公开(公告)号：US07030148B2

公开(公告)日：2006-04-18

申请号：US10032392

申请日：2001-12-21

申请人： Selvakumar Natesan ,  Jagattaran Das ,  Javed Iqbal ,  Sitaram Kumar Magadi ,  Srinivasa Rao Naga Venkata Mamidi ,  Rajagopalan Ramanujam ,  Baskaran Sundarababu ,  Braj Bhushan Lohray

发明人： Selvakumar Natesan ,  Jagattaran Das ,  Javed Iqbal ,  Sitaram Kumar Magadi ,  Srinivasa Rao Naga Venkata Mamidi ,  Rajagopalan Ramanujam ,  Baskaran Sundarababu ,  Braj Bhushan Lohray

IPC分类号： A61K31/421 ,  C07D263/04

CPC分类号： C07D263/20 ,  C07D263/22 ,  C07D263/24 ,  C07D413/10 ,  C07D413/14 ,  C07D417/10

摘要： The present invention relates to novel oxazolidinone compounds of the general formula (I) where R1, R2, R3, Y1, Y2, Y3, and Z are as defined in the description; their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutical acceptable salts, their pharmaceutically acceptable solvates and pharmaceutical compositions containing them.

摘要翻译： 本发明涉及通式（I）的新的恶唑烷酮化合物，其中R 1，R 2，R 3，Y 3， 1，Y 2，Y 3，Z如说明书中所定义; 它们的衍生物，它们的类似物，它们的互变异构形式，它们的立体异构体，它们的多晶型物，它们的药学上可接受的盐，它们的药学上可接受的溶剂合物和含有它们的药物组合物。

公开(公告)号：US06635763B2

公开(公告)日：2003-10-21

申请号：US10054101

申请日：2001-10-22

申请人： Bipin Pandey ,  Vidya Bhushan Lohray ,  Braj Bhushan Lohray

发明人： Bipin Pandey ,  Vidya Bhushan Lohray ,  Braj Bhushan Lohray

IPC分类号： C07D4704

CPC分类号： C07D495/04

摘要： The present invention relates to a process for the preparation of thieno[3,2-c]pyridine derivatives having pharmacologically significant anti-aggregating and anti-thrombotic properties.

公开(公告)号：US06313113B1

公开(公告)日：2001-11-06

申请号：US08982911

申请日：1997-12-02

申请人： Vidya Bhushan Lohray ,  Braj Bhushan Lohray ,  Rao Bheema Paraselli ,  Rajagopalan Ramanujam ,  Ranjan Chakrabarti

发明人： Vidya Bhushan Lohray ,  Braj Bhushan Lohray ,  Rao Bheema Paraselli ,  Rajagopalan Ramanujam ,  Ranjan Chakrabarti

IPC分类号： A61K31536

CPC分类号： C07D417/12 ,  C07D265/22 ,  C07D277/20 ,  C07D277/34 ,  C07D413/12

摘要： The present invention relates to novel antidiabetic compounds, their tautomeric forms, their derivatives, their analogues, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutically acceptable compositions containing them. This invention particularly relates to novel azolidinediones of the general formula (I), their analogues, their derivatives, their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, pharmaceutically acceptable solvates and pharmaceutical compositions containing them

摘要翻译： 本发明涉及新型抗糖尿病化合物，其互变异构形式，其衍生物，其类似物，其立体异构体，其多晶型物，其药学上可接受的盐，其药学上可接受的溶剂化物和含有它们的药学上可接受的组合物。 本发明特别涉及通式（I）的新型唑烷二酮类，其类似物，其衍生物，其互变异构形式，其立体异构体，其多晶型物，其药学上可接受的盐，药学上可接受的溶剂合物和含有它们的药物组合物

公开(公告)号：US6159966A

公开(公告)日：2000-12-12

申请号：US134348

申请日：1998-08-14

申请人： Braj Bhushan Lohray ,  Vidya Bhushan Lohray ,  Ashok Chennaveerappa Bajji ,  Shivaramayya Kalchar ,  Sekar Reddy Alla ,  Rajagopalan Ramanujam ,  Reeba Kannimel Vikramadithyan

