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41.发明授权Net blanket for use as a holding harness for urine collecting devices for horses 有权网毯用作用于马的尿液收集装置的固定线束公开(公告)号：US07121069B2
公开(公告)日：2006-10-17
申请号：US10740838
申请日：2003-12-22
申请人： Martin Frink , Zoltan Magosi
发明人： Martin Frink , Zoltan Magosi
IPC分类号： B68C5/00
CPC分类号： A01K23/00 , A01K13/008
摘要： A net blanket for a horse for use as an easy-to-handle holding harness for flexible and easily replaceable attachment of a urine collecting device to the horse, which net blanket comprises a net (1) for covering the predominant part of the horse's rump, the net blanket at the sides reaching down to at most approximately the lower rump line and being closed or closable in front of the breast of the horse (2). The net blanket according to the invention is useful to flexibly suspend a urine collecting device for obtaining a natural mixture of conjugated estrogens from pregnant mares' urine.
摘要翻译： 一种用于马的网毯，用作易于操作的固定线束，用于将尿液收集装置灵活且容易地替换为马，该网毯包括用于覆盖马的臀部的主要部分的网（1） ，两侧的网毯至少接近大约下臀部线，并且在马（2）的乳房前方关闭或关闭。 根据本发明的网毯可用于灵活地悬挂尿液收集装置，以获得来自怀孕母马尿的共轭雌激素的天然混合物。
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42.发明申请Pharmaceutical compositions comprising NEP-inhibitors, inhibitors of the endogenous producing system and PDEV inhibiitors 审中-公开包含NEP-抑制剂，内源性生产系统的抑制剂和PDEV抑制剂的药物组合物公开(公告)号：US20050267124A1
公开(公告)日：2005-12-01
申请号：US11127163
申请日：2005-05-12
申请人： Dieter Ziegler , Klaus Witte , Matthias Straub , Michael Weske , Dagmar Hoeltje
发明人： Dieter Ziegler , Klaus Witte , Matthias Straub , Michael Weske , Dagmar Hoeltje
IPC分类号： A61K31/519
CPC分类号： A61K45/06 , A61K31/519 , A61K31/5513 , A61K2300/00
摘要： A combination therapy for the inhibition and/or treatment of sexual dysfunction and/or cardiovascular diseases in humans and other mammals, by administering a synergistic combination of at least one inhibitor of neutral endopeptidase, at least one inhibitor of the endogenous endothelin producing system, and at least one inhibitor of phosphodiesterase 5.
摘要翻译： 一种用于抑制和/或治疗人类和其他哺乳动物中的性功能障碍和/或心血管疾病的组合疗法，其通过施用至少一种中性内肽酶抑制剂，至少一种内源性内皮素产生系统的抑制剂和 至少一种磷酸二酯酶抑制剂5。
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43.发明申请公开(公告)号：US20050250817A1
公开(公告)日：2005-11-10
申请号：US11085073
申请日：2005-03-22
CPC分类号： A61K38/54 , A61K9/1075 , A61K9/1617 , A61K9/1641 , A61K31/22 , A61K31/745 , A61K38/465 , A61K38/47 , A61K38/48 , A61K2300/00
摘要： Orally administrable pharmaceutical compositions of lipase-containing products, particularly pancreatin and pancreatin-containing products, or of enzyme products which contain at least one lipase of non-animal, especially microbial origin, which improve the lipolytic activity and particularly result in stabilization of the lipase in the acidic pH range. These oral pharmaceutical compositions contain a system which includes at least one surfactant and one co-surfactant and optionally a lipophilic phase, and are self-emulsifiable on contact with a hydrophilic and a lipophilic phase. The compositions according to the invention are suitable for treating or inhibiting maldigestion, especially maldigestion due to chronic exocrine pancreatic insufficiency, in mammals and humans.
摘要翻译： 含有脂肪酶的产品，特别是胰酶和含胰酶的产品的口服给药的药物组合物，或含有至少一种非动物，特别是微生物来源的脂肪酶的酶产品，其可改善脂肪分解活性并特别导致脂肪酶稳定 在酸性pH范围内。 这些口服药物组合物含有包含至少一种表面活性剂和一种辅助表面活性剂和任选的亲油相的系统，并且在亲水相和亲油相接触时是自乳化的。 根据本发明的组合物适用于治疗或抑制哺乳动物和人类的消化不良，特别是由于慢性外分泌胰腺功能不全引起的消化不良。
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公开(公告)号：US20050192263A1
公开(公告)日：2005-09-01
申请号：US10983887
申请日：2004-11-09
申请人： Josef Messinger , Heinrich-Hubert Thole , Bettina Husen , Bartholomeus Van Steen , Gyula Schneider , Johannes Bernardus Hulshof , Pasi Koskimies , Nina Johansson , Jerzy Adamski
发明人： Josef Messinger , Heinrich-Hubert Thole , Bettina Husen , Bartholomeus Van Steen , Gyula Schneider , Johannes Bernardus Hulshof , Pasi Koskimies , Nina Johansson , Jerzy Adamski
CPC分类号： C07J1/0059 , C07J21/008 , C07J41/0044 , C07J43/003
摘要： 3,15-substituted estrone compounds which act as inhibitors of 17β-hydroxysteroid dehydrogenase type I (17β-HSD1), salts thereof, pharmaceutical preparations containing such compounds, processes for preparing such compounds, and therapeutic uses of such compounds, particularly in the treatment or inhibition of steroid hormone dependent diseases or disorders, such as steroid hormone dependent diseases or disorders requiring the inhibition of 17β-hydroxysteroid dehydrogenase type I enzymes and/or requiring the lowering of the endogenous 17β-estradiol concentration, as well as the general use of selective 17β-hydroxysteroid dehydrogenase type 1 inhibitors which possess in addition no or only pure antagonistic binding affinities to the estrogen receptor for the treatment or inhibition of benign gynecological disorders, particularly endometriosis.
