公开(公告)号：US20200276138A1

公开(公告)日：2020-09-03

申请号：US16609124

申请日：2018-04-27

申请人： University of Virginia Patent Foundation ,  UNIVERSITAT DE BARCELONA ,  Consejo Superior de Investigaciones Cientificas

发明人： Thomas P. Loughran, JR. ,  Gemma Fabrias ,  Jose Luis Abad ,  Josefina Casas ,  David J. Feith ,  Su-Fern Tan ,  Jennifer M. Pearson ,  Antonio Delgado Cirilo

IPC分类号： A61K31/164 ,  A61P35/02

摘要： The present application provides novel compositions and methods for treating acute myeloid leukemia (AML). Compounds of the invention are acid ceramidase inhibitors, reduce AML cell viability, inhibit AML cell proliferation, increase cell death of AML cells, and induce apoptosis in AML cells. A primary compound of the invention is SACLAC: 2-chloro-N-((2S,3R)-1,3-dihydroxyoctadecan-2-yl)acetamide. The bromine analog of SACLAC (SABRAC: 2-bromo-N-((2S,3R)-1,3-dihydroxyoctadecan-2-yl)acetamide) is also useful for treating AML. SACLAC has much better activity than other know drugs used to treat AML.

公开(公告)号：US10759740B2

公开(公告)日：2020-09-01

申请号：US16086927

申请日：2017-03-24

申请人： Rutgers, The State University of New Jersey

发明人： Kathryn Uhrich ,  Yingyue Zhang ,  Allison Faig ,  Michael Chikindas

IPC分类号： C07C235/10 ,  A61K31/23 ,  A61K31/7036 ,  A61K31/4164 ,  A61K31/4168 ,  A61P31/04 ,  C07C235/06 ,  A61K45/06 ,  A61K31/164 ,  A61K31/7056

摘要： The invention provides an antibacterial compound of formula (I) or a salt thereof, as well as an antibacterial compound of formula (II) or a salt thereof, wherein R1, R2, W, X, Y and n have any of the values defined in the specification.

公开(公告)号：US10751302B2

公开(公告)日：2020-08-25

申请号：US16354070

申请日：2019-03-14

申请人： PTC Therapeutics, Inc.

发明人： Paul Mollard ,  Peter Giannousis ,  Shazad Suchit ,  Mahmoud Mirmehrabi

IPC分类号： C07C235/78 ,  C07D215/28 ,  C07C215/30 ,  C07C231/12 ,  C07C215/08 ,  A61K31/122 ,  C07C215/28 ,  C07B57/00 ,  A61K31/164

摘要： Disclosed herein are polymorphic and amorphous forms of anhydrate, hydrate, and solvates of (R)-2-hydroxy-2-methyl-4-(2,4,5-trimethyl-3,6-dioxocyclohexa-1,4-dienyl)butanamide and methods of using such compositions for treating or suppressing oxidative stress disorders, including mitochondrial disorders, impaired energy processing disorders, neurodegenerative diseases and diseases of aging. Further disclosed are methods of making such polymorphic and amorphous forms.

公开(公告)号：US10744104B2

公开(公告)日：2020-08-18

申请号：US16153299

申请日：2018-10-05

申请人： THERAVANCE BIOPHARMA R&D IP, LLC

发明人： Adam D. Hughes ,  Erik Fenster ,  Melissa Fleury ,  Roland Gendron ,  Edmund J. Moran

IPC分类号： A01N37/00 ,  A61K31/21 ,  A61K31/197 ,  C07C243/26 ,  C07C271/22 ,  C07D317/40 ,  C07C231/02 ,  C07D319/06 ,  C07D207/263 ,  C07C233/56 ,  C07C243/30 ,  A61K31/24 ,  A61K31/27 ,  A61K31/365 ,  A61K45/06 ,  C07C243/28 ,  A61K31/167 ,  A61K31/165 ,  A61K31/16 ,  A61K31/166 ,  A61K31/164

摘要： In one aspect, the invention relates to compounds having the formula: where R1-R6, a, b, and Z are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds have neprilysin inhibition activity. In another aspect, the invention relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and processes and intermediates for preparing such compounds.

公开(公告)号：US10682342B2

公开(公告)日：2020-06-16

申请号：US16277871

申请日：2019-02-15

申请人： PHARNEXT

发明人： Daniel Cohen ,  Serguei Nabirochkin ,  Ilya Chumakov ,  Rodolphe Hajj

IPC分类号： A61K31/44 ,  A61K31/137 ,  A61K31/138 ,  A61K31/185 ,  A61K31/195 ,  A61K31/42 ,  A61K31/64 ,  A61K31/145 ,  A61K31/164 ,  A61K31/197 ,  A61K31/428 ,  A61K31/445 ,  A61K45/06 ,  A61K9/20

摘要： The present invention relates to compositions and methods for the treatment of amyotrophic lateral sclerosis. More specifically, the present invention relates to novel combinatorial therapies for treating amyotrophic lateral sclerosis or a related disorder.

