phospholipase, Receptor Proteins, Enzymes, DNA Repair/Replication Proteins, Adhesion Proteins, and Proteases, as well as other protein types.

    摘要翻译： 本发明公开了在信号转导蛋白中鉴定的近474个新的磷酸化位点和人癌基因的途径，并提供磷酸化位点特异性抗体和重同位素标记肽（AQUA肽），用于选择性检测和定量这些磷酸化位点/蛋白质，如 以及使用试剂用于此目的的方法。 鉴定的磷酸化位点是发生在以下蛋白质类型中的位点：激酶，适配器/支架蛋白，磷酸酶，G蛋白调节剂/鸟嘌呤核苷酸交换因子/ GTP酶活化蛋白，细胞骨架蛋白，DNA结合蛋白，磷脂酶，受体蛋白，酶， DNA修复/复制蛋白，粘附蛋白和蛋白酶，以及其他蛋白质类型。

    METHOD OF PROCESSING INSTRUCTIONS IN PIPELINE-BASED PROCESSOR AND CORRESPONDING PROCESSOR
    45.
    发明申请
    METHOD OF PROCESSING INSTRUCTIONS IN PIPELINE-BASED PROCESSOR AND CORRESPONDING PROCESSOR 有权
    基于管道处理器和相应处理器的处理指令的方法

    公开(公告)号：US20090193424A1

    公开(公告)日：2009-07-30

    申请号：US12357910

    申请日：2009-01-22

    申请人： Wen Bo Shen ,  Peng Shao ,  Yu Li ,  Xiao Tao Chang ,  Yi Ge ,  Huayong Wang ,  Huan Hao Zou

    发明人： Wen Bo Shen ,  Peng Shao ,  Yu Li ,  Xiao Tao Chang ,  Yi Ge ,  Huayong Wang ,  Huan Hao Zou

    IPC分类号： G06F9/46

    CPC分类号： G06F1/3287 ,  G06F9/3867 ,  G06F9/3885 ,  G06F9/4818 ,  G06F11/30 ,  G06F13/18 ,  Y02D10/14

    摘要： The present invention discloses a method of processing instructions in a pipeline-based central processing unit, wherein the pipeline is partitioned into base pipeline stages and enhanced pipeline stages according to functions, the base pipeline stages being activated all the while, and the enhanced pipeline stages being activated or shutdown according to requirements for performance of a workload. The present invention further discloses a method of processing instructions in a pipeline-based central processing unit, wherein the pipeline is partitioned into base pipeline stages and enhanced pipeline stages according to functions, each pipeline stage being partitioned into a base module and at least one enhanced module, the base module being activated all the while, and the enhanced module being activated or shutdown according to requirements for performance of a workload.

    摘要翻译： 本发明公开了一种在基于流水线的中央处理单元中处理指令的方法，其中根据功能将流水线划分为基本流水线阶段和增强流水线阶段，基本流水线阶段同时被激活，增强的流水线阶段 根据工作负载的性能要求被激活或关闭。 本发明还公开了一种在基于流水线的中央处理单元中处理指令的方法，其中根据功能将流水线划分成基本流水线级和增强的流水线级，每个流水线级分为基模块和至少一增强型 模块，基本模块一直被激活，并且增强模块根据工作负载的性能要求被激活或关闭。

    Battery Connector
    47.
    发明申请
    Battery Connector 审中-公开
    电池连接器

    公开(公告)号：US20080153347A1

    公开(公告)日：2008-06-26

    申请号：US11613271

    申请日：2006-12-20

    申请人： Ming-Chun Lai ,  Yu Li

    发明人： Ming-Chun Lai ,  Yu Li

    IPC分类号： H01R3/00

    CPC分类号： H01R13/2442

    摘要： A battery connector includes a housing having a terminal recess and a plurality of electric terminals. The terminal recess has an inlay recess in the bottom of the terminal recess and a receiving cavity extending from the top of the terminal recess to the inlay recess, and an opening is dug at the end of the inlay recess. The electric terminal comprises a base portion, a contacting portion and a soldering portion. The base portion is received in the inlay recess. The contacting portion extends out of the receiving cavity for connecting the battery. The soldering portion was exposed by the opening of the housing. The repairman can replenish solder to the soldering portion by the opening of the housing if the machine omits soldering the soldering portion of the battery connector during excessive production.