摘要翻译： 作为17β-羟类固醇脱氢酶I型（17β-HSD1）的抑制剂的3,15-取代的雌酮化合物，其盐，含有这些化合物的药物制剂，制备这些化合物的方法，以及这些化合物的治疗用途，特别是在治疗 或抑制类固醇激素依赖性疾病或病症，例如需要抑制17β-羟类固醇脱氢酶I型酶和/或需要降低内源性17β-雌二醇浓度的类固醇激素依赖性疾病或病症，以及一般使用 具有额外的选择性17β-羟类固醇脱氢酶1型抑制剂，其除了雌激素受体之外还没有纯化的拮抗性结合亲和力，用于治疗或抑制良性妇科疾病，特别是子宫内膜异位症。
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公开(公告)号：US20050101811A1
公开(公告)日：2005-05-12
申请号：US11008109
申请日：2004-12-10
申请人： Max Braun , Kerstin Eichholz , Stefan Palsherm , Carsten Brosch
发明人： Max Braun , Kerstin Eichholz , Stefan Palsherm , Carsten Brosch
IPC分类号： C07C17/04 , C07C17/10 , C07C17/395 , C07C19/043 , C07C19/08 , C07C19/12 , C07C17/00
摘要： A method of producing alkanes containing chlorine by addition of chlorine to C—C double bonds or C—C triple bonds or by exchange of hydrogen for chlorine by contacting the starting compound in the gas or liquid phase with elemental chlorine and irradiating the reaction mixture with UV light having a wavelength of λ>280 nm. In this way pentachloroethane can be produced from trichloroethylene, CFC-113 from HCFC-123 or HFC-133a, CFC-112a from HCFC-142b, or HCFC-123 from HCFC-133a. The method also is suitable for separating photochlorinatable impurities from HFC-365-mfc to obtain purified HFC-365-mfc. Advantages include high yields and excellent selectivity.
摘要翻译： 通过将氯气加入到CC双键或CC三键中，或通过使气相或液相中的起始化合物与元素氯接触并将反应混合物与具有 波长> 280nm。 以这种方式，可以从三氯乙烯，来自HCFC-123的CFC-113或HFC-133a，来自HCFC-142b的CFC-112a或来自HCFC-133a的HCFC-123制备五氯乙烷。 该方法也适用于从HFC-365-mfc分离光可氯化杂质，得到纯化的HFC-365-mfc。 优点包括高产率和极好的选择性。
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![4- (4-trans-hydroxycyclohexyl)amino-2-phenyl-7H-pyrrolo [2,3D] pyrimidine hydrogen mesylate, its polymorphic forms, and methods for making same](/abs-image/US/2004/12/09/US20040248912A1/abs.jpg.150x150.jpg)
46.发明申请4- (4-trans-hydroxycyclohexyl)amino-2-phenyl-7H-pyrrolo [2,3D] pyrimidine hydrogen mesylate, its polymorphic forms, and methods for making same 有权4-（4-反 - 羟基环己基）氨基-2-苯基-7H-吡咯并[2,3d]嘧啶氢甲磺酸盐，其多晶型物及其制备方法公开(公告)号：US20040248912A1
公开(公告)日：2004-12-09
申请号：US10828650
申请日：2004-04-21
发明人： Axel Pahl , Timo Heinrich , Emil Finner , Bernd-Martin Luitjens , Jan Zorgdrager , Pieter C. Verveer
IPC分类号： A61K031/519
CPC分类号： C07D487/04
摘要： The present invention relates to the novel compound 4-(4-trans-hydroxycyclohexyl)amino-2-phenyl-7H-pyrrolonull2,3dnullpyrimidine hydrogen mesylate, the polymorphic null and null forms thereof, and a method for the production of said compounds.
