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65 条记录 (耗时 0.019 秒)

    BISPHOSPHONATE INHALANT FORMULATIONS AND METHODS FOR USING THE SAME
    51.
    发明申请
    BISPHOSPHONATE INHALANT FORMULATIONS AND METHODS FOR USING THE SAME 审中-公开
    二磷酸盐助剂配方及其使用方法

    公开(公告)号：US20080132471A1

    公开(公告)日：2008-06-05

    申请号：US11935764

    申请日：2007-11-06

    申请人： Toru Hibi ,  Akira Yamamoto ,  Maria Nakatani ,  Hidemasa Katsumi

    发明人： Toru Hibi ,  Akira Yamamoto ,  Maria Nakatani ,  Hidemasa Katsumi

    IPC分类号： A61K31/66 ,  A61K31/675 ,  A61P9/00

    CPC分类号： A61K31/66 ,  A61K31/675

    摘要： The present invention provides for methods of administering by a pulmonary route an effective amount of a bisphosphonate active agent to a subject. Aspects of the invention including administering the active agent to the subject in conjunction with one or more mucosal membrane protecting agents, where the protecting agent may include one or more of a protecting enzyme and/or a protecting amino acid and/or a protecting peptide. Also provided are inhalant compositions for use in practicing methods according to embodiments of the invention. Methods and compositions according to embodiments of the invention find use in a variety of different applications, including but not limited to, the treatment of bone adsorption disease conditions.

    摘要翻译： 本发明提供了通过肺部途径向受试者施用有效量的双膦酸酯活性剂的方法。 本发明的方面包括将活性剂与一种或多种粘膜保护剂联合施用于受试者，其中保护剂可包括保护酶和/或保护性氨基酸和/或保护肽中的一种或多种。 还提供了用于根据本发明的实施方案的实践方法中使用的吸入剂组合物。 根据本发明的实施方案的方法和组合物可用于各种不同的应用，包括但不限于骨吸收疾病状况的治疗。

    Propynylaminoindan transdermal compositions
    52.
    发明授权
    Propynylaminoindan transdermal compositions 有权

    公开(公告)号：US10918607B2

    公开(公告)日：2021-02-16

    申请号：US14114679

    申请日：2013-10-25

    申请人： TEIKOKU PHARMA USA, INC.

    发明人： Richard D. Hamlin ,  Amit Jain ,  Jianye Wen

    IPC分类号： A61K9/70 ,  A61K31/135

    摘要： Propynylaminoindan (e.g., Rasagiline) transdermal compositions are provided. Aspects of the transdermal compositions include a matrix which includes the propynylaminoindan, a pressure sensitive adhesive that includes an acrylate copolymer and a cationic acrylic copolymer. Also provided are methods of using the transdermal compositions and kits containing the transdermal compositions.

    NON-AQUEOUS TAXANE FORMULATIONS AND METHODS OF USING THE SAME
    54.
    发明申请
    NON-AQUEOUS TAXANE FORMULATIONS AND METHODS OF USING THE SAME 审中-公开

    公开(公告)号：US20160206560A1

    公开(公告)日：2016-07-21

    申请号：US15066087

    申请日：2016-03-10

    申请人： Teikoku Pharma USA, Inc.

    发明人： Kiichiro Nabeta

    IPC分类号： A61K9/10 ,  A61K47/12 ,  A61K47/26 ,  A61K47/10 ,  A61K31/337 ,  A61K47/44

    CPC分类号： A61K9/10 ,  A61K31/337 ,  A61K47/10 ,  A61K47/12 ,  A61K47/14 ,  A61K47/26 ,  A61K47/44

    摘要： Non-aqueous, ethanol-free taxane formulations are provided. Formulations of embodiments of the invention include a taxane, an oil, a non-ionic surfactant, a non-aqueous solvent, and an organic acid component, wherein the organic acid component is soluble in the non-aqueous solvent and the amount by weight of non-ionic surfactant is equal to or greater than the amount by weight of non-aqueous solvent. Also provided are methods of using the formulations, as well as kits that include the formulations. Non-aqueous, ethanol-free docetaxel formulations are provided. Formulations of embodiments of the invention include docetaxel, an oil, a non-ionic surfactant, a non-aqueous solvent, and an organic acid which is soluble in the non-aqueous solvent and is substantially free of any conjugate base. Also provided are methods of using the formulations, as well as kits that include the formulations.

    Ibuprofen Solid Oral Dosage Composition Comprising a Methacrylic Acid Copolymer
    56.
    发明申请
    Ibuprofen Solid Oral Dosage Composition Comprising a Methacrylic Acid Copolymer 审中-公开
    布洛芬固体口服组合物，包含甲基丙烯酸共聚物

    公开(公告)号：US20130261188A1

    公开(公告)日：2013-10-03

    申请号：US13836661

    申请日：2013-03-15

    申请人： TEIKOKU PHARMA USA, INC.

