公开(公告)号：US11339199B2

公开(公告)日：2022-05-24

申请号：US16458740

申请日：2019-07-01

Applicant: TRUSTEES OF DARTMOUTH COLLEGE

Inventor： Tong Zhang ,  Charles L. Sentman

IPC: A61K35/17 ,  C07K14/705 ,  A61K38/10 ,  C07K14/715 ,  A61K45/06

Abstract: The present invention relates to chimeric immune receptor molecules for reducing or eliminating tumors. The chimeric receptors are composed a C-type lectin-like natural killer cell receptor, or a protein associated therewith, fused to an immune signaling receptor containing an immunoreceptor tyrosine-based activation motif. Methods for using the chimeric receptors are further provided.

公开(公告)号：US20220151509A1

公开(公告)日：2022-05-19

申请号：US17532983

申请日：2021-11-22

Applicant: THE TRUSTEES OF DARTMOUTH COLLEGE

Inventor： Kofi ODAME ,  Justice AMOH

IPC: A61B5/08 ,  G06F16/22 ,  A61B5/00 ,  G16H20/10 ,  G16H40/67 ,  G16H10/60 ,  A61B7/00

Abstract: A system adapted to assisting patients manage asthma includes a wearable sensor for detection of asthma symptoms and inhaler use, having a microphone capable of generating an electrical signal indicative of asthma symptoms or inhaler use; a processor with firmware adapted to process the electrical signal to determine potential asthma symptoms and inhaler use; and store the electrical signal in the memory when the electrical signal potentially corresponds asthma symptoms or inhaler use. In particular embodiments, the system includes an electronic asthma diary including detected asthma symptoms and detected inhaler usage, both with timestamps, and a prescribed treatment protocol. Protocol firmware processes detected asthma symptoms an inhaler usage recorded in the asthma diary to determine if asthma is controlled, and if asthma is not determined controlled determines if a treatment change is authorized; if treatment change is authorized the treatment change is displayed in human-readable form.

公开(公告)号：US11324518B2

公开(公告)日：2022-05-10

申请号：US16658592

申请日：2019-10-21

Applicant: THE TRUSTEES OF DARTMOUTH COLLEGE

Inventor： Douglas W. Van Citters ,  Bridget E. Shaia ,  Spencer H. Amundsen ,  James A. Yang

IPC: A61B17/16 ,  A61B17/17 ,  A61F2/38 ,  A61F2/46 ,  A61B34/30 ,  A61B17/20 ,  A61F2/30

Abstract: A method of attaching prosthetic implants to bone, applicable to tibia, patella, acetabulum, glenoid, or femur, includes trimming an articular surface of the bone, leaving a trimmed surface. Holes are punched or drilled into the surface in a predetermined array before polymethyl methacrylate bone cement is used to attach the surface to the implant. In an embodiment, the holes are punched by placing a punch-plate with sharpened punch spikes on the surface, and striking the punch plate to drive punches into the trimmed surface. In another embodiment, holes are drilled using a drilling template with predrilled guidance holes placed on the surface of the bone. In another embodiment, holes are drilled by positioning a robotic drill over the trimmed surface; adjusting a drilling pattern of the robotic drill according to the trimmed surface; and using the robotic drill to drill holes of predetermined depth according to the drilling pattern.

公开(公告)号：US11301605B2

公开(公告)日：2022-04-12

申请号：US17072763

申请日：2020-10-16

Applicant: Trustees of Dartmouth College

Inventor： Te-Yen Wu ,  Jun Gong ,  Alemayehu Seyed ,  Xing-Dong Yang

IPC: G06F30/30 ,  G06F30/367 ,  G06F30/3308 ,  G06F30/31 ,  G06F115/12

Abstract: A disclosed circuit prototyping system includes a hardware interface module configured for electronically connecting to a physical electronic device, a virtual circuit design interface to construct a virtual circuit for a plurality of virtual circuit devices including a virtual counterpart of the physical electronic device, and a circuit simulator configured to simulate the virtual circuit including communicating data with the physical electronic device by way of communication with the hardware interface module.

公开(公告)号：US11279677B2

公开(公告)日：2022-03-22

申请号：US16401942

申请日：2019-05-02

Applicant: THE TRUSTEES OF DARTMOUTH COLLEGE

Inventor： Ivan Abrahamian ,  Hai Qian ,  Susnata Pramanik ,  Baihao Shao ,  Quan Li

IPC: C07D215/00 ,  C07D243/00 ,  C07D251/00 ,  C07D273/00 ,  C07D215/40 ,  B01J19/12 ,  C07C243/22 ,  C07D273/08 ,  C07D333/24 ,  C07D333/36 ,  C07D401/12 ,  C09K9/02 ,  G11C13/04 ,  C09K11/06 ,  C07C251/86 ,  C07C251/82 ,  C07C251/00 ,  B82Y10/00

Abstract: Provided herein are compounds for use as photochromic molecular switches having very long thermal isomerization half-lives and switchable fluorescence properties both in solution and the solid state.

