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公开(公告)号：US10441558B2
公开(公告)日：2019-10-15
申请号：US16055710
申请日：2018-08-06
申请人： PHARNEXT
IPC分类号： A61K31/137 , A61K31/197 , A61K31/485 , A61K31/395 , A61K9/00 , A61K9/08 , A61K9/48 , A61K31/7004 , A61K31/047 , A61P25/02 , A61K31/4164
摘要： Compositions and methods for the treatment of Charcot-Marie-Tooth disease and related disorders. Also provided are combination therapies for treating this disease by decreasing PMP22 expression in a subject.
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公开(公告)号：US10383870B2
公开(公告)日：2019-08-20
申请号：US15619074
申请日：2017-06-09
申请人： Pharnext
发明人： Daniel Cohen , Ilya Chumakov , Rodolphe Hajj , Aude Milet , Serguei Nabirochkin , Klaus-Armin Nave , Thomas Prukop , Michael Sereda
IPC分类号： A61K31/047 , A61K31/197 , A61K31/485 , C12Q1/6883
摘要： The present invention provides methods for treating, preventing, or delaying the onset of Charcot-Marie-Tooth Disease type 1A (CMT1A), by administering to a subject in need thereof a combination comprising baclofen, sorbitol and naltrexone, or a pharmaceutically acceptable salt thereof.
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公开(公告)号：US10350195B2
公开(公告)日：2019-07-16
申请号：US14954388
申请日：2015-11-30
申请人： Pharnext
IPC分类号： A61K31/42 , A61K31/255 , A61K31/155 , A61K45/06 , C07C279/26 , C07D261/20
摘要： Compositions and methods for the treatment of Alzheimer's disease and related disorders. More particularly, disclosed are combined therapies that modulate synapse function for treating the disease.
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公开(公告)号：US10342784B2
公开(公告)日：2019-07-09
申请号：US16100923
申请日：2018-08-10
申请人： PHARNEXT
IPC分类号： A61K31/137 , A61K31/138 , A61K31/428 , A61K45/06 , A61K31/44 , A61K31/145 , A61K31/164 , A61K31/185 , A61K31/195 , A61K31/197 , A61K31/42 , A61K31/445 , A61K31/64 , A61K9/20
摘要： The present invention relates to compositions and methods for the treatment of amyotrophic lateral sclerosis. More specifically, the present invention relates to novel combinatorial therapies for treating amyotrophic lateral sclerosis or a related disorder.
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公开(公告)号：US10300015B2
公开(公告)日：2019-05-28
申请号：US14896214
申请日：2014-06-05
申请人： Pharnext
IPC分类号： A61K31/047 , A61K31/195 , A61K31/485 , A61K9/08 , A61K47/12 , A61K9/00 , A61K47/14 , A61K47/26 , A61K31/197
摘要： The present invention relates to a homogeneous, stable, and palatable pharmaceutical solution comprising baclofen, sorbitol and naltrexone.
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公开(公告)号：US09636316B2
公开(公告)日：2017-05-02
申请号：US14861169
申请日：2015-09-22
申请人： PHARNEXT
IPC分类号： A61K31/255 , A61K31/205 , A61K31/19 , A61K31/197 , A61K31/445 , A61K45/06 , A61K31/185 , A61K31/13 , A61K31/27 , A61K31/55 , A61K31/195 , A61K31/325
CPC分类号： A61K31/4045 , A61K9/0053 , A61K31/13 , A61K31/185 , A61K31/195 , A61K31/197 , A61K31/27 , A61K31/325 , A61K31/445 , A61K31/55 , A61K45/06 , A61K2300/00
摘要： The present invention relates to combinations and methods for the treatment of neurological disorders related to glutamate excitotoxicity and Amyloid β toxicity. More specifically, the present invention relates to novel combinatorial therapies of Alzheimer's disease, Alzheimer's disease related disorders, amyotrophic lateral sclerosis, multiple sclerosis, Parkinson's disease, Huntington's disease, neuropathic pain, alcoholic neuropathy, alcoholism or alcohol withdrawal, or spinal cord injury, based on baclofen and acamprosate combination.