    摘要翻译： 电池连接器包括具有端子凹部和多个电端子的壳体。 端子凹部在端子凹槽的底部具有凹槽，并且从端子凹部的顶部延伸到嵌入凹槽，并且在嵌入凹槽的端部挖出开口。 电气端子包括基部，接触部和焊接部。 基部被容纳在嵌体凹部中。 接触部分延伸出接收腔，用于连接电池。 焊接部分被壳体的开口暴露。 如果在过度生产过程中机器省略焊接电池连接器的焊接部分，修理工可以通过外壳的打开将焊料补充到焊接部分。

    FPGA AND METHOD AND SYSTEM FOR CONFIGURING AND DEBUGGING A FPGA
    48.
    发明申请
    FPGA AND METHOD AND SYSTEM FOR CONFIGURING AND DEBUGGING A FPGA 有权
    用于配置和调试FPGA的FPGA和方法和系统

    公开(公告)号：US20080116919A1

    公开(公告)日：2008-05-22

    申请号：US11944408

    申请日：2007-11-21

    申请人： Yu Li ,  Guo Hui Lin ,  Qiang Liu ,  Yu Dong Yang

    发明人： Yu Li ,  Guo Hui Lin ,  Qiang Liu ,  Yu Dong Yang

    IPC分类号： G01R31/02

    CPC分类号： G01R31/31705 ,  G01R31/318519

    摘要： The present invention provides a Field Programmable Gate Array (FPGA), a system for debugging a Field Programmable Gate Array, a method for debugging a Field Programmable Gate Array, a FPGA configuration data product and a method and system for configuring a FPGA. According to one aspect of the invention, there is provided a Field Programmable Gate Array (FPGA) having a logic unit under test and comprising: a probe signal selecting unit configured to select at least one probe point from a plurality of probe points in said logic unit under test, and obtain a probe signal at said probe point; and a high speed serial transceiver configured to convert said probe signal into a high speed serial signal and transmit it to outside.

    摘要翻译： 本发明提供了现场可编程门阵列（FPGA），用于调试现场可编程门阵列的系统，用于调试现场可编程门阵列的方法，FPGA配置数据产品以及用于配置FPGA的方法和系统。 根据本发明的一个方面，提供了一种具有被测逻辑单元的现场可编程门阵列（FPGA），包括：探测信号选择单元，被配置为从所述逻辑中的多个探测点中选择至少一个探测点 并在所述探测点获取探测信号; 以及配置成将所述探测信号转换为高速串行信号并将其传输到外部的高速串行收发器。

    Reagents for the detection of protein phosphorylation in EGFR-signaling pathways
    49.
    发明申请
    Reagents for the detection of protein phosphorylation in EGFR-signaling pathways 有权
    用于检测EGFR-信号通路中蛋白质磷酸化的试剂

    公开(公告)号：US20080108795A1

    公开(公告)日：2008-05-08

    申请号：US11821130

    申请日：2007-06-21

    申请人： Ailan Guo ,  Kimberly Lee ,  Klarisa Rikova ,  Charles Farnsworth ,  Albrecht Moritz ,  Yu Li ,  Robert Polakiewicz

    发明人： Ailan Guo ,  Kimberly Lee ,  Klarisa Rikova ,  Charles Farnsworth ,  Albrecht Moritz ,  Yu Li ,  Robert Polakiewicz

    IPC分类号： C07K16/18

    CPC分类号： C07K16/2863 ,  C07B59/008 ,  C07K2317/34

    摘要： The invention discloses 168 novel phosphorylation sites identified in signal transduction proteins and pathways downstream of, and including, EGFR kinase, and provides phosphorylation-site specific antibodies and heavy-isotope labeled peptides (AQUA peptides) for the selective detection and quantification of these phosphorylated sites/proteins, as well as methods of using the reagents for such purpose. Among the phosphorylation sites identified are sites occurring in the following protein types: Actin Binding proteins, Adaptor/Scaffold proteins, Calcium-Binding Proteins, Cell Cycle Regulation proteins, Cytoskeletal proteins, DNA Binding and Replication Proteins, GTPase Activating proteins, Guanine Nucleotide Exchange Factor proteins, Lipid Kinases, Receptor Tyrosine Kinases, Receptor Tyrosine Kinase ligands, Protein Kinases, Receptor and Protein Phosphatases, Transcription Factor proteins, Tumor Suppressor proteins, and Vesicle proteins.

    摘要翻译： 本发明公开了在信号转导蛋白中识别的168个新的磷酸化位点和EGFR激酶下游和包括EGFR激酶的途径，并提供磷酸化位点特异性抗体和重同位素标记肽（AQUA肽），用于选择性检测和定量这些磷酸化位点 /蛋白质，以及使用试剂用于此目的的方法。 鉴定的磷酸化位点是以下蛋白质类型发生的位点：肌动蛋白结合蛋白，衔接/支架蛋白，钙结合蛋白，细胞周期调节蛋白，细胞骨架蛋白，DNA结合和复制蛋白，GTP酶激活蛋白，鸟嘌呤核苷酸交换因子 蛋白质，脂质激酶，受体酪氨酸激酶，受体酪氨酸激酶配体，蛋白激酶，受体和蛋白磷酸酶，转录因子蛋白，肿瘤抑制蛋白和囊泡蛋白。