公开(公告)号：US11248039B2

公开(公告)日：2022-02-15

申请号：US16566542

申请日：2019-09-10

Applicant: VIB VZW ,  UNIVERSITEIT GENT ,  THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES ,  TRUSTEES OF DARTMOUTH COLLEGE

Inventor： Xavier Saelens ,  Bert Schepens ,  Iebe Rossey ,  Barney Graham ,  Jason McLellan ,  Morgan Gilman

IPC: C07K16/10 ,  A61P31/14 ,  A61K39/12 ,  A61K39/00

Abstract: The present invention relates to immunoglobulin single variable domains (ISVDs) that are directed against respiratory syncytial virus (RSV). More specifically, it relates to ISVDs that bind to the prefusion form of the fusion (F) protein of RSV. The invention relates further to the use of these ISVDs for prevention and/or treatment of RSV infections, and to pharmaceutical compositions comprising these ISVDs.

公开(公告)号：US20220025001A1

公开(公告)日：2022-01-27

申请号：US16096562

申请日：2017-04-28

Applicant: THE TRUSTEES OF DARTMOUTH COLLEGE

Inventor： Charles L. Sentman ,  Albert Gacerez

IPC: C07K14/47 ,  C07K14/725 ,  C07K14/705 ,  C07K16/28 ,  A61K35/17 ,  C12N15/86 ,  A61P35/00

Abstract: Nucleic acid constructs, vectors, and recombinant cells harboring the nucleic acid constructs or vectors are disclosed. The nucleic acid constructs include genes encoding a chimeric antigen receptor (CAR) and/or one or more transcription factors, optionally mutated. The transcription factors include those that mediate proinflammatory cytokine expression, e.g., T-bet, STAT1, or STAT4. Methods are disclosed of co-expression of the CAR and the transcription factor in a human or non-human immune cell, preferably human T cells. Also disclosed are methods for using these cells for immunotherapy, e.g., in treating cancer, infection, autoimmunity, allergy or inflammation diseases by the administration of a prophylactically or therapeutically effective amount of one or more of the nucleic acid constructs, vectors, and/or immune cells, e.g., human CAR-T cells, described herein.

公开(公告)号：US11209376B2

公开(公告)日：2021-12-28

申请号：US14407860

申请日：2013-06-13

Applicant: The Trustees of Dartmouth College

Inventor： Joseph J. Belbruno ,  Susanne E. Tanski

IPC: G01N27/12 ,  G01N33/00

Abstract: A device for detecting airborne contaminants includes a protonated, electrically conductive sensing material with affinity for binding with, and capable of being deprotonated by, the airborne contaminant. Electronics measure a property of the sensing material that is sensitive to deprotonation and generates signals indicative of the airborne contaminant. A method for detecting airborne contaminants includes: determining a property change of the protonated, electrically conductive material; and determining presence of the airborne contaminant based on the change. A system for detecting airborne contaminants includes: a data center in remote communication with multiple sensing devices each having: protonated, electrically conductive sensing material with affinity for binding with, and capable of being depronated by, an airborne contaminant, and electronics for relaying signals indicative of a sensing material deprotonation property to the data center; and wherein a user associated with a sensing device is notified of an abnormal level of the airborne contaminant.

公开(公告)号：US11208454B2

公开(公告)日：2021-12-28

申请号：US16415309

申请日：2019-05-17

Applicant: TRUSTEES OF DARTMOUTH COLLEGE

Inventor： Tong Zhang ,  Charles L. Sentman

IPC: C07K14/47 ,  C07K14/705 ,  A61K38/10 ,  C07K14/715 ,  A61K35/17 ,  A61K45/06

Abstract: The present invention relates to chimeric immune receptor molecules for reducing or eliminating tumors. The chimeric receptors are composed a C-type lectin-like natural killer cell receptor, or a protein associated therewith, fused to an immune signaling receptor containing an immunoreceptor tyrosine-based activation motif. Methods for using the chimeric receptors are further provided.

公开(公告)号：US20210323998A1

公开(公告)日：2021-10-21

申请号：US17272091

申请日：2019-09-05

Applicant: Trustees of Dartmouth College

Inventor： Glenn C. Micalizio ,  Arti B. Gaur

IPC: C07J75/00 ,  C07J1/00 ,  C07J7/00

Abstract: The present disclosure relates to stereodefined polycyclic (e.g., tetracyclic) compounds that contain quaternary centers at one or multiple ring fusions, synthetic methods for preparing such compounds, and methods of using such compounds to treat a disease, such as a brain tumor and, particularly, a glioma.