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公开(公告)号：US09393241B2
公开(公告)日：2016-07-19
申请号：US14187841
申请日：2014-02-24
申请人： PHARNEXT
发明人： Daniel Cohen , Serguei Nabirochkin , Ilya Chumakov
IPC分类号： A61K31/485 , A61K31/047 , A61K31/197 , A61K31/436 , A61K31/192 , A61K31/4164 , A61K31/4178 , A61K31/567
CPC分类号： A61K31/485 , A61K9/0053 , A61K9/0095 , A61K31/047 , A61K31/192 , A61K31/197 , A61K31/4164 , A61K31/4178 , A61K31/436 , A61K31/567 , A61K2300/00
摘要： The present invention relates to compositions and methods for the treatment of the Charcot-Marie-Tooth disease and related disorders.
摘要翻译： 本发明涉及治疗Charcot-Marie-Tooth疾病和相关疾病的组合物和方法。
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8.发明授权公开(公告)号：US09144558B2
公开(公告)日：2015-09-29
申请号：US14479614
申请日：2014-09-08
申请人： PHARNEXT
IPC分类号： A61K31/255 , A61K31/205 , A61K31/19 , A61K31/197 , A61K31/445 , A61K45/06 , A61K31/185 , A61K31/13 , A61K31/27 , A61K31/55
CPC分类号： A61K31/4045 , A61K9/0053 , A61K31/13 , A61K31/185 , A61K31/195 , A61K31/197 , A61K31/27 , A61K31/325 , A61K31/445 , A61K31/55 , A61K45/06 , A61K2300/00
摘要： The present invention relates to combinations and methods for the treatment of neurological disorders related to glutamate excitotoxicity and Amyloid β toxicity. More specifically, the present invention relates to novel combinatorial therapies of Alzheimer's disease, Alzheimer's disease related disorders, amyotrophic lateral sclerosis, multiple sclerosis, Parkinson's disease, Huntington's disease, neuropathic pain, alcoholic neuropathy, alcoholism or alcohol withdrawal, or spinal cord injury, based on baclofen and acamprosate combination.
摘要翻译： 本发明涉及用于治疗与谷氨酸兴奋毒性相关的神经障碍和淀粉样蛋白的组合和方法。 毒性。 更具体地说，本发明涉及阿尔茨海默病，阿尔茨海默氏病相关疾病，肌萎缩性侧索硬化，多发性硬化，帕金森病，亨廷顿病，神经性疼痛，酒精神经病，酒精中毒或酒精戒断或脊髓损伤的新型组合疗法 对巴氯芬和acrosrosate组合。
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9.发明申请BACLOFEN AND ACAMPROSATE BASED THERAPY OF MACULAR DEGENERATION DISORDERS 有权胆红素和基于ACMPROSATE的麻醉性恶化病症治疗公开(公告)号：US20150238452A1
公开(公告)日：2015-08-27
申请号：US14415994
申请日：2013-07-18
申请人： PHARNEXT
发明人： Daniel Cohen , Ilya Chumakov , Serguei Nabirochkin
IPC分类号： A61K31/197 , A61K31/185
CPC分类号： A61K31/197 , A61K31/185 , A61K2300/00
摘要： The present invention relates to combinations and methods for the treatment of macular degeneration disorders. More specifically, the present invention relates to novel combinatorial therapies of Age related Macular Degeneration based on baclofen and acamprosate combination.
摘要翻译： 本发明涉及治疗黄斑变性疾病的组合和方法。 更具体地，本发明涉及基于巴氯芬和阿坎酸组合的年龄相关性黄斑变性的组合疗法。
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公开(公告)号：US10940147B2
公开(公告)日：2021-03-09
申请号：US16505000
申请日：2019-07-08
申请人： Pharnext
发明人： Daniel Cohen , Ilya Chumakov , Rodolphe Hajj , Aude Milet , Serguei Nabirochkin , Klaus-Armin Nave , Thomas Prukop , Michael Sereda
IPC分类号： A61K31/485 , A61K31/197 , C12Q1/6883 , A61K31/047
摘要： The present invention provides methods for treating, preventing, or delaying the onset of Charcot-Marie-Tooth Disease type 1A (CMT1A), by administering to a subject in need thereof a combination comprising baclofen, sorbitol and naltrexone, or a pharmaceutically acceptable salt thereof.
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