公开(公告)号：US09096882B2

公开(公告)日：2015-08-04

申请号：US13651894

申请日：2012-10-15

Applicant: MSD Consumer Care, Inc.

Inventor： Thomas A. Meyer ,  Donathan G. Beasley

IPC: A61K49/00 ,  C12Q1/02 ,  A61K8/00 ,  A61P17/00 ,  A61Q19/02 ,  A61K8/37 ,  G01N33/50 ,  A61Q17/04 ,  A61K8/97 ,  A61K8/67

CPC classification number: G01N33/92 ,  A61K8/37 ,  A61K8/678 ,  A61K8/97 ,  A61K49/00 ,  A61K2800/522 ,  A61Q17/04 ,  C12Q1/025 ,  G01N33/502 ,  G01N33/5082 ,  G01N33/5088

Abstract: The invention provides antioxidant-containing compositions and methods for confirming antioxidant activity of a composition formulated for topical application to skin. The invention also provides methods for testing a composition for the ability to inhibit both ultraviolet radiation-induced lipid peroxidation on skin and ultraviolet radiation-induced reactive oxygen species formation in the stratum corneum as well as compositions and methods for treating and preventing photodamage to skin.

Abstract translation: 本发明提供含抗氧化剂的组合物和用于确认配制用于局部施用于皮肤的组合物的抗氧化活性的方法。 本发明还提供了用于测试组合物的方法，所述组合物能够抑制皮肤上的紫外线辐射诱导的脂质过氧化和角质层中紫外线辐射诱导的活性氧形成，以及用于治疗和预防对皮肤的光损伤的组合物和方法。

公开(公告)号：US08956662B2

公开(公告)日：2015-02-17

申请号：US11756881

申请日：2007-06-01

Applicant: David Monteith ,  John O'Mullane ,  Joseph P. Reo ,  Robert T. Nowak ,  Jiansheng Wan ,  Mohammed A. Kabir ,  Malaz A. Abutarif ,  Glenn E. Fritz

Inventor： David Monteith ,  John O'Mullane ,  Joseph P. Reo ,  Robert T. Nowak ,  Jiansheng Wan ,  Mohammed A. Kabir ,  Malaz A. Abutarif ,  Glenn E. Fritz

IPC: A61K31/137 ,  A61K31/4545 ,  A61K9/14 ,  A61P11/02 ,  A61P31/16 ,  A61P37/00 ,  A61K9/48 ,  A61K9/22 ,  A61K9/24 ,  A61K9/20

CPC classification number: A61K31/137 ,  A61K9/167 ,  A61K9/2054 ,  A61K9/209 ,  A61K9/5026 ,  A61K9/5042 ,  A61K31/4545 ,  A61K47/12 ,  A61K47/38

Abstract: The invention discloses a pharmaceutical composition comprising phenylephrine or a pharmaceutically acceptable salt thereof and an erodible layer which is for oral administration wherein the composition delivers phenylephrine or a pharmaceutically acceptable salt thereof via absorption in the colon. The pharmaceutical composition comprises a core comprising phenylephrine or a pharmaceutically acceptable salt thereof and an erodible layer which is in a time-dependent, pH-dependent, or colon-specific enzyme-dependent erodible layer that degrades to expose the core to release phenylephrine in the colon. In one preferred embodiment, the erodible layer encases the core. The composition optionally further comprises phenylephrine in the erodible layer or other additional layer(s). The pharmaceutical composition can further comprise one or more additional therapeutically active agents selected from one or more of the group consisting of antihistamines, analgesics, anti-pyretics, and non-steroidal anti-inflammatory agents. The invention also discloses methods of administering phenylephrine via the colon, thereby increasing the bioavailable amount of therapeutically active unconjugated phenylephrine relative to the total phenylephrine in the plasma.

