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1.发明申请公开(公告)号：US20050250817A1
公开(公告)日：2005-11-10
申请号：US11085073
申请日：2005-03-22
CPC分类号： A61K38/54 , A61K9/1075 , A61K9/1617 , A61K9/1641 , A61K31/22 , A61K31/745 , A61K38/465 , A61K38/47 , A61K38/48 , A61K2300/00
摘要： Orally administrable pharmaceutical compositions of lipase-containing products, particularly pancreatin and pancreatin-containing products, or of enzyme products which contain at least one lipase of non-animal, especially microbial origin, which improve the lipolytic activity and particularly result in stabilization of the lipase in the acidic pH range. These oral pharmaceutical compositions contain a system which includes at least one surfactant and one co-surfactant and optionally a lipophilic phase, and are self-emulsifiable on contact with a hydrophilic and a lipophilic phase. The compositions according to the invention are suitable for treating or inhibiting maldigestion, especially maldigestion due to chronic exocrine pancreatic insufficiency, in mammals and humans.
摘要翻译： 含有脂肪酶的产品，特别是胰酶和含胰酶的产品的口服给药的药物组合物，或含有至少一种非动物，特别是微生物来源的脂肪酶的酶产品，其可改善脂肪分解活性并特别导致脂肪酶稳定 在酸性pH范围内。 这些口服药物组合物含有包含至少一种表面活性剂和一种辅助表面活性剂和任选的亲油相的系统，并且在亲水相和亲油相接触时是自乳化的。 根据本发明的组合物适用于治疗或抑制哺乳动物和人类的消化不良，特别是由于慢性外分泌胰腺功能不全引起的消化不良。
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2.发明授权公开(公告)号：US08802087B2
公开(公告)日：2014-08-12
申请号：US11085073
申请日：2005-03-22
CPC分类号： A61K38/54 , A61K9/1075 , A61K9/1617 , A61K9/1641 , A61K31/22 , A61K31/745 , A61K38/465 , A61K38/47 , A61K38/48 , A61K2300/00
摘要： Orally administrable pharmaceutical compositions of lipase-containing products, particularly pancreatin and pancreatin-containing products, or of enzyme products which contain at least one lipase of non-animal, especially microbial origin, which improve the lipolytic activity and particularly result in stabilization of the lipase in the acidic pH range. These oral pharmaceutical compositions contain a system which includes at least one surfactant and one co-surfactant and optionally a lipophilic phase, and are self-emulsifiable on contact with a hydrophilic and a lipophilic phase. The compositions according to the invention are suitable for treating or inhibiting maldigestion, especially maldigestion due to chronic exocrine pancreatic insufficiency, in mammals and humans.
摘要翻译： 含有脂肪酶的产品，特别是胰酶和含胰酶的产品的口服给药的药物组合物，或含有至少一种非动物，特别是微生物来源的脂肪酶的酶产品，其可改善脂肪分解活性并特别导致脂肪酶稳定 在酸性pH范围内。 这些口服药物组合物含有包含至少一种表面活性剂和一种辅助表面活性剂和任选的亲油相的系统，并且在亲水相和亲油相接触时是自乳化的。 根据本发明的组合物适用于治疗或抑制哺乳动物和人类的消化不良，特别是由于慢性外分泌胰腺功能不全引起的消化不良。
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3.发明申请公开(公告)号：US20050009800A1
公开(公告)日：2005-01-13
申请号：US10866095
申请日：2004-06-14
申请人： Bernd Thumbeck , Ingo Bonnacker , Martina Lerch
发明人： Bernd Thumbeck , Ingo Bonnacker , Martina Lerch
IPC分类号： A61K9/16 , A61K9/20 , A61K31/565 , A61K31/566 , A61K47/26 , A61K47/38 , A61P5/30 , A61P15/12 , A61K31/56
CPC分类号： A61K9/1676 , A61K9/1623 , A61K9/1652
摘要： A pharmaceutical preformulation in the form of a solid, free-flowing dry extract of a natural mixture of conjugated equine estrogens, which is particularly suitable use in for solid galenic forms, e.g. tabletting. The conjugated estrogens are available for further galenic processing in a form which assures the chemical stability of the hormones and permits advantageous processing into solid galenic forms, for example a tablet. The invention furthermore relates to a method for producing these preformulations in the form of a dry extract.
