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公开(公告)号：US5481029A
公开(公告)日：1996-01-02
申请号：US233622
申请日：1994-04-26
Applicant: Max Braun , Johannes Eicher , Werner Rudolph , Kerstin Eichholz
Inventor： Max Braun , Johannes Eicher , Werner Rudolph , Kerstin Eichholz
IPC: B01J31/02 , C07B61/00 , C07C45/48 , C07C45/65 , C07C45/67 , C07C49/04 , C07C49/167 , C07C67/10 , C07C67/313 , C07C67/343 , C07C69/63 , C07C69/716
CPC classification number: C07C45/48 , C07C45/676 , C07C49/167 , C07C67/10
Abstract: A process for preparing ketones, for example CF.sub.3 C(O)CH.sub.3, CF.sub.3 C(O)CH.sub.2 C(O)CF.sub.3 and CF.sub.3 C(O)CF.sub.2 H, in which .beta.-ketoesters are transesterified and decarboxylated using a carboxylic acid, for example trifluoroacetic acid, in the presence of a catalyst, particularly an "onium" salt of a carboxylic acid or an effective amount of a proton-donating acid, preferably a sulfonic acid such as alkyl- or arylsulfonic acids, or a mineral acid. The process is advantageously carried out in the absence of water, so that no formation of acetals or hydrates occurs, and no dehydrating step is needed. The process is simple to carry out, and if transesterification is carried out with a sufficiently active carboxylic acid, for example with trifluoroacetic acid, the presence of an additional catalyst is unnecessary.
Abstract translation: 制备酮的方法，例如CF 3 C（O）CH 3，CF 3 C（O）CH 2 C（O）CF 3和CF 3 C（O）CF 2 H），其中β-酮酯使用羧酸（例如三氟乙酸）进行酯交换和脱羧 存在催化剂，特别是羧酸的“鎓”盐或有效量的质子供体酸，优选磺酸如烷基或芳基磺酸或无机酸。 该方法有利地在没有水的情况下进行，使得不会发生缩醛或水合物的形成，并且不需要脱水步骤。 该方法很容易进行，如果用足够活泼的羧酸（例如三氟乙酸）进行酯交换反应，则不需要另外的催化剂的存在。
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公开(公告)号：US20100181186A1
公开(公告)日：2010-07-22
申请号：US12668779
申请日：2008-07-16
Applicant: Ercan Uenveren , Eckhard Hausmann , Johannes Eicher , Kerstin Eichholz
Inventor： Ercan Uenveren , Eckhard Hausmann , Johannes Eicher , Kerstin Eichholz
CPC classification number: C07C17/395 , C07C51/58 , C07C19/08 , C07C53/46 , C07C53/48
Abstract: The invention consequently relates, in one aspect, to a process for obtaining a hydrofluoroalkane comprising at least two carbon atoms, which is purified of unsaturated organic impurities, according to which the hydrofluoroalkane containing organic impurities including (chloro)fluoro olefins is subjected to at least one purification treatment with bromine or BrCl, preferably in the presence of, an initiator. The process is suitable, for example, to purify 1,1,1,2-tetrafluoroethane. A further aspect concerns the application of LEDs or OLEDs to support chemical reactions of the gas-gas, liquid-liquid or gas-liquid type, and a respective reactor.
Abstract translation: 因此，本发明在一方面涉及一种获得含有至少两个碳原子的氢氟烷烃的方法，该方法是不饱和有机杂质的纯化，根据该方法，含有（氯）氟烯烃的有机杂质的含氟氟烷烃至少经受 用溴或BrCl进行一次净化处理，优选在引发剂存在下进行。 该方法例如用于纯化1,1,1,2-四氟乙烷是合适的。 另一方面涉及LED或OLED的应用以支持气体，液体或气液型以及相应的反应器的化学反应。
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公开(公告)号：US07282120B2
公开(公告)日：2007-10-16
申请号：US11008109
申请日：2004-12-10
Applicant: Max Braun , Kerstin Eichholz , Stefan Palsherm , Carsten Brosch
Inventor： Max Braun , Kerstin Eichholz , Stefan Palsherm , Carsten Brosch
Abstract: A method of producing alkanes containing chlorine by addition of chlorine to C—C double bonds or C—C triple bonds or by exchange of hydrogen for chlorine by contacting the starting compound in the gas or liquid phase with elemental chlorine and irradiating the reaction mixture with UV light having a wavelength of λ≧280 nm. In this way pentachloroethane can be produced from trichloroethylene, CFC-113 from HCFC-123 or HFC-133a, CFC-112a from HCFC-142b, or HCFC-123 from HCFC-133a. The method also is suitable for separating photochlorinatable impurities from HFC-365-mfc to obtain purified HFC-365-mfc. Advantages include high yields and excellent selectivity.