发明人： Braj Bhushan Lohray ,  Vidya Bhushan Lohray ,  Ashok Chennaveerappa Bajji ,  Shivaramayya Kalchar ,  Sekar Reddy Alla ,  Rajagopalan Ramanujam ,  Reeba Kannimel Vikramadithyan

IPC分类号： C07D413/12 ,  C07D417/12 ,  C07D417/14 ,  A61K31/535 ,  A61K31/54 ,  C07D265/36 ,  C07D279/16

CPC分类号： C07D413/12 ,  C07D417/12 ,  C07D417/14

摘要： A compound of formula (I) ##STR1## its tautomeric forms, its stereoisomers, its polymorphs, its pharmaceutically acceptable salts or its pharmaceutically acceptable solvates, wherein R.sup.3, R.sup.4, R.sup.5, and R.sup.6 are the same or different; R.sup.1 and R.sup.2 together represent along with carbon atoms to which they are attached an aromatic cyclic structure containing 5-6 ring atoms which may optionally be substituted; X represents a heteroatom selected from oxygen or sulfur; R.sup.7 represents hydrogen atom, hydroxy, alkoxy, halogen, lower alkyl group or optionally substituted aralkyl group or forms a bond together with R.sup.8 ; R.sup.8 represents hydrogen atom, hydroxy, alkoxy, halogen, lower alkyl group or optionally substituted aralkyl or R.sup.8 forms a bond together with R.sup.7 ; B represents an oxygen atom or a sulfur atom; Y represents an oxygen atom or a sulfur atom, n is an integer ranging from 1 to 4 and m is an integer of zero or one, compositions containing compounds of formula (I) and methods of use of the compounds are described.

摘要翻译： 式（I）化合物其互变异构形式，其立体异构体，其多晶型物，其药学上可接受的盐或其药学上可接受的溶剂合物，其中R 3，R 4，R 5和R 6相同或不同; R1和R2一起表示与它们所连接的碳原子一起含有5-6个可以被取代的环原子的芳环结构; X表示选自氧或硫的杂原子; R 7表示氢原子，羟基，烷氧基，卤素，低级烷基或任意取代的芳烷基，或与R 8一起形成键; R8代表氢原子，羟基，烷氧基，卤素，低级烷基或任选取代的芳烷基或R8与R7一起形成一个键; B表示氧原子或硫原子; Y表示氧原子或硫原子，n表示1〜4的整数，m表示0以下的整数，或者1表示含有式（I）的化合物的组合物和使用该化合物的方法。

公开(公告)号：US6054453A

公开(公告)日：2000-04-25

申请号：US12585

申请日：1998-01-23

申请人： Braj Bhushan Lohray ,  Vidya Bhushan Lohray ,  Ashok Channaveerappa Bajji ,  Shivaramayya Kalchar ,  Rajagopalan Ramanujam ,  Ranjan Chakrabarti

发明人： Braj Bhushan Lohray ,  Vidya Bhushan Lohray ,  Ashok Channaveerappa Bajji ,  Shivaramayya Kalchar ,  Rajagopalan Ramanujam ,  Ranjan Chakrabarti

IPC分类号： C07D279/22 ,  A61K20060101 ,  A61K31/535 ,  A61K31/538 ,  A61K31/54 ,  A61K31/5415 ,  A61P3/04 ,  A61P3/06 ,  A61P3/08 ,  A61P3/10 ,  A61P5/00 ,  A61P9/10 ,  A61P13/12 ,  A61P17/06 ,  A61P19/10 ,  A61P43/00 ,  C07C20060101 ,  C07C51/353 ,  C07C59/64 ,  C07C67/343 ,  C07C69/734 ,  C07D20060101 ,  C07D265/28 ,  C07D265/38 ,  C07D279/26 ,  C07D307/81 ,  C07D413/06 ,  C07D417/06

CPC分类号： C07C59/64 ,  C07C69/734 ,  C07D265/28 ,  C07D265/38 ,  C07D279/22 ,  C07D279/24 ,  C07D279/26 ,  C07D413/06 ,  C07D417/06

摘要： Novel .beta.-aryl-.alpha.-oxysubstituted alkylcarboxylic acids of the formula (I) and compositions containing them. ##STR1## The compounds have hypolipidemic, antihyperglycemic uses.

