公开(公告)号：US106606A

公开(公告)日：1870-08-23

申请号：US106606D

CPC classification number: C07C201/02

公开(公告)号：US50617A

公开(公告)日：1865-10-24

申请号：US50617D

CPC classification number: F42B3/26 ,  C07C201/02

公开(公告)号：US20240158345A1

公开(公告)日：2024-05-16

申请号：US18275579

申请日：2021-02-03

Applicant: Nicox S.A.

Inventor： Nicoletta ALMIRANTE ,  Gael RONSIN ,  Khalid DIKER ,  Gilles GORINS ,  Jonathan COUSIN ,  Audrey BRUNEAU

IPC: C07C405/00 ,  A61K31/5575 ,  C07C201/02

CPC classification number: C07C405/0041 ,  A61K31/5575 ,  C07C201/02 ,  C07C2601/08

Abstract: The present invention relates to a process for preparing hexanoic acid, 6-(nitrooxy)-, (1S,2E)-3-[(1R,2R,3S,5R)-2-[(2Z)-7-(ethylamino)-7-oxo-2-hepten-1-yl]-3,5-dihydroxycyclopentyl]-1-(2-phenylethyl)-2-propen-1-yl ester of formula (I).




In accordance with the present invention, the compound (I) can be efficiently prepared with high purity by coupling bimatoprost in a boronate protected form with 6-(nitrooxy)hexanoyl chloride and removing the boronate protecting group.
The invention also relates to a process for the preparation of 6-(nitrooxy) hexanoic acid having a HPLC purity equal to or greater than 99% and containing an amount of 6-{[6-(nitrooxy)hexanoyl]oxy}hexanoic acid (compound (IXa) equal to or lower than 0.2%.

公开(公告)号：US20230150917A1

公开(公告)日：2023-05-18

申请号：US17919939

申请日：2021-04-21

Applicant: DSM IP ASSETS B.V.

Inventor： Peter Hans RIEBEL ,  Angela WILDERMANN

IPC: C07C201/02 ,  C07C203/02

CPC classification number: C07C201/02 ,  C07C203/02

Abstract: The invention relates to a safe and efficient process for the hydrolysis of α,ω-C3-10alkanediol mononitrate monoacylates. The process is safer to operators and allows to obtain advantageous yields on industrial scale.

公开(公告)号：US20230150916A1

公开(公告)日：2023-05-18

申请号：US17919932

申请日：2021-04-21

Applicant: DSM IP ASSETS B.V.

Inventor： Peter Hans RIEBEL ,  Angela WILDERMANN

IPC: C07C201/02

CPC classification number: C07C201/02

Abstract: The invention relates to a safe and efficient process for the nitrate ester formation of an α,ω-C3-10alkanediol monoacylate. The process is safer to operators and allows to obtain advantageous yields on industrial scale.

公开(公告)号：US20150031909A1

公开(公告)日：2015-01-29

申请号：US14374031

申请日：2012-12-21

Applicant: SHANDONG LIBAODE CHEMICAL CO., LTD.

Inventor： Deliang Xu ,  Hengtao Mao

IPC: C07C201/02

CPC classification number: C07C201/02 ,  C07C203/04

Abstract: The present invention provides a method for producing alkyl nitrate. The centrifugal extraction equipment acts as the esterification separator; a mixed acid solution containing sulfuric acid and nitric acid enters from the heavy phase inlet of the centrifugal extraction equipment; alkyl alcohol enters from the light phase inlet of the centrifugal extraction equipment; the feeding molar ratio of alkyl alcohol and nitric acid equals to 1:1.0-3.0; esterification reaction occurs with the mixed acid and alkyl alcohol at a temperature of 10˜60° C. under the rotating speed of 800-2000 r/min; under the action of centrifugal force, the generated coarse ester as a light phase and the spent acid as a heavy phase are separated; coarse ester as a light phase is discharged through the light-phase outlet of the centrifugal extractor; the spent acid as a heavy phase is discharged through the heavy-phase outlet of the centrifugal extractor; after alkali washing and water washing conventionally, coarse ester is dehydrated for drying and purified, then the refining products of alkyl nitrate is obtained. In the method of the present invention, esterification reaction, the separation of reaction products and the spent acid are finished in the same reactor simultaneously, which reduces the contact time of reaction products with the spent acid greatly, avoids the side reaction effectively, and ensures the safety of esterification process.

Abstract translation: 本发明提供硝酸烷基酯的制造方法。 离心萃取设备作为酯化分离器; 含有硫酸和硝酸的混合酸溶液从离心萃取设备的重相入口进入; 烷基醇从离心萃取设备的轻相进口进入; 烷基醇和硝酸的进料摩尔比等于1：1.0-3.0; 在混合酸和烷基醇的温度为10〜60℃，以800〜2000r / min的转速进行酯化反应; 在离心力作用下，生成的粗酯为轻质相，废酸为重相分离; 粗酯作为轻相通过离心萃取器的光相出口排出; 作为重相的废酸通过离心萃取器的重相出口排出; 在碱洗和水洗常规之后，将粗酯脱水干燥和纯化，得到硝酸烷基酯的精制产物。 在本发明的方法中，酯化反应，反应产物和废酸的分离同时在同一反应器中完成，这大大降低了反应产物与废酸的接触时间，有效避免了副反应，确保了 酯化过程的安全性。

公开(公告)号：US20140179936A1

公开(公告)日：2014-06-26

申请号：US14054063

申请日：2013-10-15

Applicant: AEL MINING SERVICES LIMITED

Inventor： Andre Pienaar ,  Laurence Justin Pienaar Wilson ,  Michael Stockenhuber

IPC: C06B49/00 ,  C07D301/12 ,  C07C201/10 ,  C07C273/18

CPC classification number: C06B49/00 ,  C07C29/36 ,  C07C201/02 ,  C07C201/10 ,  C07C273/18 ,  C07C273/1809 ,  C07C273/1863 ,  C07D301/12 ,  C07C31/24 ,  C07C275/50 ,  C07C275/06 ,  C07C203/04

Abstract: A method producing a surfactant from glycerol by converting glycerol, in a first step, to glycidol, polymerizing glycidol to an aliphatic alcohol and finally substituting a hydroxyl group with a substitute anion.

