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144 条记录 (耗时 0.012 秒)

    2-(3'-fluoro-2'-naphthyl)-benzimidazoles
    42.
    发明授权
    2-(3'-fluoro-2'-naphthyl)-benzimidazoles 失效
    2-（3'-氟-2'-萘基） - 苯并咪唑

    公开(公告)号：US3578675A

    公开(公告)日：1971-05-11

    申请号：US3578675D

    申请日：1969-06-09

    申请人： MERCK & CO INC

    发明人： HOFF DALE R ,  PETERSON LOUIS H

    IPC分类号： C07D235/10 ,  C07D49/38

    CPC分类号： C07D235/10

    摘要： ANTHELMINTICALLY ACTIVE BENZIMIDAZOLES HAVING AN OFLUORONAPHTHYL GROUP AT THE 2-POSITION ARE PREPARED BY A VARIETY OF PROCESSES INCLUDING REACTION OF AN O-NITROANILINE OR O-PHENYLENEDIAMINE WITH 3-FLUORO-2-NAPHTHOIC ACID OR AN EQUIVALENT THEREOF WHEREIN THE CARBOXYLIC ACID RADICAL IS DERIVATIZED TO A RADICAL SUCH AS AN ESTER, IMIDOESTER, AMIDE, CARBONYL HALIDE OR NITRILE.

    2-aryl- or aralkyl-substituted benzazole derivatives
    43.
    发明授权
    2-aryl- or aralkyl-substituted benzazole derivatives 失效
    2-ARYL-或ARALKYL-取代的苯扎唑衍生物

    公开(公告)号：US3574218A

    公开(公告)日：1971-04-06

    申请号：US3574218D

    申请日：1969-08-11

    申请人： EGYT GYOGYSZERVEGYESZETI GYAR

    发明人： HIDEG KALMAN ,  SZEKERES LASZLO ,  POPP GYULA

    IPC分类号： C07D235/12 ,  C07D235/18 ,  C07D277/64 ,  C07D277/66 ,  C07D85/48 ,  C07D49/38 ,  C07D91/44

    CPC分类号： C07D277/66 ,  C07D235/12 ,  C07D235/18 ,  C07D277/64 ,  Y10S514/929

    摘要： NEW COMPOUNDS HAVING THE GENERAL FORMULA

    1,2-(-X-C(-Y-(R2,PHENYLENE)-O-(CH(-R4))N-CO-R3)=N-),

    R1-BENZENE

    WHEREIN R1 IS SELECTED FROM THE GROUP CONSISTING OF HYDROGEN AND CHLORINE, R2 IS SELECTED FROM THE GROUP CONSISTING OF HYDROGEN AND LOWER ALKOXY, R3 IS SELECTED FROM THE GROUP CONSISTING OF PIPERIDINO AND A-METHYL-BENZYLAMINO RADICALS, R4 IS SELECTED FROM THE GROUP CONSISTING OF HYDROGEN AND METHYL RADICAL, X IS SELECTED FROM THE GROUP CONSISTING OF =O, =S, AND =NH, Y IS SELECTED FROM THE GROUP CONSISTING OF DIRECT BOND AND ALKYLENE HAVING FROM 1 TO 2 CARBON ATOMS, AND N IS SELECTED FROM THE GROUP CONSISTING OF 1 AND 2, AND THE POSITIONS OF R2 AND OF THE ETHER BOND IN THE PHENYL RADICAL ARE SELECTED FROM THE GROUP CONSISTING OF 2'', 3'', AND 4'', AND THEIR ACID ADDITION SALTS AND QUATERNARY AMMONIUM DERIVATIVES. THESE COMPOUNDS POSSESS VALUABLE PHARMACOLOGICAL PROPERTIES. THEY SHOW ANTI-ANGINOSE, CORONARY VASODILATOR AND PERIPHERAL CIRCULATION ENHANCING EFFECTS.