    发明人： TORU HIBI ,  ADITYA R. DAS

    IPC分类号： A61K9/00

    CPC分类号： A61K9/0056 ,  A61K9/1635 ,  A61K9/2077 ,  A61K31/192

    摘要： Aspects of the invention include organoleptically acceptable solid oral dosage compositions of ibuprofen. Solid oral dosage compositions according to certain embodiments include ibuprofen and a methacrylic acid copolymer in an amount sufficient to make the composition organoleptically acceptable for administering in an oral cavity of a subject to deliver ibuprofen to the subject. Methods for preparing and using solid oral dosage compositions of the invention are also described.

    摘要翻译： 本发明的方面包括布洛芬的感觉可接受的固体口服剂量组合物。 根据某些实施方案的固体口服剂量组合物包括布洛芬和甲基丙烯酸共聚物，其量足以使组合物感觉上可接受，以在受试者口腔内施用以将布洛芬递送至受试者。 还描述了制备和使用本发明的固体口服剂量组合物的方法。

    Transdermal Systems for the Delivery of Therapeutic Agents Including Granisetron Using Iontophoresis
    57.
    发明申请
    Transdermal Systems for the Delivery of Therapeutic Agents Including Granisetron Using Iontophoresis 有权
    用于使用离子电渗法包括格拉司琼的治疗剂递送的透皮系统

    公开(公告)号：US20130245537A1

    公开(公告)日：2013-09-19

    申请号：US13893039

    申请日：2013-05-13

    申请人： Teikoku Pharma USA, Inc.

    发明人： Carter R. Anderson ,  Walter L. Sembrowich ,  Russell L. Morris ,  Robert Cohen

    IPC分类号： A61N1/30

    CPC分类号： A61N1/30 ,  A61M2037/0007 ,  A61N1/0428 ,  A61N1/044

    摘要： A disposable skin-worn device for the transdermal delivery at least one dose of charged therapeutic substances, including granisetron, by iontophoresis, the device comprising a donor reservoir containing an amount of a therapeutic substance to be delivered transdermally by iontophoresis, a counter reservoir, a source of electric power connected in a circuit between the donor reservoir and the counter reservoir and a control system for controlling current flow in the circuit to enable at least one dose of the therapeutic substance to be delivered transdermally by iontophoresis and wherein the control system includes a control element selected from the group consisting of a sensor activated by an external signal and a switch.

    摘要翻译： 一种一次性皮肤佩戴的装置，用于透皮输送至少一个剂量的带电治疗物质，包括格拉司琼，通过离子电渗疗法，该装置包括供体储存器，该供体储存器含有通过离子电渗法透皮递送的治疗物质的量， 供电源连接在供体储存器和反向储存器之间的电路中，以及控制系统，用于控制电路中的电流流动，以使得至少一个剂量的治疗物质能够通过离子电渗疗法经皮递送，并且其中控制系统包括 从由外部信号激活的传感器和开关组成的组中选择的控制元件。

    Topical patch for pain relief using cooling agent
    60.
    发明授权
    Topical patch for pain relief using cooling agent 有权
    使用冷却剂缓解疼痛的局部贴片

    公开(公告)号：US08475836B2

    公开(公告)日：2013-07-02

    申请号：US13312744

    申请日：2011-12-06

    申请人： Jutaro Shudo

    发明人： Jutaro Shudo

    IPC分类号： A61F13/02 ,  A61F13/00 ,  A61L15/16 ,  A61K9/70

    CPC分类号： A61K31/16 ,  A61F7/10 ,  A61F7/106 ,  A61F2007/0001 ,  A61F2007/0098 ,  A61F2013/0296 ,  A61K9/7023 ,  A61K9/7061 ,  A61L15/20 ,  A61L15/44 ,  A61L2300/204 ,  A61L2300/40

    摘要： Topical patch preparations that contain an odorless physiological cooling agent, and methods for using the same are provided. The subject topical patch preparations are made up of an adhesive gel composition that is present on a support, where the adhesive gel composition includes the odorless physiological cooling agent, a water-soluble polymer gel, water and a water holding agent. In using the subject topical patch preparations, the topical patch preparations are applied to a skin surface of a subject and maintained at the site of application for a period of time sufficient for an effective amount of the an odorless physiological cooling agent to be administered to the subject. The subject invention finds use in a variety of applications.

    摘要翻译： 提供含有无味生理凉爽剂的局部贴剂制剂及其使用方法。 本发明的局部贴剂制剂由存在于载体上的粘合凝胶组合物组成，其中粘合凝胶组合物包含无味生理冷却剂，水溶性聚合物凝胶，水和保水剂。 在使用本发明的局部贴剂制剂时，将局部贴剂制剂施用于受试者的皮肤表面并保持在施用部位足以使有效量的无味生理冷却剂施用于 学科。 本发明可用于各种应用。