公开(公告)号：US20200181709A1

公开(公告)日：2020-06-11

申请号：US15737228

申请日：2016-06-14

申请人： THE JOHNS HOPKINS UNIVERSITY

发明人： Jong Chul Park ,  Leonel Francisco Maldonado Gonzalez ,  Mariana Brait Rodrigues De Oliveira ,  Mohammad O. Hoque

IPC分类号： C12Q1/6886 ,  A61K31/706 ,  A61K31/7068 ,  A61K31/164 ,  A61P35/00

摘要： The invention provides methods for detecting a cellular proliferative disorder (e.g., urothelial cancer) in a subject by assessing the methylation status of the CCND2, CCNA1 or CALCA promoter in a nucleic acid sample. The methods of the invention are useful for diagnostic, prognostic as well therapeutic regimen predictions.

公开(公告)号：US10583110B2

公开(公告)日：2020-03-10

申请号：US15627962

申请日：2017-06-20

申请人： Aventis Pharma S.A.

发明人： Sunil Gupta

IPC分类号： A61K31/337 ,  A61K31/164 ,  A61K31/56 ,  A61K31/573 ,  A61K45/06 ,  A61K38/19

摘要： The invention relates to a compound of formula: which may be in base form or in the form of a hydrate or a solvate, in combination with prednisone or prednisolone, for its use as a medicament in the treatment of prostate cancer, particularly metastatic prostate cancer, especially for patients who are not catered for by a taxane-based treatment.

公开(公告)号：US20200061100A1

公开(公告)日：2020-02-27

申请号：US16668048

申请日：2019-10-30

申请人： Gerolymatos International S.A.

发明人： Konstantinos Alevizopoulos

IPC分类号： A61K31/737 ,  A61K36/03 ,  A61K31/164 ,  A61K9/00 ,  A61K9/08 ,  A61K35/748 ,  A61K47/02 ,  A61K31/197 ,  A61K36/04 ,  A61K36/53 ,  A61K45/06 ,  A61K35/747

摘要： Disclosed herein are ionic aqueous compositions useful as nasal passage washes to aid in the resorption of edema of the respiratory mucosa, e.g., the nasal mucosa, for the treatment of respiratory tract and/or respiratory mucosal-related conditions, including, e.g., chronic rhinosinusitis, sinusitis, allergic rhinitis and nasal polyps. The composition includes an ionic aqueous solution and algae-derived constituents, such as branched, sulfated polysaccharides having an average molecular weight greater than 4 kDa and comprising L-fucose and sulfate ester groups or extracts from brown algae. Also disclosed are methods and pharmaceutical compositions for treating respiratory tract and/or respiratory mucosal-related conditions, including, e.g., chronic rhinosinusitis.

公开(公告)号：US10548860B2

公开(公告)日：2020-02-04

申请号：US16260989

申请日：2019-01-29

申请人： The Board of Trustees of the Leland Stanford Junior University ,  THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS ,  THE JOHNS HOPKINS UNIVERSITY

发明人： Mark R. Nicolls ,  Jayakumar Rajadas ,  Geoffrey C. Gurtner ,  Xinguo Jiang ,  Gundeep Dhillon ,  Gregg L. Semenza

IPC分类号： A61K31/164 ,  A61K31/436 ,  A61K31/4412 ,  A61K9/51 ,  A61K31/4196 ,  A61K45/06

摘要： Formulations and methods are provided for improving the function, i.e. clinical outcome, of solid organ transplants. Lung transplantation is of particular interest. In the methods of the invention, a nanoparticle formulation comprising an effective dose of an iron chelator active agent in nanoparticle form, including without limitation, deferoxamine (DFO), deferasirox (DFX), and deferiprone (DFP), etc. suspended in a carrier compatible with the tissue of interest, is topically applied to the surface of tissues at the site of anastomosis. The nanoparticles are comprised of the active agent and a pharmaceutically acceptable stabilizer.

公开(公告)号：US20200030281A1

公开(公告)日：2020-01-30

申请号：US16589611

申请日：2019-10-01

申请人： THERAPIX BIOSCIENCES, LTD.

发明人： Ephraim Brener ,  Elran Haber ,  Ascher Shmulewitz

IPC分类号： A61K31/352 ,  A61K45/06 ,  A61P25/30 ,  A61P25/14 ,  A61P25/00 ,  A61P29/00 ,  A61K31/164 ,  A61K36/185

摘要： The present invention provides pharmaceutical compositions comprising cannabinoids and N-acylethanolamines, and methods for their use in preventing and treating a variety of cannabinoid-treatable conditions.