Abstract translation: 通过将氯气加入到CC双键或CC三键中，或通过使气相或液相中的起始化合物与元素氯接触并将反应混合物与具有 λ> 280nm波长。 以这种方式，可以从三氯乙烯，来自HCFC-123的CFC-113或HFC-133a，来自HCFC-142b的CFC-112a或来自HCFC-133a的HCFC-123制备五氯乙烷。 该方法也适用于从HFC-365-mfc分离光可氯化杂质，得到纯化的HFC-365-mfc。 优点包括高产率和极好的选择性。
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公开(公告)号：US20050267290A1
公开(公告)日：2005-12-01
申请号：US10944418
申请日：2004-09-20
Applicant: Max Braun , Kerstin Eichholz
Inventor： Max Braun , Kerstin Eichholz
IPC: B01J19/06 , B01J19/22 , C07C231/02 , C07C233/05 , C07K1/02 , C07K14/00
CPC classification number: B01J19/22 , B01J19/06 , C07C231/02 , C07C233/05
Abstract: A method and apparatus suitable, inter alia, for producing carboxylic acid amides from carboxylic acid esters and amines in which a mixture of amide and alcohol is obtained, the mixture is maintained in a liquid state, and the alcohol which is released is progressively evaporated, after which the liquid carboxylic acid freed from alcohol contamination is discharged from the reactor, divided into small portions, and the small portions are converted by cooling into solid particles. The method and apparatus can also be used to prepare peptides and other solid organic compounds, generally.
Abstract translation: 特别是适用于从羧酸酯和胺制备羧酸酰胺的方法和装置，其中酰胺和醇的混合物得到，混合物保持液态，并且释放的醇逐渐蒸发， 之后将不含醇污染的液体羧酸从反应器中排出，分成小部分，通过冷却将小部分转化成固体颗粒。 通常该方法和装置也可用于制备肽和其它固体有机化合物。
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5.发明授权
公开(公告)号：US5405991A
公开(公告)日：1995-04-11
申请号：US233623
申请日：1994-04-26
Applicant: Heinz-Rudi Feist , Wilhelm Pohlmeyer , Joachim Frehse , Werner Rudolph , Max Braun , Kerstin Eichholz
Inventor： Heinz-Rudi Feist , Wilhelm Pohlmeyer , Joachim Frehse , Werner Rudolph , Max Braun , Kerstin Eichholz
IPC: B01J31/04 , C07B61/00 , C07C67/14 , C07C69/14 , C07C69/145 , C07C69/157 , C07C69/24 , C07C69/63 , C07C69/76 , C07C69/767 , C07C211/63 , C07C67/00
CPC classification number: C07C211/63 , C07C67/14
Abstract: A process for preparing carboxylic esters from carboxylic acid halides or carboxylic anhydrides by reacting one of these starting materials with an alcohol under the catalytic action of "onium" or metal salts of carboxylic acids to obtain high yields of products in anhydrous form in a technically simple manner. The process is especially well suited for preparing 1,1,1-trifluoroethyl trifluoroacetate.
