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    Heterocyclic coumarin derivatives
    41.
    发明授权
    Heterocyclic coumarin derivatives 失效
    杂环香豆素衍生物

    公开(公告)号：US4263299A

    公开(公告)日：1981-04-21

    申请号：US85038

    申请日：1979-10-15

    申请人： Derek R. Buckle ,  Harry Smith

    发明人： Derek R. Buckle ,  Harry Smith

    IPC分类号： C07D295/088 ,  C07D295/205 ,  C07D311/54 ,  C07D311/56 ,  C07D405/02

    CPC分类号： C07D295/088 ,  C07D295/205 ,  C07D311/54 ,  C07D311/56

    摘要： A compound of formula (I): ##STR1## and pharmaceutically acceptable salts thereof, wherein R is hydrogen or an alkyl group containing up to 6 carbon atoms; X is a bond or oxygen; Y is --(CH.sub.2).sub.n -- where n is 0 or an integer from 1 to 5 wherein one carbon atom not bound to the nitrogen atom may be optionally substituted with a hydroxy group; and Z is hydrogen or halogen; may be used in the prophylaxis and treatment of diseases whose symptoms are controlled by the mediators of the allergic response, for example asthma, hay-fever, rhinitis and allergic eczema.

    摘要翻译： 式（I）的化合物：其中R是氢或含有至多6个碳原子的烷基; X是键或氧; Y为 - （CH 2）n - 其中n为0或1至5的整数，其中未与氮原子结合的一个碳原子可任选被羟基取代; Z为氢或卤素; 可用于预防和治疗其症状由过敏反应的介质如哮喘，干热，鼻炎和过敏性湿疹控制的疾病。

    Method for synthesizing (RS)-Warfarin
    44.
    发明授权
    Method for synthesizing (RS)-Warfarin 有权

    公开(公告)号：US11845735B2

    公开(公告)日：2023-12-19

    申请号：US17971959

    申请日：2022-10-24

    申请人： Nasim Batooie

    发明人： Nasim Batooie

    IPC分类号： C07D311/56

    CPC分类号： C07D311/56

    摘要： A method for synthesizing (RS)-Warfarin comprising preparing a liquid mixture, wherein the liquid mixture comprises trihexyltetradecylphosphonium bromide, methyl salicylate, acetyl chloride, benzaldehyde, and acetone. The method may further comprise incubating the liquid mixture at a temperature between 20° C. and 30° C. for a time duration between 26 and 34 minutes, and forming (RS)-Warfarin by adding water to the incubated liquid mixture with a volume ratio (water:incubated liquid mixture) between 1:1 and 1.5:1.

    METHOD FOR SYNTHESIZING (RS)-WARFARIN
    45.
    发明公开
    METHOD FOR SYNTHESIZING (RS)-WARFARIN 审中-公开

    公开(公告)号：US20230167079A1

    公开(公告)日：2023-06-01

    申请号：US17971959

    申请日：2022-10-24

    申请人： Nasim Batooie

    发明人： Nasim Batooie

    IPC分类号： C07D311/56

    CPC分类号： C07D311/56

    摘要： A method for synthesizing (RS)-Warfarin comprising preparing a liquid mixture, wherein the liquid mixture comprises trihexyltetradecylphosphonium bromide, methyl salicylate, acetyl chloride, benzaldehyde, and acetone. The method may further comprise incubating the liquid mixture at a temperature between 20° C. and 30° C. for a time duration between 26 and 34 minutes, and forming (RS)-Warfarin by adding water to the incubated liquid mixture with a volume ratio (water:incubated liquid mixture) between 1:1 and 1.5:1.

    Genetically engineered microbes and methods for producing 4-hydroxycoumarin
    48.
    发明授权
    Genetically engineered microbes and methods for producing 4-hydroxycoumarin 有权
    遗传工程微生物和生产4-羟基香豆素的方法

    公开(公告)号：US09353390B2

    公开(公告)日：2016-05-31

    申请号：US14304105

    申请日：2014-06-13

    申请人： University of Georgia Research Foundation, Inc.

    发明人： Yajun Yan ,  Yuheng Lin

    IPC分类号： C12P17/06 ,  C07D311/46 ,  C07D311/56 ,  C12N15/52

    CPC分类号： C12P17/06 ,  C07D311/46 ,  C07D311/56 ,  C12N15/52

    摘要： Provided herein are methods for the biosynthesis of 4-hydroxycoumarin. In one embodiment, provided herein are genetically engineered microbes that include a metabolic pathway for the production of 4-hydroxycoumarin. Also provided are methods for using the genetically engineered microbes to produce 4-hydroxycoumarin, and using the 4-hydroxycoumarin as the starting point for the synthesis of other compounds.

    摘要翻译： 本文提供了4-羟基香豆素的生物合成方法。 在一个实施方案中，本文提供了包含用于生产4-羟基香豆素的代谢途径的遗传工程微生物。 还提供了使用遗传工程微生物来生产4-羟基香豆素的方法，并且使用4-羟基香豆素作为合成其它化合物的起始点。