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公开(公告)号：US09347053B2
公开(公告)日：2016-05-24
申请号：US14689900
申请日：2015-04-17
发明人： Leslie Ann Greene , Kyle P. Chiang , Fei Hong , Alain P. Vasserot , Wing-Sze Lo , Jeffry D. Watkins , Cheryl L. Quinn , John D. Mendlein
IPC分类号： C07K16/40 , G01N33/573 , C12N9/00 , A61K38/00
CPC分类号： C07K16/40 , A61K9/0019 , A61K38/00 , C07K2317/24 , C07K2317/34 , C07K2317/92 , C12N9/93 , C12Y601/01 , G01N33/573 , G01N2333/9015
摘要： Provided are compositions comprising newly identified protein fragments of aminoacyl-tRNA synthetases, polynucleotides that encode them and complements thereof, related agents, and methods of use thereof in diagnostic, drug discovery, research, and therapeutic applications.
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公开(公告)号：US09315794B2
公开(公告)日：2016-04-19
申请号：US14598717
申请日：2015-01-16
发明人： Leslie Ann Greene , Kyle P. Chiang , Fei Hong , Alain P. Vasserot , Wing-Sze Lo , Jeffry D. Watkins , Cheryl L. Quinn , John D. Mendlein
CPC分类号： C07K16/40 , A61K38/00 , A61K38/53 , C07K2317/24 , C07K2317/92 , C07K2319/00 , C12N9/93 , C12Y601/01 , G01N33/573 , G01N2333/9015
摘要： Provided are compositions comprising newly identified protein fragments of aminoacyl-tRNA synthetases, polynucleotides that encode them and complements thereof, related agents, and methods of use thereof in diagnostic, drug discovery, research, and therapeutic applications.
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公开(公告)号：US20160017311A1
公开(公告)日：2016-01-21
申请号：US14620565
申请日：2015-02-12
发明人： Leslie Ann Greene , Kyle P. Chiang , Fei Hong , Alain P. Vasserot , Wing-Sze Lo , Jeffry D. Watkins , Cheryl L. Quinn , John D. Mendlein
IPC分类号： C12N9/00 , C07K16/40 , A61K38/53 , G01N33/573
CPC分类号： C12N9/93 , A61K38/53 , C07K16/40 , C07K2317/21 , C07K2317/76 , C07K2317/92 , C12Y601/00 , C12Y601/01014 , G01N33/573 , G01N2333/9015
摘要： Provided are compositions comprising newly identified protein fragments of aminoacyl-tRNA synthetases, polynucleotides that encode them and complements thereof, related agents, and methods of use thereof in diagnostic, drug discovery, research, and therapeutic applications.
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44.发明申请INNOVATIVE DISCOVERY OF THERAPEUTIC, DIAGNOSTIC, AND ANTIBODY COMPOSITIONS RELATED TO PROTEIN FRAGMENTS OF PHENYLALANYL-ALPHA-TRNA SYNTHETASES 有权治疗，诊断和抗体组合物与苯丙氨酸 - 阿拉伯 - 泰恩合成蛋白质蛋白质相关的创新性发现公开(公告)号：US20150361410A1
公开(公告)日：2015-12-17
申请号：US14687760
申请日：2015-04-15
发明人： Leslie Ann Greene , Kyle P. Chiang , Fei Hong , Alain P. Vasserot , Wing-Sze Lo , Jeffry D. Watkins , Cheryl L. Quinn , John D. Mendlein
IPC分类号： C12N9/00 , A61K38/53 , C07K16/40 , G01N33/573
CPC分类号： C12N9/93 , A61K38/53 , C07K16/40 , C07K2317/34 , C07K2317/92 , C12N5/0602 , C12N9/96 , C12Y601/01 , C12Y601/0102 , G01N33/573 , G01N33/68 , G01N2333/9015
摘要： Provided are compositions comprising newly identified protein fragments of aminoacyl-tRNA synthetases, polynucleotides that encode them and complements thereof, related agents, and methods of use thereof in diagnostic, drug discovery, research, and therapeutic applications.
摘要翻译： 提供了包含新确定的氨酰-tRNA合成酶的蛋白质片段的组合物，编码它们的多核苷酸及其补体，相关试剂及其在诊断，药物发现，研究和治疗应用中的使用方法。
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45.发明申请INNOVATIVE DISCOVERY OF THERAPEUTIC, DIAGNOSTIC, AND ANTIBODY COMPOSITIONS RELATED TO PROTEIN FRAGMENTS OF METHIONYL-TRNA SYNTHETASIS 有权与甲硫氨酸合成酶蛋白质片段相关的治疗，诊断和抗体组合物的创新发现公开(公告)号：US20150284705A1
公开(公告)日：2015-10-08
申请号：US14619713
申请日：2015-02-11
发明人： Leslie Ann Greene , Kyle P. Chiang , Fei Hong , Alain P. Vasserot , Wing-Sze Lo , Jeffry D. Watkins , Cheryl L. Quinn , John D. Mendlein
IPC分类号： C12N9/00 , A61K38/53 , C07K16/40 , G01N33/573
CPC分类号： C07K16/40 , A61K38/53 , C07K2317/24 , C07K2317/622 , C07K2317/76 , C07K2317/92 , C12N5/0602 , C12N9/93 , C12N9/96 , C12Y601/01 , C12Y601/0101 , G01N33/573 , G01N33/68 , G01N2333/9015
摘要： Provided are compositions comprising newly identified protein fragments of aminoacyl-tRNA synthetases, polynucleotides that encode them and complements thereof, related agents, and methods of use thereof in diagnostic, drug discovery, research, and therapeutic applications.