Abstract translation: 本发明公开了一种药物组合物，其包含去氧肾上腺素或其药学上可接受的盐和用于口服给药的可溶性层，其中所述组合物通过在结肠中的吸收递送苯肾上腺素或其药学上可接受的盐。 药物组合物包含包含去氧肾上腺素或其药学上可接受的盐的核心和可溶性层，其处于时间依赖性，依赖于pH或结肠特异性的酶依赖性可溶解层，其降解以暴露核心以释放出去氧肾上腺素 结肠。 在一个优选实施例中，可侵蚀层包裹芯。 所述组合物任选地还包含可腐蚀层或其它附加层中的去氧肾上腺素。 药物组合物还可以包含一种或多种另外的治疗活性剂，其选自抗组胺剂，止痛剂，抗热解剂和非甾体抗炎剂中的一种或多种。 本发明还公开了通过结肠施用苯肾上腺素的方法，从而相对于血浆中的总去氧肾上腺素增加了治疗活性的非共轭去氧肾上腺素的生物可利用量。

公开(公告)号：USD717660S1

公开(公告)日：2014-11-18

申请号：US29407828

申请日：2011-12-02

Applicant: William Schmertz, Jr.

Designer： William Schmertz, Jr.

公开(公告)号：USRE45022E1

公开(公告)日：2014-07-22

申请号：US29415275

申请日：2012-03-08

Applicant: Heidi N. Graham ,  Kimberly Lyn McCormack ,  Laura Ann Flanagan-Kent

Inventor： Heidi N. Graham ,  Kimberly Lyn McCormack ,  Laura Ann Flanagan-Kent

公开(公告)号：US20140120039A1

公开(公告)日：2014-05-01

申请号：US14034802

申请日：2013-09-24

Applicant: MSD Consumer Care, Inc.

Inventor： Heidi Naomi Graham ,  Thomas A. Meyer ,  Stephen E. Baldwin

IPC: A61K8/04 ,  A61Q19/00 ,  A61Q17/04 ,  A61K8/19 ,  A61K8/365

CPC classification number: A61K8/046 ,  A61K8/19 ,  A61K8/365 ,  A61K9/0014 ,  A61K2800/222 ,  A61K2800/87 ,  A61Q17/04 ,  A61Q19/00

Abstract: In one aspect, the present invention is directed to formulations comprising at least one pressure generating vehicle along with at least one skincare active agent in a container such that the pressure generating vehicle would eject the formulation as foam, whipped cream or a similar form upon application of external pressure on the container.

Abstract translation: 在一个方面，本发明涉及包含至少一种压力产生载体以及在容器中的至少一种护肤活性剂的制剂，使得压力产生载体将在施用时将制剂作为泡沫，搅打奶油或类似形式喷射 容器上的外部压力。

公开(公告)号：US20140033829A1

公开(公告)日：2014-02-06

申请号：US14052297

申请日：2013-10-11

Applicant: MSD Consumer Care, Inc.

Inventor： Bin Xia ,  Harold A. Howlett ,  Charles E. Lundy

IPC: A43D1/02

CPC classification number: G06Q30/0631 ,  A43B7/24 ,  A43D1/02 ,  A43D1/022 ,  A43D1/08 ,  A61B5/1036 ,  G06Q20/20

Abstract: A kiosk apparatus that may select for a person a recommended footcare product based on pressure measurements collected from pressures sensors or calculated biomechanical data estimates. Pressure measurements and calculated biomechanical data estimates may be used to determine if a foot is unshod on the pressure sensor and also group a person into a classified subgroup. The pressure measurement and calculated biomechanical data estimates may also be used to select a recommended footcare product.

公开(公告)号：US20130326906A1

公开(公告)日：2013-12-12

申请号：US13969949

申请日：2013-08-19

Applicant: MSD Consumer Care, Inc.