Abstract translation: 通过使这些原料之一与醇在“鎓”或羧酸金属盐的催化作用下反应从羧酸卤化物或羧酸酐制备羧酸酯的方法，以技术上简单的方式获得无水形式的高产率产物 方式。 该方法特别适用于制备1,1,1-三氟乙基三氟乙酸盐。
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Patent Agency Ranking
公开(公告)号：US20050101811A1
公开(公告)日：2005-05-12
申请号：US11008109
申请日：2004-12-10
Applicant: Max Braun , Kerstin Eichholz , Stefan Palsherm , Carsten Brosch
Inventor： Max Braun , Kerstin Eichholz , Stefan Palsherm , Carsten Brosch
IPC: C07C17/04 , C07C17/10 , C07C17/395 , C07C19/043 , C07C19/08 , C07C19/12 , C07C17/00
Abstract: A method of producing alkanes containing chlorine by addition of chlorine to C—C double bonds or C—C triple bonds or by exchange of hydrogen for chlorine by contacting the starting compound in the gas or liquid phase with elemental chlorine and irradiating the reaction mixture with UV light having a wavelength of λ>280 nm. In this way pentachloroethane can be produced from trichloroethylene, CFC-113 from HCFC-123 or HFC-133a, CFC-112a from HCFC-142b, or HCFC-123 from HCFC-133a. The method also is suitable for separating photochlorinatable impurities from HFC-365-mfc to obtain purified HFC-365-mfc. Advantages include high yields and excellent selectivity.
Abstract translation: 通过将氯气加入到CC双键或CC三键中，或通过使气相或液相中的起始化合物与元素氯接触并将反应混合物与具有 波长> 280nm。 以这种方式，可以从三氯乙烯，来自HCFC-123的CFC-113或HFC-133a，来自HCFC-142b的CFC-112a或来自HCFC-133a的HCFC-123制备五氯乙烷。 该方法也适用于从HFC-365-mfc分离光可氯化杂质，得到纯化的HFC-365-mfc。 优点包括高产率和极好的选择性。
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公开(公告)号：US06583313B1
公开(公告)日：2003-06-24
申请号：US09113547
申请日：1998-07-10
Applicant: Max Braun , Kerstin Eichholz , Werner Rudolph
Inventor： Max Braun , Kerstin Eichholz , Werner Rudolph
IPC: C07C6708
Abstract: The methyl and ethyl esters of trifluoroacetic acid or chlorodifluoroacetic acid can be prepared in a technically simple manner from the corresponding acid chlorides and methanol or ethanol, respectively, in the presence of an “onium” salt of the acid as a catalyst. The alcohol is used in a stoichiometric excess, namely the molar ratio of alcohol to acid chloride is selected such that operation is in the region of a two-phase reaction. One of the phases is formed by the desired ester product, which is obtained in a high purity without any distillation.
Abstract translation: 在酸的“鎓”盐作为催化剂存在下，三氟乙酸或氯代二氟乙酸的甲酯和乙酯可以分别由相应的酰氯和甲醇或乙醇以技术上简单的方式制备。 醇以化学计量过量使用，即选择醇与酰氯的摩尔比，使得操作在两相反应的区域。 其中一个阶段由所需的酯产物形成，其在没有任何蒸馏的情况下以高纯度获得。
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公开(公告)号：US06252105B1
公开(公告)日：2001-06-26
申请号：US09348072
申请日：1999-07-06
Applicant: Max Braun , Johannes Eicher , Francine Janssens , Kerstin Eichholz , Stefan Palsherm
Inventor： Max Braun , Johannes Eicher , Francine Janssens , Kerstin Eichholz , Stefan Palsherm
IPC: C07C6963
CPC classification number: C07C67/56 , C07C51/47 , C07C51/64 , C07C53/18 , C07C67/14 , C07C67/58 , C07C53/48 , C07C59/195 , C07C69/63 , C07C69/72
Abstract: Organic compounds, e.g. fluorinated organic compounds such as fluorinated carboxylic acids or fluorinated carboxylic acid chlorides, may contain small amounts of carboxylic acid fluorides, hydrogen fluoride or hydrolyzable fluoride, which during the preparation of derivatives of the fluorinated organic compounds, for example by esterification, may yield corrosive fluorides or hydrogen fluoride. The invention is a method for the synthesis and/or purification of preferably fluorinated organic compounds such as carboxylic acids, carboxylic acid chlorides and derivatives such as esters thereof, starting from corresponding carboxylic acid chlorides containing acid fluorides or hydrolyzable fluoride, and alcohols under the catalytic action of “onium” salts of carboxylic acids, to obtain products which have a low fluoride content. Alternatively, an inorganic oxide adsorbent is utilized. The method is especially suitable for the synthesis of esters of trifluoroacetic acid, chlorodifluoroacetic acid, trifluoroacetoacetic acid and/or difluoroacetoacetic acid.