摘要翻译： 形式为固体，自由流动的共轭马雌激素混合物的自由流动干提取物的药物预配制剂，其特别适合用于固体galenic形式，例如。 压片 缀合的雌激素可用于进一步的galeration加工，其形式可保证激素的化学稳定性并且允许有利的加工成固体galenic形式，例如片剂。 本发明还涉及以干提取物的形式生产这些预制剂的方法。
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4.发明授权公开(公告)号：US08273728B2
公开(公告)日：2012-09-25
申请号：US10866095
申请日：2004-06-14
申请人： Bernd Thumbeck , Ingo Bonnacker , Martina Lerch
发明人： Bernd Thumbeck , Ingo Bonnacker , Martina Lerch
IPC分类号： A61K31/56
CPC分类号： A61K9/1676 , A61K9/1623 , A61K9/1652
摘要： A pharmaceutical preformulation in the form of a solid, free-flowing dry extract of a natural mixture of conjugated equine estrogens, which is particularly suitable use in for solid galenic forms, e.g. tabletting. The conjugated estrogens are available for further galenic processing in a form which assures the chemical stability of the hormones and permits advantageous processing into solid galenic forms, for example a tablet. The invention furthermore relates to a method for producing these preformulations in the form of a dry extract.
摘要翻译： 形式为固体，自由流动的共轭马雌激素混合物的自由流动干提取物的药物预配制剂，其特别适合用于固体galenic形式，例如。 压片 缀合的雌激素可用于进一步的galeration加工，其形式可保证激素的化学稳定性并且允许有利的加工成固体galenic形式，例如片剂。 本发明还涉及以干提取物的形式生产这些预制剂的方法。
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5.发明申请Method of analyzing enzyme compositions with lipolytic, proteolytic and amylolytic activity 有权分析脂肪分解，蛋白水解和淀粉分解活性的酶组成的方法公开(公告)号：US20050112743A1
公开(公告)日：2005-05-26
申请号：US10901436
申请日：2004-07-29
CPC分类号： C12Q1/34 , G01N2333/916 , G01N2333/924 , G01N2333/95 , G01N2333/994
摘要： A method for analyzing the identity, protein and/or peptide pattern and also the stability of samples containing physiologically acceptable enzyme mixtures with lipolytic, proteolytic and amylolytic activity, particularly mixtures of digestive enzymes such as pancreatin, for use in manufacturing medicinal products comprising such enzyme mixtures, e.g. precipitated pancreatin or pancreatin mini-microspheres.
摘要翻译： 一种用于分析身份，蛋白质和/或肽图案以及含有具有脂肪分解，蛋白水解和淀粉分解活性的生理上可接受的酶混合物的样品的特性，蛋白质和/或肽模式的稳定性的方法，特别是消化酶如胰酶的混合物，用于制造包含这种酶的药物 混合物，例如 沉淀胰酶或胰酶微球。
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6.发明授权Matrix film tablet with controlled release of a natural mixture of conjugated estrogens 失效具有受控释放的共轭雌激素的天然混合物的基质膜片剂公开(公告)号：US08268351B2
公开(公告)日：2012-09-18
申请号：US10866094
申请日：2004-06-14
申请人： Bernd Thumbeck , Klaus Budde , Gerhard Kristen , Margit Wiards
发明人： Bernd Thumbeck , Klaus Budde , Gerhard Kristen , Margit Wiards
IPC分类号： A61K9/26
CPC分类号： A61K9/205 , A61K9/2018 , A61K9/2081 , A61K9/284
摘要： A pharmaceutical matrix film tablet with controlled release of natural mixtures of conjugated estrogens which have been obtained from the urine of pregnant mares.