摘要翻译： 式（I）的新型β-芳基-α-氧代烷基羧酸和含有它们的组合物。 这些化合物具有降血脂，抗高血糖的作用。

公开(公告)号：US6011036A

公开(公告)日：2000-01-04

申请号：US982962

申请日：1997-12-02

申请人： Vidya Bhushan Lohray ,  Braj Bhushan Lohray ,  Ranga Madhavan Gurram ,  Rajagopalan Ramanujam ,  Ranjan Chakrabarti

发明人： Vidya Bhushan Lohray ,  Braj Bhushan Lohray ,  Ranga Madhavan Gurram ,  Rajagopalan Ramanujam ,  Ranjan Chakrabarti

IPC分类号： C07D265/22 ,  C07D277/20 ,  C07D277/34 ,  C07D413/12 ,  C07D417/12 ,  A61K31/50 ,  A61K31/535 ,  C07D237/30 ,  C07D265/02

CPC分类号： C07D417/12 ,  C07D265/22 ,  C07D277/20 ,  C07D277/34 ,  C07D413/12

摘要： The present invention relates to novel antidiabetic compounds, their tautomeric forms, their analogues, their derivatives, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutically acceptable compositions containing them. This invention particularly relates to novel azolidinedione compounds of the general formula (I), and their analogues, their derivatives, their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, pharmaceutically acceptable solvates and pharmaceutical compositions containing them. ##STR1##

摘要翻译： 本发明涉及新型抗糖尿病化合物，其互变异构形式，其类似物，其衍生物，其立体异构体，其多晶型物，其药学上可接受的盐，其药学上可接受的溶剂化物和含有它们的药学上可接受的组合物。 本发明特别涉及通式（I）的新的唑烷二酮化合物及其类似物，其衍生物，其互变异构形式，其立体异构体，其多晶型物，其药学上可接受的盐，药学上可接受的溶剂化物和含有它们的药物组合物。

公开(公告)号：US08841413B2

公开(公告)日：2014-09-23

申请号：US12311448

申请日：2007-09-28

申请人： Rajesh H. Bahekar ,  Braj Bhushan Lohray ,  Vidya Bhushan Lohray ,  Mukul R. Jain ,  Kaushik M. Banerjee ,  Pankaj Ramanbhai Patel

发明人： Rajesh H. Bahekar ,  Braj Bhushan Lohray ,  Vidya Bhushan Lohray ,  Mukul R. Jain ,  Kaushik M. Banerjee ,  Pankaj Ramanbhai Patel

IPC分类号： C07K7/08 ,  C07K7/06 ,  C07K14/605

CPC分类号： C07K7/08 ,  C07K7/06 ,  C07K14/605

摘要： The present invention provides novel peptidomimetics, of formula (I), which primarily act as glucose dependent insulin secretagogues. Furthermore, it was found that these peptidomimetics showed glucagon receptor antagonistic activity, along with the GLP-1 receptor agonistic activity. A-Z1—Z2—Z3—Z4—Z5—Z6—Z7—Z8—Z9—Z10—Z11—B  (I)

摘要翻译： 本发明提供式（I）的新型肽模拟物，其主要作为葡萄糖依赖性胰岛素促分泌剂。 此外，发现这些肽模拟物显示胰高血糖素受体拮抗活性，以及​​GLP-1受体激动活性。 A-Z1-Z2-Z3-Z4-Z5-Z6-Z7-Z8-Z9-Z10-Z11-B（I）

公开(公告)号：US08420851B2

公开(公告)日：2013-04-16

申请号：US12446820

申请日：2007-10-15

申请人： Saurin Raval ,  Preeti Raval ,  Braj Bhushan Lohray ,  Vidya Bhushan Lohray ,  Pankaj R. Patel

发明人： Saurin Raval ,  Preeti Raval ,  Braj Bhushan Lohray ,  Vidya Bhushan Lohray ,  Pankaj R. Patel

IPC分类号： C07C229/00 ,  A61K9/00 ,  A01N25/08

CPC分类号： C07C271/28 ,  C07C229/18 ,  C07C229/24 ,  C07C235/46 ,  C07C235/54 ,  C07C311/16 ,  C07C311/20 ,  C07C2601/04 ,  C07C2601/14 ,  C07C2602/42 ,  C07D295/192 ,  C07D295/26 ,  C07D333/28

摘要： The present invention relates to novel compounds of general formula (I) which are thyroid receptor ligands and are preferably selective for the thyroid hormone receptor beta (TR-Beta). Further, the present invention relates to processes of preparing such compounds, their tautomeric forms, novel intermediates involved in their synthesis, their pharmaceutically acceptable salts, methods for using such compounds and pharmaceutical compositions containing them.