Abstract translation: 有机化合物，例如 含氟有机化合物如氟化羧酸或氟化羧酸氯化物可含有少量羧酸氟化物，氟化氢或水解性氟化物，其在氟化有机化合物衍生物的制备过程中，例如通过酯化反应，可产生腐蚀性氟化物 或氟化氢。 本发明是一种合成和/或纯化优选氟化有机化合物如羧酸，羧酸氯化物及其衍生物如酯的方法，起始于含有酸性氟化物或可水解氟化物的相应的羧酸氯化物和催化剂下的醇 羧酸的“鎓”盐的作用，以获得具有低氟含量的产物。 或者，使用无机氧化物吸附剂。 该方法特别适用于三氟乙酸，氯二氟乙酸，三氟乙酰乙酸和/或二氟乙酰乙酸的酯的合成。
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9.发明授权Process for preparing polyfluorocarboxylic acid chlorides and perfluorocarboxylic acid chlorides 失效制备多氟羧酸氯化物和全氟羧酸氯化物的方法
公开(公告)号：US5545298A
公开(公告)日：1996-08-13
申请号：US288070
申请日：1994-08-10
Applicant: Max Braun , Werner Rudolph , Kerstin Eichholz
Inventor： Max Braun , Werner Rudolph , Kerstin Eichholz
CPC classification number: C07C51/58
Abstract: A process for preparing compounds corresponding to the formula RCFXC(O)Cl, in which X is fluorine or chlorine and R is fluorine or a perfluorinated C1- C10-alkyl group, preferably chlorodifluoroacetyl chloride, by photochemical oxidation of R122 (CF.sub.2 ClCHCl.sub.2) and the preparation of trifluoroacetyl chloride by photochemical oxidation of R123 (CF.sub.3 CHCl.sub.2) with oxygen under irradiation. The reaction is preferably carried out without pressurization and without addition of elemental chlorine.
Abstract translation: 通过R122（CF2ClCHCl2）的光化学氧化制备对应于式RCFXC（O）Cl的化合物的方法，其中X是氟或氯，R是氟或全氟化的C 1-10烷基，优选氯二氟乙酰氯 通过R123（CF3CHCl2）与氧照射下的光化学氧化制备三氟乙酰氯。 反应优选在不加压且不加入元素氯的情况下进行。
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公开(公告)号：US5532411A
公开(公告)日：1996-07-02
申请号：US233624
申请日：1994-04-26
Applicant: Max Braun , Werner Rudolph , Stefan Palsherm , Kerstin Eichholz
Inventor： Max Braun , Werner Rudolph , Stefan Palsherm , Kerstin Eichholz
Abstract: A process for preparing carboxylic acid halides and carboxylate salts by reacting metal or "onium" halides with carboxylic anhydrides, which process is very suitable for working-up anhydrous, spent catalyst preparations. The resulting carboxylic acid halide or carboxylate salt can be used as an acylating reagent or alkylating reagent, and metal halide or "onium" halide liberated during this can be reacted anew with carboxylic anhydride and regenerated, thereby making it possible to effect a hydrolysis-free alkylation or acylation without forming salt-type waste products. If the mixture of carboxylic acid halide and carboxylate salt is allowed to react with an alcohol, preferably in situ, the resulting ester can be isolated without hydrolysis.
Abstract translation: 通过使金属或“鎓”卤化物与羧酸酐反应来制备羧酸卤化物和羧酸盐的方法，该方法非常适用于加工无水的废催化剂制剂。 所得羧酸卤化物或羧酸盐可用作酰化试剂或烷化试剂，并且在此期间释放的金属卤化物或“鎓”卤化物可与羧酸酐重新反应并再生，从而可以实现无水解 烷基化或酰化而不形成盐类废物。 如果允许羧酸卤化物和羧酸盐的混合物与醇反应，优选原位，所得到的酯可以在不水解的情况下分离。
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