摘要翻译： 本发明涉及新化合物4-（4-反 - 羟基环己基）氨基-2-苯基-7H-吡咯并[2,3d]嘧啶氢甲磺酸盐，其多晶型α和β形式，以及制备 所述化合物。
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47.发明申请Net blanket for use as a holding harness for urine collecting devices for horses 有权网毯用作用于马的尿液收集装置的固定线束公开(公告)号：US20040194436A1
公开(公告)日：2004-10-07
申请号：US10740838
申请日：2003-12-22
发明人： Martin Frink , Zoltan Magosi
IPC分类号： B68C005/00
CPC分类号： A01K23/00 , A01K13/008
摘要： A net blanket for a horse for use as an easy-to-handle holding harness for flexible and easily replaceable attachment of a urine collecting device to the horse, which net blanket comprises a net (1) for covering the predominant part of the horse's rump, the net blanket at the sides reaching down to at most approximately the lower rump line and being closed or closable in front of the breast of the horse (2). The net blanket according to the invention is useful to flexibly suspend a urine collecting device for obtaining a natural mixture of conjugated estrogens from pregnant mares' urine.
摘要翻译： 一种用于马的网毯，用作易于操作的固定线束，用于将尿液收集装置灵活且容易地替换为马，该网毯包括用于覆盖马的臀部的主要部分的网（1） ，两侧的网毯至少接近大约下臀部线，并且在马（2）的乳房前方关闭或关闭。 根据本发明的网毯可用于灵活地悬挂尿液收集装置，以获得来自怀孕母马尿的共轭雌激素的天然混合物。
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公开(公告)号：US20040162345A1
公开(公告)日：2004-08-19
申请号：US10715112
申请日：2003-11-18
发明人： Claudia Berger , Yvan Fischer , Dagmar Hoeltje , Harald Waldeck , Michael Weske , Dieter Ziegler
IPC分类号： A61K031/185
摘要： Compounds having combined, particularly concurrent, inhibitory activity on neutral endopeptidase (NEP) and on a novel metalloprotease designated IGS5, or of a pharmaceutically acceptable salt or solvate or biolabile ester thereof, and related methods for treating and for the manufacture of a pharmaceutical composition for a mammal, preferably a larger mammal such as a human, suffering from or being susceptible to a disease or condition which can be alleviated or inhibited by combined or concurrent inhibition of NEP and IGS5. Treatments for diseases or conditions where big-ET-1 levels are elevated, or where ET-1 is upregulated, where such diseases or conditions can be alleviated or inhibited by combined or concurrent inhibition of NEP and IGS5.
摘要翻译： 对中性内肽酶（NEP）和指定为IGS5的新型金属蛋白酶或其药学上可接受的盐或溶剂合物或生物不稳定酯具有组合，特别并发的抑制活性的化合物，以及用于治疗和制备药物组合物的相关方法 哺乳动物，优选较大的哺乳动物（例如人）患有或易患有疾病或病症，可以通过NEP和IGS5的组合或同时抑制而被缓解或抑制。 治疗大ET-1水平升高或ET-1上调的疾病或病症，其中可以通过NEP和IGS5的组合或同时抑制来缓解或抑制这些疾病或病症。
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49.发明申请公开(公告)号：US20040138278A1
公开(公告)日：2004-07-15
申请号：US10612391
申请日：2003-07-03
发明人： Harmut Kueppers , Jochen Schrader
IPC分类号： A61K031/4184
CPC分类号： A61K31/41 , A61K31/415 , A61K31/4184
摘要： A method of preventing or inhibiting subsequent strokes by administering an AT1-receptor antagonist, in particular eprosartan, to a patient who has previously suffered a first stroke.
摘要翻译： 一种通过将AT1受体拮抗剂（特别是依普罗沙坦）给予先前患有第一次中风的患者来预防或抑制随后的中风的方法。
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公开(公告)号：US20040057944A1
公开(公告)日：2004-03-25
申请号：US10620759
申请日：2003-07-17
IPC分类号： A61K038/54
CPC分类号： A61K45/06 , A61K9/1641 , A61K9/1652 , A61K38/465 , A61K38/47 , A61K38/48 , A61K2300/00
摘要： Mixtures of microbial enzymes containing a concentrated Rhizopus delemar lipase, an Aspergillus melleus protease and an Aspergillus oryzae amylase; pharmaceutical preparations containing such mixtures; and the use of such mixtures in methods of treatment and/or prophylaxis of maldigestion, especially maldigestion caused by pancreatic insufficiency, in humans or other mammals.
摘要翻译： 含有浓缩的根霉属（Rhizopus delemar）脂肪酶，曲霉曲霉（Aspergillus melleus）蛋白酶和米曲霉淀粉酶的微生物酶的混合物; 含有这些混合物的药物制剂; 以及在人或其它哺乳动物中治疗和/或预防由于胰腺功能不全引起的消化不良，特别是消化不良的方法中使用这些混合物。
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