Abstract translation: 通过将甘油转化成缩水甘油，将缩水甘油聚合成脂肪族醇，最后用取代阴离子取代羟基，从甘油中转化甘油的方法。

公开(公告)号：US08658818B2

公开(公告)日：2014-02-25

申请号：US12953111

申请日：2010-11-23

Applicant: Nicholas A. Straessler ,  Alexander J. Paraskos ,  Michael P. Kramer

Inventor： Nicholas A. Straessler ,  Alexander J. Paraskos ,  Michael P. Kramer

IPC: C07C203/04

CPC classification number: C07C201/02 ,  C07C203/04 ,  C07C203/06

Abstract: Methods of forming a nitrate ester include combining at least one nitrate salt and sulfuric acid to form a nitrating solution and adding an aliphatic polyol to the nitrating solution. Nitrate esters formed by this method may be, for example, triethylene glycol dinitrate (TEGDN), pentaerythritol tetranitrate (PETN), diglycerol tetranitrate (DGTN), 1,1,1-tris(methylol)ethane trinitrate (TMETN), 1,2,4-butanetriol trinitrate (BTTN), nitroglycerin (NG), diethylene glycol dinitrate (DEGDN), ethylene glycol dinitrate (EGDN), metriol trinitrate (MTN), nitrocellulose (NC), or 1,2-propanediol dinitrate (PDDN).

Abstract translation: 形成硝酸酯的方法包括组合至少一种硝酸盐和硫酸以形成硝化溶液，并向该硝化溶液中加入脂族多元醇。 通过该方法形成的硝酸酯可以是例如三乙二醇二硝酸酯（TEGDN），季戊四醇四硝酸酯（PETN），二甘油四硝酸酯（DGTN），1,1,1-三（羟甲基）乙烷三硝酸酯（TMETN），1,2 硝酸甘油（NG），硝酸甘油（NG），二乙二醇二硝酸酯（DEGDN），乙二醇二硝酸酯（EGDN），三硝酸三甲酯（MTN），硝化纤维素（NC）或1,2-丙二醇二硝酸酯（PDDN）。

公开(公告)号：US20120130115A1

公开(公告)日：2012-05-24

申请号：US12953111

申请日：2010-11-23

Applicant: Nicholas A. Straessler ,  Alexander J. Paraskos ,  Michael P. Kramer

Inventor： Nicholas A. Straessler ,  Alexander J. Paraskos ,  Michael P. Kramer

IPC: C07C203/04

CPC classification number: C07C201/02 ,  C07C203/04 ,  C07C203/06

Abstract: Methods of forming a nitrate ester include combining at least one nitrate salt and sulfuric acid to form a nitrating solution and adding an aliphatic polyol to the nitrating solution. Nitrate esters formed by this method may be, for example, triethylene glycol dinitrate (TEGDN), pentaerythritol tetranitrate (PETN), diglycerol tetranitrate (DGTN), 1,1,1-tris(methylol)ethane trinitrate (TMETN), 1,2,4-butanetriol trinitrate (BTTN), nitroglycerin (NG), diethylene glycol dinitrate (DEGDN), ethylene glycol dinitrate (EGDN), metriol trinitrate (MTN), nitrocellulose (NC), or 1,2-propanediol dinitrate (PDDN).

Abstract translation: 形成硝酸酯的方法包括组合至少一种硝酸盐和硫酸以形成硝化溶液，并向该硝化溶液中加入脂族多元醇。 通过该方法形成的硝酸酯可以是例如三乙二醇二硝酸酯（TEGDN），季戊四醇四硝酸酯（PETN），二甘油四硝酸酯（DGTN），1,1,1-三（羟甲基）乙烷三硝酸酯（TMETN），1,2 硝酸甘油（NG），硝酸甘油（NG），二乙二醇二硝酸酯（DEGDN），乙二醇二硝酸酯（EGDN），三硝酸三甲酯（MTN），硝化纤维素（NC）或1,2-丙二醇二硝酸酯（PDDN）。

公开(公告)号：US07947855B2

公开(公告)日：2011-05-24

申请号：US12166739

申请日：2008-07-02

Applicant: Tiziano Scubla ,  Nevio Francescutti ,  Fausto Gorassini ,  Graziano Castaldi

Inventor： Tiziano Scubla ,  Nevio Francescutti ,  Fausto Gorassini ,  Graziano Castaldi

IPC: C07C27/26 ,  C07C201/02

CPC classification number: C07C203/04 ,  C07C201/02

Abstract: A process for the purification of 1,4-butanediol mononitrate from 1,4-butanediol dinitrate and 1,4-butanediol, by selective extraction with solvents is herein disclosed.

Abstract translation: 本文公开了通过溶剂选择性萃取从1,4-丁二醇和1,4-丁二醇纯化1,4-丁二醇单硝酸酯的方法。