摘要翻译： 提供了包含新确定的氨酰-tRNA合成酶的蛋白质片段的组合物，编码它们的多核苷酸及其补体，相关试剂及其在诊断，药物发现，研究和治疗应用中的使用方法。
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46.发明申请COMPOSITIONS AND METHODS COMPRISING HISTIDYL-TRNA SYNTHETASE SPLICE VARIANTS HAVING NON-CANONICAL BIOLOGICAL ACTIVITIES 有权包含具有非经济生物活性的HISTIDYL-TRNA SYNTHETASE SPLICE变量的组合物和方法公开(公告)号：US20140371294A1
公开(公告)日：2014-12-18
申请号：US14262272
申请日：2014-04-25
发明人： Jie Zhou , Ching-Fun Lau , Zhiwen Xu , Wing-Sze Lo , Kristi Helen Piehl , Leslie Ann Greene
IPC分类号： C12N15/113 , C12Q1/68
CPC分类号： C07K16/40 , A61K38/00 , C07K2317/24 , C07K2317/56 , C07K2317/622 , C07K2317/76 , C12N9/93 , C12N15/1137 , C12N2310/11 , C12N2310/14 , C12Q1/6876 , C12Q1/6886 , C12Q2600/136 , C12Q2600/156 , C12Y601/01021 , G01N33/573 , G01N2333/9015 , G01N2500/04 , G01N2500/10
摘要： Isolated histidyl-tRNA synthetase splice variant polynucleotides and polypeptides having non-canonical biological activities are provided, as well as compositions and methods related thereto.
摘要翻译： 提供了具有非规范生物活性的分离的组氨酰-tRNA合成酶剪接变体多核苷酸和多肽，以及与其相关的组合物和方法。
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公开(公告)号：US10717786B2
公开(公告)日：2020-07-21
申请号：US16012511
申请日：2018-06-19
发明人： Leslie Ann Greene , Kyle P. Chiang , Fei Hong , Alain P. Vasserot , Wing-Sze Lo , Jeffry D. Watkins , Cheryl L. Quinn , John D. Mendlein
IPC分类号： C07K16/40 , C12N9/00 , G01N33/573 , A61K39/395 , A61K38/00 , A61K39/00
摘要： Provided are compositions comprising newly identified protein fragments of aminoacyl-tRNA synthetases, polynucleotides that encode them and complements thereof, related agents, and methods of use thereof in diagnostic, drug discovery, research, and therapeutic applications.
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公开(公告)号：US10526419B2
公开(公告)日：2020-01-07
申请号：US16005045
申请日：2018-06-11
发明人： Jie Zhou , Ching-Fun Lau , Zhiwen Xu , Wing-Sze Lo , Kristi Helen Piehl , Leslie Ann Greene
IPC分类号： C07K16/40 , C12N9/00 , C12N15/113 , C12Q1/6886 , G01N33/573 , C12Q1/6876 , A61K38/00
摘要： Isolated histidyl-tRNA synthetase splice variant polynucleotides and polypeptides having non-canonical biological activities are provided, as well as compositions and methods related thereto.
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49.发明申请公开(公告)号：US20190264190A1
公开(公告)日：2019-08-29
申请号：US16215137
申请日：2018-12-10
发明人： Leslie Ann Greene , Kyle P. Chiang , Fei Hong , Alain P. Vasserot , Wing-Sze Lo , Jeffry Dean Watkins , Cheryl L. Quinn , John D. Mendlein
摘要： Provided are compositions comprising newly identified protein fragments of aminoacyl-tRNA synthetases, polynucleotides that encode them and complements thereof, related agents, and methods of use thereof in diagnostic, drug discovery, research, and therapeutic applications.
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公开(公告)号：US10220080B2
公开(公告)日：2019-03-05
申请号：US15599183
申请日：2017-05-18
发明人： Leslie Ann Greene , Kyle P. Chiang , Fei Hong , Alain P. Vasserot , Wing-Sze Lo , Jeffry D. Watkins , Cheryl L. Quinn , Zhiwen Xu , John D. Mendlein
IPC分类号： C12N9/00 , C12N9/96 , A61K38/00 , A61K38/53 , C07K16/40 , C12N5/071 , G01N33/573 , G01N33/68
摘要： Provided are compositions comprising newly identified protein fragments of aminoacyl-tRNA synthetases, polynucleotides that encode them and complements thereof, related agents, and methods of use thereof in diagnostic, drug discovery, research, and therapeutic applications.
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