Process for preparing a neutralized oxidized cellulose product and its
method of use
    47.
    发明授权
    Process for preparing a neutralized oxidized cellulose product and its method of use 失效
    中和的氧化纤维素产品的制备方法及其使用方法

    公开(公告)号:US5134229A

    公开(公告)日:1992-07-28

    申请号:US624452

    申请日:1990-12-13

    IPC分类号: A61L15/28 A61L31/04 C08B15/02

    摘要: Oxidized cellulose material is neutralized, by contacting an acidic oxidized cellulose material with a water and alcohol solution of a basic salt of a weak organic acid, e.g. sodium acetate, to elevate the pH of the cellulosic material to between 5 and 8. The resulting neutralized product is storage stable and has therapeutic applications, including hemostasis and adhesion prevention. Furthermore, the neutralized product may be impregnated with acid-sensitive hemostatic agents, such as thrombin, to enhance its hemostatic properties, or with acid-sensitive adhesion-preventive agents, such as t-PA, to enhace its adhesion-prevention properties.

    摘要翻译: 通过使酸性氧化纤维素材料与弱有机酸的碱性盐的水和醇溶液接触,例如氧化纤维素材料被中和。 乙酸钠,以将纤维素材料的pH升高至5至8.所得中和产物是储存稳定的并具有治疗应用,包括止血和防止粘附。 此外,中和的产物可以用酸敏感止血剂(例如凝血酶)浸渍以增强其止血性能,或用酸敏感的粘合防止剂如t-PA浸渍,以提高其粘合防止性能。