摘要翻译： 本发明涉及作为甲状腺受体配体并且优选甲状腺激素受体β（TR-β）选择性的通式（I）的新型化合物。 此外，本发明涉及制备这些化合物的方法，它们的互变异构形式，涉及其合成的新中间体，其药学上可接受的盐，使用这些化合物的方法和含有它们的药物组合物。

公开(公告)号：US08268867B2

公开(公告)日：2012-09-18

申请号：US12279407

申请日：2007-02-19

申请人： Harikishore Pingali ,  Pankaj Maganlal Makadia ,  Braj Bhushan Lohray ,  Vidya Bhushan Lohray ,  Pankaj Ramanbhai Patel

发明人： Harikishore Pingali ,  Pankaj Maganlal Makadia ,  Braj Bhushan Lohray ,  Vidya Bhushan Lohray ,  Pankaj Ramanbhai Patel

IPC分类号： A61K31/4433 ,  C07D405/12

CPC分类号： C07D319/06

摘要： The present invention relates to novel 1,3-dioxane carboxylic acids of the general formula (I), their tautomeric forms, their stereoisomers, their pharmaceutically acceptable salts, pharmaceutical compositions containing them, methods for their preparation, use of these compounds in medicine and the intermediates involved in their preparation.

摘要翻译： 本发明涉及通式（I）的新型1,3-二恶烷羧酸，其互变异构形式，其立体异构体，其药学上可接受的盐，含有它们的药物组合物，其制备方法，这些化合物在医药中的用途以及 中间体参与其制备。

公开(公告)号：US08212057B2

公开(公告)日：2012-07-03

申请号：US10592880

申请日：2002-07-25

申请人： Braj Bhushan Lohray ,  Vidya Bhushan Lohray ,  Vijay Kumar Barot ,  Saurin Khimshankar Raval ,  Preeti Saurin Raval ,  Sujay Basu

发明人： Braj Bhushan Lohray ,  Vidya Bhushan Lohray ,  Vijay Kumar Barot ,  Saurin Khimshankar Raval ,  Preeti Saurin Raval ,  Sujay Basu

IPC分类号： C07D207/30 ,  A61K31/40

CPC分类号： C07D207/325 ,  C07D207/33 ,  C07D207/333 ,  C07D207/335 ,  C07D207/36 ,  C07D207/48 ,  C07D401/04 ,  C07D405/04 ,  C07D409/04 ,  G06F3/14 ,  G06F3/1438 ,  G09G5/363 ,  G09G2360/122

摘要： The present invention relates to novel substituted pyrrole compounds, their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutically acceptable compositions containing them. This invention particularly relates to novel substituted pyrrole compounds of the general formula (I), their analogs, their derivatives, their polymorphs, their tautomeric forms, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and their pharmaceutical compositions containing them. The invention also relates to the process for preparing such compounds, a composition containing such a compound and the use of such a compound and composition in medicine. The compounds lower triglyceride levels in blood and may be useful in the treatment of obesity, hyperlipidaemia, hypercholesteremia, syndrome X and diabetes.

摘要翻译： 本发明涉及新的取代吡咯化合物，其衍生物，其类似物，其互变异构形式，其立体异构体，其多晶型物，其药学上可接受的盐，其药学上可接受的溶剂化物和含有它们的药学上可接受的组合物。 本发明特别涉及通式（I）的新型取代吡咯化合物，其类似物，其衍生物，其多晶型物，其互变异构形式，其药学上可接受的盐，其药学上可接受的溶剂合物及其含有它们的药物组合物。 本发明还涉及制备这种化合物的方法，含有这种化合物的组合物以及这种化合物和组合物在医药中的用途。 该化合物降低血液中的甘油三酯水平，并且可用于治疗肥胖，高脂血症，高胆固醇血症，综合征X和糖尿病。