摘要翻译： 一种从怀孕母马的尿液中获得的共轭雌激素天然混合物受控释放的药物基质膜片剂。
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7.发明授权公开(公告)号：US08329679B2
公开(公告)日：2012-12-11
申请号：US13483530
申请日：2012-05-30
申请人： Bernd Thumbeck , Ingo Bonnacker , Martina Lerch
发明人： Bernd Thumbeck , Ingo Bonnacker , Martina Lerch
IPC分类号： A61K31/56
CPC分类号： A61K9/1676 , A61K9/1623 , A61K9/1652
摘要： A method of producing a pharmaceutical preformulation in the form of a solid, free-flowing dry extract of a natural mixture of conjugated equine estrogens, which is particularly suitable use in for solid galenic forms, e.g. tabletting. The conjugated estrogens are available for further galenic processing in a form which assures the chemical stability of the hormones and permits advantageous processing into solid galenic forms, for example a tablet.
摘要翻译： 以固体，自由流动的共轭马雌激素混合物的自由流动干提取物的形式制备药物预配制剂的方法，其特别适用于固体盖仑形式，例如， 压片 缀合的雌激素可用于进一步的galeration加工，其形式可保证激素的化学稳定性并且允许有利的加工成固体galenic形式，例如片剂。
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8.发明授权Method of analyzing enzyme compositions with lipolytic, proteolytic and amylolytic activity 有权分析脂肪分解，蛋白水解和淀粉分解活性的酶组成的方法公开(公告)号：US07479378B2
公开(公告)日：2009-01-20
申请号：US10901436
申请日：2004-07-29
IPC分类号： C12Q1/37
CPC分类号： C12Q1/34 , G01N2333/916 , G01N2333/924 , G01N2333/95 , G01N2333/994
摘要： A method for analyzing the identity, protein and/or peptide pattern and also the stability of samples containing physiologically acceptable enzyme mixtures with lipolytic, proteolytic and amylolytic activity, particularly mixtures of digestive enzymes such as pancreatin, for use in manufacturing medicinal products comprising such enzyme mixtures, e.g. precipitated pancreatin or pancreatin mini-microspheres.
摘要翻译： 一种用于分析身份，蛋白质和/或肽图案以及含有具有脂肪分解，蛋白水解和淀粉分解活性的生理上可接受的酶混合物的样品的特性，蛋白质和/或肽模式的稳定性的方法，特别是消化酶如胰酶的混合物，用于制造包含这种酶的药物 混合物，例如 沉淀胰酶或胰酶微球。
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9.发明申请Matrix film tablet with controlled release of a natural mixture of conjugated estrogens 失效具有受控释放的共轭雌激素的天然混合物的基质膜片剂公开(公告)号：US20050019408A1
公开(公告)日：2005-01-27
申请号：US10866094
申请日：2004-06-14
申请人： Bernd Thumbeck , Klaus Budde , Gerhard Kristen , Margit Wiards
发明人： Bernd Thumbeck , Klaus Budde , Gerhard Kristen , Margit Wiards
IPC分类号： A61K9/36 , A61K9/16 , A61K9/20 , A61K9/28 , A61K31/565 , A61K47/04 , A61K47/12 , A61K47/14 , A61K47/26 , A61K47/32 , A61K47/34 , A61K47/38 , A61P5/30 , A61P15/12 , A61K9/24
CPC分类号： A61K9/205 , A61K9/2018 , A61K9/2081 , A61K9/284
摘要： A pharmaceutical matrix film tablet with controlled release of natural mixtures of conjugated estrogens which have been obtained from the urine of pregnant mares.
摘要翻译： 一种从怀孕母马的尿液中获得的共轭雌激素天然混合物受控释放的药物基质膜片剂。
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