Inventor： Harold A. Howlett ,  Bin Xia ,  Philip C. Yang

IPC: A43B13/38 ,  A43B13/40

CPC classification number: A43B13/386 ,  A43B7/142 ,  A43B7/144 ,  A43B7/223 ,  A43B13/38 ,  A43B13/40 ,  A43B17/006 ,  A43B17/023 ,  A43D1/02 ,  A43D999/00 ,  A61B5/1036 ,  A61B5/1074 ,  A61B5/411 ,  A61B5/6892 ,  A61B2562/0247 ,  A61B2562/046 ,  A61F5/14 ,  G06Q30/06

Abstract: An orthotic is disclosed. The orthotic may include a cushioning layer configured to extend from at least the metatarsal region to the proximal heel region, the cushioning layer having a heel region with a protruding heel piece integrally molded as part of the cushioning layer. The orthotic may also include an outer shell layer fixedly coupled to the cushioning layer, the outer shell layer extending longitudinally from at least the medial cuneiform-first metatarsal joint region to the calcaneus bone region of the user, the outer shell layer configured to receive the protruding heel piece.

公开(公告)号：US20130123806A1

公开(公告)日：2013-05-16

申请号：US13293902

申请日：2011-11-10

Applicant: Harold A. Howlett ,  John W. Davis ,  Ronald M. Feret

Inventor： Harold A. Howlett ,  John W. Davis ,  Ronald M. Feret

IPC: A61B17/50

CPC classification number: A61B17/50 ,  A61B17/08 ,  A61B17/083 ,  A61B2017/00747 ,  A61B2017/00761 ,  A61B2017/00774

Abstract: A device for occlusion of a skin tag projecting from a skin area includes a pressure layer having an upper side, an underside, and configured to enclose the skin tag and occlude blood flow to the enclosed skin tag, the pressure layer including a base member having an upper side, an underside, and configured to enclose the skin tag, at least one first planar spring connected to a first side of the base member at one end of the first planar spring, and a first occlusion member connected to an other end of the first planar spring for applying an occlusion force to the enclosed skin tag, and a top layer attached to the upper side of the pressure layer, the top layer covering at least a portion of the first planar spring, and the top layer having a hole configured to receive the enclosed skin tag.

Abstract translation: 用于从皮肤区域突出的皮肤标签的闭塞装置包括具有上侧，下侧的压力层，并且构造成包围皮肤标签，并将血液阻塞到封闭的皮肤标签上，该压力层包括具有 上侧，下侧，并且构造成包围皮肤标签;至少一个第一平面弹簧，其连接到第一平面弹簧的一端处的基部构件的第一侧;以及第一遮挡构件，其连接到第二平面弹簧的另一端 用于向封闭的皮肤标签施加闭塞力的第一平面弹簧和附着到压力层的上侧的顶层，顶层覆盖第一平面弹簧的至少一部分，顶层具有孔 配置为接收封闭的皮肤标签。

公开(公告)号：USD675412S1

公开(公告)日：2013-02-05

申请号：US29362665

申请日：2010-05-28

Applicant: Karla Klein ,  Pamela Curtiss ,  Brendan Reilly ,  Theresa Chee ,  Richard T. Avent ,  Swapna Purani ,  Leanne Blair ,  David Contract ,  Christopher Cortina ,  Elizabeth Morgan

Designer： Karla Klein ,  Pamela Curtiss ,  Brendan Reilly ,  Theresa Chee ,  Richard T. Avent ,  Swapna Purani ,  Leanne Blair ,  David Contract ,  Christopher Cortina ,  Elizabeth Morgan

公开(公告)号：US08328449B2

公开(公告)日：2012-12-11

申请号：US13301379

申请日：2011-11-21

Applicant: James C. Wightman ,  Michael Furey ,  Jeff Hayet ,  Robert C. Johnson

Inventor： James C. Wightman ,  Michael Furey ,  Jeff Hayet ,  Robert C. Johnson

IPC: B43K5/06

CPC classification number: A61M5/3156 ,  A45D34/042 ,  A45D2200/051 ,  A45D2200/055 ,  A46B11/0055 ,  A46B11/0058

Abstract: A click pen applicator device that provides predetermined dosing of the formulation for precise application, and rapidly primes the formulation using the dosing click mechanism to prepare the applicator for use.

Abstract translation: 一种点击式笔式涂抹器装置，其提供用于精确应用的配方的预定剂量，并使用计量点击机构快速注射制剂以制备使用的施用器。